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Potential Early Drivers of Disease in Treatment-Naive CLL Identified
[i]This study reinforces others regarding mutations that predict a short time to first treatment. I think those of us that are 11qdel are aware of the association of 11qdel with mutated ATM and unmutated IGHV status.[/i] By determining the relationship between a set of somatic mutations and established
[i]This study reinforces others regarding mutations that predict a short time to first treatment. I think those of us that are 11qdel are aware of the association of 11qdel with mutated ATM and unmutated IGHV status.[/i] By determining the relationship between a set of somatic mutations and established
Jm954
Administrator
in
CLL Support
5 years ago
Use of MRD Status Following Obinutuzumab/Ibrutinib to Guide Subsequent Intensification of Therapy in CLL
August 6, 2019 In this 2-part, single-arm, open-label, multicenter trial (Clinical Trials.gov Identifier: NCT02666898), medically fit, adult patients with treatment-naive CLL not characterized by a 17p deletion or a mutation in TP53 received 9 months of chemotherapy-free induction therapy with the combination
August 6, 2019 In this 2-part, single-arm, open-label, multicenter trial (Clinical Trials.gov Identifier: NCT02666898), medically fit, adult patients with treatment-naive CLL not characterized by a 17p deletion or a mutation in TP53 received 9 months of chemotherapy-free induction therapy with the combination
Jm954
Administrator
in
CLL Support
5 years ago
Novel Combos Are Shaking Up the CLL Landscape but FCR still has its place
Published: Saturday, Sep 14, 2019 During a presentation at the 2019 Society of Haematological Oncology Annual Meeting, Dr Jain said recent clinical trial findings have helped clarify therapy choices based on the patient’s age, comorbid conditions, and mutation status but that questions about optimal
Published: Saturday, Sep 14, 2019 During a presentation at the 2019 Society of Haematological Oncology Annual Meeting, Dr Jain said recent clinical trial findings have helped clarify therapy choices based on the patient’s age, comorbid conditions, and mutation status but that questions about optimal
Jm954
Administrator
in
CLL Support
5 years ago
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Duvelisib Dosing Modification Does Not Compromise Efficacy in Heavily Pretreated CLL/SLL
Reducing or interrupting duvelisib (Copiktra) treatment does not increase toxicity or reduce outcomes with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Furthermore, treatment with the PI3K inhibitor led to a superior median progression-free survival (PFS) compared
Reducing or interrupting duvelisib (Copiktra) treatment does not increase toxicity or reduce outcomes with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Furthermore, treatment with the PI3K inhibitor led to a superior median progression-free survival (PFS) compared
Jm954
Administrator
in
CLL Support
5 years ago
2 months post kidney transplant
Hello everyone! I am a new member here and was really happy to found this group. I am 27 years old and of my kidneys failed due to HSP (Henoch Schonlein Purpura) April of last year. I was on hemodialysis for a over year and I am super blessed to received a call from my Transplant Center back in July
Hello everyone! I am a new member here and was really happy to found this group. I am 27 years old and of my kidneys failed due to HSP (Henoch Schonlein Purpura) April of last year. I was on hemodialysis for a over year and I am super blessed to received a call from my Transplant Center back in July
Trouper
in
Kidney Transplant Patient Support
5 years ago
Bone marrow
My Bone marrow biopsy showed that I have 80% cancer in the marrow. Is this rather high for people with CLL? Do all CLL patients have a bone marrow biopsy
My Bone marrow biopsy showed that I have 80% cancer in the marrow. Is this rather high for people with CLL? Do all CLL patients have a bone marrow biopsy
tootsie2
in
CLL Support
5 years ago
CLL Society Support Group Member Resource Guide
This list was created by the LA Support Group of The CLL Society and would be useful primarily for USA residents. -
CLL Society Support Group Member Resource Guide
There are many resources for CLL patients and caregivers. This is not a complete list, but a curation of resources. [u]National
This list was created by the LA Support Group of The CLL Society and would be useful primarily for USA residents. -
CLL Society Support Group Member Resource Guide
There are many resources for CLL patients and caregivers. This is not a complete list, but a curation of resources. [u]National
lankisterguy
Volunteer
in
CLL Support
5 years ago
Fasting for colon cancer, colonoscopy and polypectomy
The benefits of fasting for some types of cancer are well established, See: https://www.medicalnewstoday.com/articles/324169.php ...but how effective is fasting for colon cancer? I fast 68 hours every month, so, when I was told I had to eat no fibre before my colonoscopy, I told the medic I would fast
