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Abiraterone [Zytiga] or Enzalutamide [Xtandi]?
" [2] *** "
Background:
Abiraterone and enzalutamide may increase the risk of cardiovascular events in patients with
castration
-resistant prostate cancer (CRPC).
" [2] *** "
Background:
Abiraterone and enzalutamide may increase the risk of cardiovascular events in patients with
castration
-resistant prostate cancer (CRPC).
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Next treatment step for mCRPC and urinary retention
My father has been resistant to
castration
(mCRPC). His PSA (May 2020) is 5.683 ng/ml with new left pelvis and inguinal lymph nodes. I read articles of treatment steps on HeathUnlocked and understand that chemotherapy should be taken before zytiga, shouldn’t it?
My father has been resistant to
castration
(mCRPC). His PSA (May 2020) is 5.683 ng/ml with new left pelvis and inguinal lymph nodes. I read articles of treatment steps on HeathUnlocked and understand that chemotherapy should be taken before zytiga, shouldn’t it?
Hidden
in
Advanced Prostate Cancer
4 years ago
Free vs Total Testosterone? - Redux.
One possible incentive for the continuation of conventional ADT may lay in the assumption of a broader mode of therapy in the
castration
-resistant state. The mechanisms that lead to the
castration
-resistant state are numerous and have been subjected to extensive research in the past.
One possible incentive for the continuation of conventional ADT may lay in the assumption of a broader mode of therapy in the
castration
-resistant state. The mechanisms that lead to the
castration
-resistant state are numerous and have been subjected to extensive research in the past.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
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Folate consumption & ADT mortality.
In parallel, we tested
castration
of C57BL/6J mice on folate-defined diet to determine if folate levels change with response to androgen deprivation.
In parallel, we tested
castration
of C57BL/6J mice on folate-defined diet to determine if folate levels change with response to androgen deprivation.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
PARP Inhibitors for Metastatic Castration-Resistant Prostate CancerInterview with Oliver Sartor MD
This study did not require chemotherapy but did require use of a novel hormone, either in the hormone-sensitive or
castration
-resistant space. All the patients, in essence, were pretreated with abiraterone and enzalutamide, and they may or may not have been pretreated for docetaxel.
This study did not require chemotherapy but did require use of a novel hormone, either in the hormone-sensitive or
castration
-resistant space. All the patients, in essence, were pretreated with abiraterone and enzalutamide, and they may or may not have been pretreated for docetaxel.
Balsam01
in
Advanced Prostate Cancer
4 years ago
Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer The New England Journal of Medicine
Of men who received relugolix, 96.7% (95% confidence interval [CI], 94.9 to 97.9) maintained
castration
through 48 weeks, as compared with 88.8% (95% CI, 84.6 to 91.8) of men receiving leuprolide.
Of men who received relugolix, 96.7% (95% confidence interval [CI], 94.9 to 97.9) maintained
castration
through 48 weeks, as compared with 88.8% (95% CI, 84.6 to 91.8) of men receiving leuprolide.
Balsam01
in
Advanced Prostate Cancer
4 years ago
Metastasis-Directed Therapy in Oligoprogressive Castration-Resistant Prostate Cancer
TAKE-HOME MESSAGE •This retrospective study reports the clinical outcomes of patients with
castration
-resistant prostate cancer treated with metastasis-directed therapy (MDT) with stereotactic ablative radiotherapy.
TAKE-HOME MESSAGE •This retrospective study reports the clinical outcomes of patients with
castration
-resistant prostate cancer treated with metastasis-directed therapy (MDT) with stereotactic ablative radiotherapy.
Balsam01
in
Advanced Prostate Cancer
4 years ago
Dad has Stage 4 Prostate Cancer; rising PSA levels?
I also understand that it isn't necessarily the end of the world, as chemo/radiation are still options, but I'm wondering if the aforementioned spikes in my Dad's PSA is indicative of his cancer being/becoming
castration
-resistant? Or is this just his cancer rising a bit before it stabilizes again?
I also understand that it isn't necessarily the end of the world, as chemo/radiation are still options, but I'm wondering if the aforementioned spikes in my Dad's PSA is indicative of his cancer being/becoming
castration
-resistant? Or is this just his cancer rising a bit before it stabilizes again?
bern5
in
Advanced Prostate Cancer
4 years ago
High Testosterone after one month Leuprolide shot
How long is supposed to take to get
castration
levels?
How long is supposed to take to get
castration
levels?
olloreda
in
Advanced Prostate Cancer
4 years ago
Sorting Through the Maze of Treatment Options for Metastatic Castration-Sensitive Prostate Cancer MedPage Today Commentary - 07/08/2020
Morgans is a regular contributor at the fine URO Today website (https://www.urotoday.com/center-of-excellence/advanced-prostate-cancer.html)[/i]
Alicia Morgans, MD, on Treatment Options for Metastatic
-Sensitive Prostate Cancer https://www.medpagetoday.com/reading-room/asco/non-prostate-genitourinary-cancer
Morgans is a regular contributor at the fine URO Today website (https://www.urotoday.com/center-of-excellence/advanced-prostate-cancer.html)[/i]
Alicia Morgans, MD, on Treatment Options for Metastatic
-Sensitive Prostate Cancer https://www.medpagetoday.com/reading-room/asco/non-prostate-genitourinary-cancer
cujoe
in
Fight Prostate Cancer
4 years ago
SPARTAN - Overall Survival.
