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Experiences with
Carbidopa / Levodopa
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Improving the Bio-availability of Levodopa
In the treatment of Parkinson’s disease, the DDC enzyme inhibitor
Carbidopa
, is co-administered with
Levodopa
, and a COMT enzyme inhibitor is also available to improve the bio-availability of Levodopa. What has this to do with Parkinson’s disease?
In the treatment of Parkinson’s disease, the DDC enzyme inhibitor
Carbidopa
, is co-administered with
Levodopa
, and a COMT enzyme inhibitor is also available to improve the bio-availability of Levodopa. What has this to do with Parkinson’s disease?
wriga
in
Cure Parkinson's
5 years ago
Myoclonus and Sleep Deprivation
Carbidopa
-
Levodopa
, my latest treatment drug, is now failing. I have given up on sleep in the wee hours to cleaning or lieing in bed in mental torment. These episodes give my AMN dire thoughts and self pity. And another day fraught with modification.
Carbidopa
-
Levodopa
, my latest treatment drug, is now failing. I have given up on sleep in the wee hours to cleaning or lieing in bed in mental torment. These episodes give my AMN dire thoughts and self pity. And another day fraught with modification.
SongStream
in
AMN EASIER
6 years ago
The Wonders of the Mucuna Bean
To quote Dr. Maldonado, from Chapter 6 of his book, Mucuna and Parkinson’s Disease: Treatment with Natural Levodopa - “To date, 50 substances have been identified in the powder of its seeds [2]. Other still unidentified components must exist in Mucuna, such as portions or mixtures of alkaloids, proteins
To quote Dr. Maldonado, from Chapter 6 of his book, Mucuna and Parkinson’s Disease: Treatment with Natural Levodopa - “To date, 50 substances have been identified in the powder of its seeds [2]. Other still unidentified components must exist in Mucuna, such as portions or mixtures of alkaloids, proteins
tarz
in
Cure Parkinson's
5 years ago
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Inbrija - Inhaled Levodopa
Has anyone tried the new inhaled “rescue “ form of levodopa? http://www.acorda.com/products/products/inbrija
Has anyone tried the new inhaled “rescue “ form of levodopa? http://www.acorda.com/products/products/inbrija
Hidden
in
Cure Parkinson's
5 years ago
Trying to find the best Mucuna Pruriens
I know there have been many discussions on this forum regarding the use of Mucuna Pruriens. My husband has been trying to figure out which brand and type may work best for him. I thought it would be a good idea for members who use Mucuna Pruriens to comment on the brand they use, type (powder or pill
I know there have been many discussions on this forum regarding the use of Mucuna Pruriens. My husband has been trying to figure out which brand and type may work best for him. I thought it would be a good idea for members who use Mucuna Pruriens to comment on the brand they use, type (powder or pill
trishjaustin
in
Cure Parkinson's
5 years ago
Getting full of supplements
What is the best recommended dose of Mercua P. if I've been taking 5-7 pills of
Carbidopa
Levodopa
with Entecapone 25mg/100 mg/200 mg? I also tak tyrosine 500 mg. about two times daily-when is the best time to take it and add to this two b1 capsule twice a day?(500 mg each)?
What is the best recommended dose of Mercua P. if I've been taking 5-7 pills of
Carbidopa
Levodopa
with Entecapone 25mg/100 mg/200 mg? I also tak tyrosine 500 mg. about two times daily-when is the best time to take it and add to this two b1 capsule twice a day?(500 mg each)?
interpreters
in
Cure Parkinson's
6 years ago
Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease. - levodopa effect.
