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Dr. Oliver Sartor on Rucaparib & Olaparib.
-Patrick [1] https://www.practiceupdate.com/content/parp-inhibitors-for-metastatic-
castration
-resistant-prostate-cancer/101910/45 (transcript below) PracticeUpdate: Could you give us an overview of PARP inhibitors currently being used in prostate cancer? Dr.
-Patrick [1] https://www.practiceupdate.com/content/parp-inhibitors-for-metastatic-
castration
-resistant-prostate-cancer/101910/45 (transcript below) PracticeUpdate: Could you give us an overview of PARP inhibitors currently being used in prostate cancer? Dr.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Blood test can guide treatment for most aggressive prostate cancer - Peter MacCallum Cancer Center, Victoria, AU
An RNA-based liquid biopsy was able to detect abnormalities in the androgen receptor gene among men with metastatic
-resistant prostate cancer, which could help guide treatment decisions.
An RNA-based liquid biopsy was able to detect abnormalities in the androgen receptor gene among men with metastatic
-resistant prostate cancer, which could help guide treatment decisions.
cujoe
in
Fight Prostate Cancer
4 years ago
Our Saga so far...and an observation about quality of care
There was never a discussion about treating the primary tumor, but his PSA nadir was 0.8 and usually stayed under 2 which the MO said was
castration
-level for someone who still had a prostate. He had two ADT vacations--the first helped a bit with his energy, the second one not at all.
There was never a discussion about treating the primary tumor, but his PSA nadir was 0.8 and usually stayed under 2 which the MO said was
castration
-level for someone who still had a prostate. He had two ADT vacations--the first helped a bit with his energy, the second one not at all.
WildRose6
in
Advanced Prostate Cancer
4 years ago
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Adverse Events Related to Abiraterone and Enzalutamide Treatment
Clinicians should consider these data when treating patients with
castration
-resistant prostate cancer with ABI or ENZ.
Clinicians should consider these data when treating patients with
castration
-resistant prostate cancer with ABI or ENZ.
Balsam01
in
Advanced Prostate Cancer
4 years ago
CTC Count Can Predict Outcome in Prostate Cancer - Dr Goldkorn describes the valuable biomarker that will help guide treatment -MedPageToday
From the MedPageToday interview article:[i] [/i] [i]"Baseline circulating tumor cell (CTC) count was found to be significantly predictive of clinical outcome in a phase III trial of metastatic
castration
-sensitive prostate cancer (mCSPC) presented at the 2020 American Society of Clinical Oncology
From the MedPageToday interview article:[i] [/i] [i]"Baseline circulating tumor cell (CTC) count was found to be significantly predictive of clinical outcome in a phase III trial of metastatic
castration
-sensitive prostate cancer (mCSPC) presented at the 2020 American Society of Clinical Oncology
cujoe
in
Fight Prostate Cancer
4 years ago
Final 5-yr Survival analysis in the PREVAIL trial.
Keywords: Enzalutamide; Metastatic
castration
-resistant prostate cancer; Multivariable model; Overall survival; Prostate-specific antigen; Safety. Copyright © 2020. Published by Elsevier B.V.
Keywords: Enzalutamide; Metastatic
castration
-resistant prostate cancer; Multivariable model; Overall survival; Prostate-specific antigen; Safety. Copyright © 2020. Published by Elsevier B.V.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Outcomes in Men With Locally Advanced Prostate Cancer Treated With Neoadjuvant ADT and EBRT Followed by Adjuvant Continuous/Intermittent ADT
The primary endpoint was modified biochemical relapse-free survival (bRFS) with respect to nonmetastatic
castration
-resistant prostate cancer (nmCRPC) progression, clinical relapse, or any cause of death. RESULTS The median follow-up time after randomization was 8.2 years.
The primary endpoint was modified biochemical relapse-free survival (bRFS) with respect to nonmetastatic
castration
-resistant prostate cancer (nmCRPC) progression, clinical relapse, or any cause of death. RESULTS The median follow-up time after randomization was 8.2 years.
