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Xtandi [Enzalutamide ]. Continuation of ADT after CRPC & chemo.
New study below [1]. There is sometimes confusion as to the reason for ADT continuation when it has "failed" [CRPC]. Androgen deprivation itself does not fail, but the cancer has found a work-around with the androgen axis generally continuing to be the major player, so it makes sense to continue ADT
New study below [1]. There is sometimes confusion as to the reason for ADT continuation when it has "failed" [CRPC]. Androgen deprivation itself does not fail, but the cancer has found a work-around with the androgen axis generally continuing to be the major player, so it makes sense to continue ADT
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Another fighter
About to begin
xtandi
and xgeva in addition to the eligard. Also poor kidney function due to some damage from the prostate. Have switched pain meds from tramacet to hydromorphone due to interaction with the
xtandi
About to begin
xtandi
and xgeva in addition to the eligard. Also poor kidney function due to some damage from the prostate. Have switched pain meds from tramacet to hydromorphone due to interaction with the
xtandi
2yearsin
in
Advanced Prostate Cancer
6 years ago
Prostate Cancer
His PSA started to increase again June of 2018 and he recently started taking
Xtandi
. My father will not do Chemo (he is 77) which I will respect his decision. He just had another PSA test and after being on the
Xtandi
for a month, the PSA is continuing to increase.
His PSA started to increase again June of 2018 and he recently started taking
Xtandi
. My father will not do Chemo (he is 77) which I will respect his decision. He just had another PSA test and after being on the
Xtandi
for a month, the PSA is continuing to increase.
lifeisabeachMC
in
Advanced Prostate Cancer
6 years ago
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PSA rise on Xtandi
4th month of
Xtandi
with declines each month until last week when it jumped from .78 (my nadir) to 1.05. MO says to start contacting our MD Anderson doc for trials. Any thoughts? Already had 10 rounds of taxotere. Wondering how long
Xtandi
lasted for others and when they determined it had failed?
4th month of
Xtandi
with declines each month until last week when it jumped from .78 (my nadir) to 1.05. MO says to start contacting our MD Anderson doc for trials. Any thoughts? Already had 10 rounds of taxotere. Wondering how long
Xtandi
lasted for others and when they determined it had failed?
joekaty
in
Advanced Prostate Cancer
6 years ago
Back from holiday in England, Scotland & Ireland....
~~I am assuming it's from my three months of being on
Xtandi
...as most of the things I read say that Provenge can spike you PSA up. Mine's been steadily going down since starting
Xtandi
. Best wishes to ALL. ~~John p.s. We were gone for 22 days...
~~I am assuming it's from my three months of being on
Xtandi
...as most of the things I read say that Provenge can spike you PSA up. Mine's been steadily going down since starting
Xtandi
. Best wishes to ALL. ~~John p.s. We were gone for 22 days...
greatjohn
in
Advanced Prostate Cancer
6 years ago
TRC253 Trial
RP, Lupron, Zytiga, Doxetel,
Xtandi
, Radium 223. Doctor says I qualify for this trial. Anyone have experience with it? All treatments have failed me, so this is a last ditch effort to stay in the fight. Thanks for your advice.
RP, Lupron, Zytiga, Doxetel,
Xtandi
, Radium 223. Doctor says I qualify for this trial. Anyone have experience with it? All treatments have failed me, so this is a last ditch effort to stay in the fight. Thanks for your advice.
flintknapper
in
Advanced Prostate Cancer
6 years ago
Alkaline Phos and Hemoglobin
He had his 4 week appointment since being switched to
Xtandi
from Zytiga. Zytiga failed after 7 months and now onto
Xtandi
. We still do not have the PSA results however we did get his hemoglobin back and his alkaline Phos.
He had his 4 week appointment since being switched to
Xtandi
from Zytiga. Zytiga failed after 7 months and now onto
Xtandi
. We still do not have the PSA results however we did get his hemoglobin back and his alkaline Phos.
Hidden
in
Advanced Prostate Cancer
6 years ago
eFFECTOR
My drug trial with
Xtandi
is coming to a close and my research doctor says this could be the next step.
My drug trial with
Xtandi
is coming to a close and my research doctor says this could be the next step.
Magnus1964
in
Advanced Prostate Cancer
6 years ago
Xtandi enzalutamide side effects dizzy/seizures
He has been on
Xtandi
for 7 months with a 6 week holiday from it due to other possible side effects and seemed to be tolerating it well. It's been somewhat working. He landed on his knees and other then bruising wasn't hurt.
He has been on
Xtandi
for 7 months with a 6 week holiday from it due to other possible side effects and seemed to be tolerating it well. It's been somewhat working. He landed on his knees and other then bruising wasn't hurt.
Grumpyswife
in
Advanced Prostate Cancer
6 years ago
What happens once stopped xtandi treatment
My father stopped
xtandi
over a Month ago and no more treatments available to him due to his age and health. The oncologist doesn't want to see us any more and we have been told to prepare ourselves but he looks so well and not sure what happens now.
My father stopped
xtandi
over a Month ago and no more treatments available to him due to his age and health. The oncologist doesn't want to see us any more and we have been told to prepare ourselves but he looks so well and not sure what happens now.