Oldie: Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease. Jiménez-Jiménez FJ, et al. Neurosci Lett. 1999. Thiamine is an essential cofactor for several important enzymes involved in brain oxidative metabolism, such as the alpha-ketoglutarate dehydrogenase complex (KGDHC),
Oldie: Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease. Jiménez-Jiménez FJ, et al. Neurosci Lett. 1999. Thiamine is an essential cofactor for several important enzymes involved in brain oxidative metabolism, such as the alpha-ketoglutarate dehydrogenase complex (KGDHC),
aspergerian13
in
Cure Parkinson's
5 years ago
No Harm in Using Levodopa Early in Parkinson's for Symptom Relief, but the Drug Does Not Provide a Disease-Modifying Effect, Study Finds
https://journals.lww.com/neurotodayonline/pages/articleviewer.aspx?year=2019&issue=03070&article=00006&type=Fulltext
https://journals.lww.com/neurotodayonline/pages/articleviewer.aspx?year=2019&issue=03070&article=00006&type=Fulltext
Cagey84
in
Cure Parkinson's
5 years ago
Effect of levodopa on handwriting tasks of different complexity in Parkinson's disease: a kinematic study.
https://www.ncbi.nlm.nih.gov/pubmed/30877380
https://www.ncbi.nlm.nih.gov/pubmed/30877380
Farooqji
in
Cure Parkinson's
5 years ago
Zandopa and Mucuna Pruriens
Hi all! I have a couple of questions for you all. My husband is 54 and was diagnosed with PD in 2015. He has tried a number of meds, but eventually found that Zandopa along with C/L worked best. However, Zandopa underwent a change several months ago and it stopped working for him like it used to.
Hi all! I have a couple of questions for you all. My husband is 54 and was diagnosed with PD in 2015. He has tried a number of meds, but eventually found that Zandopa along with C/L worked best. However, Zandopa underwent a change several months ago and it stopped working for him like it used to.
trishjaustin
in
Cure Parkinson's
5 years ago
C/L ER vs. HDT
This evening I posted Carbidopa Levadopa. My takeaway: On Time - 4 to 8 hours. C/L er On Time - 24 hours. HDT Should I choose one or both?
This evening I posted Carbidopa Levadopa. My takeaway: On Time - 4 to 8 hours. C/L er On Time - 24 hours. HDT Should I choose one or both?
Hidden
in
Cure Parkinson's
5 years ago
Sinemet - sleep problems
Started Sinemet 1/2/19. 3 x 12.5 / 50. Doubled it as instructed 3/3/19. Sleeping badly, feeling worried and low, can't taste food. Decided yesterday to go back to original dose, and hopefully bring in high dose thiamin. New to this forum. Have had brilliant advice from PwP who runs a website. She was
Started Sinemet 1/2/19. 3 x 12.5 / 50. Doubled it as instructed 3/3/19. Sleeping badly, feeling worried and low, can't taste food. Decided yesterday to go back to original dose, and hopefully bring in high dose thiamin. New to this forum. Have had brilliant advice from PwP who runs a website. She was
Yoginipoet
in
Cure Parkinson's
5 years ago
Vivid Dreams/Sleepwalking
I’m wondering if the above discussion (See @Roborn1’s recent post) about too much
carbidopa
/
levodopa
applies here also? The vivid dreams is becoming far more than a nuisance - it’s becoming dangerous! Has anyone else experienced vivid dreams?
I’m wondering if the above discussion (See @Roborn1’s recent post) about too much
carbidopa
/
levodopa
applies here also? The vivid dreams is becoming far more than a nuisance - it’s becoming dangerous! Has anyone else experienced vivid dreams?
Cjbro2000
in
Cure Parkinson's
6 years ago
Suggestions anyone?
I was dx April 2018 with Parkinson’s by a Movement Specialist. I am tremor dominate on my dominate side. I am taking Selegeline. I was not encouraged by the doctor that diagnosed me, who told me there’s no cure you; you can work until you become disabled...oh btw exercise is the only thing that’s known
I was dx April 2018 with Parkinson’s by a Movement Specialist. I am tremor dominate on my dominate side. I am taking Selegeline. I was not encouraged by the doctor that diagnosed me, who told me there’s no cure you; you can work until you become disabled...oh btw exercise is the only thing that’s known
Danasr
in
Cure Parkinson's
5 years ago
The Metabolism of L-Dopa - Are Cytochrome P450 enzymes being ignored?
