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Xtandi monotherapy is very effective

The enzalutamide monotherapy was almost as effective as enzalutamide plus leuprolide with fewer hot flushes, hypertension, falls and fractures. The reduced fractures show that the monotherapy avoids bone loss. Therefore, Xgeva is probably not required.
The enzalutamide monotherapy was almost as effective as enzalutamide plus leuprolide with fewer hot flushes, hypertension, falls and fractures. The reduced fractures show that the monotherapy avoids bone loss. Therefore, Xgeva is probably not required.
GP24 profile image
GP24
in Advanced Prostate Cancer
1 month ago

Enzalutamide & 5-year survival in mHSPC.

-Patrick [1] https://www.urologytimes.com/view/enzalutamide-sustains-survival-benefit-in-mhspc-with-over-5-years-follow-up [2] https://www.urologytimes.com/view/dr-ian-davis-on-5-year-enzalutamide-survival-data-in-mhspc
-Patrick [1] https://www.urologytimes.com/view/enzalutamide-sustains-survival-benefit-in-mhspc-with-over-5-years-follow-up [2] https://www.urologytimes.com/view/dr-ian-davis-on-5-year-enzalutamide-survival-data-in-mhspc
pca2004 profile image
pca2004
in Fight Prostate Cancer
3 days ago

Darolutamide & time to treatment discontinuation in nmCRPC

metastatic castration-resistant prostate cancer (mCRPC) vs enzalutamide and apalutamide.
metastatic castration-resistant prostate cancer (mCRPC) vs enzalutamide and apalutamide.
pca2004 profile image
pca2004
in Fight Prostate Cancer
3 days ago
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Enzalutamide plus leuprolide reduces risk of metastasis in nonmetastatic HSPC men-from Urology Times, 29 Apr 2023

The median MFS was NR (95% CI, NR-NR) in the enzalutamide monotherapy arm.
The median MFS was NR (95% CI, NR-NR) in the enzalutamide monotherapy arm.
Balsam01 profile image
Balsam01
in Advanced Prostate Cancer
1 month ago

Final STAMPEDE results for Abi with/out Enza when starting ADT.

We have not formally compared the abiraterone and enzalutamide trial with trials testing enzalutamide. But, given the similar efficacy reported when combining enzalutamide with androgen deprivation therapy, we also conclude that combining abiraterone with enzalutamide would not be more effective.
We have not formally compared the abiraterone and enzalutamide trial with trials testing enzalutamide. But, given the similar efficacy reported when combining enzalutamide with androgen deprivation therapy, we also conclude that combining abiraterone with enzalutamide would not be more effective.
pca2004 profile image
pca2004
in Fight Prostate Cancer
1 month ago

Eliquis and Xtandi - Drug Interaction

also suggest enzalutamide may inhibit P-gp, though in vivo studies have yet to corroborate this finding.
also suggest enzalutamide may inhibit P-gp, though in vivo studies have yet to corroborate this finding.
Hawk56 profile image
Hawk56
in Advanced Prostate Cancer
2 months ago

Enzalutamide/Xtandi monotherapy as ADT with fewer side effects than Lupron

Enzalutamide monotherapy could probably be used instead of Lupron after radiation too.
Enzalutamide monotherapy could probably be used instead of Lupron after radiation too.
GP24 profile image
GP24
in Advanced Prostate Cancer
3 months ago

BAT therapy - NIH article

Efficacy and safety of bipolar androgen therapy in castration-resistant prostate cancer following abiraterone or enzalutamide resistance: A systematic review. You X, Huang S, Wang X, Yi C, Gong N, Yu J, Xu C, Xiang Z.
Efficacy and safety of bipolar androgen therapy in castration-resistant prostate cancer following abiraterone or enzalutamide resistance: A systematic review. You X, Huang S, Wang X, Yi C, Gong N, Yu J, Xu C, Xiang Z.
Magnus1964 profile image
Magnus1964
in Advanced Prostate Cancer
1 month ago

Updated treatment plan for progressing MCRPC

My Question is, should I switch the abiraterone for enzalutamide. There is some evidence for switching these drugs if one is no longer working. Apparently the dexamethasone is not good for bone health. Xgeva every 3 months, Xofigo every month for 6 months and possibly add enzalutamide.
My Question is, should I switch the abiraterone for enzalutamide. There is some evidence for switching these drugs if one is no longer working. Apparently the dexamethasone is not good for bone health. Xgeva every 3 months, Xofigo every month for 6 months and possibly add enzalutamide.
Islandboy2021 profile image
Islandboy2021
in Advanced Prostate Cancer
1 month ago

Xtandi (enzalutamide) from India

Has anyone ordered enzalutamide from India? If so were there any problems, and what pharmacy did you use? There seems to be a plethora of them.
Has anyone ordered enzalutamide from India? If so were there any problems, and what pharmacy did you use? There seems to be a plethora of them.
Guber profile image
Guber
in Advanced Prostate Cancer
2 months ago

Small molecule ACK1 inhibitor (R)-9b - third generation AR receptor - clinical trial I in 2023

We have identified (R)-9b as a `third generation' of AR-antagonist, which has ability to overcome Enzalutamide and abiraterone-resistant prostate cancer.
We have identified (R)-9b as a `third generation' of AR-antagonist, which has ability to overcome Enzalutamide and abiraterone-resistant prostate cancer.
SHH696 profile image
SHH696
in Advanced Prostate Cancer
4 months ago

Enzalutamide & ARCHES trial.

