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Initial Phase 1 Data on MB-105 for Patients with PSCA-positive Castration Resistant Prostate Cancer
https://www.theglobeandmail.com/investing/markets/stocks/MBIO/pressreleases/5796662/mustang-bio-announces-initial-phase-1-data-on-mb-105-for-patients-with-psca-positive-
castration
-resistant-prostate-cancer/
https://www.theglobeandmail.com/investing/markets/stocks/MBIO/pressreleases/5796662/mustang-bio-announces-initial-phase-1-data-on-mb-105-for-patients-with-psca-positive-
castration
-resistant-prostate-cancer/
Maxone73
in
Advanced Prostate Cancer
4 months ago
PCA Cure and when?
7 months into my fight against
castration
sensitive prostate cancer. PSA is 0 on ADT and Abiraterone and methylprednisolone. Averaged 8,600 steps/day. I have just started to add occasional sprinting. I am taking multiple supplements. I am greatful that my PSA is 0.
7 months into my fight against
castration
sensitive prostate cancer. PSA is 0 on ADT and Abiraterone and methylprednisolone. Averaged 8,600 steps/day. I have just started to add occasional sprinting. I am taking multiple supplements. I am greatful that my PSA is 0.
Nowhereman9
in
Advanced Prostate Cancer
7 months ago
Regulated Induced Proximity Targeting Chimeras (RIPTAC) therapies are designed to target major solid tumours (as prostate and breast cancer)
HLD-0915, is an orally administered RIPTAC therapeutic with a novel mechanism designed to overcome drug resistance in the treatment of metastatic
castration
resistant prostate cancer (mCRPC).
HLD-0915, is an orally administered RIPTAC therapeutic with a novel mechanism designed to overcome drug resistance in the treatment of metastatic
castration
resistant prostate cancer (mCRPC).
Maxone73
in
Advanced Prostate Cancer
4 days ago
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Length of Treatment for Orgovyx (Relugolix) versus Lupron and other Longer Acting ADT drugs as Adjuvant to RT or Used for IADT?
Extrapolating out I'd say it's plausible to get the equivalent effective time of
castration
you'd have to take Orgovyx an additional 4-6 months! So 10-12 months Orgovyx = 6 months (2 shots) Lupron.
Extrapolating out I'd say it's plausible to get the equivalent effective time of
castration
you'd have to take Orgovyx an additional 4-6 months! So 10-12 months Orgovyx = 6 months (2 shots) Lupron.
jazj
in
Advanced Prostate Cancer
5 months ago
PSA Survival vs Testosterone Nadir - 1
The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be acurately measured many years ago. That makes sense to me).
The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be acurately measured many years ago. That makes sense to me).
janebob99
in
Advanced Prostate Cancer
6 months ago
PSA relapse rate vs testosterone nadir - 3
The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
janebob99
in
Advanced Prostate Cancer
6 months ago
PSA Survival vs Testosterone Nadir - 2
The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
janebob99
in
Advanced Prostate Cancer
6 months ago
Early Results from Transdermal Estrogen PATCH trial - 2
So, TDE can be more effective at
castration
than Lupron
in this study.
The lower chart shows the level of estradiol (picomol/L) after 1 month of treatment. The Lupron level is about 60, while the high-dose level is much higher, about 840 (pico mol/L) (i.e., supra-physiologic).
So, TDE can be more effective at
castration
than Lupron
in this study.
The lower chart shows the level of estradiol (picomol/L) after 1 month of treatment. The Lupron level is about 60, while the high-dose level is much higher, about 840 (pico mol/L) (i.e., supra-physiologic).
janebob99
in
Prostate Cancer Network
6 months ago
Early Results from Transdermal Estrogen PATCH trial - 2
So, TDE is more effective at
castration
than Lupron
in this study.
The lower chart shows the level of estradiol (picomol/L) after 1 month of treatment. The Lupron level is about 60, while the high-dose level is much higher, about 840 (pico mol/L) (i.e., supra-physiologic).
So, TDE is more effective at
castration
than Lupron
in this study.
The lower chart shows the level of estradiol (picomol/L) after 1 month of treatment. The Lupron level is about 60, while the high-dose level is much higher, about 840 (pico mol/L) (i.e., supra-physiologic).
janebob99
in
Advanced Prostate Cancer
6 months ago
PROTACs: another technique to help with mCRPC
I always wondered, if these protein degraders can basically destroy AR receptors, hence overcome both
castration
resistance and making the cells refractory to androgens...wouldn't it be useless to continue with ADT? Oh well... https://www.sciencedirect.com/science/article/pii/S0753332222015013
I always wondered, if these protein degraders can basically destroy AR receptors, hence overcome both
castration
resistance and making the cells refractory to androgens...wouldn't it be useless to continue with ADT? Oh well... https://www.sciencedirect.com/science/article/pii/S0753332222015013
Maxone73
in
Advanced Prostate Cancer
8 months ago
OS versus Testosterone Nadir - 5
(Ref: 2024) The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 or < 10 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
(Ref: 2024) The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 or < 10 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
janebob99
in
Advanced Prostate Cancer
6 months ago
OS versus Testosterone Nadir - 4
The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 or < 10 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
The prior definition of
castration
being < 50 ng/dL probably needs to redefined to < 20 or < 10 ng/dL. (I read that the level of 50 ng/dL may be an artifact representing the lowest limit that testosterone could be accurately measured many years ago. That makes sense to me).
