Goitre with negative tests - what next ?

[StayingPositive2024]

Hi, I have recently been diagnosed with non cancerous multinodular goitre that is pressing my windpipe and waiting to see the ENT specialist. Could someone help me understand the following from my Advanced Thyroid Function Blood Test ? I understand my vitamin D level is low and currently taking supplements

CRP HS - 1.3 mg/l

FERRITIN - 60 ug/L

FOLATE SERUM - 8.8 ug/L

VITAMIN B12 ACTIVE - 117 pmol/L

VITAMIN D - 48 nmol/L

TSH - 1.06 mlU/L

FREE T3 - 4.9 pmol/L

FREE THYROXINE - 13.5 pmol/l

THYROGLOBULIN ANTIBODIES - 15.6 IU/mL

THYROID PEROXIDASE ANTIBODIES - < 9 IU/mL

Due to the compression, I sometimes feel uncomfortable when sleeping and breathless when performing some tasks

I am wondering what could have caused my thyroid enlargement and what is the way forward ?

Many thanks

[PurpleNails Administrator]

Welcome to forum.

Please can you add ranges. Ranges vary between labs and to accurately interpret we need a range.

Your FT4 & FT3 do look low by many ranges. Antibodies are negative by most ranges?

I’m assuming you currently don’t take replacement?

What time was test, had you fasted before test?

Do you have hypothyroid symptoms? See this checklist

thyroiduk.org/wp-content/up...

Sometimes if the thyroid is struggling it can swell because it has to work harder, but you’d expect to see high TSH with this. The TSH isn’t reliable it should reflect low thyroid levels but sometimes it doesn’t or these might be normal levels for you.

[StayingPositive2024 in reply to PurpleNails]

Many thanks for your response PurpleNails. The following are the ranges:

CRP HS - 1.3 mg/l : range 0 - 5

FERRITIN - 60 ug/L : range 13 - 150

FOLATE SERUM - 8.8 ug/L : range >2.9

VITAMIN B12 ACTIVE - 117 pmol/L : range 25.1 - 165

VITAMIN D - 48 nmol/L : range 50 - 200

TSH - 1.06 mlU/L : range 0.27 - 4.2

FREE T3 - 4.9 pmol/L : range 3.1 - 6.8

FREE THYROXINE - 13.5 pmol/l : range 12 - 22

THYROGLOBULIN ANTIBODIES - 15.6 IU/mL : range 0 -115

THYROID PEROXIDASE ANTIBODIES - < 9 IU/mL : range 0 - 34

My test was 8.25am and I did fast from the night before.

No I am not taking any replacement.

All my symptoms point to hypothyroid i.e. thinning hair, sensitive to cold, weight gain, aches and weakness etc

I have a GP appointment soon and I was hoping the test will be a tool for quick referrer

Thank you

[greygoose]

Have you had your iodine tested? The thyroid can swell in an effort to absorb more iodine.

[StayingPositive2024 in reply to greygoose]

Hi greygoose, No I haven't. I will mention this on my next GP visit or try and get it done privately

Thank you

[greygoose in reply to StayingPositive2024]

You're welcome.