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FDA Grants Fast Track Designation to HP518 for AR+ TNBC
The FDA has granted fast track designation to HP518 as a potential therapeutic option for patients with androgen receptor (AR)–positive triple-negative breast cancer (TNBC).1 HP518 is a potent AR PROTAC degrader designed to degrade wild-type AR and AR ligand-binding domain mutations such as L702H.
The FDA has granted fast track designation to HP518 as a potential therapeutic option for patients with androgen receptor (AR)–positive triple-negative breast cancer (TNBC).1 HP518 is a potent AR PROTAC degrader designed to degrade wild-type AR and AR ligand-binding domain mutations such as L702H.
God_Loves_Me
in
Advanced Prostate Cancer
2 months ago
New to Doxil… any one have heart issues?
Hi Ladies- maybe you can help? In just two days, I am due for my 3rd infusion of Doxil… which started out hard but last month was fine. The problem now is that my Apple Watch keeps alarming… well by that I mean it alarms and notifies me each time my heart rate dips below 40 beats per min for 10 solid
Hi Ladies- maybe you can help? In just two days, I am due for my 3rd infusion of Doxil… which started out hard but last month was fine. The problem now is that my Apple Watch keeps alarming… well by that I mean it alarms and notifies me each time my heart rate dips below 40 beats per min for 10 solid
Bettybuckets
in
SHARE Metastatic Breast Cancer
2 months ago
Striving to walk again, more progression, radiation and Trodelvy advice and prayers most welcome.
Hello all! It has been a long time since I posted as my path has been plodding - learning to walk again, discovering even more bone progression, being pulled off Xeloda as it wasn’t working, more radiation and now Trodelvy. The extensive bone mets are making physical therapy a challenge for sure and
Hello all! It has been a long time since I posted as my path has been plodding - learning to walk again, discovering even more bone progression, being pulled off Xeloda as it wasn’t working, more radiation and now Trodelvy. The extensive bone mets are making physical therapy a challenge for sure and
Saltandlight
in
SHARE Metastatic Breast Cancer
2 months ago
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Xeloda coming to an end!
Good morning! I’m posting for mom. Last check mom was er/pr + her 2 low that was last checked July 2023 Mbc 2020 She did ibrance and femara 2 years 9 months Anfintor and Faslodex 6 weeks Xeloda- present for 8 months . Last scans were not terrible. But mild progression in bones with 2 rib
Good morning! I’m posting for mom. Last check mom was er/pr + her 2 low that was last checked July 2023 Mbc 2020 She did ibrance and femara 2 years 9 months Anfintor and Faslodex 6 weeks Xeloda- present for 8 months . Last scans were not terrible. But mild progression in bones with 2 rib
Flower1513
in
SHARE Metastatic Breast Cancer
2 months ago
Second recurrence of ovarian cancer
After surgery and 6 cycles of chemo, I was disease free for a year. With rising ca225, and PET scan showing recurrence had 6 more cycles of chemo. After 8 months of disease free life, my ca has shot upto 42 from 8. My oncologist sats as there is no symptom, let us wait for another month and decide the
After surgery and 6 cycles of chemo, I was disease free for a year. With rising ca225, and PET scan showing recurrence had 6 more cycles of chemo. After 8 months of disease free life, my ca has shot upto 42 from 8. My oncologist sats as there is no symptom, let us wait for another month and decide the
iloveidli
in
My Ovacome
2 months ago
New Mediterranean observational study
Mediterranean Diet Is Associated With Lower All-Cause and Cardiovascular Mortality Among Long-Term Cancer Survivors J Am Coll Cardiol CardioOnc. Jul 02, 2024. Epublished DOI: 10.1016/j.jaccao.2024.05.012 “High adherence to a traditional MD was independently associated with a substantial reduction
Mediterranean Diet Is Associated With Lower All-Cause and Cardiovascular Mortality Among Long-Term Cancer Survivors J Am Coll Cardiol CardioOnc. Jul 02, 2024. Epublished DOI: 10.1016/j.jaccao.2024.05.012 “High adherence to a traditional MD was independently associated with a substantial reduction
Graham49
in
Advanced Prostate Cancer
2 months ago
New Primary cancer
I have stage 4 metastatic breast cancer ER+ and her2 negative and been on Ibrance and letrozole for since December 2023 though I was diagnosed August 2023. Long story that I mentioned in a previous post. I had a recent biopsy of my upper left lung since I have lung mets. The last biopsy I had said it
I have stage 4 metastatic breast cancer ER+ and her2 negative and been on Ibrance and letrozole for since December 2023 though I was diagnosed August 2023. Long story that I mentioned in a previous post. I had a recent biopsy of my upper left lung since I have lung mets. The last biopsy I had said it
