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Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy.
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
cigafred
in
Fight Prostate Cancer
3 months ago
New diagnosis
I was just diagnosed with fibromyalgia. Four years ago, I was diagnosed with Giant Cell Arteritis and, about 2 years later, Polymyalgia Rheumatica. My life has drastically changed between the pain and total exhaustion. Any words of advice would be most welcome.
I was just diagnosed with fibromyalgia. Four years ago, I was diagnosed with Giant Cell Arteritis and, about 2 years later, Polymyalgia Rheumatica. My life has drastically changed between the pain and total exhaustion. Any words of advice would be most welcome.
Miacaro45
in
Fibromyalgia Action UK
3 months ago
weird mouth symptoms on Sulfasalazine
Has anyone experienced anything like the following? I’ve been on Sulf for 7 weeks, max dose from 4 weeks. In the last 3 days I’ve had a sore tongue which has now settled but I’ve completely lost my sense of taste. I’ve tested and am negative for covid. I can’t think what else it could be!
Has anyone experienced anything like the following? I’ve been on Sulf for 7 weeks, max dose from 4 weeks. In the last 3 days I’ve had a sore tongue which has now settled but I’ve completely lost my sense of taste. I’ve tested and am negative for covid. I can’t think what else it could be!
Charlongo79
in
NRAS
7 months ago
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ADAA Blog: OCD Strategies—We Do Not Hang Out With Bullies
"The same is true for the “bully” that is your OCD thoughts. These thoughts are not helpful things to consider in order to improve your life. This bully will only serve to make you fearful, intimidated, and immobilized. OCD holds out a promise of freedom and peace; while in reality, compulsions deliver
"The same is true for the “bully” that is your OCD thoughts. These thoughts are not helpful things to consider in order to improve your life. This bully will only serve to make you fearful, intimidated, and immobilized. OCD holds out a promise of freedom and peace; while in reality, compulsions deliver
ADAATeamRachel
Partner
in
Anxiety and Depression Support
4 months ago
Tirosint
Its been 10.5 months since my thyroidectomy. I was at .69 TSH on levothyroxine 100 mgs a day with mega side effects. Doctors just switched me Tirosint 88 mgs a day. Am I to expect more serious changes, again. I lost my voice, got chubby, lost hair, aged, and more. Its been a life-changing experience
Its been 10.5 months since my thyroidectomy. I was at .69 TSH on levothyroxine 100 mgs a day with mega side effects. Doctors just switched me Tirosint 88 mgs a day. Am I to expect more serious changes, again. I lost my voice, got chubby, lost hair, aged, and more. Its been a life-changing experience
AuthorJAR
in
Thyroid UK
8 months ago
Nagalase count
My nagalase count is declining. 1.55 -1.37 - 1.12 today. The Clioquinol +zinc +ivermicetin is still working on the way to zero. PSA is steady at 32 Nagalase is an enzyme that cancer cells produce to protect themselves from the immune system.
My nagalase count is declining. 1.55 -1.37 - 1.12 today. The Clioquinol +zinc +ivermicetin is still working on the way to zero. PSA is steady at 32 Nagalase is an enzyme that cancer cells produce to protect themselves from the immune system.
agnut
in
Fight Prostate Cancer
3 months ago
scheduled for Botox and tag removal. Possible hemrrhoidectomy
hey everyone! I’ve been dealing with anal fissures on and off ever since giving birth back in 2016. I used to be able to go months and months before having a retear. Then I started noticing I’d tear around my period. Then in 2023 I stopped working out and I noticed I got fissures every month!!! It’s
hey everyone! I’ve been dealing with anal fissures on and off ever since giving birth back in 2016. I used to be able to go months and months before having a retear. Then I started noticing I’d tear around my period. Then in 2023 I stopped working out and I noticed I got fissures every month!!! It’s
Sufferedtoolong
in
Pelvic Pain Support Network
3 months ago
PMR and brachial neuritis
It looks like I have developed a fairly rare condition called Parsonage-Turner syndrome (PTS), also called brachial neuritis. It started with terrible pain in the shoulder, so initially I thought it would appear in the other shoulder and be the beginning of a PMR relapse. But it is taking a different
It looks like I have developed a fairly rare condition called Parsonage-Turner syndrome (PTS), also called brachial neuritis. It started with terrible pain in the shoulder, so initially I thought it would appear in the other shoulder and be the beginning of a PMR relapse. But it is taking a different
dmart7
in
PMRGCAuk
5 months ago
Potential therapeutic effects and pharmacological evidence of sinomenine in central nervous system disorders
Published online 2022 Sep 16, I realize it is a rat study, but it is sinomenine is used in Traditional Chinese Medicine. Pharmacological effects of sinomenine in Parkinson’s disease PD is a common neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the
Published online 2022 Sep 16, I realize it is a rat study, but it is sinomenine is used in Traditional Chinese Medicine. Pharmacological effects of sinomenine in Parkinson’s disease PD is a common neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the
Sydney75
in
Cure Parkinson's
8 months ago
I really need to vent
Do you ever just not want to bother anyone else? I do, I'd almost would rather suffer in silence. I've been suffering with depression, anxiety, and adhd. The last year has been the worst after a seperation from my ex fiance with 2 kids involved. I self isolate myself and try to ignore everything. I
Do you ever just not want to bother anyone else? I do, I'd almost would rather suffer in silence. I've been suffering with depression, anxiety, and adhd. The last year has been the worst after a seperation from my ex fiance with 2 kids involved. I self isolate myself and try to ignore everything. I
Joemamba13
in
Anxiety and Depression Support
7 months ago
Cholestyramine
My husband has had explosive diarrhea since mid February. After blood tests, stool samples, colonoscopy, and more stool samples, they are not able to determine what is causing the diarrhea. The doctor has prescribed Cholestyramine. Has anyone had experience with this medication and did it help?
