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Xtandi
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Lynparza (olaparib )approved for mCRPC
approved olaparib (Lynparza) for the treatment of adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC) who have progressed following prior treatment with enzalutamide (
Xtandi
approved olaparib (Lynparza) for the treatment of adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC) who have progressed following prior treatment with enzalutamide (
Xtandi
Darryl
Partner
in
Advanced Prostate Cancer
4 years ago
AFIB with Xtandi - Imaging for Colonoscopy?
AFIB with
Xtandi
and Colonoscopy Hi all, 66yo male, diagnosed Nov 2016 with stage 4 aPC and three mets to bone. PSA 80 at time. On Lupron and with
Xtandi
after Lupron lost effectiveness and then Lupron/Casodex did also. Current PSA is 1.21 after two months of Lupron/
Xtandi
.
AFIB with
Xtandi
and Colonoscopy Hi all, 66yo male, diagnosed Nov 2016 with stage 4 aPC and three mets to bone. PSA 80 at time. On Lupron and with
Xtandi
after Lupron lost effectiveness and then Lupron/Casodex did also. Current PSA is 1.21 after two months of Lupron/
Xtandi
.
ppulatie
in
Advanced Prostate Cancer
5 years ago
Muscle pain
Failed
xtandi
, zytiga, and chemo. My primary symptoms affecting my QOL at this time are muscle aches involving my R deltoid, L scapula, and lateral R rib cage. These pains were precipitated by only minor injury, and seem to be taking forever to heal.
Failed
xtandi
, zytiga, and chemo. My primary symptoms affecting my QOL at this time are muscle aches involving my R deltoid, L scapula, and lateral R rib cage. These pains were precipitated by only minor injury, and seem to be taking forever to heal.
Rexwaterbury
in
Advanced Prostate Cancer
5 years ago
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Abiraterone Withdrawal Syndrome - anyone experience it?
I've even seen reports of this occurring with
Xtandi
(see below).
I've even seen reports of this occurring with
Xtandi
(see below).
Tall_Allen
in
Advanced Prostate Cancer
5 years ago
Other questions about MRI scans vs PET/CT
We cost Medicare next to nothing, since we aren't on Zytiga, or
Xtandi
or other expensive treatments. We can't use iodine contrast (he's allergic) and we usually have done an MRI without gadolinium... Can someone help me with information to help convince our doc to do an MRI.
We cost Medicare next to nothing, since we aren't on Zytiga, or
Xtandi
or other expensive treatments. We can't use iodine contrast (he's allergic) and we usually have done an MRI without gadolinium... Can someone help me with information to help convince our doc to do an MRI.
Bluebird11
in
Advanced Prostate Cancer
5 years ago
Help with next steps please
Failed
xtandi
, zytiga, docetaxel. I know hospice is around the corner and we are also waiting phone calls on a couple of immunotherapy trials. My question is there anything left to try at this point?
Failed
xtandi
, zytiga, docetaxel. I know hospice is around the corner and we are also waiting phone calls on a couple of immunotherapy trials. My question is there anything left to try at this point?
Dalipup
in
Advanced Prostate Cancer
5 years ago
Fatigue, Pain & Other Fun Stuff
Since then he’s had casodex, lupron, 6 of taxotere, Zytiga, 9 of cabazitazel + carboplatin,
Xtandi
, Keytruda, 6 more of cabazitazel + carboplatin, 5 days of radiation for pain in his hip, and has had the first of Radium 223.
Since then he’s had casodex, lupron, 6 of taxotere, Zytiga, 9 of cabazitazel + carboplatin,
Xtandi
, Keytruda, 6 more of cabazitazel + carboplatin, 5 days of radiation for pain in his hip, and has had the first of Radium 223.
Luv2fish
in
Advanced Prostate Cancer
5 years ago
Anyone taking Darolutamide develope asthenia, a known side effect? I've read similar SEs with Xtandi, so is this with all lutamide drugs?
My husband, who is mCRPC started Darolutamide 1 month ago. Shortly after, he started to become more weak in his legs, esp his knees. Last week, after taking Darolutamide for 3-1/2 weeks he suddenly developed asthenia (abnormal physical weakness or lack of energy). I had to run out and buy him a walker
My husband, who is mCRPC started Darolutamide 1 month ago. Shortly after, he started to become more weak in his legs, esp his knees. Last week, after taking Darolutamide for 3-1/2 weeks he suddenly developed asthenia (abnormal physical weakness or lack of energy). I had to run out and buy him a walker
JLS1
in
Advanced Prostate Cancer
5 years ago
STREAM. Enzalutamide + ADT with Salvage Radiation in high-risk PSA-recurrent PCa after RP
However, the addition of 6 months of
XTANDI
may change the nature of surviving PCa cells. Half of the men progressed within 3 years. How did prior
XTANDI
use affect their overall survival?
However, the addition of 6 months of
XTANDI
may change the nature of surviving PCa cells. Half of the men progressed within 3 years. How did prior
XTANDI
use affect their overall survival?
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Albumin protein in urine
He takes
Xtandi
. Also has a permanent urine catheter, doctors don't want to operate. He has Parkinson and heart arrhythmia. Has anyone had this before?
