Phytochemicals to Help Protect from Inflammation from Innate Immune Activation.

[MateoBeach]

This is a dupplicate post for my Friends on FPC.

Inflammation is one of the two main underlying drivers of "The Hallmarks of Cancer", the factors affecting cancer development and progression. The other being progressive genetic instability (DNA mutations).

Our innate immune response pathways trigger cascades of cellular mechanisms that include promoting inflammation, that often persist even after a threat of infection. These are harmful. The very comprehensive article linked below describes these mechanisms and pathways in detail. Especially the TLR4 and Nf-kB antigen response pathways and how these release inflammation. And furthermore, how epigenetic signaling control mechanisms modulate the inflammatory responses. (Through Histone modifications, DNA Hyper-methylation and mi-RNAs.)

It may be too much cellular biochemistry for many, but it includes a review of several important natural plant-derived phytochemicals that affect all of these mechanisms in potentially beneficial ways. This is a good review of their scientific basis for those who might want to include more of these food sources, or even supplement them. I am not recommending any supplements for treating prostate cancer, even though I do use several of them myself. Only Sulforaphane has a proven benefit in clinical trial.

The specific phytochemicals discussed include "the usual suspects": Resveratrol, Curcumin, Quercetin, Sulforaphane, EGCG, Genistein, Apigenin, Emodin, Anthocyanins, Ellagic Acid, Terpenoids, Carracol/Thymin, Boswellic Acid, AITC-Sinigrin, and Cinnamaldehyde.

The Anti-Inflammatory Properties of Phytochemicals and Their Effects on Epigenetic Mechanisms Involved in TLR4/NF-κB-Mediated Inflammation

ncbi.nlm.nih.gov/pmc/articl...

Note that there is a more detailed discussion on "The Hallmarks of Cancer" in one of my previous posts by that title. MB / Paul

[nobaday]

Probably does not harm to try any of these. Problem with natural products is there is no data from clinical trials and if you take with other drugs, or take several natural products you again have no idea what is working/ helping.

I took Indomethicin for a year. But this is a well known NSAID ( non steroidal anti inflammatory drug) with indisputable anti inflammatory properties. It held some of my met pains at basically zero pain for about a year. How do I know it worked. Before I started taking it I had pain, after I started taking it I had no pain. And I did not change any of my other drugs intake.

[NPfisherman]

Pablo the Hiker,

A lot of information... I take the vast majority of what you listed... Curcumin, Resveratrol, Quercetin, Boswellia Serrata, Chamomille, and more.... A grower of sprouts for years... Inflammation is one of the Four Horsemen of the Apocalypse.. Control the Horsemen and you control your destiny... Hormones, Cholesterol, Inflammation and...dang ADT....I forgot the last one tonight....likely will come back in am... will reply again....LOL....the outdoor work is wearing me down also...

Thanks for posting...

Fish

[MateoBeach in reply to NPfisherman]

And ROS damage from and to mitochondria surely is a horseman. And very difficult to control. Better take him for a run (or hike). 🐎🐎🐎🐎

[MateoBeach in reply to MateoBeach]

( K-9 and I have been discussing such from Nick Lane’s insightful book on Mitochondria: Power Sex and Suicide. Good Audiobook listen while doing your projects.)

[NPfisherman in reply to MateoBeach]

Pablo,

Well... I took my morning walk, made breakfast for the wife and I, collected scrap metal from the old garage doors and headed to the scrap yard... after that.. exterior work on the Victorian project... No rest for the wicked or the weary... will try and give Nick Lane a listen as long as he doesn't say anything that makes me fall off a ladder.. Glad you are enjoying your stay at Chez LuLu...

Fish