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Enzalutamide
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Treatment Resistance. Enzalutamide & Exenatide (synthetic exendin-4).
to
enzalutamide
."
to
enzalutamide
."
enzalutamide (XTANDI®, Astellas Pharma Inc.) for patients with metastatic castration-sensitive prostate cancer (mCSPC).
On December 16, 2019, the Food and Drug Administration approved
enzalutamide
(XTANDI®, Astellas Pharma Inc.) for patients with metastatic castration-sensitive prostate cancer (mCSPC). FDA previously approved
enzalutamide
for patients with castration-resistant prostate cancer.
On December 16, 2019, the Food and Drug Administration approved
enzalutamide
(XTANDI®, Astellas Pharma Inc.) for patients with metastatic castration-sensitive prostate cancer (mCSPC). FDA previously approved
enzalutamide
for patients with castration-resistant prostate cancer.
Update after Chemo
MO was going to recommend Aberaterone w/ Presdisone but I saw a specialist at Georgetown Hospital who (based on a clinical trial 'Arches') is recommending
Enzalutamide
. Also eliminating Zometa, Bicalumide, Predisone. Anyone familiar with the
Enzalutamide
and the Arches trial?
MO was going to recommend Aberaterone w/ Presdisone but I saw a specialist at Georgetown Hospital who (based on a clinical trial 'Arches') is recommending
Enzalutamide
. Also eliminating Zometa, Bicalumide, Predisone. Anyone familiar with the
Enzalutamide
and the Arches trial?
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more possibilities after exhausting SOC?: Enzalutamide-resistant castration-resistant prostate cancer: challenges and solutions
The results of a Phase II trial testing this strategy in mCRPC patients after progression on
enzalutamide
have been recently published.29 Nine of the 30 enrolled patients (30%; 95% CI 15%–49%) achieved a .50% PSA reduction, and 21 proceeded to
enzalutamide
rechallenge, with 15 patients (52%; 95% CI 33%
The results of a Phase II trial testing this strategy in mCRPC patients after progression on
enzalutamide
have been recently published.29 Nine of the 30 enrolled patients (30%; 95% CI 15%–49%) achieved a .50% PSA reduction, and 21 proceeded to
enzalutamide
rechallenge, with 15 patients (52%; 95% CI 33%
Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer
agent (abiraterone or
enzalutamide
).
agent (abiraterone or
enzalutamide
).
Enzalutamide and PSMA
In an attempt to find the best condition for PSMA radioligand therapy in metastatic castration-resistant prostate cancer (mCRPC) patients, we evaluated the effect of oral
enzalutamide
in patients, predominantly having previously progressed on
enzalutamide
treatment.
In an attempt to find the best condition for PSMA radioligand therapy in metastatic castration-resistant prostate cancer (mCRPC) patients, we evaluated the effect of oral
enzalutamide
in patients, predominantly having previously progressed on
enzalutamide
treatment.
Impact of Abiraterone Acetate Plus Prednisone or Enzalutamide on Patient-Reported Outcomes in Patients With Metastatic Castration-Resistant
INTERVENTION Abiraterone or
enzalutamide
treatment according to routine practise.
INTERVENTION Abiraterone or
enzalutamide
treatment according to routine practise.
Increasing PSMA
Hi, I believe I read on here about taking Xtandi or
Enzalutamide
to increase PSMA activity? Does anyone recall something like that? Thanks
Hi, I believe I read on here about taking Xtandi or
Enzalutamide
to increase PSMA activity? Does anyone recall something like that? Thanks
Enzalutamide [Xtandi] & altered sense of Taste
Changing the Timing of
Enzalutamide
Intake from Morning to before Sleep at Night Overcame
Enzalutamide
-Induced Dysgeusia. Kawahara T1, Miyoshi Y1, Yao M2, Uemura H1.
Changing the Timing of
Enzalutamide
Intake from Morning to before Sleep at Night Overcame
Enzalutamide
-Induced Dysgeusia. Kawahara T1, Miyoshi Y1, Yao M2, Uemura H1.
Zytiga vs xtandi
211 patients with metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone acetate or
enzalutamide
.
211 patients with metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone acetate or
enzalutamide
.
