Looking for peer reviewed studies about vitamins and Thyroid

[PandoraXX]

There's a lot of talk on this forum about the importance of Vitamin B, Ferritin, Selenium and others in combating thyroid disease. Before I ask my Endo to test for the levels of vitamins in my blood, I'd like to be able to substantiate these claims with some research. He typically tests for TSH, T3, T4, Vitamin D, Calcium, Potassium and a lot of other things - the significance of which, I do not know. A cursory google search yielded a website of a "doctor" who talked of the important link between Vitamin B and T4, T3 conversion. But he has dubious credential (a chiropractor who sells products and consultations). I'd really like to see some solid studies. I'm not saying that if there haven't been studies - that there's no link - but telling my doctor I read about it on a forum is not very compelling.

[PandoraXX]

Not sure how or if there's a way to edit a post. Just an FYI - my problem lately is T4, T3 conversion.

[greygoose in reply to PandoraXX]

To edit a post, click on 'More' just underneath your post. Then on edit.

[PandoraXX in reply to greygoose]

Thanks!

[helvella Administrator Thyroid UK]

PubMed is where you can find almost everything!

pubmed.ncbi.nlm.nih.gov/

The search mechanism is pretty powerful but can take a while to understand.

[Anthea55]

To edit a post you have written, click on 'More ' on the same line as 'Reply' and you will get options to Edit or Delete or Copy reply link (not sure what that does!).

[helvella Administrator Thyroid UK in reply to Anthea55]

Copy reply link allows you to get a link (URL) which goes to the precise reply - not just to the thread you are on, or the link you used to get there.

Very helpful when you want to direct someone to a specific reply on a very long thread.

Such as:

healthunlocked.com/thyroidu...

Where it has added ?responses=148077131 to the basic link to the post - and that identifies your reply. (I know you won't see this extra bit in blue in this reply. But when you click on it, or hover over it, you should see.)

[Anthea55 in reply to helvella]

Thanks Helvella, that makes sense.

[PandoraXX in reply to helvella]

Thank you!

[humanbean]

All the following links were found on Google Scholar :

Link : scholar.google.co.uk/schhp?...

.

Title : Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis

Link : liebertpub.com/doi/abs/10.1...

.

Title : The Serological Basis of the Correlation between Iron Deficiency Anemia and Thyroid Disorders in Women: A Community Based Study

Link : researchgate.net/profile/At...

.

Title : SUN-591 Severe Iron-Deficiency Anemia Leading to Hypothyroidism

Link : academic.oup.com/jes/articl...

.

Title : SAT-487 Untreated Primary Hypothyroidism Presenting as Pica with Concurrent Hyponatremia and Rhabdomyolysis

Link : academic.oup.com/jes/articl...

.

Title : Vitamin D and Hashimoto's disease

Link : europepmc.org/article/med/3...

.

Title : Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Link : karger.com/Article/Pdf/505094

.

Title : Association of Vitamin B12, Folate and Ferritin with Thyroid Hormones in Hypothyroidism

Link : researchgate.net/profile/An...

.

Title : Study of Trace Elements in Patients of Hypothyroidism with Special Reference to Zinc and Copper

Link : researchgate.net/profile/Ro...

.

Title : Effect of nutrients and dietary substances on thyroid function and hypothyroidism.

Link : thefreelibrary.com/Effect+o...

.

Title : AN OVERVIEW OF COPPER TOXICITY RELEVANCE TO PUBLIC HEALTH

Link : researchgate.net/profile/Ja...

.

Title : Selected Essential and Toxic Chemical Elements in Hypothyroidism—A Literature Review (2001–2021)

Link : mdpi-res.com/d_attachment/i...

[Marymary7 in reply to humanbean]

Great research, thanks. 😎

[PandoraXX in reply to humanbean]

Wow - thanks for doing all this! I haven't dug in yet - but most most of these articles are about Thyroid disorders such as Hashimoto's (ie. people who still have a thyroid). I wonder if the same things apply just to someone taking thyroid replacement after thyroidectomy.

[humanbean in reply to PandoraXX]

I think they probably would be relevant. Having too little thyroid hormone for any reason is likely to affect nutrients.

[PandoraXX in reply to humanbean]

I think you're probably right.

[humanbean in reply to PandoraXX]

I should point out that I'm not making any promises about the quality of these papers... But hopefully at least some of them will be useful.

[Litatamon in reply to humanbean]

Thank you so much for putting all those together. Much appreciated humanbean.

[humanbean in reply to Litatamon]

You're welcome.

[SlowDragon Administrator]

important when you test TSH ....

researchgate.net/publicatio...

“According to the current TSH reference interval, hypothyroidism was not diagnosed in about 50% of the cases in the afternoon.”

“Further analysis demonstrated inadequate compensation of hypothyroidism, which was defined in 45.5% of the morning samples and in 9% of the afternoon samples”

If delaying taking levothyroxine until after blood test, you likely want to not eat or drink anything apart from water before taking levothyroxine

It may (or may not) make a difference to TSH if fasting ….opinions differ

ncbi.nlm.nih.gov/labs/pmc/a...

ncbi.nlm.nih.gov/pubmed/252...

Iron, ferritin and thyroid

An article that explains why Low ferritin and low thyroid levels are often linked

preventmiscarriage.com/iron...

irondisorders.org/too-littl...

davidg170.sg-host.com/wp-co...

Great in-depth article on low ferritin

oatext.com/iron-deficiency-...

drhedberg.com/ferritin-hypo...

This is interesting because I have noticed that many patients with Hashimoto’s disease and hypothyroidism, start to feel worse when their ferritin drops below 80 and usually there is hair loss when it drops below 50.

Thyroid disease is as much about optimising vitamins as thyroid hormones

healthunlocked.com/thyroidu...

restartmed.com/hypothyroidi...

Post discussing just how long it can take to raise low ferritin

healthunlocked.com/thyroidu...

Never supplement iron without doing full iron panel test for anaemia first and retest 3-4 times a year if self supplementing. It’s possible to have low ferritin but high iron

Iron and thyroid link

healthunlocked.com/thyroidu...

Posts discussing why important to do full iron panel test

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

Chicken livers if iron is good, but ferritin low

healthunlocked.com/thyroidu...

[PandoraXX in reply to SlowDragon]

Thanks for this very thorough reply! I will print some of these articles out and arm myself with them when I talk to my endo on my next visit. I have to say, it is odd that I feel perfectly fine with high TSH. Had it not been for the tests, I'd have no idea there was anything wrong.