janebob99
in
Advanced Prostate Cancer
6 months ago
A Phase 1 Open-label trial of Actinium-225-macropa-pelgifatamab for Advanced Metastatic Castration Resistant Prostate Cancer (mCRPC)
Finland, UK and Netherlands: a new theranostic based on actiniun 225 for metastatic prostate cancer https://www.theranostictrials.org/studies/cl74bp9il0233ajjfrlrlvs3d/NCT06052306
Finland, UK and Netherlands: a new theranostic based on actiniun 225 for metastatic prostate cancer https://www.theranostictrials.org/studies/cl74bp9il0233ajjfrlrlvs3d/NCT06052306
Maxone73
in
Advanced Prostate Cancer
16 days ago
Could BAT be our last chance?
My husband (on Lupron,
castration
resistant and tried every treatment) checked into the hospital 10 days ago for intense bone pain that requires heavy morphine. He has weakened bone marrow with low platelets and low red blood cells. He's getting palliative radiation for pain in a few places.
My husband (on Lupron,
castration
resistant and tried every treatment) checked into the hospital 10 days ago for intense bone pain that requires heavy morphine. He has weakened bone marrow with low platelets and low red blood cells. He's getting palliative radiation for pain in a few places.
Chris_Ali
in
Advanced Prostate Cancer
4 months ago
Doubling Times and PSA acceleration - Part II
This can be accomplished by chemical
castration
by either Lupron-based ADT or transdermal estrogen (TDE) therapy (or both). Chemical
castration
with transdermal estrogen (patch or gel) eliminates most of the bad side effects associated with Lupron ADT.
This can be accomplished by chemical
castration
by either Lupron-based ADT or transdermal estrogen (TDE) therapy (or both). Chemical
castration
with transdermal estrogen (patch or gel) eliminates most of the bad side effects associated with Lupron ADT.
janebob99
in
Prostate Cancer Network
6 months ago
Becoming mCRPC despite falling PSA
He accepted this during the meeting, but afterwards didn't really unterstand why he was seen as
castration
resistant now despite the ever decreasing PSA. Could the doctor classify him as
castration
resistant just because of the result of the MRI?
He accepted this during the meeting, but afterwards didn't really unterstand why he was seen as
castration
resistant now despite the ever decreasing PSA. Could the doctor classify him as
castration
resistant just because of the result of the MRI?
kennycool
in
Advanced Prostate Cancer
7 months ago
castration after 7 years of ADT
I have been on Zoladex for nearly 7 years and am fully over any regrets of Chemical
castration
. My psa is now slowly rising and ghastly taken 2 years from undetectable to 0.65.
I have been on Zoladex for nearly 7 years and am fully over any regrets of Chemical
castration
. My psa is now slowly rising and ghastly taken 2 years from undetectable to 0.65.
Roscoaus2000
in
Advanced Prostate Cancer
10 months ago
Swollen cord-stump after castration?
It was often swollen over some days sporadically in the first year after
castration
. Than it decreased with the time. Now - shortly after a TURP at 13. Oktober - the stump got swollen again. I believe or feel until 1 cm diameter.
It was often swollen over some days sporadically in the first year after
castration
. Than it decreased with the time. Now - shortly after a TURP at 13. Oktober - the stump got swollen again. I believe or feel until 1 cm diameter.
hanseunuch
in
Advanced Prostate Cancer
9 months ago
need some guidance, feeling desperate..
My husband has advanced, Stage IV
castration
resistant prostate cancer. When he was diagnosed in May 2022 his PSA was 4700, he has widespread bone metastases. He stopped responding to Docetaxel, Pluvicto and is now not responding to Cabazitaxel, his PSA is now over 700.
My husband has advanced, Stage IV
castration
resistant prostate cancer. When he was diagnosed in May 2022 his PSA was 4700, he has widespread bone metastases. He stopped responding to Docetaxel, Pluvicto and is now not responding to Cabazitaxel, his PSA is now over 700.
Kiki27
in
Advanced Prostate Cancer
7 months ago
Arx517 updates about the trial for metastatic castration resistant prostate cancer
patients in Cohort 9 experienced rapid PSA reduction at three weeks post-treatment following the first ARX517 dose” https://www.biospace.com/article/releases/ambrx-provides-update-on-apex-01-an-on-going-phase-1-2-dose-escalation-study-evaluating-arx517-a-proprietary-psma-targeting-adc-in-metastatic-
castration
-resistant-prostate-cancer
patients in Cohort 9 experienced rapid PSA reduction at three weeks post-treatment following the first ARX517 dose” https://www.biospace.com/article/releases/ambrx-provides-update-on-apex-01-an-on-going-phase-1-2-dose-escalation-study-evaluating-arx517-a-proprietary-psma-targeting-adc-in-metastatic-
castration
-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
9 months ago
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