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21Aug21 TheraP Study: Lu177-PSMA vs Cabazitaxel
A randomised phase II trial of 177Lu-PSMA-617 (Lu-PSMA) theranostic versus cabazitaxel in metastatic
castration
resistant prostate cancer (mCRPC) progressing after docetaxel: Initial results are much more positive than earlier reported in the USA...now this is a Phase II trial (Phase III trials are scheduled
A randomised phase II trial of 177Lu-PSMA-617 (Lu-PSMA) theranostic versus cabazitaxel in metastatic
castration
resistant prostate cancer (mCRPC) progressing after docetaxel: Initial results are much more positive than earlier reported in the USA...now this is a Phase II trial (Phase III trials are scheduled
RMontana
in
Active Surveillance - Prostate Cancer
3 years ago
5α-Reductase Inhibitors are Associated with Reduced Risk of SARS-COV-2 Infection
Studies on the effect of
castration
and androgen receptor (AR) blockade have been mixed, while 5α-reductase inhibitor (5ARI) use in men with COVID-19 have shown potential benefits. We assessed the association of 5ARI use on risk of community acquired SARS-CoV-2 infection.
Studies on the effect of
castration
and androgen receptor (AR) blockade have been mixed, while 5α-reductase inhibitor (5ARI) use in men with COVID-19 have shown potential benefits. We assessed the association of 5ARI use on risk of community acquired SARS-CoV-2 infection.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Low-carb diet - ketogenesis - PSADT
Abiraterone plus prednisone in metastatic,
castration
-sensitive prostate cancer. N Engl J Med. 2017;377:352–60. - PubMed Sweeney CJ, Chen YH, Carducci M, Liu G, Jarrard DF, Eisenberger M, et al. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer.
Abiraterone plus prednisone in metastatic,
castration
-sensitive prostate cancer. N Engl J Med. 2017;377:352–60. - PubMed Sweeney CJ, Chen YH, Carducci M, Liu G, Jarrard DF, Eisenberger M, et al. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
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COMBAT-CRPC: COncurrent adMinistration of Bipolar Androgen Therapy and Nivolumab in men with mCRPC
TRANSFORMER: A Randomized Phase II Study Comparing Bipolar Androgen Therapy Versus Enzalutamide in Asymptomatic Men with
Castration
-Resistant Metastatic Prostate Cancer. J Clin Oncol. 2021 Apr 20;39(12):1371-1382.
TRANSFORMER: A Randomized Phase II Study Comparing Bipolar Androgen Therapy Versus Enzalutamide in Asymptomatic Men with
Castration
-Resistant Metastatic Prostate Cancer. J Clin Oncol. 2021 Apr 20;39(12):1371-1382.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Testosterone Therapy in Men with Biochemical Recurrence and Metastatic Prostate Cancer: Initial Observations
data revealed it was based on erratic acid phosphatase data for only 14 days in a single hormonally intact individual.16 Fowler and Whitmore reported 45 of 52 men who received TTh demonstrated an undefined “unfavorable result” within 30 days; however, all but four of these men had already undergone
castration
data revealed it was based on erratic acid phosphatase data for only 14 days in a single hormonally intact individual.16 Fowler and Whitmore reported 45 of 52 men who received TTh demonstrated an undefined “unfavorable result” within 30 days; however, all but four of these men had already undergone
castration
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Venous thromboembolism in metastatic castration-resistant cancer patients
Plasma tumor DNA (ptDNA) is an independent predictor of outcome in metastatic
castration
-resistant prostate cancer (mCRPC). We aimed to investigate the association between ptDNA and VTE in mCRPC.
Plasma tumor DNA (ptDNA) is an independent predictor of outcome in metastatic
castration
-resistant prostate cancer (mCRPC). We aimed to investigate the association between ptDNA and VTE in mCRPC.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Aging is Delayed in Castrated Males
Actually
castration
is the removal of testicles, but the effect of that is reduced testosterone. So ADT is similar to
castration
in that way, reduction of testosterone. It implies (to me) that males given ADT may outlive non-castrated males and females.
Actually
castration
is the removal of testicles, but the effect of that is reduced testosterone. So ADT is similar to
castration
in that way, reduction of testosterone. It implies (to me) that males given ADT may outlive non-castrated males and females.
NecessarilySo
in
Advanced Prostate Cancer
3 years ago
Update: FDA grants Priority Review for 177Lu-PSMA-617 for patients with metastatic castration-resistant
company’s New Drug Application (NDA) for 177Lu-PSMA-617, an investigational targeted radioligand therapy for the treatment of metastatic
castration
-resistant prostate cancer (mCRPC) in the post androgen receptor pathway inhibition, post taxane-based chemotherapy setting.
company’s New Drug Application (NDA) for 177Lu-PSMA-617, an investigational targeted radioligand therapy for the treatment of metastatic
castration
-resistant prostate cancer (mCRPC) in the post androgen receptor pathway inhibition, post taxane-based chemotherapy setting.
GregHouston
in
Advanced Prostate Cancer
3 years ago
Gut Bacteria May Fuel Prostate Cancer Growth Prostate cancer foundation
While the vast majority of prostate cancer is treatable, in 2021, nearly 34,000 patients are estimated to die of the disease – most of an advanced form known as
castration
-resistant prostate cancer (CRPC).
