Experiences with

Enzalutamide

Am I correct that when a patient becomes resistant to either enzalutamide or abiraterone, or has to stop due to arrhythmia one cannot be substitued for the other? Other than docetaxel (chemo) are there other commonly used treatments after enzalutamide or abiraterone resistance?

Pharmacokinetic analyses indicated that enzalutamide did not affect Masofaniten exposure, allowing for full dosing of enzalutamide.

I have read some people can have a change of taste as a side effect of enzalutamide. He is on relugolix , enzalutamide and have added 2000 mg metformin since a month. Anyone here experiences similar ?

Full article here: https://www.urologytimes.com/view/apalutamide-associated-with-improved-survival-vs-enzalutamide-in-mcspc

Dad has been on BPH medicine since 2011 to control symptoms of prostate enlargement - It contains tamsulosin and dutaseride Recently he has also added xtandi - enzalutamide I read online on drug interaction sites that enzalutamide can reduce efficacy of tamsulosin.

"This study reveals a previously unrecognized function of enzalutamide and AR by regulating PEX10 and suggests a new strategy of enzalutamide application in prostate cancer treatment." Not applied to any trial yet but an important finding! https://www.nature.com/articles/s41419-024-06937-7

Are any others experiencing metallic tasting food while taking enzalutamide? I’ve noticed that for myself along with poor appetite with weight loss.

“This real-world evidence showed a statistically significant and clinically meaningful improvement in survival with apalutamide over enzalutamide in patients with mCSPC at 24 months,” said Dr Neal Shore https://pharmatimes.com/news/erleada-shows-23-survival-benefit-over-enzalutamide-in-prostate-cancer-study

Results suggest darolutamide is associated with longer treatment duration and time to progression to mCRPC compared with enzalutamide and apalutamide in a routine care setting, while no differences in either outcome were found between enzalutamide and apalutamide.

“Meaning These findings suggest that darolutamide has a better tolerability profile compared with enzalutamide and apalutamide, which may be associated with an effectiveness advantage in routine clinical practice in men with nmCRPC.”

I was also taking 400mg Enzalutamide daily. I was experience serious daytime sleepiness and brain fog, so the oncologist stopped the Enzalutamide for 6 months. My weight continue to increase, so he said the Enzalutamide was not the cause and started it again.

Niclosamide and Enzalutamide in Treating Patients with Castration-Resistant, Metastatic Prostate Cancer

As Tall Allen posted, here is the link to the numbers: https://www.onclive.com/view/addition-of-radium-223-to-enzalutamide-significantly-improves-rpfs-and-os-in-mcrpc

Grade 3-5 DRAEs occurred in 28% of patients randomized to Ra-223 versus 19% of those who received single-agent enzalutamide. Fatal AEs occurred in 3% of the combination arm and 2% of the enzalutamide arm.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822420 A recent study concludes that Enzalutamide is slightly more beneficial if used before Abiraterone. This is contrary to other studies which some of you have posted recently.

Additional clinical trials with BAT are open and actively accruing: STEP-UP (sequencing BAT and Enzalutamide) APEX (sequencing BAT + Difluoromethylornithine (DFMO) with Enzalutamide) BATRAD (BAT + 223 Radium) AcroBAT (oral testosterone) However, patients with AR alterations treated with BAT trend

I read here some do enzalutamide alone without ADT or bicalutamide alone and have low psa numbers even with their testasterone being very high Whereas for those on ADT and ARSi both they say the testosterone numbers should be low and lower the better. Can someone throw some light on this 😊

MO suggested cabazitaxel (1st choice) or enzalutamide (discouraged because cancer is aggressive). Any data/experience that combined enzalutamide and cabazitaxel would be better?

Phase II trial exploring the combination of enzalutamide with five alpha-reductase inhibitors (ARIs) for castrate-sensitive prostate cancer.

I’m presuming it’s my balls starting to wither after 3 months of degarelix and enzalutamide… but maybe it’s more worrying? Balls!