Unable to get out of hypothyroid state no matte... - Thyroid UK

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Unable to get out of hypothyroid state no matter what!

ChucklesWalrus profile image
47 Replies

i have quite the story.

In 2018 I (mistakingly, I didn’t know how to properly lose weight then) crash dieted and dropped a ton of weight over a year. Because of this seriously extended caloric restriction, my body really got upset. I became hypothyroid with a low Total T3, low Free T4, but still a normal TSH?

Well my doctor put me on 25mcg levothyroxine. It didn’t do too much for me. Then we tried 50mcg, then 10mcg T3 and 50mcg T4. Nothing.

I switched doctors to try Armour thyroid. Over the months my medication has titrated until I was eventually on 4 grains of armour thyroid (38mcg T3, 152mcg T4)... even at that dose my Free T3 and Free T4 were low! TSH was crushed, however. Now I am even at a healthy weight (200lbs, 6’2”), exercise, eat healthy etc.

I am now switched over to 50mcg Liothyronine Sodium and 150mcg Levothyroxine, and it’s day three. I still feel nothing, which is crazy to me as people say T3 is so fast acting.

Looking for some insight as to why I am having trouble absorbing my T3/T4. I take it on an empty stomach, always.

My diet consist of enriched white rice, oats, eggs, egg whites, fruits, green beans/asparagus, chicken, fish, avocado, potatoes, beef, steak, almonds.

Other things are Himalayan salt, table salt (iodized), Splenda/Stevia (lots), diet sodas, coffee, vitamin water, gatorade/propel

Supplements: selenium, multivitamins, ashwaghanda, L-glutamine, EAAs, beet root, garlic, vitamin E, P5P, vitamin c, vitamin d, probiotic (10-50 billion CFU), digestive enzymes, greens blend

Other drugs: Testosterone replacement

I am currently on 50/150 Liothyronine/Levothyroxine, yet my levels are VERY subpar. I imagine there must be an absorption issue. I still feel cold, tired, holding water, etc

There have been little bouts (week or 2) where ill feel incredible, but they seem to fade with no consistency. I feel lost. What can I do?

Edit for labs:

8/21/2018, after crash diet. No meds yet.

imgur.com/a/hWKGJtN

March 14, 2019 first endo visit on 25mcg T4

imgur.com/a/xQfCzvn

July 28, 2019 on 50mcg T4

imgur.com/a/VDI3pAT

Aug 13, 2019, I believe this is when we added 5mcg T3 to the 50mcg T4

imgur.com/a/x1zwttZ

Nov 13, 2019, after we did 10mcg T3, 50mcg T4

imgur.com/a/7MADTS9

June 10, 2020 10mcg T3 50mcg T4

imgur.com/a/ZPjv2lK

9/4/2020 on 2 grains Armour

imgur.com/a/paaqIIL

2/15/2021 on 2 grains armour

imgur.com/a/5yGEcLm

5/28/21 on 4 grains armour

imgur.com/a/lnv7fqw

FT4 was 1.04 (ref .82-1.77)

7/16/21 on 4 grains armour

imgur.com/a/sNZPtL2

Always take meds on empty stomach

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ChucklesWalrus
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47 Replies
Buddy195 profile image
Buddy195Administrator

When I added T3 to my T4 it took several weeks for me to see any improvement and I did not have the ‘eureka’ moment that some members have had. I think you will have to give it longer than 3 days on your new combination dose to see if it is working for you. It would be helpful for you to post your thyroid blood results, with ranges in brackets. Have you had ferritin, folate, B12 and Vitamin D checked? Are you gluten free?

ChucklesWalrus profile image
ChucklesWalrus in reply to Buddy195

Checked some. Added my labs so you can see!

humanbean profile image
humanbean

Now I am even at a healthy weight (200lbs, 6’2”), exercise, eat healthy etc.

Lots of exercise can reduce the levels of T3 that you have.

Other things are Himalayan salt, table salt (iodized), Splenda/Stevia (lots), diet sodas, coffee, vitamin water, gatorade/propel

I don't know how much iodine is in iodized salt, but I do know that iodine was used as a treatment for hyperthyroidism i.e. overactive thyroid in decades gone by.

Diet sodas (and ordinary sodas) often have all sorts of weird chemicals in. Could you switch to carbonated water with nothing else in it apart from carbon dioxide for the fizz?

I am not familiar with vitamin water or gatorade or propel so don't know the ingredients.