This is my second paper on the subject of Cytochrome P450 enzymes in Parkinson's disease and represents a significant update on the first draft, following considerable research on recent published data and a refinement of the arguments and conclusions. It lays out where we are on the understanding of
This is my second paper on the subject of Cytochrome P450 enzymes in Parkinson's disease and represents a significant update on the first draft, following considerable research on recent published data and a refinement of the arguments and conclusions. It lays out where we are on the understanding of
wriga
in
Cure Parkinson's
5 years ago
Eliminating Sinemet
I'm 75 years old and was first diagnosed with PD by a neurologist about 15 years ago. At that time the only symptoms I remember having were that I sometimes stepped a little bit funny, and I didn't swing my arms when I walked. Anyway, the doc immediately prescribed 3 Sinemets per day, with which I complied
I'm 75 years old and was first diagnosed with PD by a neurologist about 15 years ago. At that time the only symptoms I remember having were that I sometimes stepped a little bit funny, and I didn't swing my arms when I walked. Anyway, the doc immediately prescribed 3 Sinemets per day, with which I complied
tarz
in
Cure Parkinson's
5 years ago
HDT DOSING : How Much Should We Take??? A Reference Page To Add Your Dosing Information To
With Dr. Costantini unavailable for consults due to his current health, the HU Forum and others have a definite need for HDT dosing information that other members can use as a guideline. I am asking all members who are currently testing or using HDT to please post any dosing information that you feel
With Dr. Costantini unavailable for consults due to his current health, the HU Forum and others have a definite need for HDT dosing information that other members can use as a guideline. I am asking all members who are currently testing or using HDT to please post any dosing information that you feel
Hidden
in
Cure Parkinson's
5 years ago
My First post : Parkinsons Disease
PD MEDICATION: Taking
Carbidopa
Levodopa
(C/L) 25/100 since approx. 2 years. Dose started at 4 tablets : 1-1-1-1 and then in a year became 8 tablets: 2-2-2-2; now I have made it 5 tablets in all : 1-1.5-1.5-1 (for the past 6 months).
PD MEDICATION: Taking
Carbidopa
Levodopa
(C/L) 25/100 since approx. 2 years. Dose started at 4 tablets : 1-1-1-1 and then in a year became 8 tablets: 2-2-2-2; now I have made it 5 tablets in all : 1-1.5-1.5-1 (for the past 6 months).
John_morris71
in
Cure Parkinson's
6 years ago
Inhaled levidopa to reduce “off” time episodes.
My awesome wife received a thank you letter from The Michael J. Fox Foundation after making a contribution. The letter described “INBRIJA”. Here’s a quote, “The FDA recently approved Inbrija, an inhaled levodopa powder, for patients who experience “off” episodes. This is the first Parkinson’s therapy
My awesome wife received a thank you letter from The Michael J. Fox Foundation after making a contribution. The letter described “INBRIJA”. Here’s a quote, “The FDA recently approved Inbrija, an inhaled levodopa powder, for patients who experience “off” episodes. This is the first Parkinson’s therapy
Mogul1
in
Cure Parkinson's
5 years ago
Mucana vs Sinemet
My husband was diagnosed five years ago with PD. He is 75. His biggest annoyance at this time is hallucinations. He takes Sinemet, 25/100 , 2 pills three times a day. We are aware and I follow this site, that it could be caused from his medication. We have attempted twice to reduce but can only get down
My husband was diagnosed five years ago with PD. He is 75. His biggest annoyance at this time is hallucinations. He takes Sinemet, 25/100 , 2 pills three times a day. We are aware and I follow this site, that it could be caused from his medication. We have attempted twice to reduce but can only get down
Hidden
in
Cure Parkinson's
5 years ago
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