Experiences with

Anal and rectal conditions

Hi Officially mcrpc. Can't get darolutamide so faced with choice of zytiga, xtandi or aplautamide in the coming weeks. Faced with the first two I would have opted for xtandi and hopefully worked towards taking two tablets. Maybe one but have seen a few progress at one and wonder if two would be an

New study [1]. "Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells" There have been 2 dozen CAPE papers these last 20 years. Ten of these specifically mention Akt inhibition. CAPE is found in propolis, which bees use to seal

{From a related web site} In summary, our results indicate that ivermectin suppressed the AR and E2F signaling pathways and DNA damage repair capacity by targeting FOXA1 and Ku70/Ku80 to inhibit cell proliferation and promote cell apoptosis in prostate cancer. These findings provide insight into both

New paper from Spain [1]. "... we will review those strategies and drugs that are able to resensitize cancer cells to previously used treatments through the use of "hinge" treatments with the objective of obtaining an oncological benefit. "Some examples are: [i]bipolar androgen therapy (

Hi, I have ended up in urgent care due to a lump that keeps bleeding in my belly button. I had surgery in 2020 to help remove some of the endometriosis however since then I have always had a slight lump. I thought it was just healing however last couple of months its got bigger, darker and more painful

New paper below [1]. "Between Nov 15, 2011, and Jan 17, 2014, 1003 patients were randomly assigned to standard of care (n=502) or standard of care plus abiraterone (n=501) in the abiraterone trial. "Between July 29, 2014, and March 31, 2016, 916 patients were randomly assigned to standard of care

In this study, researchers measured the level of 20 amino acids (critical components of proteins). They found that overall levels of amino acids were lower in fibromyalgia and that seven amino acids were especially low, including taurine, alanine, tyrosine, valine, methionine, phenylalanine, and threonine.The

New meta-analysis below [1] [2]. Hard to believe that there are enough BAT studies to perform this particular meta-analysis (i.e. post-Abi/Enza). Now we need to have studies of BAT (or LongBAT) to [u]prevent[/u] CRPC. "Bipolar androgen therapy (BAT) is a new endocrinologic treatment for castration-resistant

Hi all - Just found this site, and hoping it can be an opportunity to learn. I have been dealing with a hypertonic pelvic floor and some nerve pain for about 2.5 years. I've tried physical therapy, medications, and have not found any relief. I met with Dr. Hibner down in AZ and he is strongly recommending

As I am 10 months PSA undetectable and clear on basic bone scans I have started the process of consultation re staying on ADT (zoladex) and Apalutamide continuously or moving to intermittent (and what would that involve) or getting more treatment (J591 for example aimed at micromets). Following consult

The results of the EXTEND [EXTernal beam radiation to Eliminate Nominal metastatic Disease] Phase II Trial were published in JAMA Oncology this month [1]. {However, many will have seen the results, as presented at ASTRO 2022, & posted by Fish, 6 months ago [2].} Results "The study included

My last endoscopy/colonoscopy showed intraepithelial lymphocytosis and metaplaysia of my stomach linings. Any of you experience this?

hi everyone. I come back to see if anyone is suffering the same. GP wants to send a fit test off but I have refuse. I suffer bad piles. The last time I had a scan 2 years ago was clear. I am in a stressful situation at the moment and wondering if this could be the cause. Many thanks

Soon after diagnosis I joined a group headed by a man who viewed PCa as a modern disease with its origin in the womb. His bugbear was "Estrogen-like endocrine disrupting chemicals" (EEDC). I had come across the weird PCa risk factor of the second to fourth digit ratio, which seemed like voodoo science

Hiya everyone,hope you're all doing OK?I wrote a post a little while back regarding my spine and hip pain. Another mri later shows degenerative disc disease,it hasn't really been explained to me very well,does anyone else suffer with this,is it another fibro relative?one thing after another isn't it.Thankyou

See title - is this normal? Have started with thigh swelling following radical hysterectomy and pelvic surgery- feel like fluid trickling in legs but also around buttocks and feeling very scared. It is now the weekend so no help available. Had an mld the other day. Been complaining of burning and nerve

PROSTATE DRUG PETITION DENIED AGAIN — On Tuesday, the federal government rejected a petition asking the NIH to use so-called march-in rights to take ownership of patents tied to the pricey prostate cancer drug Xtandi, David reports.Such rights have yet to be used, but their aim is to help lower prices

In 2004, after my failed prostatectomy, I came across the Life Extension protocol for PCa (at that time). It included their Ultra Soy Extract. 5 caps provided a massive amount of genistein. LEF suggested taking this 4 times daily. I think that one bottle was $75 & I would need 4 for a month. I didn't

New cell study from Italy [1]. The failed SELECT study shows the danger of relying on alpha tocopherol as a vitamin E supplement.  The eight isoforms compete for uptake.  Supplement with one & you may drive down levels of another. PCa research suggests that gamma tocotrienol is the isoform with the

Can anyone please advise how they dealt with the constipation. My first chemo last week and I can honestly say I have never experienced anything like it! I ended up in hospital with faecal impaction. Ended up having an enema! Nurse called it a poobabie! Any advice would be very much appreciated xxx