Can anyone give me their views please? I've been on various levels of T4 and fought long and hard to try T3 which I succeeded at, however I didn't feel any different to be truthful on T3 (20mcgs twice a day) so I switched back to a T4/T3 mix (20mgsT3/50mcgs) taken altogether first thing in the morning. However as this still didn't alleviate my symptoms I have upped my dose to 20mcgsT3/100mcgsT4 a day, then many weeks later I decided to up the T4 again to 150mcgs which is what I'm taking now along with the 20mgs of T3. My question is that as it doesn't seem to affect me no matter what quantity I take so what does this mean? I don't feel shaky or increased heartbeat or anything when I up my medication (and I never ease into it I just upped by 50mcgs in one go each time). I'm still exhausted when I wake up but seem to feel ok by mid morning but am tired again by about 9 o'clock at night, my hair is dull, my skin is dry, (I have smelly feet which I never used to have!), I also wouldn't dream of going a full day without a shower or bath as I don't feel confident that I could miss a day. My eyes are piggy with droopy eyelids, my body is flabby and my teeth have gone a dull yellow colour in the 11 years since I've had an underactive thyroid. I don' t feel that my medication is helping me at all or is it just that my condition means that all my vitamins and minerals are useless in my body even though last time I was tested everything other than VitD was in range? Just wondered that's all?