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PSA going down, but ALP increasing
I'm 3 weeks into a clinical trial for ARV-766, an AR degrader. At 2 weeks, my PSA had dropped from 133 to 66! Bone pain is much less. All my liver numbers are fine, but alkaline phosphatase has gone from 199 when I started to 429 at two weeks and 519 at three weeks. Doc thinks may just be a surge, but
I'm 3 weeks into a clinical trial for ARV-766, an AR degrader. At 2 weeks, my PSA had dropped from 133 to 66! Bone pain is much less. All my liver numbers are fine, but alkaline phosphatase has gone from 199 when I started to 429 at two weeks and 519 at three weeks. Doc thinks may just be a surge, but
rsgdmd
in
Advanced Prostate Cancer
12 days ago
Help with blood test results and symptoms please
Hi, I have hashimotos, and had a hemithyroidectomy just before Xmas. Before the operation I had been described as sub-clinical hypothyroid, with a TSH of around 2. Since the operation I been suffering from pins and needles and a feeling of slight breathlessness, which mostly comes on in the evening
Hi, I have hashimotos, and had a hemithyroidectomy just before Xmas. Before the operation I had been described as sub-clinical hypothyroid, with a TSH of around 2. Since the operation I been suffering from pins and needles and a feeling of slight breathlessness, which mostly comes on in the evening
RuthNelson
in
Thyroid UK
2 months ago
thyroid and high blood pressure
Hi all So have been struggling to get a GP appointment to discuss my Thyroid meds. After MUCH sulking from me my medication was reduced to 75mcg from 100. Although I managed to hold out for 100 whilst I was on holiday- feel not so good so have been trying to get my meds reinstated. This since end
Hi all So have been struggling to get a GP appointment to discuss my Thyroid meds. After MUCH sulking from me my medication was reduced to 75mcg from 100. Although I managed to hold out for 100 whilst I was on holiday- feel not so good so have been trying to get my meds reinstated. This since end
Jillyb15
in
Thyroid UK
3 months ago
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RLS & Pramipexole
I'm an 81 year old active woman. I have suffered with RLS for over 10 years. Prescribed .088mg Pramipexole by my GP n just told to increase when I complain! I went to 5 at night but am weaning off myself with the help of 50mg Tramadol around 6pm. Down to alternating 2 or 3 at night slowly. Had bloods
I'm an 81 year old active woman. I have suffered with RLS for over 10 years. Prescribed .088mg Pramipexole by my GP n just told to increase when I complain! I went to 5 at night but am weaning off myself with the help of 50mg Tramadol around 6pm. Down to alternating 2 or 3 at night slowly. Had bloods
Maymount
in
Restless Legs Syndrome
13 days ago
Low blood pressure and palpitations. Thyroid, low ferritin, something else?
My ongoing investigations into possible thyroid problems continue and thanks to you lovely lot I have a direction to follow with more testing over a period of time to look for patterns. So far normalish TSH with low normal FT4 and FT3 - results below. I’m not diagnosed and don’t take thyroid meds. Feel
My ongoing investigations into possible thyroid problems continue and thanks to you lovely lot I have a direction to follow with more testing over a period of time to look for patterns. So far normalish TSH with low normal FT4 and FT3 - results below. I’m not diagnosed and don’t take thyroid meds. Feel
Bertiepuss
in
Thyroid UK
4 months ago
Low T3
Hello Everybody I am 39 years old and I was diagnosed with Graves in feb 2022. I was put on ADT . I’m currently on 5mg Carbimazole daily and I take selenium 100 daily. I also take Vitamin b complex. Until have been on top of my blood regularly but only t4 and tsh was being tested. My Endo has only
Hello Everybody I am 39 years old and I was diagnosed with Graves in feb 2022. I was put on ADT . I’m currently on 5mg Carbimazole daily and I take selenium 100 daily. I also take Vitamin b complex. Until have been on top of my blood regularly but only t4 and tsh was being tested. My Endo has only
KD786
in
Thyroid UK
4 months ago
Cortisol result help in interpreting please
Hi Hashimoto's sufferer for 40 years and ill most of that time. Worsening symptoms although I have had these symptoms before just not as long lasting or debilitating as they have been over the last 12 months. Treated with Levothyroxine only (this after being advised in writing by an endocrinologist 6
Hi Hashimoto's sufferer for 40 years and ill most of that time. Worsening symptoms although I have had these symptoms before just not as long lasting or debilitating as they have been over the last 12 months. Treated with Levothyroxine only (this after being advised in writing by an endocrinologist 6
Shebbie
in
Thyroid UK
14 days ago
Prednisolone and diabetes / high bp worried sick about all the side effects
hi everyone I was diagnosed with PMR in February this year And despite being a diabetic with high bp was put on Prednisolone and alendronic acid - I was managing my diabetes with food prior to this but have now got out of control readings with ketones present in every reading except my blood fasting
hi everyone I was diagnosed with PMR in February this year And despite being a diabetic with high bp was put on Prednisolone and alendronic acid - I was managing my diabetes with food prior to this but have now got out of control readings with ketones present in every reading except my blood fasting
Pol53
in
PMRGCAuk
15 days ago
How does synthetic t4 convert to the active t3 after a thyroidectomy?
