Once again I turned on the light in the early morning, this time at 3 am, to view the show: a furious firing of fasciculations beneath the surface of my calf. This has been my ongoing living nightmare. Carbidopa-Levodopa, my latest treatment drug, is now failing. I have given up on sleep in the wee hours to cleaning or lieing in bed in mental torment. These episodes give my AMN dire thoughts and self pity. And another day fraught with modification. I am always reminded through my stream of health Enewsletters of the dangers of poor sleep: buildup of plague in arteries and brain; higher cardiovascular risk, dementia, cancer, etc.... Most noticeably is the poor balance and gait along with cognitive stupor.
Am I sentenced to a lifetime of drug trials?
Update 2/7/19: I met with my new neurologist since my long time neuro retired and she prescribed Keppra for the first line of defense. Titrate up slowly per instructions to max of 4 tablets at bedtime at 500 m.g. each.
2/10/19: The next day after beginning Keppra, I had a sleep hangover which affected me until the afternoon. Yesterday and today was much better and I found relief along with sleep. This drug is an anticonvulsant and I hope I have some longevity before becoming resistant.
2/12/19: Myoclonus returning. Have to wait until 2/14 before increasing dosage. Note there has been no sleep "hangover" since 2/10.