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darolutamide monotherapy experience?
If you’ve had darolutamide mono therapy, I’m interested in your experience with effectiveness and side effects, especially compared to ADT like Lupron.
If you’ve had darolutamide mono therapy, I’m interested in your experience with effectiveness and side effects, especially compared to ADT like Lupron.
ron_bucher
in
Advanced Prostate Cancer
2 months ago
EMBARK Trial: Combination-therapy is better.
This chart compares the risk of developing metastasis from prostate cancer, after 5 years from curative treatment, between three different arms of the EMBARK study (published in 2023): (1) Lupron monotherapy; (2) Enzalutamide monotherapy; and (3) Enzalutamide + Lupron combination therapy. The cohort
This chart compares the risk of developing metastasis from prostate cancer, after 5 years from curative treatment, between three different arms of the EMBARK study (published in 2023): (1) Lupron monotherapy; (2) Enzalutamide monotherapy; and (3) Enzalutamide + Lupron combination therapy. The cohort
janebob99
in
Prostate Cancer Network
2 months ago
Any adverse effect if taking three-month Lupron shot two weeks late?
Hi friends, my father has been on Lupron shots every three months with Abiraterone pills for about a year now. His next shot will be 14 weeks due to some insurance problems. What is the ideal and acceptable time range between shots that won’t risks benefits of treatment? What is the out of pocket price
Hi friends, my father has been on Lupron shots every three months with Abiraterone pills for about a year now. His next shot will be 14 weeks due to some insurance problems. What is the ideal and acceptable time range between shots that won’t risks benefits of treatment? What is the out of pocket price
qidao23
in
Advanced Prostate Cancer
2 months ago
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Testosterone Recovery: Orgovyx vs Lupron, Part-II
Here's another plot summarizing data from a 2020 paper in the New England Journal of Medicine by Neil Shore, et al. that shows Orgovyx has much faster "ON" and "OFF" changes in testosterone levels, compared to Lupron. This plot compares the percentage of men who recover their testosterone (defined
Here's another plot summarizing data from a 2020 paper in the New England Journal of Medicine by Neil Shore, et al. that shows Orgovyx has much faster "ON" and "OFF" changes in testosterone levels, compared to Lupron. This plot compares the percentage of men who recover their testosterone (defined
janebob99
in
Prostate Cancer Network
2 months ago
Testosterone Recovery: Orgovyx vs Lupron, Part-I
Here's plot from a 2020 paper in the New England Journal of Medicine by Neil Shore, et al. that shows Orgovyx has much faster "ON" and "OFF" changes in testosterone levels, compared to Lupron. https://pubmed.ncbi.nlm.nih.gov/32469183/
Here's plot from a 2020 paper in the New England Journal of Medicine by Neil Shore, et al. that shows Orgovyx has much faster "ON" and "OFF" changes in testosterone levels, compared to Lupron. https://pubmed.ncbi.nlm.nih.gov/32469183/
janebob99
in
Prostate Cancer Network
2 months ago
If PSA is Suppressed by Doublet ADT, Will Salvage IMRT Cause a PSA Rise?
