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PSA fluctuations on docetaxel?
(Note: this is his first time being on chemo as he’s never been on chemotherapy before and he has had
castration
-resistant PC for 11 years, metastasized to the pelvis in 2019. He’ll be on dose #7 of docetaxel as of tomorrow).
(Note: this is his first time being on chemo as he’s never been on chemotherapy before and he has had
castration
-resistant PC for 11 years, metastasized to the pelvis in 2019. He’ll be on dose #7 of docetaxel as of tomorrow).
PHnerd
in
Advanced Prostate Cancer
1 year ago
Michael T Schweizer & BAT [Bipolar Androgen Therapy
Resistance develops in part because
castration
-resistant prostate cancer (CRPC) cells adaptively up-regulate AR levels through overexpression, amplification, and expression of ligand-independent variants in response to chronic exposure to a low-testosterone environment."
Resistance develops in part because
castration
-resistant prostate cancer (CRPC) cells adaptively up-regulate AR levels through overexpression, amplification, and expression of ligand-independent variants in response to chronic exposure to a low-testosterone environment."
pca2004
in
Fight Prostate Cancer
1 year ago
The Thymus & ADT
Many years ago, I discovered that
castration
could cause the thymus to regenerate. I wondered what that meant for PCa patients. There didn't seem to be any interest in the literature. For those who like sweetbreads (as I do), you will be eating the thymus gland.
Many years ago, I discovered that
castration
could cause the thymus to regenerate. I wondered what that meant for PCa patients. There didn't seem to be any interest in the literature. For those who like sweetbreads (as I do), you will be eating the thymus gland.
pca2004
in
Fight Prostate Cancer
1 year ago
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Lu-177-PSMA-I&T for low volume Metastatic Castration-Resistant Prostate Cancer
Is anyone familiar with Lu-177-PSMA-I&T for Metastatic
Castration
-Resistant ogliometastatic spine mets? Compared to chemo? Survival time increase? Side effects?
Is anyone familiar with Lu-177-PSMA-I&T for Metastatic
Castration
-Resistant ogliometastatic spine mets? Compared to chemo? Survival time increase? Side effects?
SViking
in
Advanced Prostate Cancer
1 year ago
PSA and Testosterone
I am of the understanding that the intent of medical
castration
is to reduce T levels so low that it will reduce PSA … I’d expect if my T is so high, I’d assume that my cancer cells would be on a Testosterone feeding frenzy, but instead, PSA has almost stabilized since the last.
I am of the understanding that the intent of medical
castration
is to reduce T levels so low that it will reduce PSA … I’d expect if my T is so high, I’d assume that my cancer cells would be on a Testosterone feeding frenzy, but instead, PSA has almost stabilized since the last.
Vp7174
in
Advanced Prostate Cancer
2 years ago
PSA #’s elevated from sex (After ADT and RT)
I’ve been on Active Surveillance since completing my ADT and RT both in 2017 &18 finally coming out of
castration
in 2019 / early 2020 with a basement T level, so I began Penile Rehab. Well over a year after that, I was able to resume (what I now refer to as) sexual relations with my wife!
I’ve been on Active Surveillance since completing my ADT and RT both in 2017 &18 finally coming out of
castration
in 2019 / early 2020 with a basement T level, so I began Penile Rehab. Well over a year after that, I was able to resume (what I now refer to as) sexual relations with my wife!
Jimhoy
in
Prostate Cancer Network
2 years ago
Elevated PSA #’s from sex (after RT & ADT)
I’ve been on Active Surveillance since completing my ADT and RT both in 2017 &18 finally coming out of
castration
in 2019 / early 2020 with a basement T level, so I began Penile Rehab. Well over a year after that, I was able to resume (what I now refer to as) sexual relations with my wife!
I’ve been on Active Surveillance since completing my ADT and RT both in 2017 &18 finally coming out of
castration
in 2019 / early 2020 with a basement T level, so I began Penile Rehab. Well over a year after that, I was able to resume (what I now refer to as) sexual relations with my wife!
Jimhoy
in
Active Surveillance - Prostate Cancer
2 years ago
A List for Newly Diagnosed that My Wife did in 2022 please add to list if anything is missed or wrong or needs updating. TIA
Bat Therapy BIPOLAR ANDROGEN THERAPY (BAT): A Treatment Option for Metastatic
Castration
-Resistant Prostate Cancer (mCRPC).
Bat Therapy BIPOLAR ANDROGEN THERAPY (BAT): A Treatment Option for Metastatic
Castration
-Resistant Prostate Cancer (mCRPC).
Shorehousejam
in
Advanced Prostate Cancer
8 months ago
More from PubMed
Deep, rapid, and durable prostate-specific antigen decline with apalutamide plus androgen deprivation therapy is associated with longer survival and improved clinical outcomes in TITAN patients with metastatic
castration
-sensitive prostate cancer.
Deep, rapid, and durable prostate-specific antigen decline with apalutamide plus androgen deprivation therapy is associated with longer survival and improved clinical outcomes in TITAN patients with metastatic
castration
-sensitive prostate cancer.
Magnus1964
in
Advanced Prostate Cancer
1 year ago
It's the tumor stupid
The bureaucracy says those and other treatments that may be curative are reserved for patients for whom
castration
and radiation have failed. The bureacracy also wants us to wait for five year survival numbers.
The bureaucracy says those and other treatments that may be curative are reserved for patients for whom
castration
and radiation have failed. The bureacracy also wants us to wait for five year survival numbers.
traxcavator
in
Advanced Prostate Cancer
2 years ago
Statin Use Is Associated with Better Prognosis of Patients with Prostate Cancer after Definite Therapies:
Castration
therapy continues to be a "popular" PCa therapy. Early resistance continues to be common, even with add-on androgen-axis drugs. One form of resistance involves the generation of androgens from cholesterol - within the cancer cell. Statin use is insurance against that.
