Experiences with

Castration

We are talking about sequential therapy in this case, triplet is a different story (and it's used in castration sensitive setting). https://www.curetoday.com/view/arpis-may-improve-survival-in-some-with-prostate-cancer

Furthermore, our findings lay the groundwork for further research into the involvement of ERα and ERβ in PCa that results in its castration stage, CRPC, and emphasises the significance of ER distribution in various study models.

We are talking about heavily pretreated castration resistant prostace cancers here...so not so easy! You can read more here below! https://www.claritypharmaceuticals.com/news/copper-67_sar-bispsma_updates/

I am a 68yr old guy who had a Rarp in August 23 for a Grade 5 T3a prostate cancer Jan this year my PSA started to rise setting of alarm bells with my Urologist further test and a PSMA PET scan confirmed Metastatic recurrence on lymph nodes and a rib I was put back on to monthly Degarelix Hormone therapy

So it's not a cure or a new therapy per se, but can be useful to delay castration resistance (or maybe even invert it, but the article does not talk about it).

CC-94676 or BMS-986365 is a highly selective AR degrade for castration resistant prostate cancer, the first good results were reported in January this year, but in September we will get more news at ESMO 2024 https://cslide.ctimeetingtech.com/esmo2024/attendee/confcal/presentation/list?

Castration resistance? I have 2 options to think about: 1) to wait untill PSA reaches around 0.7 or more and than another PSMAPETC as I did before. 2)ADT+ Zytiga immediately and see what happens. Your opinions? Thank you all.

it targets two antigens at the same time (PSMA and STEAP-1), which should give good results since in castration resistance settings STEAP-1 is expressed by 85% of cancerous cells and PSMA is 100 times more expressed in cancerous cells.

Extreme responses to immune checkpoint blockade following bipolar androgen therapy and enzalutamide in patients with metastatic castration resistant prostate cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585736/

Yes, they will start from castration resistant prostate cancer patients https://www.biospace.com/article/releases/adm-korea-announces-niclosamide-based-metabolic-anticancer-drug-s-first-clinical-trial-target-as-prostate-cancer-patients-resistant-to-hormone-therapy-/ EDIT: for some reason that link

The study also highlighted that prolonged effective castration periods might increase oncological benefits in some patient cohorts, though these observations warrant further research for confirmation. https://www.sciencedirect.com/science/article/pii/S0302283824026010?dgcid=author

I have been invited to participate in a clinical trial (phase 2) at the Univ of WA, Fred Hutch cancer center: Vorinostat to Augment Response to 177 Lutetium-PSMA-617 in the treatment of patients with PSMA- low metastatic castration resistant prostate cancer: VALOR TRIAL.

Exploring the mechanism of action of Sparganii Rhizoma-Curcumae Rhizoma for in treating castration-resistant prostate cancer: a network-based pharmacology and experimental validation study.

New article, but I think that I have already written about this...basically, it seems to delay castration resistance in prostate cancer.

Sources ncbi.nlm.nih.gov favicon pmc.ncbi.nlm.nih.gov favicon cancer.gov favicon cancer.org favicon prostatecanceruk.org favicon View 5 more Answer Based on the available research, there is no definitive "best" supplement for castration-resistant prostate cancer (CRPC).

Is it because the FDA has approved the latter only if castration resistant?

As Tall Allen posted, here is the link to the numbers: https://www.onclive.com/view/addition-of-radium-223-to-enzalutamide-significantly-improves-rpfs-and-os-in-mcrpc

Jo 9 yearWe present a case of a patient with castration-resistant prostate cancer with proven bone lesions 2 years after the onset of the disease and the current survival of over 9 years.

Both groups achieved similar rates of sustained castration, defined by low testosterone levels over one year.

I will also have a castration surgery to stop the testosterone from fueling the cancer. I am hoping to find a more natural less invasive way of slowing down the cancer and even it going back into remission if possible. Please send recommendations.