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Video Discussion of ASCO Highlights.
"Dr Neal Shore (Carolina Urologic Research Center, South Carolina, USA), Dr Joaquin Mateo (Vall d'Hebron Institute of Oncology, Barcelona, Spain) and Dr Karim Fizazi (Institut Gustave Roussy, Paris, France) discuss the treatment and management of metastatic
castration
resistant prostate cancer (mCRPC
"Dr Neal Shore (Carolina Urologic Research Center, South Carolina, USA), Dr Joaquin Mateo (Vall d'Hebron Institute of Oncology, Barcelona, Spain) and Dr Karim Fizazi (Institut Gustave Roussy, Paris, France) discuss the treatment and management of metastatic
castration
resistant prostate cancer (mCRPC
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Next Step
He has
castration
-resistant prostate cancer with progression despite abiraterone, enzalutamide, and docetaxel chemotherapy. About 4 months ago, he began treatment with radium-223, and has received 4 of 6 infusions thus far.
He has
castration
-resistant prostate cancer with progression despite abiraterone, enzalutamide, and docetaxel chemotherapy. About 4 months ago, he began treatment with radium-223, and has received 4 of 6 infusions thus far.
Amandaslp78
in
Advanced Prostate Cancer
5 years ago
ASCO 2019 Abstracts.
Here is a little background [2]: "Resistance invariably develops to antiandrogen therapies used to treat newly diagnosed prostate cancers, but effective treatments for
castration
-resistant disease remain elusive.
Here is a little background [2]: "Resistance invariably develops to antiandrogen therapies used to treat newly diagnosed prostate cancers, but effective treatments for
castration
-resistant disease remain elusive.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
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Duration of ADT until castration resistence
Are you usually
castration
resistent after that?
Are you usually
castration
resistent after that?
GP24
in
Advanced Prostate Cancer
5 years ago
LU-177 clinical trial and nueroendocrine tumors
We are so impressed by all of you and your posts, and your dedication to helping others through this horrific battle with metastatic
castration
resistant prostate cancer.
We are so impressed by all of you and your posts, and your dedication to helping others through this horrific battle with metastatic
castration
resistant prostate cancer.
MeliaQuinn
in
Advanced Prostate Cancer
5 years ago
LU-177 as a first line treatment in castration resistant non netastatic prostate cancer
did anybody hear about a study where they treat somebody with
castration
resistant prostate cancer(without any metastasis) with LU177 instead of the good old way?
did anybody hear about a study where they treat somebody with
castration
resistant prostate cancer(without any metastasis) with LU177 instead of the good old way?
sdor
in
Advanced Prostate Cancer
5 years ago
BCR after castration
Has any ones PSA gone on the rise after orchiectomy? I had Casodex for 25 days then a Lupron shot 7.5 then the next month Dec 18 the Dr switched to Eligard stating they changed vendors. The day I got the shot I could hardly walk. Called the Doc the next day he said it should work itself out. After
Has any ones PSA gone on the rise after orchiectomy? I had Casodex for 25 days then a Lupron shot 7.5 then the next month Dec 18 the Dr switched to Eligard stating they changed vendors. The day I got the shot I could hardly walk. Called the Doc the next day he said it should work itself out. After
Shegolf
in
Advanced Prostate Cancer
5 years ago
Fibrinogen
Progression was defined as
castration
-resistant or death, and the
castration
-resistant was judged according to the EAU guidelines.16 The median follow-up duration was 37.0 months (interquartile range (IQR), 24.0–50.3).
Progression was defined as
castration
-resistant or death, and the
castration
-resistant was judged according to the EAU guidelines.16 The median follow-up duration was 37.0 months (interquartile range (IQR), 24.0–50.3).
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer.
In this study, patients with
castration
-resistant prostate cancer received escalating doses of selenate orally. The MTD was 60 mg daily. Dose limiting toxicity (fatigue and diarrhea) occurred at 90 mg daily, with no grade 4 toxicity.
In this study, patients with
castration
-resistant prostate cancer received escalating doses of selenate orally. The MTD was 60 mg daily. Dose limiting toxicity (fatigue and diarrhea) occurred at 90 mg daily, with no grade 4 toxicity.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Medical castration vs actual castration.
I have been reading about Lupron and other medical treatments and it raises the question of why not just remove the testicles. I understand why not for a younger man but I am 80 yrs old and sex is on the back burner as a reason to keep them. It is cost effective but is it as effective as the medicine
I have been reading about Lupron and other medical treatments and it raises the question of why not just remove the testicles. I understand why not for a younger man but I am 80 yrs old and sex is on the back burner as a reason to keep them. It is cost effective but is it as effective as the medicine
Drphil1938
in
Advanced Prostate Cancer
5 years ago
entering testing for novel approach to killing castration-resistant prostate cancer
6/17/2019 "A team of researchers from FIU’s Biomolecular Sciences Institute will soon expand tests of their novel approach to killing
castration
-resistant prostate cancer by cutting off its ability to repair damage to its own DNA." https://news.fiu.edu/2019/06/scientists-entering-next-phase-of-promising-research-for-treatment-of-prostate-cancer
6/17/2019 "A team of researchers from FIU’s Biomolecular Sciences Institute will soon expand tests of their novel approach to killing
castration
-resistant prostate cancer by cutting off its ability to repair damage to its own DNA." https://news.fiu.edu/2019/06/scientists-entering-next-phase-of-promising-research-for-treatment-of-prostate-cancer
George71
in
Advanced Prostate Cancer
5 years ago
Merck aims for prostate cancer dominance with 3 new phase 3 Keytruda studies
After fielding promising early results for immuno-oncology star Keytruda in metastatic,
castration
-resistant forms of the disease, the New Jersey drugmaker is adding a trio of late-stage studies to its Keytruda program, hoping they'll deliver some combo approvals.
