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Are we SURE we want to increase glutathione? Is glutathione related to the glutamate Excitotoxicity that occurs in PD?
glutathione is an important antioxidant but, can it contribute to the glutamate excitoxicity that occurs in PD and is believed to lead to the GABA astrocytes that cause dopamine neurons to go dormant? Should we exercise caution in increasing glutathione? That is the question I posed which lead me
glutathione is an important antioxidant but, can it contribute to the glutamate excitoxicity that occurs in PD and is believed to lead to the GABA astrocytes that cause dopamine neurons to go dormant? Should we exercise caution in increasing glutathione? That is the question I posed which lead me
Hidden
in
Cure Parkinson's
3 years ago
Any scientific papers on DAWS (Dopamine Agonist Withdrawal Syndrome) and/or withdrawing off or tapering down dopamine agonists?
Good afternoon everyone. I had an appointment with my neurologist last week and finally convinced her that I should try reducing my Rotigotine (Neupro patch) medication (currently at 4mg). However, I am not happy with her suggestion/recommendation that I just drop down to 3mg patches. I told her that
Good afternoon everyone. I had an appointment with my neurologist last week and finally convinced her that I should try reducing my Rotigotine (Neupro patch) medication (currently at 4mg). However, I am not happy with her suggestion/recommendation that I just drop down to 3mg patches. I told her that
YodaDog
in
Restless Legs Syndrome
3 years ago
Today we announced that the US FDA has cleared IND applications for 4dpharmaplc’s LiveBiotherapeutics MRx0005 and MRx0029, Phase I
Today we announced that the US FDA has cleared IND applications for @4dpharmaplc’s #LiveBiotherapeutics MRx0005 and MRx0029 for the treatment of #Parkinsons, and Phase I trial in patients is expected to commence mid-2022 MRx0005 and MRx0029 are two unique single strain Live Biotherapeutic candidates
Today we announced that the US FDA has cleared IND applications for @4dpharmaplc’s #LiveBiotherapeutics MRx0005 and MRx0029 for the treatment of #Parkinsons, and Phase I trial in patients is expected to commence mid-2022 MRx0005 and MRx0029 are two unique single strain Live Biotherapeutic candidates
Hidden
in
Cure Parkinson's
3 years ago
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Is Parkinson's a disease of the substantia nigra or dysfunction of the hypothalamus?
Autonomic dysfunction is often one of the earliest manifestations of PD. Symptoms of autonomic failure can be cardiovascular, gastrointestinal, urogenital, thermoregulatory, pupillary, respiratory, sexual, or sleep related. I would argue that in neurodegenerative disorders, all of the above eventually
Autonomic dysfunction is often one of the earliest manifestations of PD. Symptoms of autonomic failure can be cardiovascular, gastrointestinal, urogenital, thermoregulatory, pupillary, respiratory, sexual, or sleep related. I would argue that in neurodegenerative disorders, all of the above eventually
SilentEchoes
in
Cure Parkinson's
3 years ago
Some thoughts on Gluten sensitivity
Gluten, which is found in wheat, may exacerbate Parkinson's-related symptoms in some patients. A brain scan was done on the man that showed abnormalities that were consistent with lower levels of dopamine production, which when combined with the clinical data, led the doctor to diagnose him with PD.
Gluten, which is found in wheat, may exacerbate Parkinson's-related symptoms in some patients. A brain scan was done on the man that showed abnormalities that were consistent with lower levels of dopamine production, which when combined with the clinical data, led the doctor to diagnose him with PD.
Farooqji
in
Cure Parkinson's
3 years ago
Sweetener / sugar trigger observations.
Hallo, I've been observing possible triggers of RL symptoms and would like to share this with you all. last year I did a tapering program to come off of Clonazepam, I had been on this drug for over 20 years. The RL was at its worst - after coming off of Clonazepam, it went into remission for around
Hallo, I've been observing possible triggers of RL symptoms and would like to share this with you all. last year I did a tapering program to come off of Clonazepam, I had been on this drug for over 20 years. The RL was at its worst - after coming off of Clonazepam, it went into remission for around
Lunatha
in
Restless Legs Syndrome
3 years ago
Practical suggestions for PWP Once upon a pill..
