Lab Results After Changing to NDT: I am a 54 year... - Thyroid UK

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Lab Results After Changing to NDT

arn22110 profile image
6 Replies

I am a 54 year old male and was initially diagnosed as having an overactive thyroid when I was ~12 years old, approximately 4 years later I had become hypo and have been on thyroxin for the last 38 years with the last dose being 200micro grams a day. I never was told why I had hypothyroidism and just got on with taking my meds until I found this site.

Around 3 months ago I switched from thyroxin to NDT from Thailand and been on 3 grains a day since. I would be interested in your thoughts on my results. I take no supplements but am on Atacand for high blood pressure and have just been informed that my Chloesterol and LDL are high (no treatment yet).

My temperature in the morning and afternoon is still on the cold side but I am generally feeling well, even sometimes wanting to dance on the spot! Exercise wise I cycle for 7 to 8 hours a week but still weigh in at 118kg for a height of 1.8mtrs.

FolateBA 12.88 ng/ml range = 3.1 to 12.4

Ferritin 464 ug/L range 30-400

Vitamin D 31.1 ng/mL

Vitamin B12 379 pg/ml

Anti Thyroglobulin (IU/mL) 126 range <115

Anti Thyroperoxidase (IU/mL) 231 range <34

TSH (uIU/mL) 0.65 range 0.27-4.2

FT3 (pmol/L) 5.18 range 3.1-6.8

FT4 (pmol/L) 13.62 range 12-22

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arn22110
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6 Replies

Your FT3 and FT4 levels look good, especially if you left 24 hours between taking meds and going to the lab; in that case, your FT3 levels were about 20% higher on the previous day. FT4 levels are often lowish when on NDT, and it's often recommended they are not higher than midrange as more T4 increases the risk of rT3 dominance (excess T4 is converted to reverse T3 which is inactive and competes with the active hormone free T3). So the advice to have FT4 and FT3 levels in the upper third lab ranges only applies to people on thyroxine who need to convert a lot of T4 to free T3. When on NDT, your FT3 levels should ideally be in the upper third range, but your FT4 levels not higher than midrange.

Your TSH is normal but low in range which is fine for some, but many patients with autoimmune hypothyroidism (which you have since your anti-TPO and anti-thyroglobuline levels are out of range) feel better when their TSH is suppressed (below 0). If you feel like adding another 0.5 or even a quarter grain to your current dose of NDT, it can only lower your TSH and increase your free Ts further.

The fact that you feel well means you are on the right track, and probably just need to fine-tune your dose slightly.

High LDL and cholesterol levels could be the result of years on T4 only drugs. You have not been on NDT for very long, and it takes time for the body to heal and start correcting things that have gone awry.

arn22110 profile image
arn22110 in reply to

Yes the tests were 24 hours after the last meds and done on first thing in the morning/fasted

SlowDragon profile image
SlowDragonAdministrator

Assume you are not in UK ?

Always a good idea to say as this is UK support group

Different vitamin D measuring units than in Uk

Your vitamin D is too low. You could do with taking supplements, probably all year, but definitely through winter.

Aiming for 40 ng/ml

(that's same as 100nmol in UK)

People need wide variation of dose to get improvements. You might find just 1000iu increases dose, but you may need more. Try 1000 or 2000 for 2-3 months and then test

UK Government has recommended absolutely everyone in UK supplement Oct to March at 400iu

With thyroid issues we seems to often need more

Your TPO antibodies are raised. You might try gluten free diet to see if improves symptoms and possibly lowers antibodies

arn22110 profile image
arn22110 in reply toSlowDragon

I am not currently in the UK but I was born there. I am currently in the Middle East working but my family remain at home in the South West, I get back four times a year so it is difficult managing something like hypothyroidism.

Your Vit D looks too low.

arn22110 profile image
arn22110 in reply to

Many thanks. Based on the comment from SlowDragon I will be starting supplements this weekend. It is strange given that I am working in the sunshine.

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