Is it the same place & way if one still has their thyroid? Ie. When you all note that hormones given replace the thyroid, not top it up if the thyroid is still in place, does it then not matter if one has a thyroid for this mechanism? (Not discussing taking anyone's thyroid without obvious dire need
Is it the same place & way if one still has their thyroid? Ie. When you all note that hormones given replace the thyroid, not top it up if the thyroid is still in place, does it then not matter if one has a thyroid for this mechanism? (Not discussing taking anyone's thyroid without obvious dire need
Litatamon
in
Thyroid UK
6 months ago
New blood test results
Hi all, Please see my first results 6 weeks after introducing T3. I'm on 125mcg of levo and 10mcg of lio. I am very confused because I was certain that my current symptoms were due to being undermedicated! And how can my T4 be top of range again despite me reducing my levo and introducing T3. TSH 0.007
Hi all, Please see my first results 6 weeks after introducing T3. I'm on 125mcg of levo and 10mcg of lio. I am very confused because I was certain that my current symptoms were due to being undermedicated! And how can my T4 be top of range again despite me reducing my levo and introducing T3. TSH 0.007
Cassav
in
Thyroid UK
2 months ago
Hi, I'm sure it's been answered before,but can't seem to locate...is it OK to test for I.Factor after loading doses please? If not why?
Hi, I've had one Intrinsic factor test before which came in under range. I know its a test that can take a few times to show up.pisitive & kick myself for not trying it again before this loading dose. Was concerned at asking for tests for other things & forgot about this...appreciate any thoughts & would
Hi, I've had one Intrinsic factor test before which came in under range. I know its a test that can take a few times to show up.pisitive & kick myself for not trying it again before this loading dose. Was concerned at asking for tests for other things & forgot about this...appreciate any thoughts & would
Jo5454
in
Pernicious Anaemia Society
16 days ago
Progress at last
Haven’t posted for a long time. Some of you may know that after reaching my goal of a 10k continuous run I contracted COVID in September 2022. Diagnosed with Long Covid in December 2022, really struggled to even walk 400 yards but saw an improvement last Summer and got to Week 7 all be it very slowly
Haven’t posted for a long time. Some of you may know that after reaching my goal of a 10k continuous run I contracted COVID in September 2022. Diagnosed with Long Covid in December 2022, really struggled to even walk 400 yards but saw an improvement last Summer and got to Week 7 all be it very slowly
Phdgranny
Graduate
in
Couch to 5K
16 days ago
GP not doing regular thyroid bloods.
How often should gp do thyroid bloods please? My main thyroid problem is fatigue, it’s not there all the time, comes and goes. So, I would like them done every 8 weeks, as I try different combos of Levo, T3 and Thyroid S, till I feel better. However, mine doesn’t do anything at all until I chase her
How often should gp do thyroid bloods please? My main thyroid problem is fatigue, it’s not there all the time, comes and goes. So, I would like them done every 8 weeks, as I try different combos of Levo, T3 and Thyroid S, till I feel better. However, mine doesn’t do anything at all until I chase her
Persevere99
in
Thyroid UK
6 months ago
Update on me.
