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Rising PSA post RP,IRT,ADT
Have 2 consecutive rising PSA - .04,.05,.1. Year post RP,IRT,ADT.. understand if goes to .2 new scans and possible Radiation. I surely don't like the ADT.. Any thoghts
Have 2 consecutive rising PSA - .04,.05,.1. Year post RP,IRT,ADT.. understand if goes to .2 new scans and possible Radiation. I surely don't like the ADT.. Any thoghts
ChristopherH
in
Advanced Prostate Cancer
6 months ago
First PSA after RARP
My dad had RARP on Jan 19,2024. Gleason 8(4+4) PSA 12, clean PSMA pet scan before surgery. Path report had no LN SVI or EPE but PNI and 50 percent prostate involvement. PSA today 6 weeks post surgery came out to .09. What should we do next? Age 73. Tall_Allen Please advice. Thanks a lot for your help
My dad had RARP on Jan 19,2024. Gleason 8(4+4) PSA 12, clean PSMA pet scan before surgery. Path report had no LN SVI or EPE but PNI and 50 percent prostate involvement. PSA today 6 weeks post surgery came out to .09. What should we do next? Age 73. Tall_Allen Please advice. Thanks a lot for your help
Pca2024
in
Advanced Prostate Cancer
6 months ago
Docxtel triple therapy?
Thank you for sharing your thoughts. My dad--81, advanced metastatic castrate resistant Diagnosed at 79 with stage 4 met 8 bones, including skull, no Gleason, never even saw a urologist. Diagnosed in ER and sent straight to the oncologist and palliative care doctor. PSA initially at 137 Lupron
Thank you for sharing your thoughts. My dad--81, advanced metastatic castrate resistant Diagnosed at 79 with stage 4 met 8 bones, including skull, no Gleason, never even saw a urologist. Diagnosed in ER and sent straight to the oncologist and palliative care doctor. PSA initially at 137 Lupron
lgutman
in
Advanced Prostate Cancer
6 months ago
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PSA reduction after Estrogen Patch Therapy
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
janebob99
in
Advanced Prostate Cancer
6 months ago
PSA reduction by Estrogen Patch (revised)
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
janebob99
in
Prostate Cancer Network
6 months ago
Dad's PSA risen from 0.01 to 0.05 in 2 months, 2 years post SRT. Any chance that there is no further progression?
PSA has risen 3 times in a row. I understand the figure is still low, but is this a definite indication that it will progress, or is there a chance that PSA can stabilize or fluctuate and not progress further? Things have been difficult in the family, I am hoping for a miracle that he had a curative
PSA has risen 3 times in a row. I understand the figure is still low, but is this a definite indication that it will progress, or is there a chance that PSA can stabilize or fluctuate and not progress further? Things have been difficult in the family, I am hoping for a miracle that he had a curative
MsBoBo
in
Advanced Prostate Cancer
6 months ago
PSA drop with decreasing Testosterone after Estrogen Patch Therapy
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Advanced Prostate Cancer
6 months ago
PSA drops with decreasing Testosterone
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Prostate Cancer Network
6 months ago
PSA spiked from .6 to 8.0 in 3 months
The blood test corroborates the MRI that shows spread. I am talking with Dr Goodman in the AM. Am I doomed? My PSA has never been 8. before
The blood test corroborates the MRI that shows spread. I am talking with Dr Goodman in the AM. Am I doomed? My PSA has never been 8. before
crony
in
Advanced Prostate Cancer
6 months ago
At the crossroads (again)
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
rsgdmd
in
Advanced Prostate Cancer
6 months ago
Patches (I'm depending on you, son)
Dated pop reference - sorry. While my research has continued, my oncologist has nothing to give me within the SOC to keep the PSA in check. Now I've witnessed another unwelcome visitor: facial hair (it only took me 70 yrs to start shaving....) Joking aside however, that means the T is on the rise.
Dated pop reference - sorry. While my research has continued, my oncologist has nothing to give me within the SOC to keep the PSA in check. Now I've witnessed another unwelcome visitor: facial hair (it only took me 70 yrs to start shaving....) Joking aside however, that means the T is on the rise.
CrocodileShoes
in
Advanced Prostate Cancer
6 months ago
AUS revision surgery?
