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PSA reduction by Estrogen Patch (revised)
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
janebob99
in
Prostate Cancer Network
5 months ago
Metastatic Prostate Cancer Market to Exhibit Positive Growth at a CAGR of 22%
Good to see such a significant investment in the Prostate Cancer Therapy Market. https://www.prnewswire.com/news-releases/metastatic-prostate-cancer-market-to-exhibit-positive-growth-at-a-cagr-of-22-and-7-5-for-mhspc-and-mcrpc-respectively-during-the-study-period-20192032-assesses-delveinsight-302013725
Good to see such a significant investment in the Prostate Cancer Therapy Market. https://www.prnewswire.com/news-releases/metastatic-prostate-cancer-market-to-exhibit-positive-growth-at-a-cagr-of-22-and-7-5-for-mhspc-and-mcrpc-respectively-during-the-study-period-20192032-assesses-delveinsight-302013725
rfgaus
in
Advanced Prostate Cancer
7 months ago
Dad's PSA risen from 0.01 to 0.05 in 2 months, 2 years post SRT. Any chance that there is no further progression?
PSA has risen 3 times in a row. I understand the figure is still low, but is this a definite indication that it will progress, or is there a chance that PSA can stabilize or fluctuate and not progress further? Things have been difficult in the family, I am hoping for a miracle that he had a curative
PSA has risen 3 times in a row. I understand the figure is still low, but is this a definite indication that it will progress, or is there a chance that PSA can stabilize or fluctuate and not progress further? Things have been difficult in the family, I am hoping for a miracle that he had a curative
MsBoBo
in
Advanced Prostate Cancer
5 months ago
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PSA drops with decreasing Testosterone
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Prostate Cancer Network
5 months ago
At the crossroads (again)
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
rsgdmd
in
Advanced Prostate Cancer
5 months ago
Rising PSA
I'm Poollover, Just got the results of a blood test and my PSA went up from 0.67 to 0.77. I'm on Orgovyx and Zytiga. I'm 86 years old. How concerned should I be? 8 months ago it was about 12. That was before medication. Also slightly anemic. What are my options? Terry
I'm Poollover, Just got the results of a blood test and my PSA went up from 0.67 to 0.77. I'm on Orgovyx and Zytiga. I'm 86 years old. How concerned should I be? 8 months ago it was about 12. That was before medication. Also slightly anemic. What are my options? Terry
Poollover
in
Advanced Prostate Cancer
5 months ago
Testosterone and adrenal glands
Hello all, so I finished 10 rounds of chemo docetaxel last year in September. My PSA was down to 2.8 Oct 5th. I had an orchiectomy Oct 15. My PSA started to rise. Nov 5th PSA 5.15. Dec 6th PSA 7.85. Jan 11 PSA 16.23 I have had CT and bone scan early October and another set of scans early January
Hello all, so I finished 10 rounds of chemo docetaxel last year in September. My PSA was down to 2.8 Oct 5th. I had an orchiectomy Oct 15. My PSA started to rise. Nov 5th PSA 5.15. Dec 6th PSA 7.85. Jan 11 PSA 16.23 I have had CT and bone scan early October and another set of scans early January
Eugmn
in
Advanced Prostate Cancer
6 months ago
Failed Pluvicto
Hello warriors, especially Tall Allen. I'm going on 6 years since Gleason 9 advanced metastatic diagnosis. Had a good run on Zytiga and all the usual other treatments, but just failed last ditch treatment of Pluvicto (after treatment 3). Did genetic testing and no significant mutations. My PSA is
Hello warriors, especially Tall Allen. I'm going on 6 years since Gleason 9 advanced metastatic diagnosis. Had a good run on Zytiga and all the usual other treatments, but just failed last ditch treatment of Pluvicto (after treatment 3). Did genetic testing and no significant mutations. My PSA is
jersy
in
Advanced Prostate Cancer
5 months ago
Barry
Hi, Diagnosed with advanced prostate cancer gleeson score 4+4, psa level 77, about 10 months ago on testosterone injections every 6 months (degarelix) , wondering how long i can go on like this before cancer comes back to bones and what will be my options then, can you survive for many years on just
Hi, Diagnosed with advanced prostate cancer gleeson score 4+4, psa level 77, about 10 months ago on testosterone injections every 6 months (degarelix) , wondering how long i can go on like this before cancer comes back to bones and what will be my options then, can you survive for many years on just
littlemount
in
Advanced Prostate Cancer
6 months ago
PCA Cure and when?
7 months into my fight against castration sensitive prostate cancer. PSA is 0 on ADT and Abiraterone and methylprednisolone. Averaged 8,600 steps/day. I have just started to add occasional sprinting. I am taking multiple supplements. I am greatful that my PSA is 0. I work everyday and pray for
7 months into my fight against castration sensitive prostate cancer. PSA is 0 on ADT and Abiraterone and methylprednisolone. Averaged 8,600 steps/day. I have just started to add occasional sprinting. I am taking multiple supplements. I am greatful that my PSA is 0. I work everyday and pray for
Nowhereman9
in
Advanced Prostate Cancer
6 months ago
PSA relapse rate vs testosterone nadir - 3
This plot shows the PSA relapse rate after RT and ADT, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20 ng/dL),
and the relationship
This plot shows the PSA relapse rate after RT and ADT, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20 ng/dL),
and the relationship
janebob99
in
Advanced Prostate Cancer
5 months ago
Testosterone back to normal
I was diagnosed with PC last April 2023 with PSA of 125. Darilutimide and Relogolix, along with HIIT, plant based diet, and various supplements brought it down to .006. My MO granted a holiday about 6-7 weeks ago, and yesterday, I had my testosterone score. It is back to 312, which is above the number
I was diagnosed with PC last April 2023 with PSA of 125. Darilutimide and Relogolix, along with HIIT, plant based diet, and various supplements brought it down to .006. My MO granted a holiday about 6-7 weeks ago, and yesterday, I had my testosterone score. It is back to 312, which is above the number
Cape1
in
Advanced Prostate Cancer
5 months ago
Triplet and now Radiation?