Balsam01
in
Advanced Prostate Cancer
4 years ago
FDA Approves First PARP Inhibitor Rucaparib for BRCA-mutated metastatic castration-resistant prostate cancer
https://www.fda.gov/drugs/fda-grants-accelerated-approval-rucaparib-brca-mutated-metastatic-
castration
-resistant-prostate This article explains why the BRCA mutation was mandated (as is prior treatment with an AR-directed therapy and taxane chemotherapy and ongoing chemical or physical
castration
).
https://www.fda.gov/drugs/fda-grants-accelerated-approval-rucaparib-brca-mutated-metastatic-
castration
-resistant-prostate This article explains why the BRCA mutation was mandated (as is prior treatment with an AR-directed therapy and taxane chemotherapy and ongoing chemical or physical
castration
).
Tall_Allen
in
Advanced Prostate Cancer
4 years ago
Association Between Dihydrotestosterone and Long-Term Risk for PCa Mortality
Ever since Huggins discovered that
castration
offered palliation for men with PCa, albeit temporary, there has been a belief that testosterone [T[ acts like gasoline on a fire.
Ever since Huggins discovered that
castration
offered palliation for men with PCa, albeit temporary, there has been a belief that testosterone [T[ acts like gasoline on a fire.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Searches not working! ie - TAS3681 - wondering if anyone is in this trial:Study of TAS3681 in Metastatic Castration Resistant Prostate Canc
https://healthunlocked.com/advanced-prostate-cancer/posts/138818885/trc253-trial I'm particularly interested in this clinical trial as it appears it's a rare find as it may not disqualify patients who are in bone marrow failure: Study of TAS3681 in Metastatic
Castration
Resistant Prostate Cancer https
https://healthunlocked.com/advanced-prostate-cancer/posts/138818885/trc253-trial I'm particularly interested in this clinical trial as it appears it's a rare find as it may not disqualify patients who are in bone marrow failure: Study of TAS3681 in Metastatic
Castration
Resistant Prostate Cancer https
JLS1
in
Advanced Prostate Cancer
4 years ago
FDA grants accelerated approval to rucaparib for BRCA-mutated metastatic castration-resistant prostate cancer
From the FDA: https://www.fda.gov/drugs/fda-grants-accelerated-approval-rucaparib-brca-mutated-metastatic-
castration
-resistant-prostate And to help understand the basics of PARP inhibitors in BRCA mutated PCa, here is an brief overview from CancerConnect: https://news.cancerconnect.com/prostate-cancer
From the FDA: https://www.fda.gov/drugs/fda-grants-accelerated-approval-rucaparib-brca-mutated-metastatic-
castration
-resistant-prostate And to help understand the basics of PARP inhibitors in BRCA mutated PCa, here is an brief overview from CancerConnect: https://news.cancerconnect.com/prostate-cancer
cujoe
in
Fight Prostate Cancer
4 years ago
HSD3B1 Genotype and Clinical Outcomes in Metastatic Castration-Sensitive Prostate Cancer
Hope the link below works “Key Points Question Does inheritance of the adrenal-permissive HSD3B1(1245C) allele indicate probable worse clinical outcomes in men treated with androgen deprivation therapy with or without docetaxel for metastatic
castration
-sensitive prostate cancer?
Hope the link below works “Key Points Question Does inheritance of the adrenal-permissive HSD3B1(1245C) allele indicate probable worse clinical outcomes in men treated with androgen deprivation therapy with or without docetaxel for metastatic
castration
-sensitive prostate cancer?
podsart
in
Advanced Prostate Cancer
4 years ago
Nuclear Receptor ERRα Contributes to Castration-Resistant Growth of Prostate Cancer via Its Regulation of Intratumoral Androgen Biosynthesis
The enzyme acts to circumvent
castration
by producing potent androgens that drive proliferation. Furthermore, AKR1C3 mediates chemotherapeutic resistance to the standard of care, enzalutamide, a structural analogue of apalutamide.
The enzyme acts to circumvent
castration
by producing potent androgens that drive proliferation. Furthermore, AKR1C3 mediates chemotherapeutic resistance to the standard of care, enzalutamide, a structural analogue of apalutamide.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer in patients with PSADT <10 months.
