Medichecks thyroid results: Inflammation CRP HS... - Thyroid UK

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Medichecks thyroid results

Day-skipper profile image
10 Replies

Inflammation

CRP HS 2.09 mg/L (Range: < 5)

Iron Status

Ferritin X 214 ug/L (Range: 13 - 150)

Vitamins

Folate - Serum ! Sample error

... being re-done

Vitamin B12 - Active 115.000 pmol/L (Range: > 37.5)

Vitamin D 104 nmol/L

(Range: 50 - 175)

Thyroid Hormones

TSH 1.17 mIU/L (Range: 0.27 - 4.2)

Free T3 4.43 pmol/L (Range: 3.1 - 6.8)

Free Thyroxine 17.200 pmol/L (Range: 12 - 22)

Autoimmunity

Thyroglobulin Antibodies X 445.000 kIU/L (Range: < 115

Thyroid Peroxidase Antibodies 22.5 kIU/L (Range: < 34)

From a year ago, my ferritin level is up, as is the thyroglobulin. I eat small portions of red meat 4 times a week (e.g. 1 steak cut in two). It was suggested last year that I may have Hashimotos, but it has not been formally diagnosed.

I began to take Vitamin D , B12, and selenium. Is there anything else I should be doing ?

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fuchsia-pink profile image
fuchsia-pink

How do you feel? Your free T4 is just over half way through range and free T3 just over a third. I'd like both to be higher myself, so if you don't feel tip-top maybe it's time to increase your levo by 25 mcg? Perhaps alternate days to start?

Day-skipper profile image
Day-skipper in reply to fuchsia-pink

I do feel tired a lot, and my weight has crept up a couple of pounds, although I do keep to a healthy diet. I follow all the good advice, like overnight fasting, always cooking fresh food from scratch, and only in moderate amounts. My only indulgence is a normal glass of red with dinner...I make one bottle last 3 or 4 nights! I could up my daily dose to 100mcg, but should I consult my GP before doing so?

fuchsia-pink profile image
fuchsia-pink in reply to Day-skipper

How well do you get on with your GP? How sympathetic/useful is s/he?

Given your results and SlowDragon 's useful link to prescribing by weight, I'd be inclined to talk to the GP - not least to get your prescription corrected so you don't run out of meds - unless the GP is a total nightmare :)

Also, if you get up to 100 mcg a day (perhaps in a couple of steps) you can avoid Teva if you don't particularly get on well with it! - I know you haven't mentioned issues with Teva but it's quite common and there aren't many companies that make 25 mcg tablets.

Good luck x

SlowDragon profile image
SlowDragonAdministrator

Ft4 is only 52% through range

Ft3 only 36% through range

Helpful calculator for working out percentage through range

chorobytarczycy.eu/kalkulator

How much Levothyroxine are you currently taking?

Do you always get same brand of levothyroxine?

Suggest you try dose increase in levothyroxine.....initially by 12.5mcg per day and retest in 6-8 weeks

guidelines by weight might help push GP for dose increase

Even if we don’t start on full replacement dose, most people need to increase dose slowly upwards in 25mcg steps (retesting 6-8 weeks after each increase) until on full replacement dose

NICE guidelines on full replacement dose

nice.org.uk/guidance/ng145/...

1.3.6

Consider starting levothyroxine at a dosage of 1.6 micrograms per kilogram of body weight per day (rounded to the nearest 25 micrograms) for adults under 65 with primary hypothyroidism and no history of cardiovascular disease.

gp-update.co.uk/Latest-Upda...

BMJ also clear on dose required

bmj.com/content/368/bmj.m41

bestpractice.bmj.com/topics...

The aim of Levothyroxine is to increase the dose slowly in 25mcg steps upwards until TSH is under 2 (many patients need TSH significantly under one) and most important is that FT4 is in top third of range and FT3 at least half way through range

NHS guidelines on Levothyroxine including that most patients eventually need somewhere between 100mcg and 200mcg Levothyroxine.

nhs.uk/medicines/levothyrox...

Also note what foods to avoid (eg recommended to avoid calcium rich foods at least four hours from taking Levo)

All four vitamins need to be regularly tested and frequently need supplementing to maintain optimal levels

Do you supplement magnesium?

Yes high TG antibodies suggests you have Hashimoto’s, but NHS won’t diagnose on just high TG antibodies

Are you On strictly gluten free diet?

Day-skipper profile image
Day-skipper in reply to SlowDragon

I am on 75mcg per day, my weight is 76Kg (indicates 125mcg daily!)

Brands I usually get 50 mcg - accord 25mcg TEVA

I take tablets at 8am, have a coffee with milk at 9am, lunch not until 12:30

I don't take magnesium at present

My diet is not strictly gluten free, but I avoid bread, in favour of Ryvita / cream crackers

Meals usually meat / fish with 3 veg, ...small potato, or none

I have stopped B12 for now until I re-do the folate test

Should I take more levothyroxine now, or book to see my GP first?

SlowDragon profile image
SlowDragonAdministrator in reply to Day-skipper

Levothyroxine is an extremely fussy hormone and should always be taken on an empty stomach and then nothing apart from water for at least an hour after

Many people take Levothyroxine soon after waking, but it may be more convenient and perhaps more effective taken at bedtime

verywellhealth.com/best-tim...

Many people find Levothyroxine brands are not interchangeable.

Once you find a brand that suits you, best to make sure to only get that one at each prescription.

Watch out for brand change when dose is increased or at repeat prescription.

Many patients do NOT get on well with Teva brand of Levothyroxine. Teva contains mannitol as a filler, which seems to be possible cause of problems. Teva is the only brand that makes 75mcg tablet. So if avoiding Teva for 75mcg dose ask for 25mcg to add to 50mcg or just extra 50mcg tablets to cut in half

Teva and Aristo are the only lactose free tablets

healthunlocked.com/thyroidu...

Teva poll

healthunlocked.com/thyroidu...

No other medication or supplements at same as Levothyroxine, leave at least 2 hour gap. Some like iron, calcium, magnesium, HRT, omeprazole or vitamin D should be four hours away

(Time gap doesn't apply to Vitamin D mouth spray)

Suggest you see/contact GP to discuss dose increase

Perhaps print/email NICE guidelines out for them ....might help persuade GP to agree to increase in levothyroxine

Day-skipper profile image
Day-skipper in reply to SlowDragon

Thank you for your valuable info, I will try to get an appointment soon. Will update when I have more news.

SlowDragon profile image
SlowDragonAdministrator in reply to Day-skipper

Ryvita contains Rye

There are good gluten free crackers in Free From section at supermarket

Gluten free diet does need to be absolutely strictly gluten free to be effective

Day-skipper profile image
Day-skipper in reply to SlowDragon

I spoke with my GP and she has upped my dose to 100mcg daily. I have been on this now for nearly two weeks, and I feel so much brighter. I have also seen my weight slowly dropping already.

I have switched to gluten free crackers, so it looks like that is helping.

My resting heart rate seems slightly higher at 80, is this something I should worry about?

Thanks

SlowDragon profile image
SlowDragonAdministrator in reply to Day-skipper

See how things progress

Levels can take a while to settle

Bloods should be retested 6-8 weeks after any dose increase

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