Patient summary With data presented herein, all primary and secondary study end points of SPARTAN were met; findings demonstrate the value of apalutamide as a treatment option for nonmetastatic
castration
-resistant prostate cancer. *** click on link for full text.
Patient summary With data presented herein, all primary and secondary study end points of SPARTAN were met; findings demonstrate the value of apalutamide as a treatment option for nonmetastatic
castration
-resistant prostate cancer. *** click on link for full text.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Castration Resistant?
We learned today that I am now castrate resistant, I have an appointment with the radiology oncologist tomorrow morning to get all of the pain will be starting Zytiga as soon as insurance approval goes through. In June 2019 I learned I was already stage four metastasized to bone, advanced prostate cancer
We learned today that I am now castrate resistant, I have an appointment with the radiology oncologist tomorrow morning to get all of the pain will be starting Zytiga as soon as insurance approval goes through. In June 2019 I learned I was already stage four metastasized to bone, advanced prostate cancer
Hidden
in
Advanced Prostate Cancer
4 years ago
Surgical castration?
Surgical
castration
is a medical service, so one-time cost is limited by an out-of-pocket cap. This cap will already be reached by other prostate therapy. Lutron will cost thousands for years.
Surgical
castration
is a medical service, so one-time cost is limited by an out-of-pocket cap. This cap will already be reached by other prostate therapy. Lutron will cost thousands for years.
LuckyInOregon
in
Prostate Cancer Network
4 years ago
Comparing the Clinical Efficacy and Safety of Abiraterone and Enzalutamide in Metastatic CRPC.
Keywords: Metastatic
castration
-resistant prostate cancer; abiraterone; enzalutamide; meta-analysis.
Keywords: Metastatic
castration
-resistant prostate cancer; abiraterone; enzalutamide; meta-analysis.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Patterns of Cancer Progression of Metastatic Hormone-sensitive PCa in the ECOG3805 CHAARTED Trial
However, the concordance of PSA rise and radiographic progression has not been examined previously in mHSPC, whereas this has been reported in metastatic
castration
-resistant prostate cancer.
However, the concordance of PSA rise and radiographic progression has not been examined previously in mHSPC, whereas this has been reported in metastatic
castration
-resistant prostate cancer.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Enzalutamide in Nonmetastatic Castration-Resistant Prostate Cancer
The New England Journal of Medicine Enzalutamide and Survival in Nonmetastatic
Castration
-Resistant Prostate Cancer N. Engl. J.
The New England Journal of Medicine Enzalutamide and Survival in Nonmetastatic
Castration
-Resistant Prostate Cancer N. Engl. J.
Balsam01
in
Advanced Prostate Cancer
4 years ago
hypophysectomy
I’ve read some about orchiectomy (this is a really interesting previous post by pjoshea13 https://healthunlocked.com/advanced-prostate-cancer/posts/142786599/surgical-
castration
.-why-is-it-uncommon) Then I started thinking “what the hell, the pituary gland?”
I’ve read some about orchiectomy (this is a really interesting previous post by pjoshea13 https://healthunlocked.com/advanced-prostate-cancer/posts/142786599/surgical-
castration
.-why-is-it-uncommon) Then I started thinking “what the hell, the pituary gland?”
TheTopBanana
in
Advanced Prostate Cancer
4 years ago
Androgen Receptor [AR] Degradation.
[/i]" [6] (2016)
Bioactive natural products for chemoprevention and treatment of
-resistant prostate cancer "[i]Nutraceuticals that target AR signaling (epigallocatechin gallate [EGCG], curcumin, and 5α-reductase inhibitors), AR synthesis (ericifolin, capsaicin and others) or [u]AR degradation
[/i]" [6] (2016)
Bioactive natural products for chemoprevention and treatment of
-resistant prostate cancer "[i]Nutraceuticals that target AR signaling (epigallocatechin gallate [EGCG], curcumin, and 5α-reductase inhibitors), AR synthesis (ericifolin, capsaicin and others) or [u]AR degradation
pjoshea13
in
Advanced Prostate Cancer
4 years ago
BAT & Abiraterone / Enzalutamide resensitization
Patient summary: BAT is well tolerated in metastatic
castration
-resistant prostate cancer patients. The type of prior AR-targeted therapy might affect response to BAT as well as AR-therapy rechallenge.
Patient summary: BAT is well tolerated in metastatic
castration
-resistant prostate cancer patients. The type of prior AR-targeted therapy might affect response to BAT as well as AR-therapy rechallenge.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Dr. Oliver Sartor on Rucaparib & Olaparib.
-Patrick [1] https://www.practiceupdate.com/content/parp-inhibitors-for-metastatic-
castration
-resistant-prostate-cancer/101910/45 (transcript below) PracticeUpdate: Could you give us an overview of PARP inhibitors currently being used in prostate cancer? Dr.
-Patrick [1] https://www.practiceupdate.com/content/parp-inhibitors-for-metastatic-
castration
-resistant-prostate-cancer/101910/45 (transcript below) PracticeUpdate: Could you give us an overview of PARP inhibitors currently being used in prostate cancer? Dr.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
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