Hello everyone, My husband is nearing completion of his extended pelvic salvage IMRT with boost to retrocaval lymph nodes. His radiation oncologist said it may take several months before the psa calms down, so he would like to see him in July. My question is that, since he is already undetectable due
Hello everyone, My husband is nearing completion of his extended pelvic salvage IMRT with boost to retrocaval lymph nodes. His radiation oncologist said it may take several months before the psa calms down, so he would like to see him in July. My question is that, since he is already undetectable due
103532
in
Advanced Prostate Cancer
2 months ago
Starting Third Month of Orgovyx--Update
Blood test after two months shows PSA of 1.45, down from 16.5--over a 90% drop. So, the medication is working as advertised. I believe their own stats indicate an approx. 98% drop in 90 days. This week's visit with my new MO nurse practitioner went well. She was very happy with the PSA results and
Blood test after two months shows PSA of 1.45, down from 16.5--over a 90% drop. So, the medication is working as advertised. I believe their own stats indicate an approx. 98% drop in 90 days. This week's visit with my new MO nurse practitioner went well. She was very happy with the PSA results and
mababa
in
Advanced Prostate Cancer
2 months ago
BILLY NEEDS HELP
OK troops, after 26 years of surviving post prostectomy, with a Gleason 4/3, 4/4, some 41 rounds of intermittent hormone therapy using lupron, casadex, advodart, I had a break thru last November as my psa went back up mid on cycle. After having my radiation oncologist ignore the realities of this, I
OK troops, after 26 years of surviving post prostectomy, with a Gleason 4/3, 4/4, some 41 rounds of intermittent hormone therapy using lupron, casadex, advodart, I had a break thru last November as my psa went back up mid on cycle. After having my radiation oncologist ignore the realities of this, I
billyboy3
in
Advanced Prostate Cancer
2 months ago
10th year
Ten years ago I had my Gleason 9 prostate removed. PSA was .1 for a while. It crept up over .2, and I began taking lupron. The drug brought PSA back down to >.01 for a year or so. As the level started going up again, I received whole pelvis bed radiation, moving PSA to undetectable. After a year or so
Ten years ago I had my Gleason 9 prostate removed. PSA was .1 for a while. It crept up over .2, and I began taking lupron. The drug brought PSA back down to >.01 for a year or so. As the level started going up again, I received whole pelvis bed radiation, moving PSA to undetectable. After a year or so
Jvaughan0
in
Advanced Prostate Cancer
2 months ago
Estrogen patch to improve quality of life
Could the men here who use estrogen patches at "just to feel good" levels comment on your experience? Mr. Spouse21 will be getting spot radiation to a single spinal tumor very soon. Thanks to everyone who encouraged that instead of Pluvicto at this time. His two oncologists agreed as did a radiation
Could the men here who use estrogen patches at "just to feel good" levels comment on your experience? Mr. Spouse21 will be getting spot radiation to a single spinal tumor very soon. Thanks to everyone who encouraged that instead of Pluvicto at this time. His two oncologists agreed as did a radiation
spouse21
in
Advanced Prostate Cancer
2 months ago
How do you know if radiation treatment worked?
I had 25 sessions of radiation to prostate and pelvic area as a precaution and 6 (2 months prior and 4 after radiation)months of Lupron. For 9 months post radiation PSA has been not been detectable and it has now risen to 0.04. T is in the normal range. All other blood works were normal. Meet with
I had 25 sessions of radiation to prostate and pelvic area as a precaution and 6 (2 months prior and 4 after radiation)months of Lupron. For 9 months post radiation PSA has been not been detectable and it has now risen to 0.04. T is in the normal range. All other blood works were normal. Meet with
Mgtd
in
Advanced Prostate Cancer
2 months ago
After ADT
Adrenal insufficiency after stopping ADT & steroids. My 72 year old husband had radical, robotic surgery 7 years ago. PSAs were 0 until 2 years ago, then barely detectable. Had the special PET scan, 3 spots lit up in lymph nodes, (in the area, none remote.) Had 6.5 weeks radiation therapy. Had 2 years
Adrenal insufficiency after stopping ADT & steroids. My 72 year old husband had radical, robotic surgery 7 years ago. PSAs were 0 until 2 years ago, then barely detectable. Had the special PET scan, 3 spots lit up in lymph nodes, (in the area, none remote.) Had 6.5 weeks radiation therapy. Had 2 years
Catmama5
in
Advanced Prostate Cancer
2 months ago
Please help us decide on next treatment
Hi, my Dad was diagnosed back in 2021 with stage IV, Gleason 9, oligometastatic. He had 6 weeks of radiation at the time of diagnosis and has been for the past 2.5 years on Abiraterone, Prednisone and Lupron. As I mentioned in my prior post my Dad’s PSA started going up. He had a PSMA Pet scan and it
Hi, my Dad was diagnosed back in 2021 with stage IV, Gleason 9, oligometastatic. He had 6 weeks of radiation at the time of diagnosis and has been for the past 2.5 years on Abiraterone, Prednisone and Lupron. As I mentioned in my prior post my Dad’s PSA started going up. He had a PSMA Pet scan and it
Simonapo
in
Advanced Prostate Cancer
2 months ago
Should I Add Docetaxel to Lupron and Zytiga?