This book is an in-depth look at Parkinson’s disease medications and the brain chemistry of Parkinson’s. Parkinson’s patients using L-dopa, dopamine agonists, MAO inhibitors and other dopamine- enhancing drugs and supplements were closely studied as they participated in a four-year research project
This book is an in-depth look at Parkinson’s disease medications and the brain chemistry of Parkinson’s. Parkinson’s patients using L-dopa, dopamine agonists, MAO inhibitors and other dopamine- enhancing drugs and supplements were closely studied as they participated in a four-year research project
beehive23
in
Cure Parkinson's
3 years ago
Dr. Jonathan Sackner-Bernstein - "What If I Discovered the Silver Bullet?" on Zoom at 7.30pm London time on Monday 21st Feb
I am delighted to announce that our next zoom session will be taking place at 7.30 pm London time on Monday, the 21st of February. Dr. Jonathan Sackner-Bernstein will be talking to us about: "What If I Discovered the Silver Bullet?" Motivated by a friend’s suffering from Parkinson’s, Dr. Sackner-Bernstein
I am delighted to announce that our next zoom session will be taking place at 7.30 pm London time on Monday, the 21st of February. Dr. Jonathan Sackner-Bernstein will be talking to us about: "What If I Discovered the Silver Bullet?" Motivated by a friend’s suffering from Parkinson’s, Dr. Sackner-Bernstein
Michel0220
in
Cure Parkinson's
3 years ago
Naturally boosting dopamine
So my understanding is that dopamine is lower in ADHDer's than most . Is there anyway to boost dopamine naturally besides food?
So my understanding is that dopamine is lower in ADHDer's than most . Is there anyway to boost dopamine naturally besides food?
Hidden
in
CHADD's Adult ADHD Support
3 years ago
How I went from 13 to 4 a day (Carbidopa 25/Levodopa 100)?
How I went from 13 to 4 a day (Carbidopa 25/Levodopa 100)? I started taking my L-dopa on an empty stomach (no eating 30 minutes before or 1 hour after). My prescription was written for 1-1/2 tablets 6 times a day (9 a day). With my Movement Disorder Specialist’s knowledge, I was taking 1 tablet every
How I went from 13 to 4 a day (Carbidopa 25/Levodopa 100)? I started taking my L-dopa on an empty stomach (no eating 30 minutes before or 1 hour after). My prescription was written for 1-1/2 tablets 6 times a day (9 a day). With my Movement Disorder Specialist’s knowledge, I was taking 1 tablet every
Gcf51
in
Cure Parkinson's
3 years ago
"Low oxalate" may be the only true solution
Before you read the following please take a moment and imagine how frustrating it is for someone to have figured out a non-medical treatment for RLS and then had very little luck getting anybody to listen to him. Every day this website carries stories of needless suffering and it breaks my heart. For
Before you read the following please take a moment and imagine how frustrating it is for someone to have figured out a non-medical treatment for RLS and then had very little luck getting anybody to listen to him. Every day this website carries stories of needless suffering and it breaks my heart. For
notnowdad
in
Restless Legs Syndrome
3 years ago
The ULTIMATE bedtime procrastination!!!!!!
Hello, You won't probably understand this either way, much less if you don't know what is hyperbolic discounting: https://www.lesswrong.com/posts/9o3QBg2xJXcRCxGjS/working-hurts-less-than-procrastinating-we-fear-the-twinge I suffer from ultimate bedtime procrastination!!! You have to understand I Am
Hello, You won't probably understand this either way, much less if you don't know what is hyperbolic discounting: https://www.lesswrong.com/posts/9o3QBg2xJXcRCxGjS/working-hurts-less-than-procrastinating-we-fear-the-twinge I suffer from ultimate bedtime procrastination!!! You have to understand I Am
empleat
in
Sleep Matters
3 years ago
How many of you have found that exercise helps with your movement? How many of you have tried the ''Fast Walking?'How many succeeded?
We now have two scientific studies that prove that maintained High Intensity exercise produces GDNF in the brain. That repairs the damaged glial cells and the brain can then produce more dopamine and our symptoms improve.
We now have two scientific studies that prove that maintained High Intensity exercise produces GDNF in the brain. That repairs the damaged glial cells and the brain can then produce more dopamine and our symptoms improve.
JohnPepper
in
Cure Parkinson's
3 years ago
How can I get some real relief from this RLS torture?