He takes
Xtandi
. Also has a permanent urine catheter, doctors don't want to operate. He has Parkinson and heart arrhythmia. Has anyone had this before?
JuanVV
in
Advanced Prostate Cancer
5 years ago
Xtandi v Zytiga v Docetaxel
I have been told I am now Stage 4- PSA doubled in past 2 months from 6-14, T now is 51 after 3rd Lupron shot, with sabbatical to every 6 mos. Onc gave me these 3 options along with Patient Education from Kaiser. After reading about possible side effects, has anyone had experience and suggestions for
I have been told I am now Stage 4- PSA doubled in past 2 months from 6-14, T now is 51 after 3rd Lupron shot, with sabbatical to every 6 mos. Onc gave me these 3 options along with Patient Education from Kaiser. After reading about possible side effects, has anyone had experience and suggestions for
arete1105
in
Advanced Prostate Cancer
5 years ago
Dr says Enzalutimide... what about Cabazitaxel?
Doctor recommends
Xtandi
(enzalutimide). I'm wondering about going back to chemo first with Cabazitaxel.
Doctor recommends
Xtandi
(enzalutimide). I'm wondering about going back to chemo first with Cabazitaxel.
Tak-Druk
in
Advanced Prostate Cancer
5 years ago
What to do next for treatment
My onc put me on
Xtandi
which worked for 7-8 mos but now PSA after going back down to 6.5 it slowly rose to over 22. The two main options he is talking about include a PARP inhibitor the first one is a UCLA trial in conjunction with immunotherapy (Katruda). The other is just the PARP inhibitor.
My onc put me on
Xtandi
which worked for 7-8 mos but now PSA after going back down to 6.5 it slowly rose to over 22. The two main options he is talking about include a PARP inhibitor the first one is a UCLA trial in conjunction with immunotherapy (Katruda). The other is just the PARP inhibitor.
sjpoli46
in
Advanced Prostate Cancer
5 years ago
PSA measures and Chemo
I am continuing with
Xtandi
and Lupron during the chemo.
I am continuing with
Xtandi
and Lupron during the chemo.
Shepard
in
Advanced Prostate Cancer
5 years ago
Paper published about my vaccine treatment
I did have Keytruda added in July, 2018, and did
Xtandi
for almost two years before stopping it a month ago. My SUV barely budged no matter what was added after the initial regression of around 30 tumors so it was collectively agreed that removing my prostate was the best course of action.
I did have Keytruda added in July, 2018, and did
Xtandi
for almost two years before stopping it a month ago. My SUV barely budged no matter what was added after the initial regression of around 30 tumors so it was collectively agreed that removing my prostate was the best course of action.
Fuzzman77
in
Advanced Prostate Cancer
5 years ago
PSA Up During Docetaxel, Scan indicates progression. Determined, Next step??
Or Jetvana vs
XTandi
? Thought it wouldn't be so fast.... he's been so fit, now he still drags himself on his usual route up and down hill, hurts to bend down. MO also will check on pain issue. I admit I'm shook up..... and motivated .... Glad you're here. .....
Or Jetvana vs
XTandi
? Thought it wouldn't be so fast.... he's been so fit, now he still drags himself on his usual route up and down hill, hurts to bend down. MO also will check on pain issue. I admit I'm shook up..... and motivated .... Glad you're here. .....
Barbara345
in
Advanced Prostate Cancer
5 years ago
Why is xtandi so expensive?
Why is
xtandi
so expensive.?
Why is
xtandi
so expensive.?
Bobcat64
in
Advanced Prostate Cancer
5 years ago
Chemo One More Time
Since September 2017, I have had 16 infusions (2 rounds of 6 cycles and most recent round of 4 cycles) of this same treatment, with rechallenges of
Xtandi
in between. Last round and the round beginning tomorrow includes
Xtandi
PLUS chemo combo.
Since September 2017, I have had 16 infusions (2 rounds of 6 cycles and most recent round of 4 cycles) of this same treatment, with rechallenges of
Xtandi
in between. Last round and the round beginning tomorrow includes
Xtandi
PLUS chemo combo.
vandy69
in
Advanced Prostate Cancer
5 years ago
Still confused on next step
MO wants to put me on
Xtandi
. I have had some suggestions including radiation and using MO Kwon’s oligmetestatic protocol and proton therapy. Still on Xgeva which was started with ADT. Any comments or suggestion would be very much appreciated. Thanks
MO wants to put me on
Xtandi
. I have had some suggestions including radiation and using MO Kwon’s oligmetestatic protocol and proton therapy. Still on Xgeva which was started with ADT. Any comments or suggestion would be very much appreciated. Thanks
Bobcat64
in
Advanced Prostate Cancer
5 years ago
Clinical Trial
My PSA is trndinup after 2.5 years on
Xtandi
. One of my doctors s talking to me about a clinical trial called LAE001/ Prednisone with Afuresertib.
My PSA is trndinup after 2.5 years on
Xtandi
. One of my doctors s talking to me about a clinical trial called LAE001/ Prednisone with Afuresertib.
Jrb12
in
Advanced Prostate Cancer
5 years ago
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