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Clinical trial NCT05898399: for BRCA (ATM as well I suppose) mutations
Study of ART6043 in Advanced/Metastatic Solid Tumors Patients This company is also developing an interesting ATR inhibitor for ATM mutations https://classic.clinicaltrials.gov/ct2/show/NCT05898399
Study of ART6043 in Advanced/Metastatic Solid Tumors Patients This company is also developing an interesting ATR inhibitor for ATM mutations https://classic.clinicaltrials.gov/ct2/show/NCT05898399
Maxone73
in
Advanced Prostate Cancer
9 months ago
Buprenorphine, Nausea & Zofran (Ondansetron)
I successfully take 0.4 mg day buprenorphine to treat RLS but the nausea side effect is very troublesome and there does not seem to be a satisfactory plan to get the better of it. I have unsuccessfully tried many anti nausea drugs and methods including Symprove probiotic and seem to be left with only
I successfully take 0.4 mg day buprenorphine to treat RLS but the nausea side effect is very troublesome and there does not seem to be a satisfactory plan to get the better of it. I have unsuccessfully tried many anti nausea drugs and methods including Symprove probiotic and seem to be left with only
davchar23
in
Restless Legs Syndrome
5 months ago
Alk phos on Xeloda
Moms just started her 3 cycle today of xeloda. So she’s been on it 6 weeks. Her T bili is normal her ast and alt are normal . But her Alk phos is up. Her doctor said they would continue to monitor it. Anyone else have this elevate on Xeloda ? Thanks so much!
Moms just started her 3 cycle today of xeloda. So she’s been on it 6 weeks. Her T bili is normal her ast and alt are normal . But her Alk phos is up. Her doctor said they would continue to monitor it. Anyone else have this elevate on Xeloda ? Thanks so much!
Flower1513
in
SHARE Metastatic Breast Cancer
9 months ago
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constipation!!!
Hello anyone I have got this constant gnawing ,scratching ,pinching ETC going on in my bum and for 3/4 months really bad constipation frightened to poop in case I "UNBLOCK" myself to the nasty stuff I just can't control I looked it up on DR GOOGLE and it came up with Proctalgia Fugax/ Levator Syndromeas
Hello anyone I have got this constant gnawing ,scratching ,pinching ETC going on in my bum and for 3/4 months really bad constipation frightened to poop in case I "UNBLOCK" myself to the nasty stuff I just can't control I looked it up on DR GOOGLE and it came up with Proctalgia Fugax/ Levator Syndromeas
bungi1961
in
Bowel Disease Support
8 months ago
CRS4PC and Zytiga side effects ?
My hubby is 69 and recently started Zytiga three weeks ago and it seems that he has developed moderate fatigue and low appetite since one week ago. I’m wondering if this could be a side effect of the Zytiga or if anyone thinks it’s an immunity infection attack.
My hubby is 69 and recently started Zytiga three weeks ago and it seems that he has developed moderate fatigue and low appetite since one week ago. I’m wondering if this could be a side effect of the Zytiga or if anyone thinks it’s an immunity infection attack.
Corgi16
in
Advanced Prostate Cancer
7 months ago
Colonoscopy
Hello, I’ve been having various bowel issues for the past few months, ie. constipation, bloating, slight pain in lower back, bit of diarrhoea and my Dr would like me to go for a colonoscopy. As there’s no bleeding, I assumed it could be something else. Am I wrong to think this? Any advice welcome
Hello, I’ve been having various bowel issues for the past few months, ie. constipation, bloating, slight pain in lower back, bit of diarrhoea and my Dr would like me to go for a colonoscopy. As there’s no bleeding, I assumed it could be something else. Am I wrong to think this? Any advice welcome
CoffeeLover55
in
Bowel Disease Support
7 months ago
Oxynorm
I'm too .... shattered... to give a nicely put story even a short n sweet would be too much right now. So in the meantime I would love to hear your thoughts on Oxynorm as pain relief for brutal endometriosis. It's helping reasonably well for me (though not fully I may add) Many thanks in advance
I'm too .... shattered... to give a nicely put story even a short n sweet would be too much right now. So in the meantime I would love to hear your thoughts on Oxynorm as pain relief for brutal endometriosis. It's helping reasonably well for me (though not fully I may add) Many thanks in advance
Roellen
in
Endometriosis UK
7 months ago
Long time sufferer from gastric problems
I am female, 83 years old and have had stomach problems for most of my life, I have not been diagnosed with IBS but have all the symptoms. I keep trying probiotics, imodium , kaolin and morphine mixture but nothing helps for long.
I am female, 83 years old and have had stomach problems for most of my life, I have not been diagnosed with IBS but have all the symptoms. I keep trying probiotics, imodium , kaolin and morphine mixture but nothing helps for long.
