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Almost ready for phase 1: JHU083 (or JHU-083) a selective glutamine metabolism blocker
"The drug, JHU083, is a type of molecule called a prodrug that cells inside the body convert into an active drug. Specifically, JHU083 can only be turned into its active, glutamine-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. " We all know that
"The drug, JHU083, is a type of molecule called a prodrug that cells inside the body convert into an active drug. Specifically, JHU083 can only be turned into its active, glutamine-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. " We all know that
Maxone73
in
Advanced Prostate Cancer
3 months ago
lupus ?
I have had one positive ana test ,three months later had another one that was negative?I have a rash on my cheeks &nose & forehead, pain in my hands& fingers &toes feels like frostbite, my legs feel really heavy, pain in my stomach & chest pain, sensitive to sunlight & bright lights. I was diagnosed
I have had one positive ana test ,three months later had another one that was negative?I have a rash on my cheeks &nose & forehead, pain in my hands& fingers &toes feels like frostbite, my legs feel really heavy, pain in my stomach & chest pain, sensitive to sunlight & bright lights. I was diagnosed
GGHolly
in
LUPUS UK
21 days ago
Struggling with disimpaction regime
Hello, really hoping someone has some advice as I’m at the end of my tether! My son is 5, he has struggled with constipation since he was 6 months old. He went onto Movicol (just x1 sachet a day) which was working fine to keep his stools soft and passable however when he began potty training at 3y/o
Hello, really hoping someone has some advice as I’m at the end of my tether! My son is 5, he has struggled with constipation since he was 6 months old. He went onto Movicol (just x1 sachet a day) which was working fine to keep his stools soft and passable however when he began potty training at 3y/o
Lem14
in
ERIC
3 months ago
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Pm scl 100
Brychni 23 hours ago•3 Replies Hello 👋 I posted this message on the Raynaud's and scleroderma group but after some research wondered if anyone here can help.me: Got my blood results back from rheumatology today, they were looking for scleroderma because of my worsening Raynaud's and finger ulcers.
Brychni 23 hours ago•3 Replies Hello 👋 I posted this message on the Raynaud's and scleroderma group but after some research wondered if anyone here can help.me: Got my blood results back from rheumatology today, they were looking for scleroderma because of my worsening Raynaud's and finger ulcers.
Brychni
in
Myositis UK
23 days ago
Vitamin B12 Sublingual - Why do I feel sleepy?
Hello Everyone Just took a tablet of Vitamin B12 Sublingual today morning just after breakfast and felt v sleepy and took a short nap after noon. Is this expected? Has anyone experienced this? This is the brand that I bought: https://www.cytoplan.co.uk/vitamin-b12-sublingual-as-methylcobalamin-adenosylcobalamin
Hello Everyone Just took a tablet of Vitamin B12 Sublingual today morning just after breakfast and felt v sleepy and took a short nap after noon. Is this expected? Has anyone experienced this? This is the brand that I bought: https://www.cytoplan.co.uk/vitamin-b12-sublingual-as-methylcobalamin-adenosylcobalamin
BookLover2020
in
Thyroid UK
3 months ago
Newly diagnosed. Looking for advice
Good morning. I've sadly recently been diagnosed with ulcerative colitis. I was suffering 5 years ago with calprotectin score 450 and had a urgent colonoscopy that found polyps and piles which were removed biopsied/ banded. Continued to have on off blood in stools for a few years each time I was blaming
Good morning. I've sadly recently been diagnosed with ulcerative colitis. I was suffering 5 years ago with calprotectin score 450 and had a urgent colonoscopy that found polyps and piles which were removed biopsied/ banded. Continued to have on off blood in stools for a few years each time I was blaming
Raerae2781
in
Crohn's and Colitis Support
3 months ago
PM Scl 100
Hello lovely peopleGot my blood results back from rheumatology today, they were looking for scleroderma because of my worsening Raynaud's and finger ulcers. Thankfully I tested negative for everything except the one in the title : PM Scl 100. Does anyone know what this means, if anything. To recap I
Hello lovely peopleGot my blood results back from rheumatology today, they were looking for scleroderma because of my worsening Raynaud's and finger ulcers. Thankfully I tested negative for everything except the one in the title : PM Scl 100. Does anyone know what this means, if anything. To recap I
Brychni
in
Scleroderma & Raynaud's UK (SRUK)
24 days ago
Please Help Me.