More from ASCO 2023 [1]: “We found in ARCHES that in the men who developed radiographic progression while on ADT-enzalutamide [Xtandi], two thirds of these patients, when they had radiographic progression, did not meet PSA progression criteria, and one third didn't have any rise at all in their PSA,
More from ASCO 2023 [1]: “We found in ARCHES that in the men who developed radiographic progression while on ADT-enzalutamide [Xtandi], two thirds of these patients, when they had radiographic progression, did not meet PSA progression criteria, and one third didn't have any rise at all in their PSA,
pca2004 profile image
pca2004
in Fight Prostate Cancer
3 days ago

Enzalutamide or Darolutamide

Hi, I have advanced metastatic hormone sensitive prostate cancer and as well as my usual three monthly ADT (Lucrin-Depot) injection, I have been offered either Enzalutamide (Xtandi) or Darolutamide (Nubeqa). My PSA is currently below 0.1 due to the Lucrin-Depot.
Hi, I have advanced metastatic hormone sensitive prostate cancer and as well as my usual three monthly ADT (Lucrin-Depot) injection, I have been offered either Enzalutamide (Xtandi) or Darolutamide (Nubeqa). My PSA is currently below 0.1 due to the Lucrin-Depot.
x-rays1 profile image
x-rays1
in Advanced Prostate Cancer
3 months ago

Enzalutamide at half strength?

I have high volume mrpca and have had triplit therapy with enzalutamide at 160 mg per day. My response has been great with PCA falling from 700 at diagnosis to undetectable at 3 measurements over the last 6 months.
I have high volume mrpca and have had triplit therapy with enzalutamide at 160 mg per day. My response has been great with PCA falling from 700 at diagnosis to undetectable at 3 measurements over the last 6 months.
Jim53 profile image
Jim53
in Advanced Prostate Cancer
2 months ago

BAT in Argentina

Interestingly, the PSA-PFS for enzalutamide increased from 3.8 months after abiraterone to 10.9 months after BAT, and PFS2 with BAT followed by enzalutamide was significantly longer than with enzalutamide followed by BAT, proving the hypothesis that BAT can re-sensitise CRPC to subsequent antiandrogen
Interestingly, the PSA-PFS for enzalutamide increased from 3.8 months after abiraterone to 10.9 months after BAT, and PFS2 with BAT followed by enzalutamide was significantly longer than with enzalutamide followed by BAT, proving the hypothesis that BAT can re-sensitise CRPC to subsequent antiandrogen
pjoshea13 profile image
pjoshea13
in Fight Prostate Cancer
3 months ago

Enzalutamide induced non-ischemic cardiomyopathy. Case report & review of literature on anti-androgen therapy-related cardiovascular events

This is a one-off case, but I wanted to share, just to help those of you on Enzalutamide, to be aware that this is possible: https://cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-023-00160-7
This is a one-off case, but I wanted to share, just to help those of you on Enzalutamide, to be aware that this is possible: https://cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-023-00160-7
GeorgeGlass profile image
GeorgeGlass
in Advanced Prostate Cancer
4 months ago

Abiraterone/enzalutamide+PARP inhibitor better than abiraterone/enzalutamide alone for mCRPC, even without BRCA+

By combining the PARP inhibitor (Lynparza (olaparib) or Talzenna (talazoparib)) with either abiraterone or enzalutamide, cancer progression was slowed, even in men who were BRCA-.
By combining the PARP inhibitor (Lynparza (olaparib) or Talzenna (talazoparib)) with either abiraterone or enzalutamide, cancer progression was slowed, even in men who were BRCA-.
Tall_Allen profile image
Tall_Allen
in Advanced Prostate Cancer
4 months ago

I've Prostate Cancer Stage 4 Mets to lymph nodes & bones. On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?

On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?
barry0405 profile image
barry0405
in Advanced Prostate Cancer
5 months ago

I've Prostate Cancer Stage 4 Mets to lymph nodes & bones. On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?

On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?
barry0405 profile image
barry0405
in Advanced Prostate Cancer
5 months ago

I've Prostate Cancer Stage 4 Mets to lymph nodes & bones. On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?

On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?
barry0405 profile image
barry0405
in Advanced Prostate Cancer
5 months ago
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