Castration
therapy continues to be a "popular" PCa therapy. Early resistance continues to be common, even with add-on androgen-axis drugs. One form of resistance involves the generation of androgens from cholesterol - within the cancer cell. Statin use is insurance against that.
pjoshea13
in
Fight Prostate Cancer
2 years ago
Efficacy and safety of BAT in CRPC following Abi or Enza resistance: A systematic review
"Bipolar androgen therapy (BAT) is a new endocrinologic treatment for
castration
-resistant prostate cancer (CRPC) that can restore some patients' sensitivity to drugs such as abiraterone (Abi) and enzalutamide (Enz). ...
"Bipolar androgen therapy (BAT) is a new endocrinologic treatment for
castration
-resistant prostate cancer (CRPC) that can restore some patients' sensitivity to drugs such as abiraterone (Abi) and enzalutamide (Enz). ...
pjoshea13
in
Fight Prostate Cancer
1 year ago
Cytoreductive Prostatectomy & Oligometastatic PCa.
. “… time to {
castration
-resistant prostate cancer} was statistically significant in the {cytoreductive prostatectomy} group in all analyses ({randomized controlled trial}; HR=0.44 …) ({non-randomized controlled trials}; HR=0.64 …). “… {cancer-specific-survival} was not statistically different
. “… time to {
castration
-resistant prostate cancer} was statistically significant in the {cytoreductive prostatectomy} group in all analyses ({randomized controlled trial}; HR=0.44 …) ({non-randomized controlled trials}; HR=0.64 …). “… {cancer-specific-survival} was not statistically different
pca2004
in
Fight Prostate Cancer
1 year ago
PTEN loss is not a determinant of time to castration-resistance following androgen-deprivation therapy in prostate cancer
Keywords: ADT; CRPC; Jordan; PTEN;
castration
resistance; prostate cancer. ©2023 JOURNAL of MEDICINE and LIFE.
Keywords: ADT; CRPC; Jordan; PTEN;
castration
resistance; prostate cancer. ©2023 JOURNAL of MEDICINE and LIFE.
Magnus1964
in
Advanced Prostate Cancer
1 year ago
Cabergoline/ Dostinex/ Casodex - Prolactin suppression to remain Hormone sensitive
This leads to the development of “androgen-independent” malignancy; which is the status of advanced prostate cancer (
castration
resistant prostate cancer; CRPC). Androgen-independent advanced prostate cancer results in patient death generally in 2-5 years.
This leads to the development of “androgen-independent” malignancy; which is the status of advanced prostate cancer (
castration
resistant prostate cancer; CRPC). Androgen-independent advanced prostate cancer results in patient death generally in 2-5 years.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Genetics - Some answers but not all
ERG induces taxane resistance in
castration
-resistant prostate cancer. Nat. Commun. 2014;5:5548. doi: 10.1038/ncomms6548. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
ERG induces taxane resistance in
castration
-resistant prostate cancer. Nat. Commun. 2014;5:5548. doi: 10.1038/ncomms6548. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
spw1
in
Advanced Prostate Cancer
1 year ago
How can I increase blood platelets?
This coincides with
castration
resistance setting in. Are there certain supplements that can raise the platelet count? What is the likely cause of the lower platelet count, which is normally about 130-140k for me. My recent tests have shown the count to be 100, 90, 86 and 110.
This coincides with
castration
resistance setting in. Are there certain supplements that can raise the platelet count? What is the likely cause of the lower platelet count, which is normally about 130-140k for me. My recent tests have shown the count to be 100, 90, 86 and 110.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Xtandi (enzalutamide) alone is superior to ADT alone at preventing metastases in "high-risk" recurrent men
Also improved time to PSA progression/
castration
-resistance and time to chemo. No data yet on overall survival. Men achieving PSA≤ 0.2 ng/ml were given a vacation from therapy until PSA rose again. No QOL data yet.
Also improved time to PSA progression/
castration
-resistance and time to chemo. No data yet on overall survival. Men achieving PSA≤ 0.2 ng/ml were given a vacation from therapy until PSA rose again. No QOL data yet.
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
actual castration instead of ADT
I’m just throwing this out for discussion. I’m 62 in good over shape and recently started Lupron and Zytiga. I am told I will be on these or some form of ADT for the rest of my life. Since the goal is to eliminate testosterone wouldn’t it make sense to remove the source of it? By doing so one could
I’m just throwing this out for discussion. I’m 62 in good over shape and recently started Lupron and Zytiga. I am told I will be on these or some form of ADT for the rest of my life. Since the goal is to eliminate testosterone wouldn’t it make sense to remove the source of it? By doing so one could
OldGuysRule
in
Advanced Prostate Cancer
2 years ago
European Society for Medical Oncology Congress - ESMO 2023 - Two Significant Lutetium Trials -mCRPC
https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147459-esmo-2023-enza-p-anzup-1901-enzalutamide-and-177lu-psma-617-in-poor-risk-metastatic-
castration
-resistant-prostate-cancer-mcrpc-a-randomized-phase-2-trial.html?
https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147459-esmo-2023-enza-p-anzup-1901-enzalutamide-and-177lu-psma-617-in-poor-risk-metastatic-
castration
-resistant-prostate-cancer-mcrpc-a-randomized-phase-2-trial.html?
marnieg46
in
Fight Prostate Cancer
7 months ago
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