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Time to PSA Nadir is related to progression-free-survival
This graph from Teoh (2014) plots the relationship between Time to PSA Nadir (months) versus Time to Progression (months) (i.e., Progression Free Survival). Cohort: ADT monotherapy (No RP or RT), all metastatic patients, median 74 y.o., GS = 8-10, N=419. A cubic spline curve fit matched the data points
This graph from Teoh (2014) plots the relationship between Time to PSA Nadir (months) versus Time to Progression (months) (i.e., Progression Free Survival). Cohort: ADT monotherapy (No RP or RT), all metastatic patients, median 74 y.o., GS = 8-10, N=419. A cubic spline curve fit matched the data points
janebob99
in
Advanced Prostate Cancer
6 months ago
Spine metastasis
My father in law is 78 year old male with PCA with what appears to be a single spine metastasis. Gleason 7 ( 4+3) We have an appointment coming up with the radiation oncologist . Is this something they would get a PSMA TEST for to confirm and also would he just receive ADT with radiation to primary site
My father in law is 78 year old male with PCA with what appears to be a single spine metastasis. Gleason 7 ( 4+3) We have an appointment coming up with the radiation oncologist . Is this something they would get a PSMA TEST for to confirm and also would he just receive ADT with radiation to primary site
Telegraph2022
in
Advanced Prostate Cancer
9 months ago
significant free fluid in pouch of douglas
Hello I have been suffering with terrible pain in my right side lower groin. I described to the Gap that it feels like I am carrying something or a pressure in lower back and at times causes my right thigh to actually go numb. I went to the GP and was referred for an ultrasound for a hernia. No hernia
Hello I have been suffering with terrible pain in my right side lower groin. I described to the Gap that it feels like I am carrying something or a pressure in lower back and at times causes my right thigh to actually go numb. I went to the GP and was referred for an ultrasound for a hernia. No hernia
brontec
in
Endometriosis UK
6 months ago
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Using Enzalutamide, Darolutamide, Apalutamide only.
I've seen a number of posters here and there who say they use one of the "mides" listed above with no ADT like Lupron, Eligard, Firmagan, or Orgovyx, etc. If so, did you begin that regimen after being on first level ADT for a while along with the 'mide," or did you start on the "mide" alone at the start
I've seen a number of posters here and there who say they use one of the "mides" listed above with no ADT like Lupron, Eligard, Firmagan, or Orgovyx, etc. If so, did you begin that regimen after being on first level ADT for a while along with the 'mide," or did you start on the "mide" alone at the start
dhccpa
in
Prostate Cancer Network
6 months ago
nervous about starting Levo
As of January this year TSH ; 7.28 Free T4: 11 TPO antibodies greater than 600 My history is in 2018( 56yrs old) I had acute thyroiditis, commenced Levo for a week, intolerant, so I went to functional Dr who recommended a diet for me Gluten,Diary and soya free, I have been stable
As of January this year TSH ; 7.28 Free T4: 11 TPO antibodies greater than 600 My history is in 2018( 56yrs old) I had acute thyroiditis, commenced Levo for a week, intolerant, so I went to functional Dr who recommended a diet for me Gluten,Diary and soya free, I have been stable
glutendairysoya
in
Thyroid UK
6 months ago
Pelvic pain on prostap
Hello, i am experiencing very bad pelvic and lower back pain. i am 35 with adenomyosis, i didn't know i had this until i had an MRI. They put me on prostap 3 and i have had none stop pelvic pain and on/off bleeding. I am nearly 9 weeks in to the 3 monthly injection. Please help, is this normal? i haven't
Hello, i am experiencing very bad pelvic and lower back pain. i am 35 with adenomyosis, i didn't know i had this until i had an MRI. They put me on prostap 3 and i have had none stop pelvic pain and on/off bleeding. I am nearly 9 weeks in to the 3 monthly injection. Please help, is this normal? i haven't
SallyK2589
in
Endometriosis UK
6 months ago
What are the most promising drugs/treatments on the horizon for PD symptom relief,slowing progression?
I see Buntanetap,Celeste light therapy and Cue1 as potentials. anyone have any thoughts? i dont know how much longer I can hang on.
I see Buntanetap,Celeste light therapy and Cue1 as potentials. anyone have any thoughts? i dont know how much longer I can hang on.