Hello all! I'm a 29 year old guy from the UK. I've had diarrearh for nearly 6 weeks. I have severe bloating. I was admitted to Hospital last week, they've asked me to do a Bowel cancer sample test (which I've done) During the blood tests they've found my Liver Enzymes are elevated. They've ordered
Hello all! I'm a 29 year old guy from the UK. I've had diarrearh for nearly 6 weeks. I have severe bloating. I was admitted to Hospital last week, they've asked me to do a Bowel cancer sample test (which I've done) During the blood tests they've found my Liver Enzymes are elevated. They've ordered
Lmm4
in
British Liver Trust
3 months ago
Peripheral neuropathy and neurology's response
Hi. I've posted a couple of times recently so I'll start with a precise and then my ask! I was diagnosed with Vitamin B12 deficiency in 2015 - I wasn't tested for PA. I have self-injected for 4 years (hydroxocobalamin) - and got my life back by injecting every other day (sometimes increasing to daily
Hi. I've posted a couple of times recently so I'll start with a precise and then my ask! I was diagnosed with Vitamin B12 deficiency in 2015 - I wasn't tested for PA. I have self-injected for 4 years (hydroxocobalamin) - and got my life back by injecting every other day (sometimes increasing to daily
LizWilsonpa
in
Pernicious Anaemia Society
3 months ago
Bloating for 2 months
Hi, does anyone suffer with bloating but all the time? For the last couple of months my stomach has felt bloated most days and more recently I have had a gurgling stomach, mucus in my poo, lower back pain, urgency and acid reflux. I am currently having bloods, stool samples etc to rule out other things
Hi, does anyone suffer with bloating but all the time? For the last couple of months my stomach has felt bloated most days and more recently I have had a gurgling stomach, mucus in my poo, lower back pain, urgency and acid reflux. I am currently having bloods, stool samples etc to rule out other things
Starshine83
in
IBS Network
3 months ago
PSMA/PET SCAN methodology
I'm having PSMA next week and am confused a little about the equipment used. In all my reading about the test, a CT or MRI is used in conjunction with the PSMA Pet, When I looked at my upcoming test on the portal it says PET SKULLBASE TO MIDTHIGH NOPR SUBSEQUENT. That tells me it's a PET Scan and
I'm having PSMA next week and am confused a little about the equipment used. In all my reading about the test, a CT or MRI is used in conjunction with the PSMA Pet, When I looked at my upcoming test on the portal it says PET SKULLBASE TO MIDTHIGH NOPR SUBSEQUENT. That tells me it's a PET Scan and
hwrjr
in
Prostate Cancer Network
6 months ago
Pre Op assessment
I was diagnosed in July with stage 4 endo/adeno, bilateral endometriomas and a frozen pelvis, large ovarian cysts, enlarged falopian tubes following MRI and various ultrasounds. I have been on prostrop since, while on the waiting list for surgery. Last month I received a call from the endo nurse saying
I was diagnosed in July with stage 4 endo/adeno, bilateral endometriomas and a frozen pelvis, large ovarian cysts, enlarged falopian tubes following MRI and various ultrasounds. I have been on prostrop since, while on the waiting list for surgery. Last month I received a call from the endo nurse saying
EvilEdna77
in
Endometriosis UK
6 months ago
Functional Gerd/Heartburn
Good day everyone, has anyone ever researched this topic ? I was diagnosed with AIG few months back, started EOD injections and recently developed what feels like heartburn, which I have never had before. The pain is usually in bottom chest area and is accompanied with flatulence and burping. I read
Good day everyone, has anyone ever researched this topic ? I was diagnosed with AIG few months back, started EOD injections and recently developed what feels like heartburn, which I have never had before. The pain is usually in bottom chest area and is accompanied with flatulence and burping. I read
Canadian77
in
Pernicious Anaemia Society
3 months ago
2nd recurrence
Hi Ladies as you know I have already posted that I have started treatment for a 2nd recurrence of my Stage 2 OC. I was diagnosed in 2021 and had surgery and 6 cycles of successful Chemo. I started to feel unwell around October time with upper right back pain. CT and MRI were clear. CA125 did start
