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Xtandi
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Erleada vs Xtandi - what are the differences?
I was not eligible for the Erleada because I have already been switched over to Zytiga...but Erleada and
Xtandi
will be potential options for me in the future. 1. Will those who have taken
Xtandi
but have grown resistant- now get a benefit from Erleada in the future? Or vice versa? 2.
I was not eligible for the Erleada because I have already been switched over to Zytiga...but Erleada and
Xtandi
will be potential options for me in the future. 1. Will those who have taken
Xtandi
but have grown resistant- now get a benefit from Erleada in the future? Or vice versa? 2.
westjl2
in
Advanced Prostate Cancer
6 years ago
Learning about salvage therapies
The list of meds to learn about is daunting (Zytiga,
Xtandi
, Avodart, Lupron, Apiraterone, etc. etc.) Is there an overview somewhere of secondary treatments and when they are appropriate? Also, what about radiation to the prostate bed.
The list of meds to learn about is daunting (Zytiga,
Xtandi
, Avodart, Lupron, Apiraterone, etc. etc.) Is there an overview somewhere of secondary treatments and when they are appropriate? Also, what about radiation to the prostate bed.
hogwell
in
Advanced Prostate Cancer
6 years ago
Help on next step - Chemo or Xtandi?
Now, my question is, will it be better to do chemo or
Xtandi
? Would
Xtandi
still work if Zytiga stops working? Also, does the side effects of radiation outweigh the benefits which is the reason why our MO doesnt like to include it in our treatment protocol?
Now, my question is, will it be better to do chemo or
Xtandi
? Would
Xtandi
still work if Zytiga stops working? Also, does the side effects of radiation outweigh the benefits which is the reason why our MO doesnt like to include it in our treatment protocol?
dvcarola
in
Advanced Prostate Cancer
6 years ago
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Update on Dad...I'm Feeling scared and sad
He is on day 6 of
Xtandi
and so far he's feeling fatigued around 3pm. I'm just plain scared..this is all new to me. For the last 10 years, my Dad has been pretty stable with only ADT shots every 6mos. Now, everything is different. Bone Mets and nodes... and now on
Xtandi
.
He is on day 6 of
Xtandi
and so far he's feeling fatigued around 3pm. I'm just plain scared..this is all new to me. For the last 10 years, my Dad has been pretty stable with only ADT shots every 6mos. Now, everything is different. Bone Mets and nodes... and now on
Xtandi
.
savingdaddy
in
Advanced Prostate Cancer
6 years ago
Titan Study Apalutamide on MPC gets approval
However the good news is we now have another option to use, although Erleada is very similar to
Xtandi
.
However the good news is we now have another option to use, although Erleada is very similar to
Xtandi
.
westjl2
in
Advanced Prostate Cancer
6 years ago
HPN424 Shows Promising Safety, Immune Activation in Metastatic CRPC
Trial with patients already through
Xtandi
and/or Zytiga. Trial is still recruiting for those that may be interested and qualify. Article has trial link. https://prostatecancernewstoday.com/2019/02/07/interim-phase-1-trial-data-shows-potential-of-hpn424-against-mcrpc/?
Trial with patients already through
Xtandi
and/or Zytiga. Trial is still recruiting for those that may be interested and qualify. Article has trial link. https://prostatecancernewstoday.com/2019/02/07/interim-phase-1-trial-data-shows-potential-of-hpn424-against-mcrpc/?
Moespy
in
Advanced Prostate Cancer
6 years ago
Input after rising Chemo PSA and Zytiga liver #'s
He mentioned possibly Provenge or
Xtandi
depending on my PSA numbers. Here are my liver and PSA numbers from Sept to January. Any input or suggestions much appreciated.....Saludos!
He mentioned possibly Provenge or
Xtandi
depending on my PSA numbers. Here are my liver and PSA numbers from Sept to January. Any input or suggestions much appreciated.....Saludos!