Over the months my medication has titrated until I was eventually on 4 grains of armour thyroid (38mcg T3, 152mcg T4)... even at that dose my Free T3 and Free T4 were low!

Over recent decades doctors have reduced and reduced and reduced the levels of thyroid hormones that they prescribe, mainly on the basis of TSH. Before the TSH test was invented doctors wouldn't have batted an eyelid at a dose of 4 grains of NDT, it really isn't that high. I've seen higher.

Supplements: selenium, multivitamins, ashwaghanda, L-glutamine, EAAs, beet root, garlic, vitamin E, P5P, vitamin c, vitamin d, probiotic (10-50 billion CFU), digestive enzymes, greens blend

Multivitamins - These are not a good idea, for the reasons given by greygoose in this post :

healthunlocked.com/thyroidu...

Ashwaghanda - this may reduce your cortisol. This is fine if your cortisol is high, but not good if it is at a healthy level or low.

EAAs - I don't know what these are.

You would be better taking a good quality B Complex with activated B vitamins rather than the P5P (vitamin B6) on its own. It is not a good idea to supplement just one or two B vitamins and let all the others drop.

One of the ones often recommended on here is :

thorne.com/products/dp/basi...

I should point out that Vitamin B6 is the only B vitamin that has toxic effects if levels are too high. See these links :

Deficiency : en.wikipedia.org/wiki/Vitam...

Toxicity : en.wikipedia.org/wiki/Megav...

ChucklesWalrus profile image
ChucklesWalrus in reply to humanbean

Added labs to help!

SlowDragon profile image
SlowDragonAdministrator

You need to test vitamin D, folate, ferritin and B12

Exactly what’s in the multivitamins

Multivitamins are never recommended on here. Most contain iodine

What are your most recent thyroid results

Bloods should ONLY be retested after 6-8 weeks on constant unchanging dose and brand of levothyroxine and T3

Always test as early as possible in morning before eating or drinking anything other than water and last dose levothyroxine 24 hours before test

Do you normally split T3 into 3 doses spread through the day

Even if you don’t do this normally, on day before test you need to do so ….taking last 1/3rd of T3 approx 8-12 hours before test

Have you had thyroid antibodies tested. TPO and TG antibodies

Have you had coeliac blood test done

ChucklesWalrus profile image
ChucklesWalrus in reply to SlowDragon

No celiac bloods done, but the thyroid stuff yes. I added labs.

greygoose profile image
greygoose

I became hypothyroid with a low Total T3, low Free T4, but still a normal TSH?

Total T3 is a pretty useless test. It doesn't give you any helpful information. What you need is the FT3 tested.

And, on the subject of testing, you'll get more meaningful replies if you give your actual numbers: doses and dates, results and ranges. Then we'll know what we're talking about.

Well my doctor put me on 25mcg levothyroxine. It didn’t do too much for me.

It wouldn't. It's a starter dose for children. And that just goes to show that your doctor has very limited knowledge of thyroid. So, beware.

I still feel nothing, which is crazy to me as people say T3 is so fast acting.

SOME people say that. Not every one. I could start on 100 mcg T3 and not feel a thing for weeks. It depends on so many factors. And, we don't have enough information about you to even hazard a guess as to why.

Looking for some insight as to why I am having trouble absorbing my T3/T4. I take it on an empty stomach, always.

As I said, we don't know that much about you to hazard a guess. For example, you may take it on an empty stomach, but how long do you wait before eating/drinking coffee/taking supplements/etc.?

Splenda/Stevia (lots), diet sodas, coffee, vitamin water, gatorade/propel

Are you kidding? That sounds like an awful lot of artificial sweeteners. And even a small dose of those can be poison. You'd be better off with real sugar. Sugar has been demonised by those with their own agenda, and replaced by things that are much, much worse - same could be said of salt and butter, by the way. If it doesn't grow naturally, don't consume it. You can't go wrong with that motto.

humanbean has dealt very well with your supplement regime, so I won't go into that.

I feel lost. What can I do?

The path to good health starts with comprehensive testing and 'intelligent' analysis of resutl - which rules out doctors for a start. Give us your numbers and let's see what we can find. :)

ChucklesWalrus profile image
ChucklesWalrus in reply to greygoose

Added labs. Always take on an empty stomach.

greygoose profile image
greygoose in reply to ChucklesWalrus

Always take on an empty stomach.

Yes, so you said. But, you didn't answer my question: you may take it on an empty stomach, but how long do you wait before eating/drinking coffee/taking supplements/etc.? Because you don't seem to be absorbing that T3 in the gut.

