I read somewhere (here?) that ARA is a good predictor of BAT efficacy and that Johns Hopkins has a test for it. I have been trying to track down such a test, at Johns Hopkins or elsewhere, with no success. Any suggestions?
Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC This work identifies high AR activity as a predictive biomarker of response to BAT and supports a treatment paradigm for prostate cancer involving alternating between AR inhibition and activation. ncbi.nlm.nih.gov/pmc/articl...
The AR activity of a metastasis sample was defined by its relative expression levels of genes predefined to be associated with canonical AR activity; AR, FOXA1, HOXB13, KLK2, KLK3, NKX3-1, STEAP2, and TMPRSS2, as previously described [9]. 9. Ylitalo EB, Thysell E, Jernberg E, Lundholm M, Crnalic S, Egevad L, et al. Subgroups of castration-resistant prostate cancer bone metastases defined through an inverse relationship between androgen receptor activity and immune response. Eur Urol. 2017;71:776–87.