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Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms- Published: 01 April 2022
This gets a little deep, but nonetheless may explain some things:
Abstract
Interferons (IFNs) are key initiators and effectors of the immune response against malignant cells and also directly inhibit tumor growth. IFNα is highly effective in the treatment of myeloproliferative neoplasms (MPNs
This gets a little deep, but nonetheless may explain some things:
Abstract
Interferons (IFNs) are key initiators and effectors of the immune response against malignant cells and also directly inhibit tumor growth. IFNα is highly effective in the treatment of myeloproliferative neoplasms (MPNs
PhysAssist
in
MPN Voice
1 year ago
Retested: low D & B12, high ferritin
I have retested with medicheck because I'm in the queue to see a private endocrinologist about my symptoms. I was hoping that treating my vitamins and minerals may give a different thyroid hormone picture. Iron 239ug/L (range 30-150) I am under haematology, treated for iron deficiency anaemia. Tested
I have retested with medicheck because I'm in the queue to see a private endocrinologist about my symptoms. I was hoping that treating my vitamins and minerals may give a different thyroid hormone picture. Iron 239ug/L (range 30-150) I am under haematology, treated for iron deficiency anaemia. Tested
Insomania
in
Thyroid UK
1 year ago
PBC and another auto immune
My doctor gave me Ursodiol 500 mg and propranolol 10 mg. If I take 500 mg it will give me watery diarrhea. When I take 250 mg it is ok for several doses. It will get to the point of not feeling well, unablre to function very well and I get very mean which isn't my personally. So, I stop taking the
My doctor gave me Ursodiol 500 mg and propranolol 10 mg. If I take 500 mg it will give me watery diarrhea. When I take 250 mg it is ok for several doses. It will get to the point of not feeling well, unablre to function very well and I get very mean which isn't my personally. So, I stop taking the
Max1942mmm
in
PBCers Organization
1 year ago
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Help with latest results and possible taking T3
Hi there These are my latest results with a private test through Monitor my health. I had recently done a GP test the week before with TSH of 1.34 Both tests in the morning around 8am No Meds. I had been trialling some extra T4 for about 8 weeks. Originally I had been on 75 for a while, over a
Hi there These are my latest results with a private test through Monitor my health. I had recently done a GP test the week before with TSH of 1.34 Both tests in the morning around 8am No Meds. I had been trialling some extra T4 for about 8 weeks. Originally I had been on 75 for a while, over a
Doubleelephant
in
Thyroid UK
1 year ago
cholesterol levels for thyroid people
Hi Peeps I was wondering if you could enlighten me a bit about cholesterol if you’re a ( treated ) hypothyroid person . I’ll give you a bit of background… I had been on plant sterols ( natural statins ) for a couple of years with no adverse effects , until June this year when I started getting
Hi Peeps I was wondering if you could enlighten me a bit about cholesterol if you’re a ( treated ) hypothyroid person . I’ll give you a bit of background… I had been on plant sterols ( natural statins ) for a couple of years with no adverse effects , until June this year when I started getting
Yellup1
in
Thyroid UK
1 year ago
Advice about plan of treatment
I am 67, was diagnosed with PMR 2 weeks ago after 4 weeks of symptoms (stiffness and pain in neck, arms, shoulders, couldn't raise arms above shoulders, immense tiredness etc). Initial GP contact was excellent - he identified the problem, blood tests same day, consult 2 days later to confirm diagnosis
I am 67, was diagnosed with PMR 2 weeks ago after 4 weeks of symptoms (stiffness and pain in neck, arms, shoulders, couldn't raise arms above shoulders, immense tiredness etc). Initial GP contact was excellent - he identified the problem, blood tests same day, consult 2 days later to confirm diagnosis
MarionA
in
PMRGCAuk
1 year ago
Random Heavy bleeding with severe pain
Hi I take Provera to manage my symptoms and things have been settled bleeding wise for a while now. this past weekend I got really heavy bleeding with pain which made me collapse and then the pain settled for a couple days and then again yesterday, I got really heavy bleeding again and such bad pain
Hi I take Provera to manage my symptoms and things have been settled bleeding wise for a while now. this past weekend I got really heavy bleeding with pain which made me collapse and then the pain settled for a couple days and then again yesterday, I got really heavy bleeding again and such bad pain
Endowarrior1807
in
Endometriosis UK
1 year ago
Barbara
I have osteoporosis and I took Fosamax for a while and then lost 6 teeth! I stopped taking it a while ago, but my back is giving me grief now. I am taking calcium and Vitamin D, but I need to find out whether there are any alternatives to alendronic acid.
I have osteoporosis and I took Fosamax for a while and then lost 6 teeth! I stopped taking it a while ago, but my back is giving me grief now. I am taking calcium and Vitamin D, but I need to find out whether there are any alternatives to alendronic acid.
babayaga
in
Bone Health and Osteoporosis UK
1 year ago
NDT has raised my thyroid anti-bodies. What's next?
Hi All, As I just made a post with my update on NDT (good T3 and T4 levels, but TSH is 0.017, so too low), I received my latest anti-bodies results. And they went up! I've heard some people shared how their anti-bodies went up as well on NDT. Yes, I'm on a gluten-free, whole food diet, been on
Hi All, As I just made a post with my update on NDT (good T3 and T4 levels, but TSH is 0.017, so too low), I received my latest anti-bodies results. And they went up! I've heard some people shared how their anti-bodies went up as well on NDT. Yes, I'm on a gluten-free, whole food diet, been on
Juliet_22
in
Thyroid UK
1 year ago
Pain Medication after Laparoscopy
Hi all, Can anyone offer advice on which medication they used after surgery for pain management? Due to my other medical issues I can’t take any NSIADS including: ibuprofen, naproxen, diclofenac, celecoxib, mefenamic acid, etoricoxib & indomethacin. I normally take just cocodamol and rest when
Hi all, Can anyone offer advice on which medication they used after surgery for pain management? Due to my other medical issues I can’t take any NSIADS including: ibuprofen, naproxen, diclofenac, celecoxib, mefenamic acid, etoricoxib & indomethacin. I normally take just cocodamol and rest when
Cats1311
in
Endometriosis UK
1 year ago
Goat whey, casein, IGF-1 etc. - Do they promote or slow cancer growth?
