Paper linking low vitamin D to cognitive impairment in patients with Hashimoto's

[diogenes]

This paper is downloadable in:

NMC Endocrine Disorders

Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis

Jun Xu, Xiang-yun Zhu, Hui Sun, Xiao-qin Xu, Song-ao Xu, Yuan Suo, Li-jun Cao, Qiang Zhou, Hui-jie Yu and Wei-zhong Cao

BMC Endocrine Disorders 2018;18:87

doi.org/10.1186/s12902-018-...

Open Peer Review reports

Abstract

Background

Cognitive impairment is commonly observed in patients with Hashimoto thyroiditis (HT). Low levels of vitamin D have been correlated with cognitive impairment in non-HT population. We examined the association of vitamin D levels with cognitive impairment in patients with HT.

Methods

We recruited 194 patients with HT and 200 healthy volunteers. Levels of serum 25-hydroxyvitamin D (25(OH)D) were measured using a competitive protein-binding assay. Cognitive funtion was assessed using Montreal Cognitive Assessment score (MoCA). Subjects with a MoCA scores < 26 are considered as having mild cognitive impairment (MCI). Multivariate analysis was performed using logistic regression models.

Results

Fifty-five HT patients (28.4%) were diagnosed as having MCI. Patients with MCI had significantly lower 25(OH)D levels when compared with patients without MCI (33.9 ± 6.2 vs. 44.3 ± 9.6 nmol/L, P < 0.001). Significant differences in 25(OH)D quartiles of HT patients were observed between the patients with MCI and the patients without MCI (P < 0.001). In multivariate analyses, serum 25(OH)D levels (≤ 34.0 and ≥ 47.1 nmol/L) were significantly associated with cognitive impairment in patients with HT (OR 6.279, 95% CI 2.673–14.834, P < 0.001; OR 0.061, 95% CI 0.008–0.491, P = 0.009, respectively).

Conclusion

Our results demonstrate an important association between serum vitamin D levels and cognitive impairment in patients with HT.

[Marz]

Scroll down to RELATED POSTS where you can also read the post by helvella some five years ago - about research carried out in Crete about VitD and auto-immunity ...

[RedApple Administrator in reply to Marz]

Or you can click this link to go straight to that post by Helvella healthunlocked.com/thyroidu...

[Hidden]

That is interesting! Since supplementing with D3 (also B complex and B12) as well as taking Levo, my concentration has gradually become much better.

I asked 2 or 3 times for a vitamin D test but was ignored. Eventually I did a private test and it was rather low, so I bought supplementation of 5,000iu with K2 and magnesium. When that ran out I decided to save money by going down to 2,200iu, hoping the levels were now OK. Another test after a few months showed that the level had still only improved a bit, so I am now taking 4,000iu (the most economical higher dose I could find).

The GP did take notice of the private result and I was prescribed D3 with Calcium. The last blood test showed calcium was near the top of the range, so that was the last thing I need. Then I realised that the total dose of D3 only added up to 800iu!!! What use is 800 when I probably need about 5 x that, maybe more?!!! Because of the large amount of added calcium it was impossible to raise the dose of D3 and it's still sitting unopened while I continue to pay for my own. Grrr!

[Treepie]

Read a headline from some

uS site that supplementing not as effective as the sun.

[ilyfunnybunny]

"serum 25(OH)D levels (≤ 34.0 and ≥ 47.1 nmol/L) were significantly associated with cognitive impairment in patients with HT"

Doesn't this say that high levels of vitamin D can be just as harmful as low levels?

Specifically, anything outside the range of 34.1 - 47.0 nmol/L was found to be associated with MCI?

Correct me if I'm reading that wrong, but this would be a significant finding given that the recommended Vitamin D level on this forum is at least 80nmol/L, nearly twice the level at which these researchers found evidence of cognitive impairment...