Hidden
in
Advanced Prostate Cancer
6 years ago
New here..looking for others experience with XTANDI
His PSA is now around 300 and just started taking
Xtandi
today and continuing to take Lupron shots. It is Metastatic to the bone and a few lymphnodes. Anybody with good outcomes with
XTANDI
??? Ive heard great things from a pharmacist.
His PSA is now around 300 and just started taking
Xtandi
today and continuing to take Lupron shots. It is Metastatic to the bone and a few lymphnodes. Anybody with good outcomes with
XTANDI
??? Ive heard great things from a pharmacist.
savingdaddy
in
Advanced Prostate Cancer
6 years ago
DES
Started
Xtandi
and it has slowed finally after 3 months but is currently at 56. Onc is thinking DES before doing another set of chemo rounds. This all depends if
Xtandi
doesn’t start lowering PSA. Is it too old school or out of the box?
Started
Xtandi
and it has slowed finally after 3 months but is currently at 56. Onc is thinking DES before doing another set of chemo rounds. This all depends if
Xtandi
doesn’t start lowering PSA. Is it too old school or out of the box?
Nutters85
in
Advanced Prostate Cancer
6 years ago
Might Enzalutamide [Xtandi] sensitize PCa to radiation?
New UK/Spanish cell study [1]. "A pre-treatment of LNCaP cells with IC50 concentrations of enzalutamide significantly sensitized them to radiotherapy through enhanced apoptosis. In contrast, enzalutamide resistant PC-3 cells were not sensitized to radiotherapy by androgen blockade." LNCaP & PC-3 (with
New UK/Spanish cell study [1]. "A pre-treatment of LNCaP cells with IC50 concentrations of enzalutamide significantly sensitized them to radiotherapy through enhanced apoptosis. In contrast, enzalutamide resistant PC-3 cells were not sensitized to radiotherapy by androgen blockade." LNCaP & PC-3 (with
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Please shoot holes in this plan.
Plan to pause Lupron/
Xtandi
for 2 quarters, receive SBRT in Sep, cavitaxel w/carboplatin/resume Lupron/
Xtandi
in Oct with Avodart.
Plan to pause Lupron/
Xtandi
for 2 quarters, receive SBRT in Sep, cavitaxel w/carboplatin/resume Lupron/
Xtandi
in Oct with Avodart.
Crabcrushe
in
Advanced Prostate Cancer
6 years ago
Decision time...looking for input
My husband is post chemo and now has had 4 consecutive rises on
Xtandi
. His doubling time is 2.2 months though he is still at a low number- 2.5 (up from a nadir of .78). Dr.
My husband is post chemo and now has had 4 consecutive rises on
Xtandi
. His doubling time is 2.2 months though he is still at a low number- 2.5 (up from a nadir of .78). Dr.
joekaty
in
Advanced Prostate Cancer
6 years ago
Indo...Indo... Indomethacin....This Stuff Works
I have been on
Xtandi
mono therapy for 18 months and my PSA has never gotten less than .3.....for the last 30 days I went on
Xtandi
/Indomethacin 50mg and my last PSA on Jan 14 was <.1...synergistic with
Xtandi
and Zytiga and can reverse resistance to either drug and knocks down AR-V7...google Indomethacin
I have been on
Xtandi
mono therapy for 18 months and my PSA has never gotten less than .3.....for the last 30 days I went on
Xtandi
/Indomethacin 50mg and my last PSA on Jan 14 was <.1...synergistic with
Xtandi
and Zytiga and can reverse resistance to either drug and knocks down AR-V7...google Indomethacin
gusgold
in
Advanced Prostate Cancer
6 years ago
ARV-110 clear phase 1 for mCRPC very promising.
AR-110 , has demonstrated to be superior to Zytiga and
Xtandi
for cancer cell to develop resistance to. In preclinical studies, ARV-110 reduced AR levels by 95-98% in several prostate cancer cell lines. Additionally, in a mouse model inhibited tumor growth by up to 100%.
