I have just read a really interesting Kindle E-book (a free one!) written by someone (I think) called M. Azziz. He provides some hugely intriguing data and facts, complete with proper medical references, plus his own observations and experiences of the massive benefits of taking sufficient D3 - in most cases, that equates to about 10,000 iu's a day, using blood tests as required to check that you aren't taking it too far.
It's called "Why Vitamin D Should Be Flying Off The Shelves", and I urge all of you to read it.
I have to say that I was keen to try it - I've been struggling very badly for months and months (I mean more than usual) - so I took 5,000 iu's for two days and have now upped it to 10,000 iu's. I've looked at my usual supplement supplier's site, and read the reviews on one 10,000 iu product, and have ordered it. I have had 2 patches of a few hours each, when I have felt like my brain is working, and that I might even be able to get up and actually DO something. I am trying to be patient, and haven't leapt out of bed and done anything. I am trying to do the pacing thing.
I wondered if anyone here has tried this high dosing with D3.
I would respectfully ask that if you only have something negative to say about the alleged toxicity of more than 400 iu's, with stories of kidney stones, osteomalacia, etc etc (all from studies done with either D2, or with inadequate D3, or with D3 but no Vitamin K to drive calcium to the bones), then please please don't waste time trying to tell me of the "dangers" of using 10k iu's I'm aware of all those things. It's obviously important to understand how things work, what their mechanism of action is, along with any possible downsides, and it's clear that if you supplement with a) only calcium, b) calcium and D but no Vitamin K, c) Vitamin D with no K or calcium, or d) Vitamin D2 instead of D3, then you'd quickly be in trouble. I am aware of all that.
What I'm interested in is hearing if anyone has experienced any benefit, any remission of pain, increase of energy, increased cognitive function, increased mobility, etc. There are a lot of studies out there that show it to be highly beneficial, and very high doses are used in treating MS, too. The author of this e-book, and his autistic brother who developed osteomalacia,, have been taking between 5,000 and 12,500 iu's for more than 6 years with nothing but beneficial effects. No kidney stones, osteomalacia reversed.