You're first labs were what we might expect for someone on a starvation diet: drastically low nutrients and low T3. The T3 would be low because you need optimal levels of nutrients to convert T4 to T3, and you need calories.

So, are you eating correctly now? Have you been supplementing your low nutrients?

Have you had a thorough investigation of your gut, so see if you have leaky gut or something that might affect your absorption?

ChucklesWalrus profile image
ChucklesWalrus in reply to greygoose

I wait about 1-2 hours before. Usually 2. I take my vitamin D, enzymes, greens, and probiotic with breakfast. Wait till later to take the rest.

Yes I am eating well now. Plenty of nutrients and calories.

Who would I see to assess my gut health? If my gut is the issue, how do I resolve it?

greygoose profile image
greygoose in reply to ChucklesWalrus

Vit D should be taken four hours away from thyroid hormone. So, that might be a problem.

You need to see a gastroenterologist for gut health. How you resolve it depends on the problem.

ChucklesWalrus profile image
ChucklesWalrus in reply to greygoose

Will co. Honestly I thought T3 absorption was much less strict than T4. Guess not.

greygoose profile image
greygoose in reply to ChucklesWalrus

Yes, a lot of people think that. And, for some people it doesn't seem to matter. But, for a lot of people, their blood test results tell an entirely different story. You see, these myths about, and no-one really questions them, or puts them too the test. They just accept them as true. But reading on here for any length of time gives quite a few insights that you wouldn't otherwise have. :)

ChucklesWalrus profile image
ChucklesWalrus in reply to greygoose

Looks like my next move is going to a GI doc

humanbean profile image
humanbean

I've taken a look at the results you've posted. I haven't paid attention to your thyroid results, I took note of your vitamin D and ferritin.

Your vitamin D has never risen in all the tests you've had done over the last two years. It has been in the Insufficient range for all five tests. Can you give us a link to the supplement you are actually taking, and at what dose, please. How many times a week do you take it?

Ferritin results :

21/8/2018 143 (30 - 400) Approx 32% of the way through the range

14/3/2018 63 (11 - 172) Approx 32% of the way through the range

13/11/2019 43 (38 - 380) Approx 1% of the way through the range

28/5/2021 64 (30 - 400) Approx 9% of the way through the range

1) Have you been taking any iron supplements?

2) If yes, what kind, how often, and at what dose?

You haven't given us any test results for vitamin B12 and folate - these are important.

humanbean profile image
humanbean in reply to humanbean

Oh, and I'm genuinely curious. Why do you eat egg whites? Why not just eat the whole egg? Much better for your health, in my opinion.

ChucklesWalrus profile image
ChucklesWalrus in reply to humanbean

I eat both egg and egg white. 3 whole, 200g egg whites. I bodybuild so I need a lot of protein.

humanbean profile image
humanbean in reply to ChucklesWalrus

Personally, I'd still eat the whole egg, but clearly it is a personal choice.

Could you answer my reply where I asked about your vitamin D and iron supplements, please.

ChucklesWalrus profile image
ChucklesWalrus in reply to humanbean

Just standard 1000iu kroger brand... probably not best?

And I do still eat whole eggs, I just said bro. I need lots of protein, so for some I just eat the whites.

gabkad profile image
gabkad in reply to ChucklesWalrus

Vitamin D3 is a fat soluble vitamin. It needs to be taken when you've eaten a meal that contains fat. Your regimen is not like that.Also 1000 iu = 25 mcg. MICRO. It's nothing. Generally doses of Vitamin D3 need to be significantly higher than what you are taking for there to be any improvement.

Taking 4,000 IU per day in order to raise levels is not unusual. Even so it may take a few months in order to reach adequate.

I take 15,000 IU twice per week at this time. That keeps me in the sweet spot,

114 nmol/l.

And as Humanbean states, vitamin D3 in oil capsules is absorbed better than tablets.

I take Doctor's Best 5,000 IU.

ChucklesWalrus profile image
ChucklesWalrus in reply to gabkad

I do take it with food. 5000 IU daily.

humanbean profile image
humanbean in reply to ChucklesWalrus

I do take it with food. 5000 IU daily.

This is different to what you said in your earlier post :

Just standard 1000iu kroger brand... probably not best?

