Experiences with
Colonic polyps2,422 public posts
Smoking and Effects on the Stomach
Polyps
The risk of developing colonic polyps is high in people with the smoking habit. Colonic polyps develop on the mucosal lining of the colon or rectum. While a few polyps are benign or noncancerous, others may tend to become malignant.
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Review article summarises management strategies for those with CLL harbouring complex karyotype
On 6 January 2025, the journal [i]BJ Haem[/i] published a review article titled [i]Management strategies for patients with chronic lymphocytic leukaemia harbouring complex karyotype[/i] written by a team from Padua, Italy. The article summary explains its aims:
[i]"Chronic lymphocytic leukaemia
LP-168 (Rocbrutinib), a Novel Covalent and Non-Covalent Next-Generation Inhibitor of Bruton's Tyrosine Kinase. Phase 1 trial results.
Rocbrutinib is a new drug offering hope to patients with what are known as gatekeeper mutations that confer resistance to Pirtobrutinib. This BTKi is unique in being both a covalent and non covalent inhibitor of BTK.
Patients with gatekeeper mutations have poor outcomes and short survival and demonstrate
Pirtobrutinib Delays Progression in CLL Already Treated With a BTK Inhibitor. (BRUIN CLL-321 Phase III trial results reported at ASH2024)
Pirtobrutinib is the first FDA approved non-covalent BTK inhibitor (BTKi) for the treatment of CLL. The previously approved BTKi drugs (acalabrutinib, ibrutinib and zanubrutinib) bond covalently. Eventually, these drugs can stop inhibiting CLL, when DNA changes in the BTK enzyme prevent the BTKi from