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Optimal Treatment Combinations in the Management of CLL/SLL Jeff Sharman, MD Provided by Clinical Care Options, LLC
Optimal Treatment Combinations in the Management of CLL/SLL Jeff Sharman, MD An installment of the educational program: Advances in Chronic Lymphocytic Leukemia Care: A Master Class for the Community Multidisciplinary Team
Key Takeaways
• Obinutuzumab is the preferred anti-CD20
Optimal Treatment Combinations in the Management of CLL/SLL Jeff Sharman, MD An installment of the educational program: Advances in Chronic Lymphocytic Leukemia Care: A Master Class for the Community Multidisciplinary Team
Key Takeaways
• Obinutuzumab is the preferred anti-CD20
lankisterguy
Volunteer
in
CLL Support
2 years ago
"Three-drug combination highly effective in patients with high-risk forms of chronic lymphocytic leukemia"
Three-drug combination highly effective in patients with high-risk forms of chronic lymphocytic leukemia - https://www.news-medical.net/news/20221212/Three-drug-combination-highly-effective-in-patients-with-high-risk-forms-of-chronic-lymphocytic-leukemia.aspx - small USA trial (68) with acalabrutinib
Three-drug combination highly effective in patients with high-risk forms of chronic lymphocytic leukemia - https://www.news-medical.net/news/20221212/Three-drug-combination-highly-effective-in-patients-with-high-risk-forms-of-chronic-lymphocytic-leukemia.aspx - small USA trial (68) with acalabrutinib
JIDD
in
CLL Support
2 years ago
Treatment of Richter's syndrome - ASH 2022 Education Program
This year's American Society of Hematology (ASH) annual conference is now underway and the ASH Education Program, Volume 2022, Issue 1 booklet that was published on 9 December 2022 is now available at: https://ashpublications.org/hematology/issue/2022/1 It contains three review articles from sessions
This year's American Society of Hematology (ASH) annual conference is now underway and the ASH Education Program, Volume 2022, Issue 1 booklet that was published on 9 December 2022 is now available at: https://ashpublications.org/hematology/issue/2022/1 It contains three review articles from sessions
CLLerinOz
Administrator
in
CLL Support
2 years ago
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Polyp removal
Hello ladies, I want to have a small polyp in my uterus removed before further IVF treatment. Any recommendation for a reputable specialist at reasonable price? I'm living in Basingstoke. Best wishes for you all!
Hello ladies, I want to have a small polyp in my uterus removed before further IVF treatment. Any recommendation for a reputable specialist at reasonable price? I'm living in Basingstoke. Best wishes for you all!
Goldenfeather123
in
Fertility Network UK
2 years ago
Chronic lymphocytic leukemia treatment algorithm 2022
This 29 November 2022 review article published in the [i]Blood Cancer Journal[/i] presents an up-to-date treatment algorithm for CLL. https://www.nature.com/articles/s41408-022-00756-9 [i]"The treatment landscape for patients with chronic lymphocytic leukemia (CLL) has changed considerably with the
This 29 November 2022 review article published in the [i]Blood Cancer Journal[/i] presents an up-to-date treatment algorithm for CLL. https://www.nature.com/articles/s41408-022-00756-9 [i]"The treatment landscape for patients with chronic lymphocytic leukemia (CLL) has changed considerably with the
CLLerinOz
Administrator
in
CLL Support
2 years ago
Stopped using Evusheld
I received this message from UCSF. I believe, soon they will stop using it everywhere else too. In recent weeks, California has seen a rapid increase and dominance in circulation of COVID-19 Omicron subvariants which are resistant to our current monoclonal antibody treatment (bebtelovimab) and prophylaxis
I received this message from UCSF. I believe, soon they will stop using it everywhere else too. In recent weeks, California has seen a rapid increase and dominance in circulation of COVID-19 Omicron subvariants which are resistant to our current monoclonal antibody treatment (bebtelovimab) and prophylaxis
shazie
in
CLL Support
2 years ago
Fed Up with everything.