I've been trying for many years to decide whether to take a protein powder supplement to help maintain muscle mass. Since I started on ADT in 2016, I've lost 30 pounds. I don't know how much is due to the ADT, and how much is due to my diet. I'm 172 pounds now. I was muscular and athletic at 202,
I've been trying for many years to decide whether to take a protein powder supplement to help maintain muscle mass. Since I started on ADT in 2016, I've lost 30 pounds. I don't know how much is due to the ADT, and how much is due to my diet. I'm 172 pounds now. I was muscular and athletic at 202,
GeorgeGlass
in
Advanced Prostate Cancer
1 year ago
MCT Oil
in another thread someone posted today about MCT oil. I hadn’t heard of this and have tried to research it. It seems to be useful in a variety of situations and claims include support in weight gain, increased energy, constipation t and pain relief. Really it sounds a bit of a ‘cure all’. I’m wondering
in another thread someone posted today about MCT oil. I hadn’t heard of this and have tried to research it. It seems to be useful in a variety of situations and claims include support in weight gain, increased energy, constipation t and pain relief. Really it sounds a bit of a ‘cure all’. I’m wondering
Hidden
in
Thyroid UK
1 year ago
canceling zoledronic acid infusion because of ppi use.
hi,I think I will be canceling my zoledronic acid infusion because of increased fracture with my use of lansoprazole 30mgs and not absorbing calcium with ppi, has anyone safely had a infusion while taking ppis,
hi,I think I will be canceling my zoledronic acid infusion because of increased fracture with my use of lansoprazole 30mgs and not absorbing calcium with ppi, has anyone safely had a infusion while taking ppis,
Radars
in
Bone Health and Osteoporosis UK
1 year ago
GP has prescribed Alendronic Acid 70mg
Hi all My Dad’s GP has prescribed Alendronic Acid 70mg tablets without explaining why. My Dad is now on Adcal -D3 1x daily, 9mg Prednisolone daily and 1x weekly Alendronic Acid. Is it normal to be prescribed Alendronic Acid? Also, how far apart should this be taken from Pred? Thanks Lindsay
Hi all My Dad’s GP has prescribed Alendronic Acid 70mg tablets without explaining why. My Dad is now on Adcal -D3 1x daily, 9mg Prednisolone daily and 1x weekly Alendronic Acid. Is it normal to be prescribed Alendronic Acid? Also, how far apart should this be taken from Pred? Thanks Lindsay
Lindsayf
in
PMRGCAuk
1 year ago
Calcium supplement before zoledronic acid infusion.
Hi,I am going for a zoledronic acid infusion on the 25th, the gp prescribed adcal with lemon chewable 1500,I have a hiatus hernia so not taking them,would I be better buying some calcium citrate before my infusion
Hi,I am going for a zoledronic acid infusion on the 25th, the gp prescribed adcal with lemon chewable 1500,I have a hiatus hernia so not taking them,would I be better buying some calcium citrate before my infusion
Radars
in
Bone Health and Osteoporosis UK
1 year ago
antibiotics and osteoporosis
hi,I have just started amoxicillin for blepharitis, 3×500mg a day, I go for my blood test next week prior to starting zoledronic acid infusion, will antibiotics have any effect.
hi,I have just started amoxicillin for blepharitis, 3×500mg a day, I go for my blood test next week prior to starting zoledronic acid infusion, will antibiotics have any effect.
Radars
in
Bone Health and Osteoporosis UK
1 year ago
Safe to take Gabapentin for life?
I haven’t been able to find any reliable info on whether Gabapentin is safe to take for life (30+ years), specifically for severe PLMD with pain. My husband has this and has not started it yet, as his neurology visit isn’t until later this week. His case seems to be different than any we have read about
I haven’t been able to find any reliable info on whether Gabapentin is safe to take for life (30+ years), specifically for severe PLMD with pain. My husband has this and has not started it yet, as his neurology visit isn’t until later this week. His case seems to be different than any we have read about
Nightbird11
in
Restless Legs Syndrome
1 year ago
ppis and zoledronic acid infusion
I am taking 30mgs of lansoprazole is it still OK to take it with zoledronic acid infusion along with my other supplements I take.
I am taking 30mgs of lansoprazole is it still OK to take it with zoledronic acid infusion along with my other supplements I take.
Radars
in
Bone Health and Osteoporosis UK
1 year ago
supplements and zoledronic acid
I have been talking to a nurse at the royal osteoporosis society regarding supplements before I have my zoledronic acid infusion, and she said don't take anything with retinol or zinc in it,anyone heard of that.
I have been talking to a nurse at the royal osteoporosis society regarding supplements before I have my zoledronic acid infusion, and she said don't take anything with retinol or zinc in it,anyone heard of that.
Radars
in
Bone Health and Osteoporosis UK
1 year ago
Beef Liver Capsules?
Has anyone tried a long term supplementation of Beef Liver Capsules, they are a good source of Heme Iron, and vitamins, as well as other minerals, and Amino acids?
Has anyone tried a long term supplementation of Beef Liver Capsules, they are a good source of Heme Iron, and vitamins, as well as other minerals, and Amino acids?
Wanman4
in
Restless Legs Syndrome
1 year ago
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