Jmellano
in
Cure Parkinson's
11 months ago
Recommendations via direct message for endo
Morning all, hoping to hear if anyone has worked successfully with an endo based in London/south east who specialise in thyroid AND menopause? Private or NHS.... Thank you. As per the rules of the board, please direct message me with these. Need help starting on hrt at same time as starting thyroid
Morning all, hoping to hear if anyone has worked successfully with an endo based in London/south east who specialise in thyroid AND menopause? Private or NHS.... Thank you. As per the rules of the board, please direct message me with these. Need help starting on hrt at same time as starting thyroid
Astrido
in
Thyroid UK
6 months ago
Newly diagnosed metastatic PC treatment options
Hi, I'm 68 years old. Here are the key points in my story so far: In July 2023 a blood test showed a PSA value of 45. On September 26 2023, prostate MRI showed a dominant tumor in the prostate with extension into the right seminal vesicle. Also the fat plane between the rectum and prostate is lost
Hi, I'm 68 years old. Here are the key points in my story so far: In July 2023 a blood test showed a PSA value of 45. On September 26 2023, prostate MRI showed a dominant tumor in the prostate with extension into the right seminal vesicle. Also the fat plane between the rectum and prostate is lost
ShorePine
in
Advanced Prostate Cancer
11 months ago
Studies re: PSA > 0.5% after RT
Can anyone interpret the gist of these studies? Correct me if I am wrong (and I sure hope to be) but from what I am gleaning, it seems that for those who have RT and a concurrent round of ADT: 1) Researchers and studies are showing that waiting 18 months to reach a post RT nadir isn't necessary to determine
Can anyone interpret the gist of these studies? Correct me if I am wrong (and I sure hope to be) but from what I am gleaning, it seems that for those who have RT and a concurrent round of ADT: 1) Researchers and studies are showing that waiting 18 months to reach a post RT nadir isn't necessary to determine
quietcorner
in
Advanced Prostate Cancer
6 months ago
6 Month Eligard
I got my results from PSA/PET last week, showing no metastatic activity anywhere, bones and lymph nodes clear. My last Gleason score was 4+3 in 1 sample, 3+3 in 2 more same side, but focus of intraductal cancer in 2 cores on other side. Last PSA 5.3 in February, stable between 5.0 and 5.8 last 2 years
I got my results from PSA/PET last week, showing no metastatic activity anywhere, bones and lymph nodes clear. My last Gleason score was 4+3 in 1 sample, 3+3 in 2 more same side, but focus of intraductal cancer in 2 cores on other side. Last PSA 5.3 in February, stable between 5.0 and 5.8 last 2 years
SherpaT
in
Prostate Cancer Network
6 months ago
pelvic pain and no hrt withdrawal bleed
Hello all, I would be grateful for some advice or reassurance please. I have been on Sequential HRT for 5 years, as started having perimenopause symptoms around then. I have always had a withdrawal bleed once a month. I have found that taking hrt does make me a bit bloated and my tummy a bit uncomfortable
Hello all, I would be grateful for some advice or reassurance please. I have been on Sequential HRT for 5 years, as started having perimenopause symptoms around then. I have always had a withdrawal bleed once a month. I have found that taking hrt does make me a bit bloated and my tummy a bit uncomfortable
girlwithcurls
in
Pelvic Pain Support Network
6 months ago
Cyberknife+IMRT combination treatment for High Risk PCa, that has spread to the seminal vesicle.
Has anyone done a cyberknife-imrt combination radiation treatment for prostate cancer? My PCa has spread to the Seminal Vesicle. So, instead of a planned 5 session cyberknife treatment to the prostate only ( when the PCa was thought to be confined to the prostate), my doc is putting me on 3 cyberknife
Has anyone done a cyberknife-imrt combination radiation treatment for prostate cancer? My PCa has spread to the Seminal Vesicle. So, instead of a planned 5 session cyberknife treatment to the prostate only ( when the PCa was thought to be confined to the prostate), my doc is putting me on 3 cyberknife
Sushupthi
in
Advanced Prostate Cancer
4 months ago
3year Updates w/PSA Graph
Hi Everyone, I'd like to report my 3 year journey. Initial PSA 27 in 6/20. Diagnosed w/PC 10/20. Gleason score is 3+4 (high-risk). My T-stage is T2a/T2b. CT Scan showed no lymph node & Bone Scan showed some indication of met. PSMA/PET in 1/12/21 showed no met outside. Started ADT (Lupron
Hi Everyone, I'd like to report my 3 year journey. Initial PSA 27 in 6/20. Diagnosed w/PC 10/20. Gleason score is 3+4 (high-risk). My T-stage is T2a/T2b. CT Scan showed no lymph node & Bone Scan showed some indication of met. PSMA/PET in 1/12/21 showed no met outside. Started ADT (Lupron
brucesam
in
Advanced Prostate Cancer
6 months ago
Length of Treatment for Orgovyx (Relugolix) versus Lupron and other Longer Acting ADT drugs as Adjuvant to RT or Used for IADT?