Hi all - just wanting your thoughts on this. In my profile you would see full details but I will summarize here. 50yr old diagnosed Aug 2nd with PCA with spread to L5 and pubic bone. Original PSA was around 9 and put on Casodex for month, then Lupron every 3 months, plus Darolutamide. Just completed
Hi all - just wanting your thoughts on this. In my profile you would see full details but I will summarize here. 50yr old diagnosed Aug 2nd with PCA with spread to L5 and pubic bone. Original PSA was around 9 and put on Casodex for month, then Lupron every 3 months, plus Darolutamide. Just completed
Yzinger
in
Advanced Prostate Cancer
5 months ago
No more enzalutamide: docetaxel next up
So enzalutamide has stopped doing its thing. PSA up to 3.9 but it’s worked for 3.5 years. Also got a new lesion in my thoracic spine so in addition to docetaxel, a single dose of radiotherapy. Hope that will all be underway within a couple of weeks. Some fear for a while about the meds not working and
So enzalutamide has stopped doing its thing. PSA up to 3.9 but it’s worked for 3.5 years. Also got a new lesion in my thoracic spine so in addition to docetaxel, a single dose of radiotherapy. Hope that will all be underway within a couple of weeks. Some fear for a while about the meds not working and
FortyWinks
in
Advanced Prostate Cancer
5 months ago
Advanced Prostate Cancer
I have Advanced prostate cancer. Prostate removed, radiation, lupron for the last 4 years, Now I am on abiraterone with the lupron, because PSA was up . See Dr in Feb to see if PSA is stable Is anyone else on the 2 drugs Thank you Mark
I have Advanced prostate cancer. Prostate removed, radiation, lupron for the last 4 years, Now I am on abiraterone with the lupron, because PSA was up . See Dr in Feb to see if PSA is stable Is anyone else on the 2 drugs Thank you Mark
Retrievertrainer
in
Advanced Prostate Cancer
6 months ago
Warren Farr
Hi, my name is warren I was diagnosed in late November 2023 with Prostrate Cancer from a MRI I then had a PSMA CT Scan and the next day Robotic removal of my prostrate RRP. The Biopsy showed staging pT3b 30% ductal after a Gleason score of 5+4=9 My PSA after removal was 0.22 then 4 weeks later 0.38
Hi, my name is warren I was diagnosed in late November 2023 with Prostrate Cancer from a MRI I then had a PSMA CT Scan and the next day Robotic removal of my prostrate RRP. The Biopsy showed staging pT3b 30% ductal after a Gleason score of 5+4=9 My PSA after removal was 0.22 then 4 weeks later 0.38
Snoopy8125
in
Advanced Prostate Cancer
5 months ago
NX 1607 - phase 1 trial, will also recruit prostate cancer patients but not from the beginning
Also some prostate cancer patients will be included in the trial further down the road...let's just keep this in mind https://www.cancernetwork.com/view/trial-will-assess-nx-1607-safety-and-tolerability-in-advanced-malignancies
Also some prostate cancer patients will be included in the trial further down the road...let's just keep this in mind https://www.cancernetwork.com/view/trial-will-assess-nx-1607-safety-and-tolerability-in-advanced-malignancies
Maxone73
in
Advanced Prostate Cancer
7 months ago
Immunotherapy could surprise us: Columbia study about mCRPC patients
"Immunotherapy has been disappointing as a prostate cancer treatment, but a new Columbia study suggests that the powerful treatments have potential when the disease starts to spread." https://www.cuimc.columbia.edu/news/metastatic-prostate-cancer-immunotherapy-may-have-unexpected-potential
"Immunotherapy has been disappointing as a prostate cancer treatment, but a new Columbia study suggests that the powerful treatments have potential when the disease starts to spread." https://www.cuimc.columbia.edu/news/metastatic-prostate-cancer-immunotherapy-may-have-unexpected-potential
Maxone73
in
Advanced Prostate Cancer
7 months ago
Have not seen an answer to this question
Senior on abiraterone and prednisone due to metastatic cancer in lymph nodes…..wife and I still interested…….do not know if it will work but will I recharge the cancer and cause harm by using Viagra ?
Senior on abiraterone and prednisone due to metastatic cancer in lymph nodes…..wife and I still interested…….do not know if it will work but will I recharge the cancer and cause harm by using Viagra ?
Mbnm
in
Advanced Prostate Cancer
7 months ago
severe neck pain
I’m a couple of months in on eligard,abiraterone and prednisone(5mg). Mercifully I’m relatively SE free at this point but know it’s early…..what I DO have after the first few weeks is a chronically stiff neck that makes it impossible to move my head to the right…..Wondering if anyone has ever heard of
I’m a couple of months in on eligard,abiraterone and prednisone(5mg). Mercifully I’m relatively SE free at this point but know it’s early…..what I DO have after the first few weeks is a chronically stiff neck that makes it impossible to move my head to the right…..Wondering if anyone has ever heard of
Tommyj2
in
Advanced Prostate Cancer
7 months ago
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