ChucklesWalrus profile image
ChucklesWalrus in reply to humanbean

1000iu per pill. I take 5 pills.

gabkad profile image
gabkad in reply to ChucklesWalrus

I have no solid evidence, but I think it makes more sense to take the oil filled gelcaps to maximize absorption. Pills are full of excipients.

SlowDragon profile image
SlowDragonAdministrator in reply to gabkad

I found only one works for me is mouth spray, as avoids poor gut absorption

4000iu as maintenance dose, plus as much sunshine as possible

Higher dose to bring levels up

Took 6 months at 6000iu daily to go from 65nmol to 96nmol

But obviously everyone is different

Some people find tiny dose rapidly increases levels

That’s why it’s so important to regularly retest vitamin D, especially when first start supplementing

Then test twice year going forward

gabkad profile image
gabkad in reply to SlowDragon

Agreed. But in Ontario we have to pay $45 for a vitamin D test unless done in hospital. So I do it occasionally and have had no nasty surprises. Probably mygut absorption is excellent. One less problem we hypos seem to have. Thankfully.

At the same time, unlike the person asking for help in this thread, I never ever

consume any commercial drinks product. I don't think that stuff is good for health.

The artificially sweetened soft drinks and Gatorade etc. are full of phosphoric acid.

Not something we need that much of. It can reduce calcium in the body and also

dissolve teeth.

SlowDragon profile image
SlowDragonAdministrator in reply to gabkad

Vitamin D test here is £29

£23 if you buy ten at a time

NIKEGIRL profile image
NIKEGIRL in reply to humanbean

Hi. Sorry to butt in. This person will eat the egg whites because the whites will have 3 grams of protein per egg. The yolk in the egg is 3 grams of fat. So eating a lot of egg whites gets the protein into the body without the fat.

ChucklesWalrus profile image
ChucklesWalrus in reply to NIKEGIRL

Thanks NIKEGIRL, didn’t seem to be able to get them to understand lol 😂

humanbean profile image
humanbean

If you use this vitamin D calculator :

grassrootshealth.net/projec...

and put in the appropriate figures you'll find that you need about 5000 iU per day to raise your level to 40 ng/mL which is the bottom of optimal. Optimal is 40 - 60 ng/mL, so you could aim for a higher level than the default 40 ng/mL.

Info on the best vitamin D supplements :

1) Always take Vitamin D3 not Vitamin D2.

2) The best supplements are gel capsules of some kind containing nothing but oil and vitamin D3. Some people don't tolerate vitamin D terribly well and prefer vitamin D supplements which can be sprayed in the mouth.

3) Vitamin D is a fat soluble vitamin/hormone and should be taken with the fattiest meal of the day for best absorption.

Supplementing with vitamin D raises calcium absorption from the diet. If you aren't careful that could end up lining your arteries which is obviously undesirable. To avoid this it should be taken with co-factors vitamin K2 and magnesium. Please search through posts written by SeasideSusie on the subject of magnesium and K2. There are lots of different forms of magnesium supplement, some which are good, some which are useless, so you need to know what to buy.

healthunlocked.com/user/sea...

...

Are you trying to raise your iron and ferritin? If you aren't I think you should be.

ChucklesWalrus profile image
ChucklesWalrus in reply to humanbean

Ty bro

humanbean profile image
humanbean in reply to ChucklesWalrus

For some reason the forum isn't playing ball when I post some links. This forum has a lot of bugs on occasion, and this particular bug has happened before. I'll try to update the ones that didn't post properly tomorrow.

SlowDragon profile image
SlowDragonAdministrator

Low vitamin D

Exactly what vitamin D and how much are you taking

Do you also supplement magnesium

Calculator for working out dose you may need to bring level to 40ng/ml = 100nmol

grassrootshealth.net/projec...

Vitamin D and thyroid disease

grassrootshealth.net/blog/t...

ChucklesWalrus profile image
ChucklesWalrus in reply to SlowDragon

I’m taking Kroger brand D3 5,000 IU daily with breakfast

SlowDragon profile image
SlowDragonAdministrator in reply to ChucklesWalrus

Vitamin D mouth spray by Better You is very effective as it avoids poor gut function. There’s a version made that also contains vitamin K2 Mk7

amazon.co.uk/BetterYou-Dlux...

One spray = 1000iu

You might need 6000iu-7000iu daily to increase vitamin D levels…..possibly even higher dose

Then trial and error what dose will need as maintenance

ChucklesWalrus profile image
ChucklesWalrus in reply to SlowDragon

Is there any form of T3 that’ll bypass poor gut function? Or T4?

