Experiences with

Anal and rectal conditions

Because sometimes it's nice to know the actual outcomes in day to day clinical practice. A retrospective real-world study analyzed the effectiveness of apalutamide (APA) combined with androgen-deprivation therapy (ADT) as a first-line treatment for metastatic hormone-sensitive prostate cancer (mHSPC

The WOMBAT Trial (Working Out M0 Bipolar Androgen Therapy) investigates the efficacy of bipolar androgen therapy (BAT) in extending metastasis-free survival for patients with M0 castration-resistant prostate cancer (CRPC) experiencing rising PSA levels on darolutamide, without visible metastases. This

KPG-121 is an experimental cereblon modulator aimed at metastatic castration-resistant prostate cancer (mCRPC). Early research shows it binds more strongly than lenalidomide to a key immune-regulating protein, potentially boosting anti-cancer effects. In a Phase 1 study of 16 mCRPC patients already taking

Hi, I have tried gtn and diltiazem creams for a chronic fissure which did not work, has anyone here had laser treatment for a fissure?

Repurposing existing drugs, such as rifaximin, can accelerate the development of new treatments because their safety profiles are already established. A recent study screened 3,800 FDA-approved drugs and identified rifaximin as a promising lead compound for PIM-1 inhibition. The potential of rifaximin

A Phase 3 trial is recruiting 675 patients to be randomized to Xaluritamig versus cabazitaxel or an AR switch, aiming to establish its superiority as a second-line treatment. Xaluritamig is a STEAP1-targeted T-cell engager being developed for metastatic castration-resistant prostate cancer (mCRPC).

My daughter had a diagnostic lap in august and was told there wasn't any endo but she might have adenomyosis. My daughter had noticed a peri anal lump which didn't mention at the time because she thought it was a pile. She has been managing her menstrual symptoms with desogestrel. she has since been

It's worth checking! https://reporter.nih.gov/project-details/10695499

With all the caveats of an observational study, even if the publisher is highly regarded... A study in JBMR plus found that bone-modifying agents like bisphosphonates and denosumab are linked to improved overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC). The

Exciting progress... - https://www.urologytimes.com/view/janx007-demonstrates-encouraging-clinical-activity-in-mcrpc Key takeaways... JANX007 showed promising anti-tumor activity in mCRPC patients, with significant PSA declines and disease control rates observed. Two once-weekly dosing regimens

A statistical method, Matching-Adjusted Indirect Comparison (MAIC), has been used to evaluate the effectiveness of different PARP inhibitor combinations for treating metastatic castration-resistant prostate cancer (mCRPC). The study, published on Nature, found that a combination of talazoparib and

I had an anal fissure caused by constipation about 4 years ago during Covid . I was fortunate that due to the extreme discomfort after a bowel movement I had a minor operation where Botox was injected to relieve the spasm and I had no more pain . I’ve recently had open heart surgery to replace a faulty

another door opens, hopefully a good one… Researchers found that high expression of the PPP1CA gene is linked to a worse prognosis for patients. They discovered that silencing PPP1CA made cancer cells more susceptible to abiraterone, while overexpressing it had the opposite effect. This suggests that

The AMPLITUDE clinical trial (NCT04497844) is evaluating the effectiveness of Akeega, a combination of the PARP inhibitor niraparib and abiraterone acetate, along with prednisone, for treating metastatic castration-sensitive prostate cancer (mCSPC). This combination therapy is being compared to the

69 years, good health, no medications. 4 cores 3+3=6 Adenocarcinoma 2 cores 3+4=7 intraductal with cribriform 2 cores 4+3=7 Intraductal with cribriform (50%). MD anderson surgeon said he could not get good margins. Suggest radiation. Radiologist wants to use Brachytherapy plus proton beam, which

Does anybody else suffer from headaches with Polymyalgia Rheumatica without Giant Cell Arteritis diagnosis? I don’t know if my morning headaches are PR symptoms or triggering migraines!

Here is an insightful interview with Mark Cuban about his creation of Cost Plus Online Drug Company. Below is a condensed excerpt transcribed from the 35 min podcast. This is the first of a new series of Reason podcasts focused of healthcare, so you might want to put it on your calendar for future episodes

Hi I have had IBS C for many years and I get pain most early mornings but I now seem to wake up more feeling the urge to pee! Often I cant go or have to wait for a few mins before going. Flow can be poor. I have had all the prostate tests and a TURP a few years ago but I am getting really frustrated

For those who have yet to be treated, are considering RT (vs surgery), and are getting treatment at a center with both IMRT and Proton Beam capabilities. * * * [u][i]Quality of Life Similar With Proton Beam Therapy vs IMRT for Prostate Cancer[/i][/u][i] — "It really shows us that we have

I'm new here but would like to know if anyone has similar symptoms... I have been diagnosed with probable IBS (D but sometimes C) by my GP (exclusion diagnosis after various tests). My main symptom is discomfort in the upper right abdomen which is just about always present. Occasionally it is more painful