Starting Chemo in May via trial

[4tunate1]

Thanks to everyone for all of their great questions and converstions on this site.

Check my bio for background. 2 months into ADT therapy after diagnosis in January. I am starting docetaxyl chemo via an NIH trial in May. M9241 - ncbi.nlm.nih.gov/pmc/articl.... We are hopeful for both good chemo results as well as a positive response for the immunotherapy. This trial stage is mostly to test feasability or delivering immunotherapy along with chemotherapy.

Is anyone familiar with, or perhaps a patient, of this study that can share any thoughts?

[God_Loves_Me]

Great strategy and also actions plan. Thank you for sharing

Conclusions: M9241 was found to be safe and well tolerated in PCa pts. PSA declines occurred in 5 of 8 evaluable pts. As with the phase 1 study, increases in NK subpopulations were seen in the small number of evaluable pts. These preliminary findings of a necrosis-targeting immunocytokine will be evaluated further in combination studies with cytotoxic therapy. M9241 is currently being evaluated in combination with docetaxel in metastatic prostate cancer (NCT04633252).

Important notes I would consider is work with MO for all side effects seriously. Write down all side effects and share list with MO and make sure to make progress on it.

[God_Loves_Me]

ONLY request for you, Please update about clinical trials and results. It helps others to make decision for similar clinical trials

[4tunate1 in reply to God_Loves_Me]

I'll be sure to update on my progress and experience throughout. I do feel I am doing this not just for myself, but for others.

[WisdomSeeking]

Are you or a 2nd generation ADT (abiraterone (Zytiga) /enzalutamide (Xtandi)/ ..) or only on 1st generation ADT (Lupron)?

[4tunate1 in reply to WisdomSeeking]

Just diagnosed in Jan 2024. started ADT therapy in February first with degarelix shots in the belly and oral abiraterone/prednisone. Got first Lupron shot in March. Still taking abiraterone/prednisone daily. Xtandi has not been part of my therapy.

[j-o-h-n]

May this May be a fruitful one for you. I was treated with Keytruda (immunotherapy) for my Melanoma Lung metastasis, and it worked. God Bless...

Good Luck, Good Health and Good Humor.

j-o-h-n