I am pleased , but also envious, to see that many people have benefited from medicinal marijuana. I finally managed to obtain some THC/CBD oil here in Sydney in the hope it would help me get off Pregabalin which is no longer working for me after many years on 300mg nightly, but I have found that, not
I am pleased , but also envious, to see that many people have benefited from medicinal marijuana. I finally managed to obtain some THC/CBD oil here in Sydney in the hope it would help me get off Pregabalin which is no longer working for me after many years on 300mg nightly, but I have found that, not
feetgrind
in
Restless Legs Syndrome
3 years ago
Gene therapy for genetic disorder affecting brain dopamine metabolism shows success; same delivery technique being investigated for PD
Really exciting report of disease reversal in children with AADC (aromatic L-amino acid decarboxylase deficiency); article mentions same delivery technique is being used for GDNF gene therapy in Parkinson's. https://wexnermedical.osu.edu/departments/innovations/neuronews/gene-therapy-new-approach
Really exciting report of disease reversal in children with AADC (aromatic L-amino acid decarboxylase deficiency); article mentions same delivery technique is being used for GDNF gene therapy in Parkinson's. https://wexnermedical.osu.edu/departments/innovations/neuronews/gene-therapy-new-approach
Rhyothemis
in
Cure Parkinson's
3 years ago
Instant help
I would like to inform you about a funny instant release that I came across recently. When I am in bed trying to sleep and my legs are jumping because my dopamine agonist doesn’t work, then I stand on my cold balcony only in my underwear for about 5 minutes (at the moment it is maybe about 0 and 8 degree
I would like to inform you about a funny instant release that I came across recently. When I am in bed trying to sleep and my legs are jumping because my dopamine agonist doesn’t work, then I stand on my cold balcony only in my underwear for about 5 minutes (at the moment it is maybe about 0 and 8 degree
Happyfriday123
in
Restless Legs Syndrome
3 years ago
Lower lip
Lower lip curls inward over teeth, I get both shots in feet and calves, but Dr . Said he didn't want to do lower lip, because one side could be uneven. Dr. Said we'll talk about it when I go in for next appointment. This is very uncomfortable, I have to pull lip down to talk, another low dopamine
Lower lip curls inward over teeth, I get both shots in feet and calves, but Dr . Said he didn't want to do lower lip, because one side could be uneven. Dr. Said we'll talk about it when I go in for next appointment. This is very uncomfortable, I have to pull lip down to talk, another low dopamine
akgirlsrock
in
Cure Parkinson's
3 years ago
Recording now available of presentation by Prof Barker - Cambridge University: "Can we repair the brain in PD using cell-based therapies?"
Thank you to all of you who joined us on Monday evening. We were all treated to an amazing presentation by Professor Roger Barker, explaining in great depth and with simplicity the journey so far and future hopes of cell-based dopamine replacement therapies. It is certainly an exciting area of research
Thank you to all of you who joined us on Monday evening. We were all treated to an amazing presentation by Professor Roger Barker, explaining in great depth and with simplicity the journey so far and future hopes of cell-based dopamine replacement therapies. It is certainly an exciting area of research
Michel0220
in
Cure Parkinson's
3 years ago
Monoamine Oxidase Inhibitors: A Review of Their Anti-Inflammatory Therapeutic Potential and Mechanisms of Action
Article from 30 April 2021 https://www.frontiersin.org/articles/10.3389/fphar.2021.676239/full
Concluding Remarks and Future Perspectives
MAO inhibitors have a long history of successful clinical use to manage CNS diseases such as depression, Parkinson’s, and Alzheimer’s.
There is also an
Article from 30 April 2021 https://www.frontiersin.org/articles/10.3389/fphar.2021.676239/full
Concluding Remarks and Future Perspectives
MAO inhibitors have a long history of successful clinical use to manage CNS diseases such as depression, Parkinson’s, and Alzheimer’s.
There is also an
Hidden
in
Cure Parkinson's
3 years ago
How do I setup cues and systems in place to be able to exercise more often?
I recently listened to this podcast and I liked the idea. https://open.spotify.com/episode/2TqH8caM1EfY2xTUXd5vnK?si=ghqIhNazSqa-keWokeneUA (Summary: Make it harder to do the thing you tend to do and make it easier to do the thing you want to. And plan ahead and setup systems and cues to make that
I recently listened to this podcast and I liked the idea. https://open.spotify.com/episode/2TqH8caM1EfY2xTUXd5vnK?si=ghqIhNazSqa-keWokeneUA (Summary: Make it harder to do the thing you tend to do and make it easier to do the thing you want to. And plan ahead and setup systems and cues to make that
shnamb
in
CHADD's Adult ADHD Support
3 years ago
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