Karmj
in
Advanced Prostate Cancer
6 years ago
PSMA LU177 THERAPY IN GERMANY
Tried Docetaxel, Zytiga,
Xtandi
, Radium . Nothing helped . Currently on Lupron only. I am thinking and planning to get him into Germany. 1. Is university hospital Munich rechts der Isar a good place? 2. Is Dr Markus Schwaiger one of the best ? 3. Is one session enough ? 4.
Tried Docetaxel, Zytiga,
Xtandi
, Radium . Nothing helped . Currently on Lupron only. I am thinking and planning to get him into Germany. 1. Is university hospital Munich rechts der Isar a good place? 2. Is Dr Markus Schwaiger one of the best ? 3. Is one session enough ? 4.
Cladius
in
Advanced Prostate Cancer
6 years ago
Xtandi
He was on casodex 18 months and then switched to
Xtandi
one year ago. His PSA was never more than 4 but alk phos was 4000. His PSA has been < .1 for two years but last month it was .2. Doctor doesn’t think it’s significant but articles I’ve seen sound like it could be. Any experience with this?
He was on casodex 18 months and then switched to
Xtandi
one year ago. His PSA was never more than 4 but alk phos was 4000. His PSA has been < .1 for two years but last month it was .2. Doctor doesn’t think it’s significant but articles I’ve seen sound like it could be. Any experience with this?
Bball
in
Advanced Prostate Cancer
6 years ago
Cyberknife is in my future
Since January I've also been on Enzalutmide/
Xtandi
as PSA was rising with Zoladex alone, so was declared castration resistant. The
Xtandi
has managed to keep my PSA in check (it's currently 0.67 and stable) but I have a lot of cancer in the prostate which is causing issues.
Since January I've also been on Enzalutmide/
Xtandi
as PSA was rising with Zoladex alone, so was declared castration resistant. The
Xtandi
has managed to keep my PSA in check (it's currently 0.67 and stable) but I have a lot of cancer in the prostate which is causing issues.
paulofaus
in
Advanced Prostate Cancer
6 years ago
zytigia or Xtandi with Prednisone and insulin resistance?
Anyone experience glucose/insulin control problems when undergoing these second line ADT treatments? Wondering about this as it seems it would be a negative for insulin stimulated cancer growth?
Anyone experience glucose/insulin control problems when undergoing these second line ADT treatments? Wondering about this as it seems it would be a negative for insulin stimulated cancer growth?
sammamish
in
Advanced Prostate Cancer
6 years ago
Xtandi
Aside from fatigue what other side effects if any are people experiencing?
Aside from fatigue what other side effects if any are people experiencing?
willshake
in
Advanced Prostate Cancer
6 years ago
A history of PSA readings, how accurate are they?
(PSMA PET Gallium scans showed bone metastasis in shoulders and lower back pre Lutetium treatment as well) From JULY 2018 PSA starting to rise again to 51 then started on Enzalutamide or
Xtandi
for 3 months to see if this would halt the rise .
(PSMA PET Gallium scans showed bone metastasis in shoulders and lower back pre Lutetium treatment as well) From JULY 2018 PSA starting to rise again to 51 then started on Enzalutamide or
Xtandi
for 3 months to see if this would halt the rise .
C0zm0cat
in
Advanced Prostate Cancer
6 years ago
taxotere may be last thing left
CR to zytiga and
xtandi
. PSA went from 3 to 290 in last 4 months. Had 4 bone mets and 22 rounds of radiation that just ended last week. In two weeks I start taxotere. Does anyone know what I can expect from the taxotere? Chances of working?
CR to zytiga and
xtandi
. PSA went from 3 to 290 in last 4 months. Had 4 bone mets and 22 rounds of radiation that just ended last week. In two weeks I start taxotere. Does anyone know what I can expect from the taxotere? Chances of working?
truckerbob
in
Advanced Prostate Cancer
6 years ago
Genetic testing results
I have read that ar L702H which I have can be caused by prednisone and possibly switching to dex would allow zytiga or
xtandi
to work, Thank You
I have read that ar L702H which I have can be caused by prednisone and possibly switching to dex would allow zytiga or
xtandi
to work, Thank You
Dan59
in
Advanced Prostate Cancer
6 years ago
Buying Xtandi
Anyone have experience buying
Xtandi
from Canadian Pharmacies? Could you recommend a trustworthy pharmacy?
Anyone have experience buying
Xtandi
from Canadian Pharmacies? Could you recommend a trustworthy pharmacy?
Raff5757
in
Advanced Prostate Cancer
6 years ago
Low sugar with enzalutamide
Has any one experienced low blood sugar after being on Enzalutamide\
Xtandi
? Did you take any medication for it or just kept monitoring? Right now bisphosphonates(Zoledronic acid) 3 monthly is also going on for him since May 2016, he has done 14 doses till now and onco had asked to take total 24.
Has any one experienced low blood sugar after being on Enzalutamide\
Xtandi
? Did you take any medication for it or just kept monitoring? Right now bisphosphonates(Zoledronic acid) 3 monthly is also going on for him since May 2016, he has done 14 doses till now and onco had asked to take total 24.
caretkr
in
Advanced Prostate Cancer
6 years ago
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