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Why we add an AART drug to ADT?
In response to a post asking if adding enzalutamide to ADT is beneficial: Xtandi would increase T levels if not simultaneously using an LHRH ADT. It blocks AR in hypothalamus leading to perception of deficit and increased LH and testicular testosterone. So enzalutamide or apalutamide used without ADT
In response to a post asking if adding enzalutamide to ADT is beneficial: Xtandi would increase T levels if not simultaneously using an LHRH ADT. It blocks AR in hypothalamus leading to perception of deficit and increased LH and testicular testosterone. So enzalutamide or apalutamide used without ADT
MateoBeach
in
Fight Prostate Cancer
1 year ago
Is Xtandi necessary or even helping me?
This may be a stupid question but it's been on my mind for a while. I started on Prostap (Lupron) last July and my testosterone dropped to less than 1.0 by October while on just that. My PSA was also below 1.0 by then. My MO started me on Xtandi towards the end of October and my T and PSA appear to
This may be a stupid question but it's been on my mind for a while. I started on Prostap (Lupron) last July and my testosterone dropped to less than 1.0 by October while on just that. My PSA was also below 1.0 by then. My MO started me on Xtandi towards the end of October and my T and PSA appear to
Benkaymel
in
Fight Prostate Cancer
1 year ago
Squalene Monooxygenase
New Australian study below [1]. When tumors outgrow their blood supply, they experience hypoxia (insufficient oxygen). The normal defence for any cell is the generation of hypoxia-inducible factors [HIFs]. HIFs have cell survival functions. In PCa, HIF-1alpha is the most studied. It triggers the
New Australian study below [1]. When tumors outgrow their blood supply, they experience hypoxia (insufficient oxygen). The normal defence for any cell is the generation of hypoxia-inducible factors [HIFs]. HIFs have cell survival functions. In PCa, HIF-1alpha is the most studied. It triggers the
pjoshea13
in
Fight Prostate Cancer
1 year ago
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Night Pain , Left -Flank
Hello All ,I have been on Eligard , Zytiga , pred since Feb. 2022 . I have this pain on left flank about 8 o'clock right below the rib cage for about 8 months . The pain is at night but hardly during the day .I had a CT scan , x-ray , MRi , and nothing shows . I e-mailed my MO at V.A. yesterday and she
Hello All ,I have been on Eligard , Zytiga , pred since Feb. 2022 . I have this pain on left flank about 8 o'clock right below the rib cage for about 8 months . The pain is at night but hardly during the day .I had a CT scan , x-ray , MRi , and nothing shows . I e-mailed my MO at V.A. yesterday and she
reconjj
in
Fight Prostate Cancer
1 year ago
2022 Top Story in Metastatic Breast Cancer: Improving Discussions of Palliative Care
Published in Oncology and Expert Opinion / Commentary · December 19, 2022
Written by
Lillie D. Shockney RN, BS, MAS, HON-ONN-CG "Palliative care intervention provides meaningful benefit in end-of-life care planning for patients with metastatic breast cancer. We are long overdue in involving
Published in Oncology and Expert Opinion / Commentary · December 19, 2022
Written by
Lillie D. Shockney RN, BS, MAS, HON-ONN-CG "Palliative care intervention provides meaningful benefit in end-of-life care planning for patients with metastatic breast cancer. We are long overdue in involving
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
Enhertu (Do your research first ALWAYS)
I am HER2- and was given this "infusion" on 11/18 after being told I was out of any more options and had about 3 months left. It has been hell since then. I do not believe it was the medication as I did in the beginning. I believe it was the errors of the cancer center I have been going to. I am
I am HER2- and was given this "infusion" on 11/18 after being told I was out of any more options and had about 3 months left. It has been hell since then. I do not believe it was the medication as I did in the beginning. I believe it was the errors of the cancer center I have been going to. I am
kearnan
in
SHARE Metastatic Breast Cancer
2 years ago
ET and dental treatment
Hi all Am due to have a tooth out, am seeing consultant in 10 days....my dentist refused to do treatment as on aspirin and hydroxycarmabide. Has anyone else had an extraction and if so did you stop taking aspirin beforehand. Many thanks..
Hi all Am due to have a tooth out, am seeing consultant in 10 days....my dentist refused to do treatment as on aspirin and hydroxycarmabide. Has anyone else had an extraction and if so did you stop taking aspirin beforehand. Many thanks..
SazzaC
in
MPN Voice
2 years ago
Kwells / Hyoscine Hydrobromide contraindication
Does anyone happen to know why those with thyroid problems or heart conditions and those over 60, (I have all three) should speak to their doctor before taking these for motion sickness. A pharmacist who was aware of my medical conditions suggested Kwells for me. Only just read the pil in full. I haven
Does anyone happen to know why those with thyroid problems or heart conditions and those over 60, (I have all three) should speak to their doctor before taking these for motion sickness. A pharmacist who was aware of my medical conditions suggested Kwells for me. Only just read the pil in full. I haven
Aurealis
in
Thyroid UK
2 years ago
What else could it be
Ive had an on, off, mild, pain, irritated feeling in various places, in my left armpit, for 3 months. Not had surgery, so it cant be an infection. It just feels odd. The same applies to my left breast (various places, I'm a 44 year old female. Sometimes it feels like its on the back wall behind my breast
Ive had an on, off, mild, pain, irritated feeling in various places, in my left armpit, for 3 months. Not had surgery, so it cant be an infection. It just feels odd. The same applies to my left breast (various places, I'm a 44 year old female. Sometimes it feels like its on the back wall behind my breast
Milky99
in
Women's Health
2 years ago
Anal fissure
I was diagnosed with Hypothyroidism several years ago. I also suffer from a painful anal fissure. I see from my research that the 2 maybe connected. Can anyone shed any light on this? Much appreciated…,
I was diagnosed with Hypothyroidism several years ago. I also suffer from a painful anal fissure. I see from my research that the 2 maybe connected. Can anyone shed any light on this? Much appreciated…,
Whizzer2
in
Thyroid UK
2 years ago
eXroid treatment for Piles
For those who suffer in silence, are petrified of surgery or other invasive treatments for piles and are fed up with the horrible pain (like me) - look at eXroid treatment. The website is exroid.com
For those who suffer in silence, are petrified of surgery or other invasive treatments for piles and are fed up with the horrible pain (like me) - look at eXroid treatment. The website is exroid.com
Crazymouse
in
IBS Network
2 years ago
Isn't it time for Constipation,like Mr Dangerfield to get some respect?