I'm seeking advice on having a second AUS surgery. My background: I had a prostatectomy in 2016 and radiation a year later because the cancerous tumor had penetrated the sack. I have since had undetected PSA but have suffered with severe stress incontinence. I had AUS surgery in 2018 but it failed because
I'm seeking advice on having a second AUS surgery. My background: I had a prostatectomy in 2016 and radiation a year later because the cancerous tumor had penetrated the sack. I have since had undetected PSA but have suffered with severe stress incontinence. I had AUS surgery in 2018 but it failed because
allnewstuff
in
Advanced Prostate Cancer
6 months ago
Pain Management
Dear All can anyone help. Diagnosed with stage 1V advanced metastatic prostate cancer December 2022. 6 sessions of Chemo, then Firmagon and Nubeqa PSA was 349 now about 1 but has been increasing. Cancer was in most bones but no organs - primarily pelvis and hips - have had radiation treatment but still
Dear All can anyone help. Diagnosed with stage 1V advanced metastatic prostate cancer December 2022. 6 sessions of Chemo, then Firmagon and Nubeqa PSA was 349 now about 1 but has been increasing. Cancer was in most bones but no organs - primarily pelvis and hips - have had radiation treatment but still
Nyon
in
Advanced Prostate Cancer
6 months ago
Rising PSA
I'm Poollover, Just got the results of a blood test and my PSA went up from 0.67 to 0.77. I'm on Orgovyx and Zytiga. I'm 86 years old. How concerned should I be? 8 months ago it was about 12. That was before medication. Also slightly anemic. What are my options? Terry
I'm Poollover, Just got the results of a blood test and my PSA went up from 0.67 to 0.77. I'm on Orgovyx and Zytiga. I'm 86 years old. How concerned should I be? 8 months ago it was about 12. That was before medication. Also slightly anemic. What are my options? Terry
Poollover
in
Advanced Prostate Cancer
6 months ago
Estradiol, QoL and inflammation
Although I have been following the exchanges of this group for several months, this my first posting. I have (at 79) learned a lot from the pooled knowledge and experience of the group members. My inquiry ties in with posts regarding estradiol and the PATCH trial that have appeared the last couple
Although I have been following the exchanges of this group for several months, this my first posting. I have (at 79) learned a lot from the pooled knowledge and experience of the group members. My inquiry ties in with posts regarding estradiol and the PATCH trial that have appeared the last couple
Cliff-hanger
in
Advanced Prostate Cancer
6 months ago
Failed Pluvicto
Hello warriors, especially Tall Allen. I'm going on 6 years since Gleason 9 advanced metastatic diagnosis. Had a good run on Zytiga and all the usual other treatments, but just failed last ditch treatment of Pluvicto (after treatment 3). Did genetic testing and no significant mutations. My PSA is
Hello warriors, especially Tall Allen. I'm going on 6 years since Gleason 9 advanced metastatic diagnosis. Had a good run on Zytiga and all the usual other treatments, but just failed last ditch treatment of Pluvicto (after treatment 3). Did genetic testing and no significant mutations. My PSA is
jersy
in
Advanced Prostate Cancer
6 months ago
Next Steps
My brother was dDiagnosed in March 2023 with widespread prostate cancer metastasized to the spine, pelvic bones, ribs both left and right, and skull and lymph nodes. No progression to any organs. He had a orchiectomy, is on ABIRATERONE 500MG and has just completed six treatments of Doxetaxel .
My brother was dDiagnosed in March 2023 with widespread prostate cancer metastasized to the spine, pelvic bones, ribs both left and right, and skull and lymph nodes. No progression to any organs. He had a orchiectomy, is on ABIRATERONE 500MG and has just completed six treatments of Doxetaxel .
Sparlingo
in
Advanced Prostate Cancer
6 months ago
PSA relapse rate vs testosterone nadir - 3
This plot shows the PSA relapse rate after RT and ADT, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20 ng/dL),
and the relationship
This plot shows the PSA relapse rate after RT and ADT, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20 ng/dL),
and the relationship
janebob99
in
Advanced Prostate Cancer
6 months ago
Testosterone back to normal
I was diagnosed with PC last April 2023 with PSA of 125. Darilutimide and Relogolix, along with HIIT, plant based diet, and various supplements brought it down to .006. My MO granted a holiday about 6-7 weeks ago, and yesterday, I had my testosterone score. It is back to 312, which is above the number
I was diagnosed with PC last April 2023 with PSA of 125. Darilutimide and Relogolix, along with HIIT, plant based diet, and various supplements brought it down to .006. My MO granted a holiday about 6-7 weeks ago, and yesterday, I had my testosterone score. It is back to 312, which is above the number
Cape1
in
Advanced Prostate Cancer
6 months ago
PSA Survival vs Testosterone Nadir - 2
This plot shows the Biochemical Relapse Free Survival after RT and ADT, after 10 years , for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20
This plot shows the Biochemical Relapse Free Survival after RT and ADT, after 10 years , for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20
janebob99
in
Advanced Prostate Cancer
6 months ago
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