My husband has had explosive diarrhea since mid February. After blood tests, stool samples, colonoscopy, and more stool samples, they are not able to determine what is causing the diarrhea. The doctor has prescribed Cholestyramine. Has anyone had experience with this medication and did it help?
lowraind
in
IBS Network
3 months ago
Serum ferritin level & RBC count help please
Hi there, just wondered If anyone could please tell me if a Ferritin level of 44ng/ml and a RBC count of 3.76 (whilst actually already taking Ferrous Fumerate 210mg twice per day) is still pretty low and ‘could’ maybe be the reason I’m still feeling exhausted/heavy tired legs?? Thank you in advance
Hi there, just wondered If anyone could please tell me if a Ferritin level of 44ng/ml and a RBC count of 3.76 (whilst actually already taking Ferrous Fumerate 210mg twice per day) is still pretty low and ‘could’ maybe be the reason I’m still feeling exhausted/heavy tired legs?? Thank you in advance
CandiR
in
Pernicious Anaemia Society
8 months ago
Drugs interactions
I am on Lupron as the only current PC treatment. Testosterone is <>1% as of Dec/18. PCP is looking to get me on (very expensive , hard to get) Serostim to help me with HIV/PC wasting SE's Thoughts, please be kind as ADT makes me get upset for nothing. Thank you.
I am on Lupron as the only current PC treatment. Testosterone is <>1% as of Dec/18. PCP is looking to get me on (very expensive , hard to get) Serostim to help me with HIV/PC wasting SE's Thoughts, please be kind as ADT makes me get upset for nothing. Thank you.
Blueribbon63
in
Advanced Prostate Cancer
7 months ago
Help with My Son who is 19
I am struggling with the recent experience I have had with my son. He has had a very hard freshman year in college as I think most due especially in this time in our lives. he did not do well and got into trouble therefore not asked back this semester sophomore year, therefore home with mom. I am divorced
I am struggling with the recent experience I have had with my son. He has had a very hard freshman year in college as I think most due especially in this time in our lives. he did not do well and got into trouble therefore not asked back this semester sophomore year, therefore home with mom. I am divorced
Ana80
in
Anxiety and Depression Support
10 months ago
Losing track of where you are while driving
Have you ever lost track of where you are while driving? I've probably had this occur 3-4 times in the last year in places I have gone to many times. Twice this was when I was approaching a street where I had to turn. Suddenly I didn't know if I needed to keep going or turn, or had taken the wrong
Have you ever lost track of where you are while driving? I've probably had this occur 3-4 times in the last year in places I have gone to many times. Twice this was when I was approaching a street where I had to turn. Suddenly I didn't know if I needed to keep going or turn, or had taken the wrong
Doxy46
in
MPN Voice
8 months ago
Suspected Bechets - affecting me mentally & physically
Hello, So sorry for the long post! So my doctor believes I have Bechets and I am currently undergoing tests/waiting for results. I have suffered with horrendous mouth ulcers ever since I had glandular fever at the age of 19 (now 36), and after a couple of years back and forth to the doctors about it,
Hello, So sorry for the long post! So my doctor believes I have Bechets and I am currently undergoing tests/waiting for results. I have suffered with horrendous mouth ulcers ever since I had glandular fever at the age of 19 (now 36), and after a couple of years back and forth to the doctors about it,
TigerLily42
in
Behçet's UK
5 months ago
Anxiety
Been suffering g with anxiety all my life. Started having anxiety attacks at 18. Depression too. Looking to discuss with others manageable techniques and a forum to discuss with same. 🙂
Been suffering g with anxiety all my life. Started having anxiety attacks at 18. Depression too. Looking to discuss with others manageable techniques and a forum to discuss with same. 🙂
ArloGuthrie
in
Anxiety and Depression Support
7 months ago
Bolt's Failed Pickle Experiment (Lectins) :(
First off, for those who don't know me, I have NOT been diagnosed with PD
. I was diagnosed with REM Sleep Behavior Disorder back in April 21, which the experts say will lead to PD or something worse. When I was diagnosed I did have some other odd symptoms. Mild balance issues, Seborrheic dermatitis
First off, for those who don't know me, I have NOT been diagnosed with PD
. I was diagnosed with REM Sleep Behavior Disorder back in April 21, which the experts say will lead to PD or something worse. When I was diagnosed I did have some other odd symptoms. Mild balance issues, Seborrheic dermatitis
Bolt_Upright
in
Cure Parkinson's
8 months ago
Mirtazapine
Hi I've not posted for a very long time.I've been on 15mg for quite a few years now. Has anyone increased to 22.5mg and how have you felt? I upped it a couple of years ago but if I remember I split the doses as it was all too much in one go I used to take the lower dose in the morning. I'm going
Hi I've not posted for a very long time.I've been on 15mg for quite a few years now. Has anyone increased to 22.5mg and how have you felt? I upped it a couple of years ago but if I remember I split the doses as it was all too much in one go I used to take the lower dose in the morning. I'm going
Charl-
in
Anxiety Support
7 months ago
Thrush but not a bird
I have been given the wrong dose of my inhaler for Asthma. Now have to use two puffs instead of one to obtain the same amount. Will this increase my sore throat and oral thrush burden ? It is something I struggle with. Nothing to be done until Monday. Any advice would be welcome.
I have been given the wrong dose of my inhaler for Asthma. Now have to use two puffs instead of one to obtain the same amount. Will this increase my sore throat and oral thrush burden ? It is something I struggle with. Nothing to be done until Monday. Any advice would be welcome.
Dottie11
in
Lung Conditions Community Forum
6 months ago
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