I have been on haemodialysis since May. Having completed all the tests etc at the beginning of November, I was just waiting to go live in the transplant list. My previous consultant, who is now on maternity leave, said my results were good and she even said, I would probably receive a new kidney before
I have been on haemodialysis since May. Having completed all the tests etc at the beginning of November, I was just waiting to go live in the transplant list. My previous consultant, who is now on maternity leave, said my results were good and she even said, I would probably receive a new kidney before
Ziggydoodah
in
Kidney Dialysis
2 years ago
Promising research is currently underway to use humanized bispecific single-domain antibodies
I was wondering if anyone has seen this new trial for applicable candidates https://cllsociety.org/2022/11/ash-2021-bispecific-v%CE%B39v%CE%B42-t-and-type-1-nkt-cell-engager-lava-051-as-first-in-class-clinical-candidate-to-target-cd1d-expressing-cll-mm-and-aml/ ASH 2021: Bispecific Vγ9Vδ2-T and
I was wondering if anyone has seen this new trial for applicable candidates https://cllsociety.org/2022/11/ash-2021-bispecific-v%CE%B39v%CE%B42-t-and-type-1-nkt-cell-engager-lava-051-as-first-in-class-clinical-candidate-to-target-cd1d-expressing-cll-mm-and-aml/ ASH 2021: Bispecific Vγ9Vδ2-T and
spi3
in
CLL Support
2 years ago
STATIC now beginning to open at sites in the UK
The long awaited successor to FLAIR for patients randomised to one of the Ibrutinib arms is finally ready to open at sites in the UK. When each site is ready will be up to local researchers and resource availability but the trial will be conducted in 100 NHS Centres in the UK (England, Wales, Scotland
The long awaited successor to FLAIR for patients randomised to one of the Ibrutinib arms is finally ready to open at sites in the UK. When each site is ready will be up to local researchers and resource availability but the trial will be conducted in 100 NHS Centres in the UK (England, Wales, Scotland
Jm954
Administrator
in
CLL Support
2 years ago
Long term steroids returning IBS
on long term steroids and Montelukast and now Alendronic Acid tablets my IBS D. has come back with a vengeance given Colofac as I have glaucoma in both eyes, I feel this has made my IBS worse with pains and constant diarrhea. Anyone any suggestions Dr not really interested.
on long term steroids and Montelukast and now Alendronic Acid tablets my IBS D. has come back with a vengeance given Colofac as I have glaucoma in both eyes, I feel this has made my IBS worse with pains and constant diarrhea. Anyone any suggestions Dr not really interested.
nana4me
in
IBS Network
2 years ago
Concise summary of the treatment history of CLL from the 1950s to the present, by Dr Bruce Cheson, contributor to the iwCLL and much more
I knew Chlorambucil use for CLL dated back to the 1950's but I hadn't appreciated that was also the case for cyclophosphamide, (the 'C' in FCR). It took until the early 90's before Fludarabine, the 'F' in FCR joined, then Rituximab (the 'R') just over 20 years ago, started the long reign of FCR as the
I knew Chlorambucil use for CLL dated back to the 1950's but I hadn't appreciated that was also the case for cyclophosphamide, (the 'C' in FCR). It took until the early 90's before Fludarabine, the 'F' in FCR joined, then Rituximab (the 'R') just over 20 years ago, started the long reign of FCR as the
AussieNeil
Partner
in
CLL Support
2 years ago
Treatment-naive or relapsed CLL patients will soon have zanubrutinib/Brukinsa as a treatment option in the EU
[i]The EC approval is based on positive results from two Phase 3 clinical trials: SEQUOIA (NCT03336333), in patients with previously untreated CLL, and ALPINE (NCT03734016), in patients with R/R CLL. In these two trials, BRUKINSA demonstrated superior efficacy versus either bendamustine plus rituximab
[i]The EC approval is based on positive results from two Phase 3 clinical trials: SEQUOIA (NCT03336333), in patients with previously untreated CLL, and ALPINE (NCT03734016), in patients with R/R CLL. In these two trials, BRUKINSA demonstrated superior efficacy versus either bendamustine plus rituximab
AussieNeil
Partner
in
CLL Support
2 years ago
Peritoneal dialysis and Neck pain at night during exchanges ……any help? Asking for my mother
Reaching out to this expert community to see if anyone has any experience and advice so I can help my mother. She has been on peritoneal dialysis for about 3-4years. Her exchanges happen at night on machine (not manually). Most recently she has been dealing with pretty significant neck pain. That happens
Reaching out to this expert community to see if anyone has any experience and advice so I can help my mother. She has been on peritoneal dialysis for about 3-4years. Her exchanges happen at night on machine (not manually). Most recently she has been dealing with pretty significant neck pain. That happens
Fight2016
in
Kidney Dialysis
2 years ago
Has anyone tried Hydroxychloroquin for CLL?
