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From the CLL14 Study: Venetoclax Plus Obinutuzumab Prolongs Progression Free Survival, Not Overall Survival , in CLL
These results, from the CLL14 study (ClinicalTrials.gov Identifier: NCT02242942), were presented at the European Hematology Association (EHA) 2021 Virtual Congress. Extended follow-up suggests that venetoclax plus obinutuzumab prolongs progression-free survival (PFS), but not overall survival (OS), when
These results, from the CLL14 study (ClinicalTrials.gov Identifier: NCT02242942), were presented at the European Hematology Association (EHA) 2021 Virtual Congress. Extended follow-up suggests that venetoclax plus obinutuzumab prolongs progression-free survival (PFS), but not overall survival (OS), when
Jm954
Administrator
in
CLL Support
3 years ago
STELLAR Trial in the UK for Richter's
Just a reminder that there is a UK trial at 17 centres around the UK for patients who have a Richter's transformation of their CLL. The usual treatment for Richter’s syndrome is R-CHOP. This is a combination of chemotherapy drugs and a targeted drug called rituximab. This treatment can help and cure
Just a reminder that there is a UK trial at 17 centres around the UK for patients who have a Richter's transformation of their CLL. The usual treatment for Richter’s syndrome is R-CHOP. This is a combination of chemotherapy drugs and a targeted drug called rituximab. This treatment can help and cure
Jm954
Administrator
in
CLL Support
3 years ago
Sunday Lunches
My sister lives abroad and comes over to the UK each year for our summer months. Last year with all that was going on only stayed 4/5wks in case Barbados put the UK on their no entry list etc. I was fine meeting her at our favourite restaurants for Sunday lunch and/or even additional mid week, as
My sister lives abroad and comes over to the UK each year for our summer months. Last year with all that was going on only stayed 4/5wks in case Barbados put the UK on their no entry list etc. I was fine meeting her at our favourite restaurants for Sunday lunch and/or even additional mid week, as
Makingmebetter
in
Lung Conditions Community Forum
3 years ago
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BTK inhibitors for the treatment of CLL - the current state of play of 'brutinibs'
In just a short time, in many places, BTK inhibitors (BTKi) have largely replaced chemoimmunotherapy (CIT) for treatment naive CLL patients, while also playing an important role in relapsed/refractory CLL. For a
detailed list of the many BTK inhibitors
in the pipeline, check out @AussieNeil’s
In just a short time, in many places, BTK inhibitors (BTKi) have largely replaced chemoimmunotherapy (CIT) for treatment naive CLL patients, while also playing an important role in relapsed/refractory CLL. For a
detailed list of the many BTK inhibitors
in the pipeline, check out @AussieNeil’s
CLLerinOz
Administrator
in
CLL Support
3 years ago
CLL and Night Sweats
I have been on W&W for 1-1/2 years. Lymph % is 69.7, Lymph # 10.26 and WBC at 14.73. Just started having night sweats. What does one do? I am waiting on response from my doc but thought I would get feedback here. Thank you all for caring!
I have been on W&W for 1-1/2 years. Lymph % is 69.7, Lymph # 10.26 and WBC at 14.73. Just started having night sweats. What does one do? I am waiting on response from my doc but thought I would get feedback here. Thank you all for caring!
CBME
in
CLL Support
3 years ago
Down to 10mg Pred instantly!
Hello again, Just seen a rheumatologist for the first time, having been diagnosed with PMR in early January this year. Went from 15mg pred to 12.5mg by March. She has put me down instantly to 10mg, which she says I should be on after six months, then reduce by 1mg every six weeks. This I think, is
Hello again, Just seen a rheumatologist for the first time, having been diagnosed with PMR in early January this year. Went from 15mg pred to 12.5mg by March. She has put me down instantly to 10mg, which she says I should be on after six months, then reduce by 1mg every six weeks. This I think, is
Silver-Babe
in
PMRGCAuk
3 years ago
How do I safely live my life with CLL if my antibody test results are one of three scenarios?
I am a stage zero CLL patient of 5 years awaiting the results of my antibody test ordered by my oncologist due to the recent news that CLL patients are often not getting as many antibodies produced as hoped resulting from their CoVid vaccines. I had 2 doses Moderna (Feb and March). I have been very
I am a stage zero CLL patient of 5 years awaiting the results of my antibody test ordered by my oncologist due to the recent news that CLL patients are often not getting as many antibodies produced as hoped resulting from their CoVid vaccines. I had 2 doses Moderna (Feb and March). I have been very
learning2021
in
CLL Support
3 years ago
Husband with CLL - struggling with no energy, motivation and depression. Help.