Hi Ladies as you know I have already posted that I have started treatment for a 2nd recurrence of my Stage 2 OC. I was diagnosed in 2021 and had surgery and 6 cycles of successful Chemo. I started to feel unwell around October time with upper right back pain. CT and MRI were clear. CA125 did start
Hota
in
My Ovacome
6 months ago
Upper left pain and soreness
Hi …. Does anyone else suffer from upper left quarter / centre pain and discomfort. Side almost feels sore (almost like muscular soreness). Constant belching and flatulence, sometimes loose or constipated. Been going on for 4 months. Had colonoscopy and Abdominal and Pelvic CT scan, all clear but symptoms
Hi …. Does anyone else suffer from upper left quarter / centre pain and discomfort. Side almost feels sore (almost like muscular soreness). Constant belching and flatulence, sometimes loose or constipated. Been going on for 4 months. Had colonoscopy and Abdominal and Pelvic CT scan, all clear but symptoms
Dh19
in
IBS Network
3 months ago
Confused about potential ibs c with overflow diagnosis
So after having a constant list of other symptoms unrelated to bowels i have finally spoke to a gastro who is assuming i have ibs c with overflow. I am on the waiting list for a colonoscopy so this potential diagnosis has been made on a 5 min phone call not an in person appointment. My confusion comes
So after having a constant list of other symptoms unrelated to bowels i have finally spoke to a gastro who is assuming i have ibs c with overflow. I am on the waiting list for a colonoscopy so this potential diagnosis has been made on a 5 min phone call not an in person appointment. My confusion comes
Confused1806
in
IBS Network
3 months ago
bowel blockage
Had bowel resection 6 years ago . Iliostomy bag and then successful reversal . Had an appendectomy about a year later, because my appendix were stuck to my ileostomy scar internally. I had pain and went to the hospital, but my surgery wasn’t emergency. I was scheduled about two weeks later for the appendectomy
Had bowel resection 6 years ago . Iliostomy bag and then successful reversal . Had an appendectomy about a year later, because my appendix were stuck to my ileostomy scar internally. I had pain and went to the hospital, but my surgery wasn’t emergency. I was scheduled about two weeks later for the appendectomy
Gardeningbuff
in
Bowel Disease Support
3 months ago
Lymph node Metastasis
After 7 years, and multiple PSMA scans, my husband had a FDG CT scan and it showed what they quoted as “several” metastasis In the lymphs In the para aortic area in abdomen. One doc wants to biopsy to check if cancer DNA has changed from original pathology in 2017. Another doc says… No to biopsy due
After 7 years, and multiple PSMA scans, my husband had a FDG CT scan and it showed what they quoted as “several” metastasis In the lymphs In the para aortic area in abdomen. One doc wants to biopsy to check if cancer DNA has changed from original pathology in 2017. Another doc says… No to biopsy due
JolleySprings
in
Advanced Prostate Cancer
5 months ago
History of continued low and fluctuating iron levels - advice?
hi folks. Just had my latest bloods back from helpful GP (he’s actually happy for me to sort my thyroid with Roseway! TSH barely exists) My iron is pretty abysmal tho .. Last time i had my transferrin saturation index done it was 40% so bang on mid way. January I think it was. It’s now dropped to19%
hi folks. Just had my latest bloods back from helpful GP (he’s actually happy for me to sort my thyroid with Roseway! TSH barely exists) My iron is pretty abysmal tho .. Last time i had my transferrin saturation index done it was 40% so bang on mid way. January I think it was. It’s now dropped to19%
Starseed56
in
Thyroid UK
3 months ago
pelvic pain
Has anyone tried MRI Defecography tests for rectum and anal pain? It’s a first suggested to me. Don’t know if this may help diagnose this pain.
Has anyone tried MRI Defecography tests for rectum and anal pain? It’s a first suggested to me. Don’t know if this may help diagnose this pain.
Sissy8-1-2019
in
Pelvic Pain Support Network
3 months ago
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