Anyone have success after several donor egg FET transfers?

[Mellia]

Hi everyone

I'm 45 years old and have done 5 FET transfers with only one positive (a chemical pregnancy that was an early loss.) I told myself I was done with IVF, but part of me wants to try one more time. I have done all the testing imaginable- karyotype, genetic, immune, ERA, emdomitritis etc- all normal. My last FET transfer I had the best lining I ever had at 8.7 mm with a stimulated FET transfer and was so hopeful but I had a negative with my last transfer from donor eggs. I was also doing an autoimmune protocol with Prednisone 10 mg, aspirin 81 mg, Lovenox, Famotodine and Claritin daily in addition to daily estrogen tabs and progesterone in oil injections. I had 3 PGT tested chromosomally normal blastocysts from frozen donor eggs fail (first transfer was early loss and the next two were negative.) Then my doctor advised I do fresh donor eggs saying it would give me "more chances" but only 2 out of 28 eggs that were fertilized with my husband's made it to blastocyst. I had a 5 day untested 3AA blast with 70% chance of success and a 6 day 3BA untested blast with 50% chance per my doctor.

The two FET transfers from the fresh donor eggs failed. My doctor initially blamed my husband saying it was poor sperm quality, but when we reviewed our last failed transfer she apologized and said the problem was " poor egg quality" as almost all the eggs were compacting and were arresting by day 3 so the sperm was not the problem. She said there is a chance with my age of course and history of failed transfers that there also may be an unidentified issue with me that is part of the problem. I'm heartbroken and devastated, but part of me wants to try one more time with donor eggs. Am I foolish for wanting to try one more time with a different egg donor and different clinic or should I try again? I would love to hear if anyone had success stories after multiple failed donor egg transfers and what they think made the difference in their successful cycle. Thanks so much for taking the time to read this long post and reply.

[Batsford]

Hi Mellia, I’m so sorry to hear of your experiences. I’ve been told that if you have repeated implantation failure or early miscarriages from PGS tested embryos then it is usually an immune issue. I appreciate you have tried an immune protocol but I was wondering if it’s strong enough. If you do want a second opinion on this I would definitely recommend Professor Shehata at the Centre for Reproductive Immunology in Epsom. I am also using donor egg embryos and he’s been treating me for some severe immune issues. I would definitely recommend him. Best of luck.

[LadyM2019]

You are not foolish at all Melia. Your desire comes from love.. Take time to process what has happened and be really open about what you’re willing to consider as next steps. Assuming the clinic is already doing IMSI, then maybe a younger donor, or donor sperm.