Hi all, New member seeking support here. My husband was diagnosed with CLL about 6 years ago when his WBC was at 24000. We chose naturopathic therapy (vit C infusions, colon hydrotherapy and hyperbaric oxygen treatments). After several months with no symptoms, he stopped treatments and continued his
Hi all, New member seeking support here. My husband was diagnosed with CLL about 6 years ago when his WBC was at 24000. We chose naturopathic therapy (vit C infusions, colon hydrotherapy and hyperbaric oxygen treatments). After several months with no symptoms, he stopped treatments and continued his
qtrhorsechic
in
CLL Support
3 years ago
Worried about mums blood test results.
My mum has had a high platelet count for around 8/9 years now. She was referred to a hematologist who thought she had essential thrombocythemia, her platelets were high, her red cells low and white within normal range! However she had a blood test done a week ago and her white cells were 100,000 , her
My mum has had a high platelet count for around 8/9 years now. She was referred to a hematologist who thought she had essential thrombocythemia, her platelets were high, her red cells low and white within normal range! However she had a blood test done a week ago and her white cells were 100,000 , her
Mummytonoah15
in
CLL Support
3 years ago
Richter Transformation Update 21-06-2021
Hello everyone. I would like to update the information of our Ricther Transformation group. A month and a half ago, a 42-year-old patient died. He had been transforming Ricther for nine months and was very aggressive. He had it spread all over his body. He was treated with R-Chop and in the middle
Hello everyone. I would like to update the information of our Ricther Transformation group. A month and a half ago, a 42-year-old patient died. He had been transforming Ricther for nine months and was very aggressive. He had it spread all over his body. He was treated with R-Chop and in the middle
Priss69
in
CLL Support
3 years ago
Awake worrying? Stop it. You deserve a free online 2nd Opinion from a CLL expert: CLL Society's Expert Access™ Program. Apply today:)
Awake worrying? If you are not seeing a CLL expert and worry is keeping you awake because you are less than confident in the treatment your current provider recommends, or you are facing a treatment decision and have received conflicting advice, CLL Society's Expert Access Program™ might be for you
Awake worrying? If you are not seeing a CLL expert and worry is keeping you awake because you are less than confident in the treatment your current provider recommends, or you are facing a treatment decision and have received conflicting advice, CLL Society's Expert Access Program™ might be for you
bkoffman
CLL CURE Hero
in
CLL Support
3 years ago
ACA & Anti CENP B
Hey all, Hope you are doing well - and a big thank you to those who took time to reply to my first post. Follow on from my neurologist nightmare (where he dismissed my ANA result as insignificant and spurious & said males don’t get lupus) , I had my bloods redone and they came back ANA positive for a
Hey all, Hope you are doing well - and a big thank you to those who took time to reply to my first post. Follow on from my neurologist nightmare (where he dismissed my ANA result as insignificant and spurious & said males don’t get lupus) , I had my bloods redone and they came back ANA positive for a
Northerner1
in
LUPUS UK
3 years ago
Iceland reimposes COVID restrictions after cases surge
Iceland, one of the first nations in the world to lift all Covid restrictions for vaccinated tourists, yesterday announced new curbs following a spate of infections. At the end of June, Iceland lifted rules around social distancing, mask-wearing, limits on public gatherings and the opening hours of
Iceland, one of the first nations in the world to lift all Covid restrictions for vaccinated tourists, yesterday announced new curbs following a spate of infections. At the end of June, Iceland lifted rules around social distancing, mask-wearing, limits on public gatherings and the opening hours of
2greys
in
Lung Conditions Community Forum
3 years ago
What dosage of calcium supplement is recommended when on prednisolone?