I have been on Lupron and Abiraterone for most of my almost 12 years of treatment. Triplet therapy was not SOC when I was first dx'd. I am just wondering why, Docetaxel isn't routinely added to those of us who started on doublet therapy before we become resistant to the doublet therapy. My guess is that
I have been on Lupron and Abiraterone for most of my almost 12 years of treatment. Triplet therapy was not SOC when I was first dx'd. I am just wondering why, Docetaxel isn't routinely added to those of us who started on doublet therapy before we become resistant to the doublet therapy. My guess is that
jfoesq
in
Advanced Prostate Cancer
2 months ago
What is Your Opinion on Docetaxel Added to Doublet Therapy for Early Oligorecurrent Metaststic M1a Prostate Cancer?
Hello, I have touched on this subject before, but it is something that is nagging at me and giving me some sleepless nights. My husband’s bio is updated for reference. At one year post prostatectomy with Stage 3b, he rose from 0.06 to 0.273 in three mos. At psa of 0.16 , a PSMA scan showed three sub
Hello, I have touched on this subject before, but it is something that is nagging at me and giving me some sleepless nights. My husband’s bio is updated for reference. At one year post prostatectomy with Stage 3b, he rose from 0.06 to 0.273 in three mos. At psa of 0.16 , a PSMA scan showed three sub
103532
in
Advanced Prostate Cancer
2 months ago
Why do MO's continue to prescribe Lupron ADT for Castrate-Resistant men?
I've never understood why MO's continue to prescribe Lupron ADT (or equivalent ) for men who are
castrate-resistant (CRPC
). Isn't that the definition of CRPC, namely, that ADT is no longer working for those men? Why continue to prescribe a drug that no longer works and that causes such suffering
I've never understood why MO's continue to prescribe Lupron ADT (or equivalent ) for men who are
castrate-resistant (CRPC
). Isn't that the definition of CRPC, namely, that ADT is no longer working for those men? Why continue to prescribe a drug that no longer works and that causes such suffering
janebob99
in
Advanced Prostate Cancer
2 months ago
question for those who have stopped Lupron after many years of ADT
I have been on Lupron for 8 years with the short-term exception of a high/T clinical trial,( but even during the trial I stayed on Lupron). Anyway I’m undetectable and decided to stop Lupron. 3 months after not getting my shot my T is now a whopping 37. I am curious to hear from some of you who
I have been on Lupron for 8 years with the short-term exception of a high/T clinical trial,( but even during the trial I stayed on Lupron). Anyway I’m undetectable and decided to stop Lupron. 3 months after not getting my shot my T is now a whopping 37. I am curious to hear from some of you who
Chugach
in
Advanced Prostate Cancer
2 months ago
lupron 4th shot strong reaction
just had my fourth Lupron shot, three months. Also on Zytiga and finished radiation in December. Everything has been great. I feel excellent physically and mentally. But this Monday after my fourth Lupron shot I became very depressed pissed off and side effects such as hot flashes came back much more
just had my fourth Lupron shot, three months. Also on Zytiga and finished radiation in December. Everything has been great. I feel excellent physically and mentally. But this Monday after my fourth Lupron shot I became very depressed pissed off and side effects such as hot flashes came back much more
pj1121
in
Advanced Prostate Cancer
2 months ago
Waiting for me to die
Just wondering if anyone else has experienced this. Sometimes i get the feeling that friends and family members are waiting for me to die. I was diagnosed stage 4b metastasis in January 2021 and have been on treatment Lupron and Xtandi since April 2021 3 years now. From an outward appearance I don't
Just wondering if anyone else has experienced this. Sometimes i get the feeling that friends and family members are waiting for me to die. I was diagnosed stage 4b metastasis in January 2021 and have been on treatment Lupron and Xtandi since April 2021 3 years now. From an outward appearance I don't
rogerandme
in
Advanced Prostate Cancer
2 months ago
ADT IS DONE. NEXT?
Lupron and Zytiga will have completed 2 years of each in June. I've read some continue Lupron for 3 years or longer. How do you know how long to take? Monitor testosterone and PSA how often? 2 or 3 months?
Lupron and Zytiga will have completed 2 years of each in June. I've read some continue Lupron for 3 years or longer. How do you know how long to take? Monitor testosterone and PSA how often? 2 or 3 months?
rfgh20
in
Advanced Prostate Cancer
2 months ago
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