cal428orie
in
IBS Network
7 months ago
Confusing news from oncologist
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
StayingSTRNG
in
Advanced Prostate Cancer
9 months ago
SBRT #4
Update on yesterday's SBRT #4. The machine that is treating me (Varian Edge) takes two revolutions to administer the fraction. They line you up with lasers and images before, track the fiducials during the rotation (and the machine automatically holds the beam if you and/or your prostate move out of
Update on yesterday's SBRT #4. The machine that is treating me (Varian Edge) takes two revolutions to administer the fraction. They line you up with lasers and images before, track the fiducials during the rotation (and the machine automatically holds the beam if you and/or your prostate move out of
ToolBeltZia
in
Prostate Cancer Network
9 months ago
new members
I know all too well how overwhelming this diagnosis can be to anyone. All of the emotions that can follow are hard to deal with for sure. If any new member doesn't feel comfortable posting anything here initially, please feel free to send me a message via 'chat'. We have all been exactly where you
I know all too well how overwhelming this diagnosis can be to anyone. All of the emotions that can follow are hard to deal with for sure. If any new member doesn't feel comfortable posting anything here initially, please feel free to send me a message via 'chat'. We have all been exactly where you
DonnaBoll
Administrator
in
PBC Foundation
5 months ago
Got a job interview. Plus my top 3 choice for therapists in my homecity. Overthinking the decisions
Okay so yesterday was a mayhem. Mom decided to clean while she's off work and got the house upside down, before that the night before that telling sis over and over again to drink water and telling me to tell her. Sis was avoiding me, asked me to stay in the car instead in the café with her, yelled at
Okay so yesterday was a mayhem. Mom decided to clean while she's off work and got the house upside down, before that the night before that telling sis over and over again to drink water and telling me to tell her. Sis was avoiding me, asked me to stay in the car instead in the café with her, yelled at
Against_the_current
in
Anxiety and Depression Support
3 months ago
carbimazole and iron supplements
hi all, I have very low ferritin and need to supplement iron. Do I need to take my carbimazole away from iron or it doesn’t matter?
hi all, I have very low ferritin and need to supplement iron. Do I need to take my carbimazole away from iron or it doesn’t matter?
Kari55
in
Thyroid UK
7 months ago
help/advice
Hello, I recently switched to Prozac after being on Lexapro for about a year and a half. The experience started great, I cross tapered with 5mg of lexapro. I had renewed interest in things I enjoyed like films and books and games. However, Wednesday on my way to work I experienced a horrible panic
Hello, I recently switched to Prozac after being on Lexapro for about a year and a half. The experience started great, I cross tapered with 5mg of lexapro. I had renewed interest in things I enjoyed like films and books and games. However, Wednesday on my way to work I experienced a horrible panic
treyjeff
in
Anxiety Support
5 months ago
Antidepressants
Hi all, Increased anxiety has become one of my worst symptoms of B12 deficiency and (possible*) PA. I’m on 4 weekly B12 injections (Hydrocobalamin 1mg) on the NHS but I’ve not noticed any improvements so far. I’ve had the 6 loading doses and 2 further injections so far. I’m taking D3/K2 (3000iu/100ug
Hi all, Increased anxiety has become one of my worst symptoms of B12 deficiency and (possible*) PA. I’m on 4 weekly B12 injections (Hydrocobalamin 1mg) on the NHS but I’ve not noticed any improvements so far. I’ve had the 6 loading doses and 2 further injections so far. I’m taking D3/K2 (3000iu/100ug
Pa234aw
in
Pernicious Anaemia Society
7 months ago
A plea from your brother
Click here to securely donate in any currency: https://malecare.org/donate Click here to securely donate in any currency:A Plea from Your Brother My prostate cancer diagnosis introduced me to Malecare - with the commanding encouragement of my urologist. My experiences validated the organization's remarkable
Click here to securely donate in any currency: https://malecare.org/donate Click here to securely donate in any currency:A Plea from Your Brother My prostate cancer diagnosis introduced me to Malecare - with the commanding encouragement of my urologist. My experiences validated the organization's remarkable
Darryl
Partner
in
Prostate Cancer Network
9 months ago
A plea from your brother
Click here to securely donate in any currency: https://malecare.org/donate A Plea from Your Brother My prostate cancer diagnosis introduced me to Malecare - with the commanding encouragement of my urologist. My experiences validated the organization's remarkable efforts in supporting men like me. I'm
Click here to securely donate in any currency: https://malecare.org/donate A Plea from Your Brother My prostate cancer diagnosis introduced me to Malecare - with the commanding encouragement of my urologist. My experiences validated the organization's remarkable efforts in supporting men like me. I'm
Darryl
Partner
in
Advanced Prostate Cancer
9 months ago
Blood in Urine
Hi fellow fighters Had blood in my urine the last 10 days. Hoped it was a UTI but a course of antibiotics has failed. I had a bladder neck incision last June to help urinary flow. The urologist saw a suspicious patch and a biopsy confirmed it my prostate cancer has spread to my bladder. I’m hoping
Hi fellow fighters Had blood in my urine the last 10 days. Hoped it was a UTI but a course of antibiotics has failed. I had a bladder neck incision last June to help urinary flow. The urologist saw a suspicious patch and a biopsy confirmed it my prostate cancer has spread to my bladder. I’m hoping
Tonyliv
in
Advanced Prostate Cancer
9 months ago
New Challenge!
Hi, I haven’t been on here for a while as was diagnosed with stage 2 breast cancer following a mammogram in late September. I underwent surgery for a mastectomy with a reconstruction on 15 th December and now starting my recovery! So going to be tricky managing my PMR symptoms as well as deal with this
Hi, I haven’t been on here for a while as was diagnosed with stage 2 breast cancer following a mammogram in late September. I underwent surgery for a mastectomy with a reconstruction on 15 th December and now starting my recovery! So going to be tricky managing my PMR symptoms as well as deal with this
GwenTheHen16
in
PMRGCAuk
9 months ago
Continued Journey
I’ve had the Bone Marrow Transplant!!! That was actually the easiest part. 5 hours of fluids leading up to the BMT and the previous 5 days of chemo infusions (day5 was the worst) were much harder. Chemo: Fladarabine -6 thru-2 with addition of Melphalan on day-2. When you start treatment (chemo) for
I’ve had the Bone Marrow Transplant!!! That was actually the easiest part. 5 hours of fluids leading up to the BMT and the previous 5 days of chemo infusions (day5 was the worst) were much harder. Chemo: Fladarabine -6 thru-2 with addition of Melphalan on day-2. When you start treatment (chemo) for
FiArt12X
in
CLL Support
3 months ago
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