I'm on 7.5mg of prednisolone. At my rheumatologists appointment today I advised him that I wouldn't be taking up his recommendation of Alendronic Acid despite having a very small amount of osteoporosis in my lower lumber region. I advised him that I was taking Caltrate which has 600mg calcium/200 IU
I'm on 7.5mg of prednisolone. At my rheumatologists appointment today I advised him that I wouldn't be taking up his recommendation of Alendronic Acid despite having a very small amount of osteoporosis in my lower lumber region. I advised him that I was taking Caltrate which has 600mg calcium/200 IU
Pr0jection
in
PMRGCAuk
3 years ago
No Antibodies after Vaccine
Just got my results back for Covid Antibodies after Vaccination. It was Negative with a reported level of less than 0.4(U/mL). I took two doses of Pfizer, 8 weeks apart. I've been on Ibrutinib for CLL for 7 months now, and the first vaccine dose was 3 months after starting treatment. Really peed off
Just got my results back for Covid Antibodies after Vaccination. It was Negative with a reported level of less than 0.4(U/mL). I took two doses of Pfizer, 8 weeks apart. I've been on Ibrutinib for CLL for 7 months now, and the first vaccine dose was 3 months after starting treatment. Really peed off
MovingForward4423
in
CLL Support
3 years ago
AbbVie Pharm--positive phase 3 for CLL!
Hey, all, see this article about AbbVie pharma! AbbVie Sees Continued Positive Results for Leukemia Treatment 7:05 am ET June 11, 2021 (Dow Jones) Print By Chris Wack AbbVie said it saw continued positive results from a four-year follow-up analysis of its Phase 3 CLL14 trial. The pharmaceutical company
Hey, all, see this article about AbbVie pharma! AbbVie Sees Continued Positive Results for Leukemia Treatment 7:05 am ET June 11, 2021 (Dow Jones) Print By Chris Wack AbbVie said it saw continued positive results from a four-year follow-up analysis of its Phase 3 CLL14 trial. The pharmaceutical company
Vlaminck
in
CLL Support
3 years ago
No Antibodies shown after taking the Moderna Vaccine
I am new to CLL only a year on W&W. My Lymphs are #10.26 and % is 69.7. WBC is 14.73. I had the Moderna vaccine in Feb and March. Just had an antibody test and the result was negative - no antibodies. To say the least I am heartbroken and disappointed. Does anyone have any ideas as to what I should
I am new to CLL only a year on W&W. My Lymphs are #10.26 and % is 69.7. WBC is 14.73. I had the Moderna vaccine in Feb and March. Just had an antibody test and the result was negative - no antibodies. To say the least I am heartbroken and disappointed. Does anyone have any ideas as to what I should
CBME
in
CLL Support
3 years ago
It’s official Study shows T cells are activated against Covid after vaccination
Just heard on the Irish Radio from Professor Luke O’Neill, a super immunologist in Trinity College Dublin, results of a study on Leukemia patients show T Cells show response to the vaccine. Sorry I can’t remember the name of the study he mentioned . Great news he thought. It’s nature.com and Eureka
Just heard on the Irish Radio from Professor Luke O’Neill, a super immunologist in Trinity College Dublin, results of a study on Leukemia patients show T Cells show response to the vaccine. Sorry I can’t remember the name of the study he mentioned . Great news he thought. It’s nature.com and Eureka
Hidden
in
CLL Support
3 years ago
First results of a head-to-head trial of acalabrutinib versus ibrutinib in previously treated chronic lymphocytic leukemia.
Background: Increased selectivity of the Bruton tyrosine kinase inhibitor (BTKi) acalabrutinib (Aca) vs ibrutinib (Ib) may improve tolerability. We conducted an open-label, randomized, noninferiority, phase 3 trial to compare Aca vs Ib in patients (pts) with chronic lymphocytic leukemia (CLL). Methods
Background: Increased selectivity of the Bruton tyrosine kinase inhibitor (BTKi) acalabrutinib (Aca) vs ibrutinib (Ib) may improve tolerability. We conducted an open-label, randomized, noninferiority, phase 3 trial to compare Aca vs Ib in patients (pts) with chronic lymphocytic leukemia (CLL). Methods
Jm954
Administrator
in
CLL Support
3 years ago
CLL: from molecular pathogenesis to novel therapeutic strategies
September 2020 An interesting paper "CLL is a well-defined lymphoid neoplasm with very heterogeneous biological and clinical behavior. The last decade has been remarkably fruitful in novel findings elucidating multiple aspects of the pathogenesis of the disease. These include mechanisms of genetic susceptibility
September 2020 An interesting paper "CLL is a well-defined lymphoid neoplasm with very heterogeneous biological and clinical behavior. The last decade has been remarkably fruitful in novel findings elucidating multiple aspects of the pathogenesis of the disease. These include mechanisms of genetic susceptibility
Jm954
Administrator
in
CLL Support
3 years ago
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