So it's been a while since I posted here. Still waiting to see a pulmonologist. That will be happening in June provided there's no cancellations or delays because of industrial action. Had spirometry done both FEV1 and FVC were 91. Not indicative of airway obstruction. Relieving and frustrating at
So it's been a while since I posted here. Still waiting to see a pulmonologist. That will be happening in June provided there's no cancellations or delays because of industrial action. Had spirometry done both FEV1 and FVC were 91. Not indicative of airway obstruction. Relieving and frustrating at
JHutton1994
in
Lung Conditions Community Forum
17 days ago
Had the ablation.
Monday I had the procedure under general anesthesia-safely and successfully. The did give IV cortef at the start of the procedure. Since they needed to intubate my throat is sore for days but my ears-especially the right one are achy. I was debating why aching now; pollen count is moderate,and my jaw
Monday I had the procedure under general anesthesia-safely and successfully. The did give IV cortef at the start of the procedure. Since they needed to intubate my throat is sore for days but my ears-especially the right one are achy. I was debating why aching now; pollen count is moderate,and my jaw
Karenjaninaz
in
PMRGCAuk
18 days ago
Help with Thyroid results please.
hi everyone, I would be grateful for some advice on thyroid results for my younger brother please. I have Auto immune Hypo since 2004 and so does one of my brothers and my mum. My other brother has had lots of symptoms of depression and has deteriorated recently. He has high anxiety and slightly paranoid
hi everyone, I would be grateful for some advice on thyroid results for my younger brother please. I have Auto immune Hypo since 2004 and so does one of my brothers and my mum. My other brother has had lots of symptoms of depression and has deteriorated recently. He has high anxiety and slightly paranoid
CarolineAnne
in
Thyroid UK
3 months ago
Management of Carbimazole/hyperthyroidism and other symptoms
Hi all, I’m new here, I’ve written out my history in my profile including all test results so won’t go into too much depth. Essentially found to have hyperthyroidism in October and have been on 15mg Carbimazole a day since then. The doctor openly told me she ‘doesn’t know much about hyperthyroidism as
Hi all, I’m new here, I’ve written out my history in my profile including all test results so won’t go into too much depth. Essentially found to have hyperthyroidism in October and have been on 15mg Carbimazole a day since then. The doctor openly told me she ‘doesn’t know much about hyperthyroidism as
LeopardLegs
in
Thyroid UK
3 months ago
Confused and scared and looking for insights :-)
Hi all :) I'm a little confused about what's happening in my body and am in the middle of investigations. To cut my story as short as possible: - Last May and again in June I had a very subtle rash on my cheeks that lasted a day each time. It was accompanied with itching over my face, up the inside
Hi all :) I'm a little confused about what's happening in my body and am in the middle of investigations. To cut my story as short as possible: - Last May and again in June I had a very subtle rash on my cheeks that lasted a day each time. It was accompanied with itching over my face, up the inside
Pinyet
in
LUPUS UK
3 months ago
Nickel as a potential disruptor of thyroid function: benchmark modelling of human data
Nickel is used in many ways - plating of things like door and cabinet furniture, in making margarine (used a finely divided nickel catalyst - but spreads are not now made in this way), most stainless steel, coinage, silver plating (electro-plated nickel silver - EPNS), many special alloys, elements of
Nickel is used in many ways - plating of things like door and cabinet furniture, in making margarine (used a finely divided nickel catalyst - but spreads are not now made in this way), most stainless steel, coinage, silver plating (electro-plated nickel silver - EPNS), many special alloys, elements of
helvella
Thyroid UK
in
Thyroid UK
6 months ago
7dp5dt pregnancy test
Hi ladies, Some word of advise needed here. I early tested on 6dp6dt and it came a wonderful BFP straight away!Our first ever positive pregnancy test so we’re over the moon even tho its early days🩵👼 Anyway i decided to do a digital one witch came up as 1-2 weeks today. May i ask if anyone experienced
Hi ladies, Some word of advise needed here. I early tested on 6dp6dt and it came a wonderful BFP straight away!Our first ever positive pregnancy test so we’re over the moon even tho its early days🩵👼 Anyway i decided to do a digital one witch came up as 1-2 weeks today. May i ask if anyone experienced
Claublsk
in
Fertility Network UK
6 months ago
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