After fielding promising early results for immuno-oncology star Keytruda in metastatic,
castration
-resistant forms of the disease, the New Jersey drugmaker is adding a trio of late-stage studies to its Keytruda program, hoping they'll deliver some combo approvals.
JLS1
in
Advanced Prostate Cancer
5 years ago
Efficacy of Radium-223 in Bone-Metastatic Castration-Resistant Prostate Cancer With and Without Homologous Repair Gene Defects
TAKE-HOME MESSAGE Somatic tumor and germline DNA testing are becoming more meaningful in the management of patients with advanced prostate cancer. This study evaluated the potential impact of germline or somatic homologous recombination deficiency (HRD) mutations on radium-223 efficacy in metastatic
TAKE-HOME MESSAGE Somatic tumor and germline DNA testing are becoming more meaningful in the management of patients with advanced prostate cancer. This study evaluated the potential impact of germline or somatic homologous recombination deficiency (HRD) mutations on radium-223 efficacy in metastatic
snoraste
in
Advanced Prostate Cancer
5 years ago
Drug Effective in 80% of Men With BRCA-mutant Prostate Cancer
(the list of Abstracts) https://abstracts.asco.org/239/CatAbstView_239_733_AT.html (the Abstract) https://abstracts.asco.org/239/AbstView_239_254043.html "TOPARP-B: A phase II randomized trial of the poly(ADP)-ribose polymerase (PARP) inhibitor olaparib for metastatic
castration
resistant prostate cancers
(the list of Abstracts) https://abstracts.asco.org/239/CatAbstView_239_733_AT.html (the Abstract) https://abstracts.asco.org/239/AbstView_239_254043.html "TOPARP-B: A phase II randomized trial of the poly(ADP)-ribose polymerase (PARP) inhibitor olaparib for metastatic
castration
resistant prostate cancers
pjoshea13
in
Advanced Prostate Cancer
5 years ago
VERU Inc.
The Company plans to conduct an open label Phase 1b/2 clinical trial in men with metastatic
castration
resistant prostate cancer that have also become resistant to, or who have failed to respond to, abiraterone or enzalutamide.
The Company plans to conduct an open label Phase 1b/2 clinical trial in men with metastatic
castration
resistant prostate cancer that have also become resistant to, or who have failed to respond to, abiraterone or enzalutamide.
Magnus1964
in
Advanced Prostate Cancer
5 years ago
Apalutamide for Metastatic Castration-Sensitive Prostate Cancer
"TAKE-HOME MESSAGE The authors of this double-blind, phase III trial randomly assigned 525 patients with metastatic,
castration
-sensitive prostate cancer to receive apalutamide or placebo, added to ADT. The study allowed for previous treatment for localized disease and previous docetaxel therapy.
"TAKE-HOME MESSAGE The authors of this double-blind, phase III trial randomly assigned 525 patients with metastatic,
castration
-sensitive prostate cancer to receive apalutamide or placebo, added to ADT. The study allowed for previous treatment for localized disease and previous docetaxel therapy.
snoraste
in
Advanced Prostate Cancer
5 years ago
Testosterone [T] Recovery after Cessation of ADT.
KEYWORDS: Androgen Deprivation Therapy;
Castration
; Prostate Cancer; Testosterone Deficiency; Testosterone Recovery PMID: 31080102 DOI: 10.1016/j.jsxm.2019.03.273
KEYWORDS: Androgen Deprivation Therapy;
Castration
; Prostate Cancer; Testosterone Deficiency; Testosterone Recovery PMID: 31080102 DOI: 10.1016/j.jsxm.2019.03.273
pjoshea13
in
Advanced Prostate Cancer
5 years ago
ADT (sort of) on screen
., it seem the answer to my questions is that
castration
at an early age is an entirely different thing, but let's not let that little fact keep us from having a bit of humor :-)
., it seem the answer to my questions is that
castration
at an early age is an entirely different thing, but let's not let that little fact keep us from having a bit of humor :-)
tom67inMA
in
Advanced Prostate Cancer
5 years ago
Intermittent ADT
Would it potentially lengthen the time to
Castration
Resistance??
Would it potentially lengthen the time to
Castration
Resistance??
Tommyj2
in
Advanced Prostate Cancer
5 years ago
combining Abiraterone with Avadart have synergistic benefit
“While more work is needed to determine the ultimate clinical effect of biochemically altering abiraterone metabolism in this way, our team has identified a promising new combination therapy that stands to improve the care of men with metastatic
castration
-resistant prostate cancer.” https://consultqd.clevelandclinic.org
“While more work is needed to determine the ultimate clinical effect of biochemically altering abiraterone metabolism in this way, our team has identified a promising new combination therapy that stands to improve the care of men with metastatic
castration
-resistant prostate cancer.” https://consultqd.clevelandclinic.org
George71
in
Advanced Prostate Cancer
5 years ago
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