Some references re: statins and RYR

[PCaWarrior]

. References

1. Excellent unbiased coverage of possible statin benefits for advanced PCa: Statins and prostate cancer—hype or hope? The epidemiological perspective | Prostate Cancer and Prostatic Diseases

nature.com/articles/s41391-...

2. Statin Therapy Versus Placebo Prior to Prostatectomy ClinicalTrials.gov

clinicaltrials.gov/ct2/show...

3. Statins decrease c-Myc. C-Myc inhibition is an SPA induced action and directly impacts BAT performance. Statins decrease the expression of c-Myc protein in cancer cell lines – PubMed pubmed.ncbi.nlm.nih.gov/330...

4. “Statins lead to decreased pregnenolone”: PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion – PMC ncbi.nlm.nih.gov/pmc/articl...

5. Statins decrease pregnenolone which decreases progesterone. “An increase in progesterone is associated with poor clinical outcomes in patients and may be used as a predictive biomarker. Overall, we demonstrate that progesterone acts as an oncogenic hormone in prostate cancer, and strategies to eliminate its oncogenic effects may benefit prostate cancer patients.”: Inhibiting 3βHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer – ScienceDirect sciencedirect.com/science/a...

6. Statins appear beneficial, but metformin results are inconsistent: Statin and metformin use and outcomes in patients with castration-resistant prostate cancer treated with enzalutamide: A meta-analysis of AFFIRM, PREVAIL and PROSPER.

urotoday.com/recent-abstrac...

7. Statin Use and Survival Among Men Receiving Androgen-Ablative Therapies for Advanced Prostate Cancer: A Systematic Review and Meta-analysis | Cardiology | JAMA Network Open | JAMA Network

jamanetwork.com/journals/ja...

8. Targeting intratumoral androgens: statins and beyond - PMC

ncbi.nlm.nih.gov/pmc/articl...

9. Low-dose no benefit: Adjuvant Low-dose Statin Use after Radical Prostatectomy: The PRO-STAT Randomized Clinical Trial - PubMed

pubmed.ncbi.nlm.nih.gov/340...

10. Long-Term Treatment with Simvastatin Leads to Reduced Migration Capacity of Prostate Cancer Cells - PubMed

pubmed.ncbi.nlm.nih.gov/366...

11. Lipophilic statins superior to hydrophilic statins for PCa control: Statins: a repurposed drug to fight cancer - PMC

ncbi.nlm.nih.gov/pmc/articl...

12. Statins reduce ApoB and LDLs: New dimension of statin action on apoB atherogenicity - PMC

ncbi.nlm.nih.gov/pmc/articl...

13. Statins reduce ApoB and LDLs: Using apolipoprotein B to manage dyslipidemic patients: time for a change? - Abstract - Europe PMC

europepmc.org/article/pmc/2...

14. Atorvastatin Calcium and Celecoxib in Treating Patients with Rising PSA Levels After Local Therapy for Prostate Cancer ClinicalTrials.gov

clinicaltrials.gov/ct2/show...

15. Safety of Red Yeast Rice for High Cholesterol in Individuals With Statin Intolerance - Study Results - ClinicalTrials.gov

clinicaltrials.gov/ct2/show...

16. Statins lengthen time to CRPC among men with metabolic syndrome (most men): Metabolic syndrome and its pharmacologic treatment are associated with the time to castration-resistant prostate cancer - PubMed

pubmed.ncbi.nlm.nih.gov/350...

36. Red Yeast Rice (RYR)

i. Chinese red yeast rice versus lovastatin effects on prostate cancer cells with and without androgen receptor overexpression – PubMed pubmed.ncbi.nlm.nih.gov/190...

ii. Chinese Red Yeast Rice Inhibition of Prostate Tumor Growth in SCID mice – PMC ncbi.nlm.nih.gov/pmc/articl...

iii. Frontiers | Red Yeast Rice: A Systematic Review of the Traditional Uses, Chemistry, Pharmacology, and Quality Control of an Important Chinese Folk Medicine | Pharmacology frontiersin.org/articles/10...

iv. Anti-Cancer Effects of Chinese Red Yeast Rice beyond Monacolin K alone in Colon Cancer Cells – PMC ncbi.nlm.nih.gov/pmc/articl...

37. Side effects vs. placebo:

i. Clinical trial that shows side effects aren’t common and serious events occur about as frequently regardless of whether you take a statin: Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic Patients ClinicalTrials.gov clinicaltrials.gov/ct2/show...

ii. Side Effect Patterns in Statin, Placebo, and No Treatment - American College of Cardiology acc.org/latest-in-cardiolog...

iii. Examining the Nocebo Effect of Statins Through Statin Adverse Events Reported in the Food and Drug Administration Adverse Event Reporting System | Circulation: Cardiovascular Quality and Outcomes ahajournals.org/doi/10.1161...

iv. SAMSON Trial: 90% of Statin Complaints Are Nocebo Effect | MedPage Today medpagetoday.com/meetingcov...

Don't take RYR and a statin at the same time. I use a statin a few weeks, stop a week, and then use RYR for a week, stop a week, repeat...