AR-110 , has demonstrated to be superior to Zytiga and
Xtandi
for cancer cell to develop resistance to. In preclinical studies, ARV-110 reduced AR levels by 95-98% in several prostate cancer cell lines. Additionally, in a mouse model inhibited tumor growth by up to 100%.
bboby
in
Advanced Prostate Cancer
6 years ago
Test of a new Lu-177-PSMA-based radiopharmaceutical at UCSF
It is for those with mCRPC who have tried docetaxel (but not Jevtana), and have failed Zytiga or
Xtandi
. Here are the details: https://clinicaltrials.gov/ct2/show/NCT03822871 In NYC, Scott Tagawa at Weill Cornell is testing the J591 ligand.
It is for those with mCRPC who have tried docetaxel (but not Jevtana), and have failed Zytiga or
Xtandi
. Here are the details: https://clinicaltrials.gov/ct2/show/NCT03822871 In NYC, Scott Tagawa at Weill Cornell is testing the J591 ligand.
Tall_Allen
in
Advanced Prostate Cancer
6 years ago
Dukoral question
I am taking
xtandi
, lupron and xgeva, my psa was 900 6 months ago now psa is . 6 I am thinking about taking Dukoral does anyone have any experience taking Dukoral for advanced prostate cancer.
I am taking
xtandi
, lupron and xgeva, my psa was 900 6 months ago now psa is . 6 I am thinking about taking Dukoral does anyone have any experience taking Dukoral for advanced prostate cancer.
delbert110
in
Advanced Prostate Cancer
6 years ago
Combining Xtandi and Keytruda - early promise
https://www.prostatepedia.net/blogs/prostatepedia/combining-keytruda-pembrolizumab-and-
xtandi
-enzalutamide-for-prostate-cancer?ct=t(EMAIL_CAMPAIGN_1_22_2019_13_29)&goal=0_bc8795358a-11be6fbc68-199204141&mc_cid=11be6fbc68&mc_eid=b98939f19a
https://www.prostatepedia.net/blogs/prostatepedia/combining-keytruda-pembrolizumab-and-
xtandi
-enzalutamide-for-prostate-cancer?ct=t(EMAIL_CAMPAIGN_1_22_2019_13_29)&goal=0_bc8795358a-11be6fbc68-199204141&mc_cid=11be6fbc68&mc_eid=b98939f19a
TNCanuck
in
Advanced Prostate Cancer
6 years ago
Xtandi causing pain?
Could the
Xtandi
be causing this or cancer progression? Any feedback or suggestions are greatly appreciated. Thank you.
Could the
Xtandi
be causing this or cancer progression? Any feedback or suggestions are greatly appreciated. Thank you.
ann1919
in
Advanced Prostate Cancer
6 years ago
When Is Enough Enough???
In this time he has gone through castration, 50 rounds of radiation (various areas), multiple chemotherapy (Taxotere,
Xtandi
, Radium 223, Jevtana and now back on Taxotere again.
In this time he has gone through castration, 50 rounds of radiation (various areas), multiple chemotherapy (Taxotere,
Xtandi
, Radium 223, Jevtana and now back on Taxotere again.
Jashelby
in
Advanced Prostate Cancer
6 years ago
hmmm....BIRM and PSA ...so far. Still feeling much Better.
BIRM diary PSA 3 weeks BEFORE starting 0.88 with Much Improved Axumin Pet Scan from
Xtandi
/Lupron. **Started BIRM Nov. 15th 2018 Started having more energy and strength right away.
BIRM diary PSA 3 weeks BEFORE starting 0.88 with Much Improved Axumin Pet Scan from
Xtandi
/Lupron. **Started BIRM Nov. 15th 2018 Started having more energy and strength right away.
greatjohn
in
Advanced Prostate Cancer
6 years ago
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