There are studies showing HCQ causes apoptosis in CLL, lowering the WBC. Did anyone take HCQ for covid and find their WBC dropped?
There are studies showing HCQ causes apoptosis in CLL, lowering the WBC. Did anyone take HCQ for covid and find their WBC dropped?
sharksalive
in
CLL Support
2 years ago
PCV 20 Guidelines ? Get 20 if you already had 13 and 23 - or not ?
One pharmacist in Florida refused to give PCV 20 "because guidelines say that if you had other previous pneumo vaccinations you do not need PCV 20 !" I got PCV 13 in 2015 and PCV 23 in 2005. My understanding of the literature is that PCV20 is now "updated" and everybody should get it who may get it
One pharmacist in Florida refused to give PCV 20 "because guidelines say that if you had other previous pneumo vaccinations you do not need PCV 20 !" I got PCV 13 in 2015 and PCV 23 in 2005. My understanding of the literature is that PCV20 is now "updated" and everybody should get it who may get it
janvog
in
CLL Support
2 years ago
IgHV - unmutated and Acalabrutinib
Saw my CLL specialist yesterday and he had the results of the IgHV testing he requested. It seems I am unmutated status which isn't great news. At the time of starting treatment, we were in 1st year of pandemic and Acalabrutinib was offered. As he said normally I would have been offered FCR because
Saw my CLL specialist yesterday and he had the results of the IgHV testing he requested. It seems I am unmutated status which isn't great news. At the time of starting treatment, we were in 1st year of pandemic and Acalabrutinib was offered. As he said normally I would have been offered FCR because
Eucalyptus22
in
CLL Support
2 years ago
New to this and very afraid
Hello folks...My GP feels my bloods indicate CLL...PANIC. Referring me to a Haematology Doctor 58 with dependent kids and mortgage Any information re the below would be great. Immunophenotyping PB has been done with Tcell Tcell helper cells and cytoxiccell all low.. L22 L14 L7 B cells High 64 66
Hello folks...My GP feels my bloods indicate CLL...PANIC. Referring me to a Haematology Doctor 58 with dependent kids and mortgage Any information re the below would be great. Immunophenotyping PB has been done with Tcell Tcell helper cells and cytoxiccell all low.. L22 L14 L7 B cells High 64 66
Stew64
in
CLL Support
2 years ago
My MD Anderson doctor is leaving
I received a letter on Saturday that my oncologist at MD Anderson, Dr. Philip Thompson, is leaving effective January 3, 2023. Nooooooooo! Dr. Thompson is originally from Australia and has made the decision to return to Melbourne and join the Low-Grade Lymphoma and CLL group at the Peter MacCallum Cancer
I received a letter on Saturday that my oncologist at MD Anderson, Dr. Philip Thompson, is leaving effective January 3, 2023. Nooooooooo! Dr. Thompson is originally from Australia and has made the decision to return to Melbourne and join the Low-Grade Lymphoma and CLL group at the Peter MacCallum Cancer
Lisa-1959
in
CLL Support
2 years ago
Our 2022 Christmas Donations Appeal Will you help us to reach and support more CLL patients this Christmas?
This year has been another difficult year for everyone, especially for the vulnerable and the charities that support them, like CLL Support UK, the charity of which HealthUnlocked CLL Support is the online support presence.
We know that this
Christmas
may be more relaxed than the last
This year has been another difficult year for everyone, especially for the vulnerable and the charities that support them, like CLL Support UK, the charity of which HealthUnlocked CLL Support is the online support presence.
We know that this
Christmas
may be more relaxed than the last
AussieNeil
Partner
in
CLL Support
2 years ago
Colofac tabs
Hi Gracie i would suggest Digestive Enzymes. Take them before main meals.
Hi Gracie i would suggest Digestive Enzymes. Take them before main meals.
Cosm
in
IBS Network
2 years ago
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