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In vivo/vitro: Dickkopf-1 (DKK1) drives growth and metastases in castration-resistant prostate cancer
...does "kopf" mean head? because I could switch to call my cancer dickkopf in that case! Anyway, thanks to CRISPR we have discovered another pathway...they have discovered another pathway! https://communities.springernature.com/posts/dickkopf-1-dkk1-drives-growth-and-metastases-in-castration-resistant-prostate-cancer
...does "kopf" mean head? because I could switch to call my cancer dickkopf in that case! Anyway, thanks to CRISPR we have discovered another pathway...they have discovered another pathway! https://communities.springernature.com/posts/dickkopf-1-dkk1-drives-growth-and-metastases-in-castration-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
2 months ago
InkMune clinical trial goes on: second cohort is being treated
In phase 1/2 CaRe PC trial (NCT06056791) evaluating INKmune, a biologic therapy In its announcement on Monday, INmune said it successfully completed nine INKmune administrations in the outpatient setting within the first cohort in the trial. None of the patients who have received INKmune so far have
In phase 1/2 CaRe PC trial (NCT06056791) evaluating INKmune, a biologic therapy In its announcement on Monday, INmune said it successfully completed nine INKmune administrations in the outpatient setting within the first cohort in the trial. None of the patients who have received INKmune so far have
Maxone73
in
Advanced Prostate Cancer
2 months ago
Pulmonary Node revealed with PET scan not growing
During my treatment for PC the first Pet scan showed a pulmonary node. There were no Mets beyound the prostate. Three DRs., Urologist, Oncologist and Pulmonary, did not attribute the node to the PC, since it was so far removed and there were no other mets revealed. A subsquent MRI 3 months later indicated
During my treatment for PC the first Pet scan showed a pulmonary node. There were no Mets beyound the prostate. Three DRs., Urologist, Oncologist and Pulmonary, did not attribute the node to the PC, since it was so far removed and there were no other mets revealed. A subsquent MRI 3 months later indicated
Eadgbe
in
Advanced Prostate Cancer
2 months ago
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Antibiotics for UTI symptoms
I suspect I have endometriosis after years of painful periods, painful sex and occasional bloating. My symptoms were menstruation specific. The last 2 years I have been almost been symptom free (for some unknown reason) but since Feb I have been having the classic tugging pain from my upper abdomen down
I suspect I have endometriosis after years of painful periods, painful sex and occasional bloating. My symptoms were menstruation specific. The last 2 years I have been almost been symptom free (for some unknown reason) but since Feb I have been having the classic tugging pain from my upper abdomen down
Mint_all_day
in
Endometriosis UK
2 months ago
Coffee - links to autoimmune?
Dear PA members - there seems to be many articles about negative and positive impacts of coffee/caffeine on autoimmune diseases. Does anyone know /researched if coffee has a negative or positive impact on AG PA? Its not clear. Many thanks
Dear PA members - there seems to be many articles about negative and positive impacts of coffee/caffeine on autoimmune diseases. Does anyone know /researched if coffee has a negative or positive impact on AG PA? Its not clear. Many thanks
PAapr22
in
Pernicious Anaemia Society
2 months ago
Occupational health
F 58 years old UK As per previous posts I have RLS at least 14 years every day. Am currently on Ropinirol and Gabapentin. I'm experiencing refractory RLS. I have been sleep deprived for years, 4 hours sleep or less means I don't dream, now I'm getting 5 hours I do dream and wake up exhausted! I have
F 58 years old UK As per previous posts I have RLS at least 14 years every day. Am currently on Ropinirol and Gabapentin. I'm experiencing refractory RLS. I have been sleep deprived for years, 4 hours sleep or less means I don't dream, now I'm getting 5 hours I do dream and wake up exhausted! I have
Louless9
in
Restless Legs Syndrome
2 months ago
Seeking pain relief tips bowel movements
Im currently on my last week of RT treatment (38 sessions). Last week has been tough everytime I need to make a bowel movent. Painful to the point Im thinking of going on a liquid diet. Anyone else exp this and have any tips. Im using Aquaphor which was recommended by nurse but hasnt really helped
Im currently on my last week of RT treatment (38 sessions). Last week has been tough everytime I need to make a bowel movent. Painful to the point Im thinking of going on a liquid diet. Anyone else exp this and have any tips. Im using Aquaphor which was recommended by nurse but hasnt really helped
Drago101
in
Advanced Prostate Cancer
2 months ago
Salvage options?
