I have been on parnate, an MAOI, for the past 24 years for depression and it has worked great for me. 2 years ago, my cardiologist put me on bisoprolol, a beta blocker, for an erratic BP. Shortly after, I started to get low grade anxiety which only intensified as time went on. The dr weaned me off, but after 8 months, I'm still dealing with the insane physical symptoms of anxiety (nervousness, jitteriness, agitation). And I've never had anxiety my whole life, not even when I was going through my depression years ago. So I know the bisoprolol is what caused all of this.In case anyone doesn't know, beta blockers like bisoprolol help decrease the stress hormones we have to deal with, norepinephrine and epinephrine. Which are 2 of the hormones that parnate increases to help depression. I just assumed that after a few weeks or a month, my system would reset itself to dealing with these hormones like it did before I took bisoprolol. But it hasn't. And I am at my wits end trying to find a doctor to help me. Is anyone going through this, or has gone through this issue?
Anyone develop anxiety after weaning off b... - Anxiety Support
Anyone develop anxiety after weaning off bisoprolol or a beta blocker, and are also on a MAO Inhibitor for depression?


You might look into natural supplements to increase norepinephrine and epinephrine like L-Tyrosine. You can do a lot of research on google and youtube about it and also check out Trudy Scott, who has a book and info on treating anxiety/depression naturally.
I don't want to increase epinephrine or norepinephrine. Those are the stress hormones that were suppressed by the beta blocker. And after I came off of it, my system was flooded with dealing with 100% of the stress hormones like before, instead of just a portion of it when I was on the beta blocker for 2 years. And on top of that, they are dealing with more epinephrine and norepinephrine that the parnate is increasing to work. So my system is being flooded with stress hormones, which is probably the cause of my anxiety.I'm just trying to find a doctor who can figure out what I need to take or do next to get rid of this anxiety.