While the vast majority of prostate cancer is treatable, in 2021, nearly 34,000 patients are estimated to die of the disease – most of an advanced form known as
castration
-resistant prostate cancer (CRPC).
podsart
in
Advanced Prostate Cancer
3 years ago
Assumptions to increase life expendency
My understanding is that I will then not be able to benefit from physical
castration
to get extra years of life. Please help me understand.
My understanding is that I will then not be able to benefit from physical
castration
to get extra years of life. Please help me understand.
Burnett1948
in
Advanced Prostate Cancer
3 years ago
Phase 3 trial 177-Lu-PSMA-617
It’s for anyone with
castration
-Resistant PC and Mets to distant site a participant??
It’s for anyone with
castration
-Resistant PC and Mets to distant site a participant??
Bubasurf6
in
Advanced Prostate Cancer
3 years ago
Lynparza (olaparib) +Zytiga (abiraterone) better than Zytiga alone for mCRPC regardless of BRCA status
It DOES apply to men who have progressed to metastatic
castration
-resistant PCa after previous prostatectomy and primary or salvage radiation, and are chemo and second-line hormonal naive. The surprise is that Lynparza works so well in combination with abiraterone.
It DOES apply to men who have progressed to metastatic
castration
-resistant PCa after previous prostatectomy and primary or salvage radiation, and are chemo and second-line hormonal naive. The surprise is that Lynparza works so well in combination with abiraterone.
Tall_Allen
in
Advanced Prostate Cancer
3 years ago
Help for Husband
I said that's what the
castration
process does. We'd already talked about these side effects.. BIG mistake using that "castrate" word. He had completely freaked out, angry, making himself physically ill.
I said that's what the
castration
process does. We'd already talked about these side effects.. BIG mistake using that "castrate" word. He had completely freaked out, angry, making himself physically ill.
JWPMP
in
Advanced Prostate Cancer
3 years ago
High ALP after tE2 failure
Is the best alternative for these men surgical
castration
? (As I am still free of pain and symptoms, I will probably avoid that for now.)
Is the best alternative for these men surgical
castration
? (As I am still free of pain and symptoms, I will probably avoid that for now.)
noahware
in
Advanced Prostate Cancer
3 years ago
Abiraterone Active in Androgen Receptor-Positive Salivary Tumors — Disease control in 62.5% of a small cohort . . . MedPage Today - 10/14/21
xid=nl_mpt_DHE_2021-10-15 and also to the ASCO full report out of Italy:
Abiraterone Acetate in Patients With
-Resistant, Androgen Receptor–Expressing Salivary Gland Cancer: A Phase II Trial https://ascopubs.org/doi/full/10.1200/JCO.21.00468 [i] Knowledge is power, so stay Informed
xid=nl_mpt_DHE_2021-10-15 and also to the ASCO full report out of Italy:
Abiraterone Acetate in Patients With
-Resistant, Androgen Receptor–Expressing Salivary Gland Cancer: A Phase II Trial https://ascopubs.org/doi/full/10.1200/JCO.21.00468 [i] Knowledge is power, so stay Informed
cujoe
in
Fight Prostate Cancer
3 years ago
The Movember Global Action Plan 1 (GAP1) - Unique Prostate Cancer Tissue Microarray Resource - medRxiv preprint - posted June 04, 2021
TMA2 was designed to address questions regarding risk of
castration
resistant prostate cancer (CRPC) and response to suppression of the androgen receptor/androgen axis, and characterization of the
castration
-resistant phenotype.
TMA2 was designed to address questions regarding risk of
castration
resistant prostate cancer (CRPC) and response to suppression of the androgen receptor/androgen axis, and characterization of the
castration
-resistant phenotype.
cujoe
in
Fight Prostate Cancer
3 years ago
ADT vs physical castration pros and cons
I understand that unlike a physical
castration
which cannot be undone , adt can be stopped.
I understand that unlike a physical
castration
which cannot be undone , adt can be stopped.
Mascouche
in
Advanced Prostate Cancer
3 years ago
Glutaminase inhibitor trial
There were some posts recently re the possible role of the glutaminase switch in leading to
castration
resistance.
There were some posts recently re the possible role of the glutaminase switch in leading to
castration
resistance.
hg115pb
in
Advanced Prostate Cancer
3 years ago
Androgen Receptor Signalling Inhibitors – Post-Chemotherapy, Pre-Chemotherapy and now in castration sensitive prostate cancer - ERC -6.15.21
Androgen Receptor Signalling Inhibitors – Post-Chemotherapy, Pre-Chemotherapy and now in
sensitive prostate cancer - Nicholas Mitsiades and Salma Kaochar, Dept. of Medicine and Dept. of Molecular and Cellular Biology, Baylor College of Medicine, Houston,TX 77030.
Androgen Receptor Signalling Inhibitors – Post-Chemotherapy, Pre-Chemotherapy and now in
sensitive prostate cancer - Nicholas Mitsiades and Salma Kaochar, Dept. of Medicine and Dept. of Molecular and Cellular Biology, Baylor College of Medicine, Houston,TX 77030.
cujoe
in
Fight Prostate Cancer
3 years ago
Prostate cancer castrate resistant progression usage of non-canonical androgen receptor signaling and ketone body fuel - MDA/UBA, 01.15.2021
In summary, our studies reveal the key metabolites fueling
castration
resistant progression in the context of a partial or complete loss of AR dependence.
In summary, our studies reveal the key metabolites fueling
castration
resistant progression in the context of a partial or complete loss of AR dependence.
cujoe
in
Fight Prostate Cancer
3 years ago
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