Statin use in advanced PCA with ADT or abiraterone/enzalutamide
"Databases were searched using keywords (abiraterone OR
enzalutamide
OR androgen deprivation therapy) AND statin. In total, nine eligible studies from 111 references were included for final analysis."
"Databases were searched using keywords (abiraterone OR
enzalutamide
OR androgen deprivation therapy) AND statin. In total, nine eligible studies from 111 references were included for final analysis."
Have question about drug Talazoparib.
Or info or involvement in trial using
Enzalutamide
and Talazoparib?
Or info or involvement in trial using
Enzalutamide
and Talazoparib?
STREAM. Enzalutamide + ADT with Salvage Radiation in high-risk PSA-recurrent PCa after RP
"Six months of ADT with 160 mg/d
enzalutamide
and 66 Gy RT to the prostate bed." "The primary endpoint of 2-yr {progression-free survival} was 65% ... versus 51% ... [u]in a trial of men with similar eligibility treated with salvage RT and adjuvant docetaxel[/u]."
"Six months of ADT with 160 mg/d
enzalutamide
and 66 Gy RT to the prostate bed." "The primary endpoint of 2-yr {progression-free survival} was 65% ... versus 51% ... [u]in a trial of men with similar eligibility treated with salvage RT and adjuvant docetaxel[/u]."
Pseudoprogression.
Participants were men from the
enzalutamide
groups of the 2 studies with a decrease in prostate-specific antigen level at any time or with stable disease or soft-tissue disease responding to treatment based onradiologic findings. INTERVENTION:
Enzalutamide
, 160 mg once daily.
Participants were men from the
enzalutamide
groups of the 2 studies with a decrease in prostate-specific antigen level at any time or with stable disease or soft-tissue disease responding to treatment based onradiologic findings. INTERVENTION:
Enzalutamide
, 160 mg once daily.
Bipolar Androgen Therapy [BAT] & CRPC - Sam Denmeade, Hopkins.
favored the
enzalutamide
arm (3.8 vs 2.8 months; p=0.012).
favored the
enzalutamide
arm (3.8 vs 2.8 months; p=0.012).
William K. Oh, MD [Mount Sinai] & ENZAMET
v=Ey7Pn-aamMg ENZAMET [1] compared "ADT" +
Enzalutamide
with ADT + an older antiandrogen in newly diagnosed metastatic PCa. The Enza combo worked better. However, some men opted to also have chemo, & the benefit of Enza was not seen in those men.
v=Ey7Pn-aamMg ENZAMET [1] compared "ADT" +
Enzalutamide
with ADT + an older antiandrogen in newly diagnosed metastatic PCa. The Enza combo worked better. However, some men opted to also have chemo, & the benefit of Enza was not seen in those men.
Indirect Comparisons of Efficacy Between Combination Approaches in Metastatic Hormone-Sensitive Prostate Cancer
In all, seven trials met eligibility criteria using either docetaxel, abiraterone acetate,
enzalutamide
, or apalutamide in combination with ADT.
In all, seven trials met eligibility criteria using either docetaxel, abiraterone acetate,
enzalutamide
, or apalutamide in combination with ADT.
Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer
agent (abiraterone or
enzalutamide
).
agent (abiraterone or
enzalutamide
).
2019 Top Stories in Advanced Prostate Cancer: Cabazitaxel vs Abiraterone or Enzalutamide in Metastatic Prostate Cancer
) in men who had previously been treated with docetaxel or the other androgen signaling–targeted inhibitor (ie, abiraterone or
enzalutamide
).
) in men who had previously been treated with docetaxel or the other androgen signaling–targeted inhibitor (ie, abiraterone or
enzalutamide
).
Flutamide, bicalutamide, nilutamide, apalutamide or enzalutamide?
According to the cancer.gov fact sheet for Hormone Therapy for Prostate Cancer, there are 5 types of CAB, Complete Androgen Blockade. I've been on bical. for about 20 months. However, against advice, I have not had radiation nor surgery. The combo I'm using is finasteride, tamsulosin and bicalutamide
According to the cancer.gov fact sheet for Hormone Therapy for Prostate Cancer, there are 5 types of CAB, Complete Androgen Blockade. I've been on bical. for about 20 months. However, against advice, I have not had radiation nor surgery. The combo I'm using is finasteride, tamsulosin and bicalutamide
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