Hello again, I have a few more questions, to help my husband decide between surgery and brachyboost. For context, he is localized Gleason 9. (1) Is the course of salvage radiation after RP typically the same as it would have been if the initial treatment had been radiation therapy? Or would it require
Hello again, I have a few more questions, to help my husband decide between surgery and brachyboost. For context, he is localized Gleason 9. (1) Is the course of salvage radiation after RP typically the same as it would have been if the initial treatment had been radiation therapy? Or would it require
EvFC
in
Advanced Prostate Cancer
3 months ago
Very worried about Mom
Hello everyone - wish you all a healthy path.My Mother was admitted to the hospital Monday morning and we found out she had urinary infection that went to her kidney and then blood. She had stopped taking venetoclax since Sunday. They are giving her antibiotics but her blood counts are out of whack.
Hello everyone - wish you all a healthy path.My Mother was admitted to the hospital Monday morning and we found out she had urinary infection that went to her kidney and then blood. She had stopped taking venetoclax since Sunday. They are giving her antibiotics but her blood counts are out of whack.
Hidden
in
CLL Support
3 months ago
CRISPR news: protein arginine methyltransferase 7 as a novel essential gene in prostate cancer metastasis (in vitro)
Now, tell me how to deal with it! https://pubmed.ncbi.nlm.nih.gov/38432581/
Now, tell me how to deal with it! https://pubmed.ncbi.nlm.nih.gov/38432581/
Maxone73
in
Advanced Prostate Cancer
3 months ago
CAR-T: new phase 1 trial will soon start to enroll
P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Advanced Salivary Gland Cancers (SGC) Promising preclinical tests, but it's a phase 1 trial https://clinicaltrials.gov/study/NCT04249947
P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Advanced Salivary Gland Cancers (SGC) Promising preclinical tests, but it's a phase 1 trial https://clinicaltrials.gov/study/NCT04249947
Maxone73
in
Advanced Prostate Cancer
3 months ago
Surgery or radiation, looking for some advices
Hi everyone, I’m looking for some advices for my father. He was recently diagnosed with prostate cancer. He probably already had it for a long time. Quite high PSA (way over 20), and spread to multiple lymph nodes. The surgeon said surgery is still doable, followed by radiation. Radiation oncologist
Hi everyone, I’m looking for some advices for my father. He was recently diagnosed with prostate cancer. He probably already had it for a long time. Quite high PSA (way over 20), and spread to multiple lymph nodes. The surgeon said surgery is still doable, followed by radiation. Radiation oncologist
Healing1826
in
Advanced Prostate Cancer
3 months ago
Discomfort
Hi all. I'm getting discomfort in my upper abdomen. It's not pain exactly but it's uncomfortable. It's like IBS, which I suffer with, but can't take peppermint oil anymore. Has anyone else experienced this? Is it normal? It's not bloated like I had when I was diagnosed with cirrhosis. Apart from this
Hi all. I'm getting discomfort in my upper abdomen. It's not pain exactly but it's uncomfortable. It's like IBS, which I suffer with, but can't take peppermint oil anymore. Has anyone else experienced this? Is it normal? It's not bloated like I had when I was diagnosed with cirrhosis. Apart from this
Littlelizzy11
in
British Liver Trust
3 months ago
Prolia shots
After 4+ years of Actonel is Prolia a good choice for continued treatment of osteoporosis? I will be asking my rheumatologist the same question next time I see her. I am due for another bone scan so she will most likely want to see that first but based on the first 2 tests I am going downhill bone-wise
