"The drug, JHU083, is a type of molecule called a prodrug that cells inside the body convert into an active drug. Specifically, JHU083 can only be turned into its active, glutamine-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. "
We all know that PCa is glutamine dependent but that glutamine is super useful in many biological processes inside our body, so simply blocking it would not be feasible...but these guys seem to have found a solution! Hopefully soon!