Reducing or interrupting duvelisib (Copiktra) treatment does not increase toxicity or reduce outcomes with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).
Furthermore, treatment with the PI3K inhibitor led to a superior median progression-free survival (PFS) compared with ofatumumab (Arzerra) while producing rapid and durable responses in heavily pretreated patients.
Results from 2 analyses of the phase III DUO trial presented as posters at the 2019 SOHO Annual Meeting suggest that duvelisib monotherapy is a viable therapy for a patient population that has limited treatment options.
There is a Duvelisib/Venetoclax trial going on at Dana Farber for relapsed SLL/CLL. I haven’t heard much about Duvelisib lately. Thoughts on this trial? There is so much research going on it is confusing. I keep hoping that the research efforts lead to a silver bullet. Venetoclax always seems to be in the mix.
Mark, Duvelisib seems more promising than Idelasilib and I’m not aware of any of the severe toxicity’s such as pneumonitis with it that were too common with Idelasilib.
I guess if you failed a BTK it would be good. Combo ‘s seem to look best. But these PI3k’s are third in line following ibrutinib or Acalabrutinib then Venetoclax.
Hi Jeff: Thanks for your comment. I agree that the medicines you mention are being relied upon more than Duvelisib, which seems to be used as a salvage therapy. That being said, I find it interesting that it is now paired with Venetoclax..
How are you feeling? Is your energy good? I hope you are on the mend.
I guess if you failed ibrutinib then Venetoclax was going to be next anyhow. Might as well pair it up with Duvelisib and maybe throw in obina.
I’m a little over a month on ibrutinib after getting obina at MDA. I’ve had the roving joint and muscle pain with swelling but it never lasts more than a week for me. All my labs look normal and my energy is back just in time to house train a new puppy. He’s exhausting me but I’m making progress.
I go back to Houston in a year. Thanks for checking. How are you doing?
It is good to hear things are well with you. Training a puppy is a lot of work but it is also very rewarding. My dog is coming up on 2-years so we are in a good zone. I’m also doing well. I’m still in remission at about 11- months after BR chemo. I go in for a quarterly check up next month. I’m hoping for another couple of years before I need to make any decisions. At present I feel as good as I have in years. No fatigue, etc. I'm thankful I don’t have to make any treatment decisions today. Enjoying every day as if it were my last.
Next Thursday would have been 5 years since beginning BR. If you count the 6 months too, I got almost 5 1/2 years remission from BR even being unmutated and 11q-
I wasn’t completely myself for 2 years so the best is yet to come for you.
Not necessarily Jeff, if you have certain comorbidities or need anticoagulation then this could move up the ranking but I agree it wouldn't be my first choice until there is more supporting data.
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FDA Frontline Approval of Venetoclax and Obinituzumab in the USA
Aussies, please consider enrolling in this study into the personal impact of CLL and help our world wide CLL/SLL community
Sequential And Combination Treatments With Novel Agents (Oct. 2019)
