Could anyone enlighten me on these results. I had a full blood test but no T3 although it was asked for..., everything looks normal but not sure about these. Have an appt on Thursday to go through it with the Dr.
Cal1961, TPOab 40 means you are negative for autoimmune thyroid disease as a cause of hypothyroidism. It might be worth having it retested in 12 months.
Have you made an error with FT4 range? It is usually expressed (12-22) although the values may be different.. TSH 0.1 is low but doesn't mean you are overmedicated unless FT4 is considerably over range. FT4 18.1 is good, almost in the top quadrant, if the range is 12-22.
PAS say B12 is optimal 1,000. If you are supplementing excess will be excreted in urine.
High creatinine can mean kidneys aren't working well but yours is barely over range and may be due to dehydration at the time of testing.
High MCH mirrors MCV:
Indicates RBCs are larger than normal (macrocytic), for example in anemia caused by vitamin B12 or folate deficiency, myelodysplasia, liver disease, hypothyroidism
Cal1971, you should resist any attempt to decrease dose to raise TSH as your FT4 is only just over half way through range. You aren't overmedicated just because TSH is low.
Thanks for your reply- I have an appointment on Thursday, will request a T3 test again, and maybe on this basis (FT4 only being halfway through the range) ask to increase my levo then? I am currently on 125mg with twice a week 150... I want to go up to 150mg daily I think?
As Clutter has already indicated, MCH is elevated in B12def. and your symptoms suggest this might be so, especially as autoimmune thyroid disease and PA/B12 are often interlinked. Have you been supplementing with B12? ***In any case, the serum B12 is only an indication of levels in the blood and not in the tissues, so you can still be deficient if you have a problem with absorption.
The following is a helpful link with lots of advice and information, with templates for writing to your doctor, as well as an excellent film:
Latest BMJ Research Document with summary re. tests, diagnosis and treatment:
cmim.org/pdf2014/funcion.ph...
Cmim/BMJ document. " Summary:
* Vitamin B12 deficiency is a common but serious condition
* Clinical presentation may not be obvious thus leading to complex issues around diagnosis and treatment.
* There is no ideal test to define deficiency and therefore the clinical condition of the patient is of utmost importance."
* There is evidence that new techniques, such as measurement of holotranscobalamin and methylmalonic acid levels seem useful in more accurately defining deficiency.
* If clinical features suggest deficiency, then it is important to treat patients to avoid neurological impairment even if there may be discordance between test results and clinical features.
Severe deficiency shows evidence of bone marrow suppression, clear evidence of
neurological features and risk of cardiomyopathy.
It is important to recognise that clinical features of deficiency can manifest without anaemia and ***also without low serum vitamin B12 levels. In these cases, treatment should still be given without delay."
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