SlowDragon profile image
SlowDragonAdministrator in reply to ChucklesWalrus

No currently all thyroid hormones are swallowed

There is research going on into slow release patches …but likely years away

You need to work on improving low vitamin levels, eating proper nutrient rich foods

Look at increasing stomach acid. Many hypothyroid patients have LOW stomach acid

Frequently strictly gluten free diet helps or is essential

Lactose intolerance can be an issue too

ChucklesWalrus profile image
ChucklesWalrus in reply to SlowDragon

I eat incredibly nutrient rich foods. I plug every day into Cronometer.

SlowDragon profile image
SlowDragonAdministrator

200lb = 91 kilo approx

Guidelines on dose by weight of levothyroxine alone is approx 1.6mcg per kilo of your weight

So on levothyroxine alone, assuming optimal vitamin levels and good gut function you would likely need around 146mcg levothyroxine per day

But if exercising a lot you might well need higher dose

It takes many weeks/months on constant unchanging dose to slowly see improvements

Now on T3 plus levothyroxine

Are you splitting T3 into two doses or three doses through the day

currently vitamin D is far too low

Ferritin low, especially for a bloke

No folate or B12 results

Definitely look at getting rid of all that stevia, fizzy drinks etc

ChucklesWalrus profile image
ChucklesWalrus in reply to SlowDragon

I do have folate and B12 results in the latest test. They are good.

SlowDragon profile image
SlowDragonAdministrator in reply to ChucklesWalrus

Couldn’t see folate or B12 results or ranges

ChucklesWalrus profile image
ChucklesWalrus in reply to SlowDragon

I am indeed splitting it 2x. I feel like I have some absorption issue, as I eat plenty of iron. And I’ve supped with D for a long time now. Always taking it with fats.

SlowDragon profile image
SlowDragonAdministrator in reply to ChucklesWalrus

If you put your weight of 200lb and current dose vitamin D 5000iu in this calculator it suggests you need 8000iu-9000iu daily to bring vitamin D to 40ng/ml in 3 months

grassrootshealth.net/projec...

radd profile image
radd

ChucklesWalrus,

Welcome to our forum,

Great advice above re optimising nutrients. Damage incurred by aggressive dieting can be difficult to unpick because thyroid hormones (own or medicated) don’t work in isolation but are reliant upon basic cofactors being met before becoming optimally effective.

You are supplementing testosterone. Most circulating testosterone is bound to SHBG (sex hormone-binding globulin) with a lesser fraction bound to albumin, and a small amount 'free'. Cortisol becomes elevated with chronic stress (dieting/inadequte thyroid hormone) & prolonged elevations decrease the liver’s ability to clear excess testosterone, oestrogens, etc from the blood.

These excess increase levels of TBG (thyroid hormone transporters), much like when a female supplements HRT. When thyroid hormone is bound to TBG, it is inactive as has to be cleaved from TBG to become ‘free’. Were you actually deficient in testosterone or using extra to build muscle? Have you had comprehensive sex hormone testing including SHBG, TBG, Total/Free testosterone & other androgens? (Free is calculated from total testosterone & SHBH, which in men can be referred to as testosterone-binding globulin). SHBG levels usually allows assessment of how the body is absorbing T3 because it positively correlates, but because you are supplementing testosterone results will be skewed.

If chronic stress has been prolonged, adrenocortical activity can eventually decrease but you will need balanced cortisol levels to raise the glucose required allowing T3 into the cells, along with enough carbs. This will be working with ATP & mitochondria to produce energy. Raising thyroid hormones will improve adrenal health but you need adrenal health to raise thyroid hormones. Are you eating adequate carbs? Have you good blood glucose levels? Insulin & leptin resistance are common in people with thyroid/adrenal issues, and both have been associated with low Vit D levels which you have.

Your supplements are good but you need to address deficiencies with individualised doses that can offer higher amounts, as opposed to combos. Is there an iron level result anywhere?

ChucklesWalrus profile image
ChucklesWalrus in reply to radd

Yes I needed testosterone as I was hypogynonadal after the crash diet.

I eat plenty of carbs, about 600g a day (I do bodybuild, and am currently bulking) so that’s not an issue.

Yes I have tested my hormones. On my TRT my testosterone sits around 1000 ng/dL.

radd profile image
radd in reply to ChucklesWalrus

CW,

And the rest?

ChucklesWalrus profile image
ChucklesWalrus in reply to radd

imgur.com/a/ZnVqwf2

I just need TBG

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