I'm curious if anyone has had any discussion with their MO or Radiation Oncologist about having to take a longer course of Orgovyx compared to Lupron or other longer acting ADT drugs because Testosterone comes back so much quicker on Orgovyx? It would seem to me, 6 months of Orgovyx is like the equivalent
I'm curious if anyone has had any discussion with their MO or Radiation Oncologist about having to take a longer course of Orgovyx compared to Lupron or other longer acting ADT drugs because Testosterone comes back so much quicker on Orgovyx? It would seem to me, 6 months of Orgovyx is like the equivalent
jazj
in
Advanced Prostate Cancer
6 months ago
strange thyroid blood results
my wife is subclinical Hypo, been on 1 grain of Thyroid-S for the past couple of years. Started HRT in Aug 2023, blood test done in Dec, numbers had gone down, increase to 2 grain. Last bloodwork done Mar 2024. Numbers gone down again but TSH is now suppressed. I’m completely confused. Any thoughts
my wife is subclinical Hypo, been on 1 grain of Thyroid-S for the past couple of years. Started HRT in Aug 2023, blood test done in Dec, numbers had gone down, increase to 2 grain. Last bloodwork done Mar 2024. Numbers gone down again but TSH is now suppressed. I’m completely confused. Any thoughts
gazzamate
in
Thyroid UK
6 months ago
HRT and B12
So I went to see an actual Doctor, having been diagnosed with PA by the nurses last summer, with a B12 level of 143.His opening gambit, having looked at the September blood results, serum vitamin B12 = 496, was "You do not have Pernicious Anemia!" Stupid me hadn't SId for 4 days, because I wanted the
So I went to see an actual Doctor, having been diagnosed with PA by the nurses last summer, with a B12 level of 143.His opening gambit, having looked at the September blood results, serum vitamin B12 = 496, was "You do not have Pernicious Anemia!" Stupid me hadn't SId for 4 days, because I wanted the
Oneash
in
Pernicious Anaemia Society
6 months ago
microvascular angina result/reading query
Hi all ! I had an angiogram that looked at Micro Vascular issues and had an IMR reading (index of microcirculatory resistance IMR) of 30 - which means a diagnosis of Micro Vascular Angina.. But does anyone know what this means? Is it good or bad? Barely on the charts or well along? I’ve tried googling
Hi all ! I had an angiogram that looked at Micro Vascular issues and had an IMR reading (index of microcirculatory resistance IMR) of 30 - which means a diagnosis of Micro Vascular Angina.. But does anyone know what this means? Is it good or bad? Barely on the charts or well along? I’ve tried googling
Nicola06
in
British Heart Foundation
6 months ago
Subclinical hypothyroidism advice for next appointment
Hi, I was told I was I had Subclinical hypothyroidism in 2017 but was not significant so no further input. Unsure of exact results but TSH was raised, but <10 with normal T4 (but do not have a copy of the results). Past few years have noticed hair loss, muscle aches & pains, tiredness, some weight gain
Hi, I was told I was I had Subclinical hypothyroidism in 2017 but was not significant so no further input. Unsure of exact results but TSH was raised, but <10 with normal T4 (but do not have a copy of the results). Past few years have noticed hair loss, muscle aches & pains, tiredness, some weight gain
bluepenguin
in
Thyroid UK
6 months ago
Prostap injection
Hi, I currently just starting taking prostap injection and taking hrt tablets and as soon after ive got bleeding and what feels like period pain. Is this normal? The consultant said the injections will stop all bleeding and I shouldn’t have periods im wondering is theres a time delay before this happens
Hi, I currently just starting taking prostap injection and taking hrt tablets and as soon after ive got bleeding and what feels like period pain. Is this normal? The consultant said the injections will stop all bleeding and I shouldn’t have periods im wondering is theres a time delay before this happens
Rashid-89
in
Endometriosis UK
6 months ago
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