The benefits of fasting for some types of cancer are well established, See: https://www.medicalnewstoday.com/articles/324169.php ...but how effective is fasting for colon cancer? I fast 68 hours every month, so, when I was told I had to eat no fibre before my colonoscopy, I told the medic I would fast
S11m
in
Colon Cancer Connected
5 years ago
Newbie 🖐
Hi all I have no official diagnosis but have all the signs. I'm 44 and had a mirena coil inserted in march during hysteroscopy and polypectomy. Since then my pain is increasing 10 fold and the bleeding is brown/black mixed with red and dark clots. My tv scan 6 weeks ago showed another haemorrhagic cyst
Hi all I have no official diagnosis but have all the signs. I'm 44 and had a mirena coil inserted in march during hysteroscopy and polypectomy. Since then my pain is increasing 10 fold and the bleeding is brown/black mixed with red and dark clots. My tv scan 6 weeks ago showed another haemorrhagic cyst
Jublyt
in
Endometriosis UK
5 years ago
CLL, Spleen Recovery+recommendations
Hi All, I was hoping to draw on your knowledge, wisdom and experience in dealing with CLL. I was diagnosed in 7/2008 and for almost 11 years was doing quite well but 3 months ago my spleen started to get enlarged, wbc were 76K and swollen lymph nodes to say the least. I had my first dose of Gazyva or
Hi All, I was hoping to draw on your knowledge, wisdom and experience in dealing with CLL. I was diagnosed in 7/2008 and for almost 11 years was doing quite well but 3 months ago my spleen started to get enlarged, wbc were 76K and swollen lymph nodes to say the least. I had my first dose of Gazyva or
SCE2AUX
in
CLL Support
5 years ago
Colonoscopy and polypectomy
I have had diverticulitis (and haemorrhoids) for years - when I get discomfort, it usually means I will need the loo within half an hour. I found a lump in my sigmoid, which was slightly uncomfortable, so I sent off the bowel screening kit and had a colonoscopy and a polypectomy (which was clipped),
I have had diverticulitis (and haemorrhoids) for years - when I get discomfort, it usually means I will need the loo within half an hour. I found a lump in my sigmoid, which was slightly uncomfortable, so I sent off the bowel screening kit and had a colonoscopy and a polypectomy (which was clipped),
S11m
in
Colon Cancer Connected
5 years ago
Patient Power Video updates on Blood Testing and New Treatment updates
Patient Power email here: https://www.patientpower.info/index.cfm?objectid=0F37AC70-C38E-11E9-9C33000D3A30C4F8 - Includes video updates from two of my favorite doctors that can explain complex subjects using understandable language. Dr. Susan LeClair and Dr. Nicole Lamanna. - https://www.patientpower.info
Patient Power email here: https://www.patientpower.info/index.cfm?objectid=0F37AC70-C38E-11E9-9C33000D3A30C4F8 - Includes video updates from two of my favorite doctors that can explain complex subjects using understandable language. Dr. Susan LeClair and Dr. Nicole Lamanna. - https://www.patientpower.info
lankisterguy
Volunteer
in
CLL Support
5 years ago
The Effect of Flavored E-cigarettes on Murine Allergic Airways Disease. (Asthma)
Electronic cigarette (e-cigarette) use has dramatically increased in recent years due to its portrayal as a healthier alternative to tobacco cigarettes. E-cigarette use amongst high school aged children in the US jumped from 1.5% in 2011 to over 15% in 20151. Similarly, almost 9% of 18–24 year olds are
Electronic cigarette (e-cigarette) use has dramatically increased in recent years due to its portrayal as a healthier alternative to tobacco cigarettes. E-cigarette use amongst high school aged children in the US jumped from 1.5% in 2011 to over 15% in 20151. Similarly, almost 9% of 18–24 year olds are
2greys
in
Lung Conditions Community Forum
5 years ago
Relapsing after remission
I've been in remission for about two years now. Just came from a routine 6 month check-up. My Hematologist noticed that my platelets have dropped below normal and that my absolute lymphocytes are above normal. I will checked again in three months. Has anyone relapsed from remission? If so, did they
I've been in remission for about two years now. Just came from a routine 6 month check-up. My Hematologist noticed that my platelets have dropped below normal and that my absolute lymphocytes are above normal. I will checked again in three months. Has anyone relapsed from remission? If so, did they
dianejoyce
in
CLL Support
5 years ago
2nd Update on Possible Richters Transformation
The upside is I don’t have RT, but I did pick up some more high risk markers in addition to : 11q and unmutated. I learned in July the results of the DNA sequencing study. I picked up TP53, Notch1, ATM and few other ones that predispose me to head and neck cancer and cognitive decline. They did not
The upside is I don’t have RT, but I did pick up some more high risk markers in addition to : 11q and unmutated. I learned in July the results of the DNA sequencing study. I picked up TP53, Notch1, ATM and few other ones that predispose me to head and neck cancer and cognitive decline. They did not
ReneeSusan
in
CLL Support
5 years ago
Flavoring Ingredient Exceeds Safety Levels in E-Cigarettes and Smokeless Tobacco.
