Thyroid gland dysfunction and vitamin D receptor gene polymorphism in keratoconus

[helvella]

In the very recent supplements are useless? thread, did anyone notice them checking the impact on keratoconus? I thought not…

healthunlocked.com/thyroidu...

The VITAL studies might question some of the vitamin D claims. But they do not, in my view, constitute a "do not".

Keratoconus

Keratoconus is a non-inflammatory eye condition in which the normally round dome-shaped clear window of the eye (cornea) progressively thins causing a cone-like bulge to develop. This eventually impairs the ability of the eye to focus properly, potentially causing poor vision.

moorfields.nhs.uk/condition...

Eye (Lond). 2022 Aug 1.

doi: 10.1038/s41433-022-02172-6. Online ahead of print.

Thyroid gland dysfunction and vitamin D receptor gene polymorphism in keratoconus

Eman A Awad 1 , Magda A Torky 2 , Rania M Bassiouny 2 , Abeer M Khattab 2 , Rasha R Elzehery 3 , Rania M Elhelaly 3

Affiliations

• PMID: 35915233

• DOI: 10.1038/s41433-022-02172-6

Abstract

Objectives: To detect the serum level of thyroid hormones, vitamin D and vitamin D receptors (VDR) polymorphism in keratoconus (KC) patients and to identify the association between vitamin D deficiency and thyroid dysfunction in KC.

Methods: This cross sectional study included 177 KC patients with no thyroid disorders compared to 85 healthy controls with normal corneal tomography. Measurements of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4) and serum 25-OH vitamin D were done using Enzyme linked immusoassay (ELISA test). VDR polymorphisms were tested including [Taq I (rs731236), Apa I (rs7975232) and Bsm I (rs1544410)] using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results: An increase in frequency of thyroid disorders (P = 0.04), decrease in serum 25(OH) vitamin D level (P < 0.001), Taq 1 and tt genotype (P < 0.001) were significantly distributed in KC patients. A significantly higher serum 25(OH) vitamin D level was reported in TT genotype, while insufficient level was more common in Tt genotype (P < 0.001). A deficient serum 25(OH) vitamin D level was predominant in tt genotype (P < 0.001). A 95% confidence interval was in TSH (1.603, 2.946), FT4 (24.145, 77.06), hypothyroidism (1.062, 67.63), insufficient (2.936, 11.643) and deficient vitamin D (5.283, 28.704) and all were significant risk factors for KC with (P < 0.05).

Conclusions: Both thyroid disorders and low vitamin D are potential factors for KC development. Studying VDR at the molecular level provides interesting avenues for future research toward the identification of new KC cases.

pubmed.ncbi.nlm.nih.gov/359...

[arTistapple]

Well done helvella finding this bit of research. Ha! To those who pooh pooh Vit D.

[RedApple]

Looking at the relationship between keratoconus and thyroid only:

Association Between Keratoconus and Thyroid Gland Dysfunction: A Cross-Sectional Case–Control Study

CONCLUSIONS:This study showed that there is a possible association between keratoconus and thyroid gland dysfunction, but more studies are needed to build upon these results.

journals.healio.com/doi/10....

[helvella in reply to RedApple]

I got fired up by the vitamin D issue I forgot to point that out!

Have also just added a comment to the vitamin D post pointing out the (possible) genetic component to the vitamin D receptor having a causative effect.