Mean overall survival was 67 months. "Enzalutamide was associated with a delay in the use of a new subsequent antineoplastic therapy (hazard ratio for the use of any subsequent antineoplastic therapy, 0.29; 95% CI, 0.25 to 0.35) (Fig. S2A). The median time to first use of new antineoplastic therapy
Mean overall survival was 67 months. "Enzalutamide was associated with a delay in the use of a new subsequent antineoplastic therapy (hazard ratio for the use of any subsequent antineoplastic therapy, 0.29; 95% CI, 0.25 to 0.35) (Fig. S2A). The median time to first use of new antineoplastic therapy
tango65
in
Advanced Prostate Cancer
4 years ago
Ipatasertib - Phase III study with Abiraterone,
So it's no great surprise to discover that: "[i]Phase 3 data showed that the addition of the AKT inhibitor ipatasertib to standard therapy boosted radiographic progression-free survival in patients with advanced
castration
-resistant prostate cancer whose tumors had PTEN loss[/i]."
So it's no great surprise to discover that: "[i]Phase 3 data showed that the addition of the AKT inhibitor ipatasertib to standard therapy boosted radiographic progression-free survival in patients with advanced
castration
-resistant prostate cancer whose tumors had PTEN loss[/i]."
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Veru Initiates Phase 2 Clinical Trial of VERU-111, First-in-Class, Oral, Advanced Prostate Cancer Drug
term=Veru-111&rank=1 Sounds safe, even for those with very low blood counts: "In preclinical effectiveness and toxicity studies, orally administered VERU-111 demonstrated significant antitumor activity against
castration
and novel androgen blocking agent (abiraterone or enzalutamide) resistant human
term=Veru-111&rank=1 Sounds safe, even for those with very low blood counts: "In preclinical effectiveness and toxicity studies, orally administered VERU-111 demonstrated significant antitumor activity against
castration
and novel androgen blocking agent (abiraterone or enzalutamide) resistant human
JLS1
in
Advanced Prostate Cancer
4 years ago
RP vs radiation. Survival from time of metastasis.
"One theory for the finding is that [u]early use of ADT as well as RT may potentiate epithelial-mesenchymal transition[/u], which mediates tumor invasion, metastasis, and development of
castration
-resistant tumors, leading to a worse outcome ..."
"One theory for the finding is that [u]early use of ADT as well as RT may potentiate epithelial-mesenchymal transition[/u], which mediates tumor invasion, metastasis, and development of
castration
-resistant tumors, leading to a worse outcome ..."
pjoshea13
in
Advanced Prostate Cancer
4 years ago
NF-κB Signaling Promotes Castration-Resistant Prostate Cancer Initiation and Progression
Unfortunately, patients with advanced PCa can develop incurable
castration
-resistant PCa (CRPCa) due to mutated, variant, or overexpressed AR. Conversely, low or no AR accumulation or activity can also underlie
castration
resistance.
Unfortunately, patients with advanced PCa can develop incurable
castration
-resistant PCa (CRPCa) due to mutated, variant, or overexpressed AR. Conversely, low or no AR accumulation or activity can also underlie
castration
resistance.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
COVID-19, ADT & the Immune Response
"The atrophy is due to the increased circulating level of sex hormones, and chemical or physical
castration
of an adult results in the thymus increasing in size and activity." *** Who knew that ADT had an upside?
"The atrophy is due to the increased circulating level of sex hormones, and chemical or physical
castration
of an adult results in the thymus increasing in size and activity." *** Who knew that ADT had an upside?
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Frailty, G-8 Score & PCa outcome.
The overall survival was significantly different between Geriatric 8 scores ≤13 and >13 in metastatic hormone-naïve prostate cancer patients, and between Geriatric 8 scores ≤12 and >12 in
castration
-resistant prostate cancer patients.
The overall survival was significantly different between Geriatric 8 scores ≤13 and >13 in metastatic hormone-naïve prostate cancer patients, and between Geriatric 8 scores ≤12 and >12 in
castration
-resistant prostate cancer patients.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
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