monkeygirl62
in
The Roy Castle Lung Cancer Foundation
2 months ago
New Primary cancer
I have stage 4 metastatic breast cancer ER+ and her2 negative and been on Ibrance and letrozole for since December 2023 though I was diagnosed August 2023. Long story that I mentioned in a previous post. I had a recent biopsy of my upper left lung since I have lung mets. The last biopsy I had said it
I have stage 4 metastatic breast cancer ER+ and her2 negative and been on Ibrance and letrozole for since December 2023 though I was diagnosed August 2023. Long story that I mentioned in a previous post. I had a recent biopsy of my upper left lung since I have lung mets. The last biopsy I had said it
monkeygirl62
in
SHARE Metastatic Breast Cancer
2 months ago
Is this decision right for me
I had a PSMA pet scan on 7/16/2024. The result shows a single tumor in my left lung measuring 8mm. My MO wants me to have the tumor radiated and monitor the PSA and its doubling time. A little background, I'm just short of 83 years old. I had prostatectomy in 2009, PSA undetectable until 2017. I had
I had a PSMA pet scan on 7/16/2024. The result shows a single tumor in my left lung measuring 8mm. My MO wants me to have the tumor radiated and monitor the PSA and its doubling time. A little background, I'm just short of 83 years old. I had prostatectomy in 2009, PSA undetectable until 2017. I had
old64horn
in
Advanced Prostate Cancer
2 months ago
mini pill to stop ovulation/ interstitial cystitis or Endo?
Hi all i am on the waiting list for Laparoscopy as I have all the symptoms, plus I have confirmed PCOS from scans- I am 44 so can’t take the combined pill but my mid cycle is horrendous! Bladder pain, rectal pain and bleeding, leg pain and severe pelvic pain more so on left hand side, painful sex, nausea
Hi all i am on the waiting list for Laparoscopy as I have all the symptoms, plus I have confirmed PCOS from scans- I am 44 so can’t take the combined pill but my mid cycle is horrendous! Bladder pain, rectal pain and bleeding, leg pain and severe pelvic pain more so on left hand side, painful sex, nausea
SJ0514
in
Endometriosis UK
1 year ago
AS is over:-(
On second biopsy GG 2 lesion found. :-( Thoughts welcome on next steps. ----------Biopsy results----------------------------------------- A. Right Apex Prostate: Needle Core Biopsy: Benign prostatic tissue B. Right Mid Prostate: Needle Core Biopsy: Benign prostatic tissue C. Right Base
On second biopsy GG 2 lesion found. :-( Thoughts welcome on next steps. ----------Biopsy results----------------------------------------- A. Right Apex Prostate: Needle Core Biopsy: Benign prostatic tissue B. Right Mid Prostate: Needle Core Biopsy: Benign prostatic tissue C. Right Base
witantric
in
Fight Prostate Cancer
2 months ago
plural effusion
I nave plural effusion in my left lung metastasis from ovarian cancer. I had a surgery last September 23 with WATS. Now I’m on strong chemo but this plural effusion is the same. I had five line of carboplatin, Bevacizumab, zentabun. Noting helps. I will try 3-4 more and if it’s not change I will stop
I nave plural effusion in my left lung metastasis from ovarian cancer. I had a surgery last September 23 with WATS. Now I’m on strong chemo but this plural effusion is the same. I had five line of carboplatin, Bevacizumab, zentabun. Noting helps. I will try 3-4 more and if it’s not change I will stop
Green999
in
My Ovacome
2 months ago
Mays Cancer Center seeks HCC survivors/caregivers in South Texas
The
Mays Cancer Center
would like to speak with survivors and caregivers of cervical cancer,
liver cancer
, and pediatric leukemia
[i]
living in South Texas
[/i]
to identify, describe, and reflect on experiences around the delivery of care, care needs, and participating
The
Mays Cancer Center
would like to speak with survivors and caregivers of cervical cancer,
liver cancer
, and pediatric leukemia
[i]
living in South Texas
[/i]
to identify, describe, and reflect on experiences around the delivery of care, care needs, and participating
AndreaWilson_Founder
Caregiver
in
Blue Faery Liver Cancer
2 months ago
results of nail biopsy
At the end of last week I got my results of my nail biopsies. It is no fungus, no infection and best of all no cancer. They do not know what it actually is despite using numerous tests. A very happy outcome, as all medics seen in the process suspected subungual melanoma. I can live with not knowing
At the end of last week I got my results of my nail biopsies. It is no fungus, no infection and best of all no cancer. They do not know what it actually is despite using numerous tests. A very happy outcome, as all medics seen in the process suspected subungual melanoma. I can live with not knowing
artydutch
in
MPN Voice
2 months ago
MRI prior to HDR Brachy and HDR intensity.