In order for this post to survive I, We cannot offend anyone. So please no slang terms/words. Scientific words, terms and phrases are always acceptable. If our gut is that closely aligned with certain parts of the brain, we need to start showing some respect before someone gets --it Faced!!
In order for this post to survive I, We cannot offend anyone. So please no slang terms/words. Scientific words, terms and phrases are always acceptable. If our gut is that closely aligned with certain parts of the brain, we need to start showing some respect before someone gets --it Faced!!
Isthistheone
in
Cure Parkinson's
2 years ago
Taste.
Does anyone find that they haven't got a good sense of taste? I have not had covid either.
Does anyone find that they haven't got a good sense of taste? I have not had covid either.
falcon68
in
Lung Conditions Community Forum
2 years ago
closing my mouth and not drooling
I am having difficulty keeping my mouth closed all of the saliva that I’ve produced Runs down my face. Any advice to keep my mouth closed so I can swallow. I have no problem swallowing food. The saliva is excessive and my gums gums feel swollen. I can’t brush very well.
I am having difficulty keeping my mouth closed all of the saliva that I’ve produced Runs down my face. Any advice to keep my mouth closed so I can swallow. I have no problem swallowing food. The saliva is excessive and my gums gums feel swollen. I can’t brush very well.
Marcia123
in
Cure Parkinson's
2 years ago
Fed Up with everything.
I have been on haemodialysis since May. Having completed all the tests etc at the beginning of November, I was just waiting to go live in the transplant list. My previous consultant, who is now on maternity leave, said my results were good and she even said, I would probably receive a new kidney before
I have been on haemodialysis since May. Having completed all the tests etc at the beginning of November, I was just waiting to go live in the transplant list. My previous consultant, who is now on maternity leave, said my results were good and she even said, I would probably receive a new kidney before
Ziggydoodah
in
Kidney Dialysis
2 years ago
Bleeding internal haemorrhoids
Hi all, does anyone have regular problems with bleeding internal haemorrhoids? If my motions are soft, I have no problems, but as soon as they are the least bit hard, then the bleeding and soreness start up again! I have tried all sorts of lotions and potions, some on prescriptions, but it never goes
Hi all, does anyone have regular problems with bleeding internal haemorrhoids? If my motions are soft, I have no problems, but as soon as they are the least bit hard, then the bleeding and soreness start up again! I have tried all sorts of lotions and potions, some on prescriptions, but it never goes
Art78
in
IBS Network
2 years ago
Yes, Malecare helped write the ‘‘Comprehensive Cancer Survivorship Act’
I received several nice phone calls this morning, so I thought to share some good news and also highlight more of Malecare's brilliant work. Working with the congressional office of U.S. Rep. Debbie Wasserman Schultz (FL-23) and several of my counterparts, I, representing Malecare and the prostate cancer
I received several nice phone calls this morning, so I thought to share some good news and also highlight more of Malecare's brilliant work. Working with the congressional office of U.S. Rep. Debbie Wasserman Schultz (FL-23) and several of my counterparts, I, representing Malecare and the prostate cancer
Darryl
Partner
in
Advanced Prostate Cancer
2 years ago
Tocilizumab side effects
I started TCZ injections three weeks ago and am experiencing side effects of mouth ulcers, cold sores and runny, sore nose. Does anyone else have these and if so, how long did they last, I've been told should go after a few weeks.
I started TCZ injections three weeks ago and am experiencing side effects of mouth ulcers, cold sores and runny, sore nose. Does anyone else have these and if so, how long did they last, I've been told should go after a few weeks.
PQXZT
in
PMRGCAuk
2 years ago
what’s next after teriparatide
What have people taken after finishing teriparatide? I have a potential problem now as my DEXA was due on Monday which would have given me time at least to discuss a follow on with the specialist nurse. But of course it’s been cancelled 😠 and I can’t get one till 24 October when I will have finished
What have people taken after finishing teriparatide? I have a potential problem now as my DEXA was due on Monday which would have given me time at least to discuss a follow on with the specialist nurse. But of course it’s been cancelled 😠 and I can’t get one till 24 October when I will have finished
Nuthatch
in
Bone Health and Osteoporosis UK
2 years ago
BATMAN
Yesterday, when I complained of the apparent lack of interest in using BAT to prevent CRPC, I should have briefly mentioned the old BATMAN study (2016). Although BATMAN involved hormone-sensitive men, there was no castration phase. Therefore, the BATMAN protocol was not designed to prevent CRPC.
Yesterday, when I complained of the apparent lack of interest in using BAT to prevent CRPC, I should have briefly mentioned the old BATMAN study (2016). Although BATMAN involved hormone-sensitive men, there was no castration phase. Therefore, the BATMAN protocol was not designed to prevent CRPC.
pca2004
in
Fight Prostate Cancer
2 years ago
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