After 4+ years of Actonel is Prolia a good choice for continued treatment of osteoporosis? I will be asking my rheumatologist the same question next time I see her. I am due for another bone scan so she will most likely want to see that first but based on the first 2 tests I am going downhill bone-wise
Alebeau
in
PMRGCAuk
3 months ago
Pet Scan Below, Does Non Avid PSMA Liver Lesions mean possible Neuroendocrine Cancer
EXAM: PET-CT SKULL BASE TO MID-THIGH CLINICAL HISTORY: Metastatic prostate cancer, rising PSA TECHNIQUE: PET/CT skull base to thigh-subsequent treatment strategy F18 PYL dose: 10.00 millicuries Injection site: L AC Time of injection: 17:00 Time of emission scan: 18:06 Oral Contrast
EXAM: PET-CT SKULL BASE TO MID-THIGH CLINICAL HISTORY: Metastatic prostate cancer, rising PSA TECHNIQUE: PET/CT skull base to thigh-subsequent treatment strategy F18 PYL dose: 10.00 millicuries Injection site: L AC Time of injection: 17:00 Time of emission scan: 18:06 Oral Contrast
Shorehousejam
in
Advanced Prostate Cancer
3 months ago
Urinary Issues
I have had urinary issues for a long time. Urgency, frequency, retention, pain. No "incontinence" if i can get to a toilet or get the dick out to pee on the ground fast enough. Every day is a different combination of the above and I have never been able to figure out what causes each symptom or how
I have had urinary issues for a long time. Urgency, frequency, retention, pain. No "incontinence" if i can get to a toilet or get the dick out to pee on the ground fast enough. Every day is a different combination of the above and I have never been able to figure out what causes each symptom or how
spencoid2
in
Advanced Prostate Cancer
3 months ago
Restless legs syndrome
Hi. Wondering if anyone knows if the following pain meds would trigger my rls.In south africa it's called synaleve: meprobamate and codeine Xefo: lornoxicam I'm not sure what UK brands are but these are the ingredients Many thanks
Hi. Wondering if anyone knows if the following pain meds would trigger my rls.In south africa it's called synaleve: meprobamate and codeine Xefo: lornoxicam I'm not sure what UK brands are but these are the ingredients Many thanks
AzraCG
in
Restless Legs Syndrome
3 months ago
Had Pet Scan, PSA rising 0.77 Found Liver Metastases, Am I a dead man? What can I do?
Going for MRI and Biopsy What can I do?
Going for MRI and Biopsy What can I do?
Shorehousejam
in
Advanced Prostate Cancer
3 months ago
Starting Chemo in May via trial
Thanks to everyone for all of their great questions and converstions on this site. Check my bio for background. 2 months into ADT therapy after diagnosis in January. I am starting docetaxyl chemo via an NIH trial in May. M9241 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230972/. We are hopeful
Thanks to everyone for all of their great questions and converstions on this site. Check my bio for background. 2 months into ADT therapy after diagnosis in January. I am starting docetaxyl chemo via an NIH trial in May. M9241 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230972/. We are hopeful
4tunate1
in
Advanced Prostate Cancer
3 months ago
microscopic haematuria
so about a month ago i was getting vaginal infections that cause soreness and itchyness as well as burning to wee. It was put down to a UTI and was given antibiotics.i also had pelvic pain on my right side that came and went like a stitch. It never cleared so I ended up have 3 lots of antibiotics. Every
so about a month ago i was getting vaginal infections that cause soreness and itchyness as well as burning to wee. It was put down to a UTI and was given antibiotics.i also had pelvic pain on my right side that came and went like a stitch. It never cleared so I ended up have 3 lots of antibiotics. Every
Jellycat123
in
Bladder Health UK
3 months ago
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