A potential carcinogen that has been banned as a food additive is present in concerningly high levels in electronic cigarette liquids and smokeless tobacco products, according to a new study from Duke Health. The chemical -- called pulegone (pronounced pju-leh-goan) – is contained in menthol and mint
A potential carcinogen that has been banned as a food additive is present in concerningly high levels in electronic cigarette liquids and smokeless tobacco products, according to a new study from Duke Health. The chemical -- called pulegone (pronounced pju-leh-goan) – is contained in menthol and mint
2greys
in
Lung Conditions Community Forum
5 years ago
Factors Identified for Risk of Second Cancer in CLL Following BTK Inhibition
There was hope that non-chemo CLL treatments would avoid the increased risk of subsequent secondary cancers, with concern about Myelodysplasia Syndromes and Acute Lymphocytic Leukaemia (MDS and ALL) of particular concern with FCR, due to possible DNA damage to bone marrow stem cells. It was thought
There was hope that non-chemo CLL treatments would avoid the increased risk of subsequent secondary cancers, with concern about Myelodysplasia Syndromes and Acute Lymphocytic Leukaemia (MDS and ALL) of particular concern with FCR, due to possible DNA damage to bone marrow stem cells. It was thought
AussieNeil
Partner
in
CLL Support
5 years ago
Adoport
New to group. Have had liver transplant 6 years ago due to hep c through contaminated blood transfusion. Prograf used for immune suppressant but now been told I’ve to change to Adoport to save money. Cannot find any real info on adoport which is new product offered. I got hep c because government wanted
New to group. Have had liver transplant 6 years ago due to hep c through contaminated blood transfusion. Prograf used for immune suppressant but now been told I’ve to change to Adoport to save money. Cannot find any real info on adoport which is new product offered. I got hep c because government wanted
Tourguide
in
British Liver Trust
5 years ago
Mebeverine supply
mebeverine supply Is anyone else having problems getting hold of mebeverine? The last few prescriptions I’ve had huge problems getting filled - I’ve had to call quite a few chemists (last time 6), to get hold of any. The pharmacies say they can only get hold of the branded, much more expensive Colofac
mebeverine supply Is anyone else having problems getting hold of mebeverine? The last few prescriptions I’ve had huge problems getting filled - I’ve had to call quite a few chemists (last time 6), to get hold of any. The pharmacies say they can only get hold of the branded, much more expensive Colofac
Suze109
in
IBS Network
5 years ago
Mirena coil/Hysteroscopy/Polypectomy
I’m 48 years old and been experiencing unusually heavy periods, severe cramping, passing clots etc for last 18+ months - much out of character. My periods have changed from every 28 days exactly to every 3 weeks and last for 7 days on average instead of the previous 3-5 days. I was referred to the gynaecologist
I’m 48 years old and been experiencing unusually heavy periods, severe cramping, passing clots etc for last 18+ months - much out of character. My periods have changed from every 28 days exactly to every 3 weeks and last for 7 days on average instead of the previous 3-5 days. I was referred to the gynaecologist
LizzyH
in
Women's Health
5 years ago
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