Well I have a a hard time these past couple of months I had my mother in law in and out of hospital she got cancer on one of her kidneys and had removed them in her bladder got that removed and now we are gonna start some type of therapy!
As for my mom she has been ok we’re still with a low dose of venetoclax and ibruvica her whites are low again 2.6 and what worries me is her b2 microglobin is 2.8 the max is 2.5.
That was always very low from march I saw an elevation but the haematologist didn’t comment.
Has anyone had this before I’m thinking all this treatment isn’t working or the malt lymphoma on the lining of the stomach hasn’t gone away or progressed…
Hope everyone is doing ok wishing everyone a peaceful and full of health Christmas and a great 2024
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Eirinik
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Inflammations from various sources can affect beta 2 microglobulin, it isn't specific only to cancers. So viral infections, and diseases causing inflammation of, say, kidney or liver, may also contribute. People with inflammatory bowel disease may have changing levels. It's a molecule that's integral to our body.
And remember "normal levels" of lab values are across broad populations; fluctuations a few tenths of a percent are usually not clinically significant. A change in a lab number, without changes in other signs and symptoms, is often just random.
As an example, a few years ago my bilirubin slowly crept up slightly out of normal, and stayed slightly elevated for most of a year, before going back to "normal". I didn't have any other signs/symptoms like jaundice, or pain. Who knows why it did that!
I’m no expert, but I dont think 2.8 beta 2 microglobulin for a Cll patient is a big deal. I’m doing well on calquence for a few yrs now, and my beta 2 is almost always higher than normal. I addressed it with my doc once and he said it’s fine being slightly elevated. It’s something n to keep an eye on and address with her doctor next visit. Good luck.
My B2M was 2.7 at diagnosis in 2015. My CLL specialist said that was fine and that it can be higher than the lab range as we age and still be considered normal.
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