Experiences with

Carbidopa / Levodopa

This is a comprehensive paper on the impact of medicines on bone density, osteoporosis and fracture. Thyroid hormones are listed but their impact appears considerably lower than for Proton Pump Inhibitors (PPIs), Methotrexate, Steroids, Hydroxychloroquine, and others. It is also often mentioned here

Has anyone had any experience of combining Ropinerole with high strength Mucuna Pruriens L-Dopa extract capsules food supplement? I am on 0.5mg of Ropinerole and reluctant to increase the dosage due to augmentation so I have just started to take Muncuna early in the evening followed by Ropinerole before

Sinemet is the Origina make/brand for levodopa and I have always had this made by Merrick Sharp Dohme Recently in found to my cost that it longer under special licence and it can be made by anyone now, but I was unaware that they would have such a different effect on me. They don’t work well at

Those of you that have had or are having experience with grapefruit juice, how is it going?

REFINING MY QUESTION (,,, food for thought...) Tyrosine is a dopamine percursor and as such appears to be a good option for supplementation in PSP. “Tyrosine hydroxylase” is the enzyme responsible for catalyzing the conversion of the amino acid L- tyrosine to L-DOPA. Tyrosine can also be made of phenylalanine

Last September, my hwp for 16 years, started mannitol. Over the next months, this gradually allowed him to reduce his dopamine meds, first eliminating the Neupro patch, then gradually eliminating Rytary. He has cognitive impairment and too much of those 2 meds would cause hallucinations. But dialing

I won't go as deep as Art does on Melatonin, but am picking up on a point Art makes often: Dosing! I read all these papers and frankly skim over a lot. Today somebody on FB reposted one of my favorites: 2021 - Melatonin as a Chronobiotic and Cytoprotective Agent in Parkinson’s Disease https://www.ncbi.nlm.nih.gov

Hi, your suggestions would help a lot. I am beginning to have dyskinesia more frequently. Mostly worse at night. I take Rytary 3pills 145mg, (8am,12noon,4pm and 8pm). My MDS thinks it is motor fluctuations, caused by uneven plasma level of Levodopa. He suggested that I should add two more pills,

I have found it challenging to schedule taking my medication: one hour before a meal and two hours after a meal. Recently with my Doctor's approval, I increased my Carbopa/Levodopa 25 dosage from 3 times a day to 4 times a day. The increase has made a difference. I still have difficulty scheduling

Karishma Smart*, Raymon Durso, Jonathan Morgan and Patrick McNamaraA potential case of remissionof Parkinson’s diseaseDOI 10.1515/jcim-2016 https://mindandculture.org/wordpress6/wp-content/uploads/2018/05/SmartDursoMorganMcNamara-A-Potential-Case-of-Remission-of-Parkinsons-Disease.pdf The patient meditates

About half a century ago, the merrRAdical profession established carbidopa/levodopa as the standard treatment for Parkinson’s disease; and it has been so ever since. But replacing dopamine is not a cure, does not always work, and can lose effectiveness over time.

Hi everyone, do you use Mucuna P for your PD treatment? Do you have dyskinesia before using Mucuna? Did it help decrease or stop the dyskinesia? If you answer YES to all the above questions ,kindly let me know your brand of Mucuna, the % concentration of Levodopa and where to purchase it. Thanks

Restated, this should be the Carbidopa/Levodopa dose identified as optimal; the sleep benefit requires a full dose. Another dose may be taken upon awakening in the middle of the night, if necessary to sustain sleep.” Full optimal dose, two 100 mg tablets for a total of 200 mg.

I posted this as a reply to Bass of Spade's optimistic post regarding gene therapy, but I think it's worthy of being the subject of a separate post. Gene Therapy Offers Long-Awaited Hope for Children with Rare, Incurable Disorder. Patients with Parkinson’s, Alzheimer’s May Benefit from Novel Treatment

My husband's been on Modopar (BC/L) for 18 months now and still waiting for the honeymoon to begin !! He's finding it harder and harder to walk in the afternoon, due to overworking aswell. His doc who we see wvery 6 months to dictate the prescription just wants to up the dose (currently at 4 x 25/100

I have raised my carbidopa levodopa to 1,400mg total a day. I was diagnosed, 2012. Four years ago I was Stage 3 - 4, going down hill fast. THREE years ago I was "blessed" by Doctor Costantini. Presently Stage 1--2.

I am 53 and was diagnosed PD 8 years . I am currently on 1/2 spoon of Zandopa and 1/4 Sinemet, 4 times a day. The medication only lasts for about 2 hours, so each day has been a hell for me. I am currently deciding on whether I should go with dopamine agonists first, or I should add more zandopa/ Macuna

Plantago ovata husk (psyllium) administration caused a smoothing and homogenization of levodopa absorption, providing more stable concentrations and final higher levels, resulting in a great benefit for patients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139609/

During the past 3 years I have been consistently reducing weights in the gym along with increased fatigue and weakness. I have noted this seems to be related to the intake of levodopa, because at evening/ night when not medicated I feel alert and more strength but then suffer insomnia. I’m on my 15

Anavex Life Sciences Announces ANAVEX®2-73 (Blarcamesine) Improved both Primary Cognitive and Secondary MDS-UPDRS Efficacy Endpoints with Significant Biomarker Correlation in Placebo-Controlled Phase 2 Clinical Trial for the Treatment of Patients with Parkinson’s Disease Dementia. ANAVEX®2-73 treatment