Almost ready for phase 1: JHU083 (or JHU-083) a selective glutamine metabolism blocker

[Maxone73]

"The drug, JHU083, is a type of molecule called a prodrug that cells inside the body convert into an active drug. Specifically, JHU083 can only be turned into its active, glutamine-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. "

We all know that PCa is glutamine dependent but that glutamine is super useful in many biological processes inside our body, so simply blocking it would not be feasible...but these guys seem to have found a solution! Hopefully soon!

sciencedaily.com/releases/2...

[OsloN]

Especially if the tocxicity is absent, this treatment could be added to other treatments making the combinations superior. But again, clinical trials will take years.

[j-o-h-n]

All this activity going on finding solutions here and there.......... And when they delivered the pizza that I ordered, of course they forgot the anchovies...Life's a bitch.....

Good Luck, Good Health and Good Humor.

j-o-h-n

[Maxone73 in reply to j-o-h-n]

how right you are!

[Shams_Vjean in reply to j-o-h-n]

Pizza without anchovies is like____ (? fill in the blank).

I’ll start…like sex without a lover.

[j-o-h-n in reply to Shams_Vjean]

A huge air leak in your blow up doll....

Good Luck, Good Health and Good Humor.

j-o-h-n

[Shams_Vjean in reply to j-o-h-n]

So deflating….

[j-o-h-n in reply to Shams_Vjean]

Yep it was, But I got some solace when trying to blow her up where she had been punctured.

Good Luck, Good Health and Good Humor.

j-o-h-n