Hi Friends, Hey, I'm doing well to date in coping with HT and have just had 10 of my 23 VMAT radiation sessions. So far so good. BUT recently I was told that the radiation sessions are nothing compared to the "Brutal" HDR Brachy Boost I am having in mid-August. That wasn't what I wanted to hear, so
Hi Friends, Hey, I'm doing well to date in coping with HT and have just had 10 of my 23 VMAT radiation sessions. So far so good. BUT recently I was told that the radiation sessions are nothing compared to the "Brutal" HDR Brachy Boost I am having in mid-August. That wasn't what I wanted to hear, so
Mike58
in
Advanced Prostate Cancer
2 months ago
Help deciding on treatment
Discovered this forum a month ago and have found it to be a wealth of information, with very educated/informed members. Hoping that you can spread some of your wisdom and help my finalize my decision with treatment. I've posted more details in my profile as well as write ups from MSKCC on my Biopsy
Discovered this forum a month ago and have found it to be a wealth of information, with very educated/informed members. Hoping that you can spread some of your wisdom and help my finalize my decision with treatment. I've posted more details in my profile as well as write ups from MSKCC on my Biopsy
MrGreenJeans
in
Prostate Cancer Network
2 months ago
Any Herceptin / Prejeta long term survivors? I really need to hear from you.
The death of Shannon Doherty has made me think about my own journey. It is not like I was a huge fan, but she was diagnosed with MBC the same time as I was- Feb 2020. so I have followed her and her open dialogue about her cancer. Her death of course has made me go to the darkest of places.I have been
The death of Shannon Doherty has made me think about my own journey. It is not like I was a huge fan, but she was diagnosed with MBC the same time as I was- Feb 2020. so I have followed her and her open dialogue about her cancer. Her death of course has made me go to the darkest of places.I have been
Onedayatatime60
in
SHARE Metastatic Breast Cancer
2 months ago
Please join us Tuesday, July 16th, for our Living Room discussion on The Best of ASCO 2024!
Hello, Please join us in our San Carlos office Tuesday July 16th in person or if you don’t live in the area, you can join us virtually on GO2's YouTube Live channel. We are thrilled to have Dr. Roy S.Herbst, MD, Yale Cancer Center. Learn about the new discoveries and clinical advancements shared
Hello, Please join us in our San Carlos office Tuesday July 16th in person or if you don’t live in the area, you can join us virtually on GO2's YouTube Live channel. We are thrilled to have Dr. Roy S.Herbst, MD, Yale Cancer Center. Learn about the new discoveries and clinical advancements shared
Michelezeh
Administrator
in
Lung Cancer Support
3 months ago
MBC and diet
Hi everyone I was first diagnosed with BC in 2000. I had a recurrence (2nd primary) 17 years later. 6 years later I was diagnosed with MBC. I had a small tumor present in my dermis at the masectomy scar sight. They followed with surgery (a lumpectomy to the reconstructed breast and targeted radiation
Hi everyone I was first diagnosed with BC in 2000. I had a recurrence (2nd primary) 17 years later. 6 years later I was diagnosed with MBC. I had a small tumor present in my dermis at the masectomy scar sight. They followed with surgery (a lumpectomy to the reconstructed breast and targeted radiation
CalGal56
in
SHARE Metastatic Breast Cancer
3 months ago
Buprenorphine
Hello, have many UK people found it easy or hard to get Buprenorphine px by GP to control pain from RLS? I have been withdrawing from Pramepexole and using only codeine however it is now not effective in controlling my pain. I have a GP appointment in a few days and was going to ask for Buprenorphine
Hello, have many UK people found it easy or hard to get Buprenorphine px by GP to control pain from RLS? I have been withdrawing from Pramepexole and using only codeine however it is now not effective in controlling my pain. I have a GP appointment in a few days and was going to ask for Buprenorphine
Cookiebum24
in
Restless Legs Syndrome
6 months ago
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